Experimental Bacteremic Vascular Graft Infection with Staphylococcus aureus. Comparative Colonization of Two Graft Materials and Prophylaxis of Late Infection
In a dog model reproducing colonization of a vascular graft through an experimental bacteremia caused by Staphylococcus aureus, Dacron grafts were more colonized than ePTFE grafts for durations of graft function of 2 hours up to 2 months, while at 6 months the inverse trend was observed, both material being still more susceptible than normal aortas. A single injection of ceftriaxone 90 minutes before the bacteremic challenge completely prevented late graft infection.
KeywordsHPLC Agar Bacillus Palladium Fibrinogen
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