Summary
Infection of metallic devices is one of the major complications of orthopaedic surgery. The role of host proteins, such as f ibronectin (Fn), in promoting adherence of Staphylococcus aureus and Staphylococcus epidermidis onto metallic surfaces used in orthopaedic surgery, is still not clear. Pure Fn was deposited on 0.64 cm2 coverslips made of either stainless steel, pure titanium or titanium-aluminium-niobium (TAN). First results showed that adherence of two strains of Staphylococcus aureus and one of Staphylococcus epidermidis was significantly increased over albumin-coated controls in the following order: steel<pure titanium<TAN. Similar results were observed with coverslips implanted during 4 weeks in the subcutaneous space of guinea pigs and tested ex-vivo.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Fuller RA, Rosen JJ. Materials for medicine. Scientif Amer 255: 118–125, 1986.
Dankert J, Hogt AH, Feijen J. Biomedical polymers: bacterial adhesion, colonization and infection. CRC Critical Rev Biocompatib 2: 219–301, 1986.
Hirshman HP, Schurm an DJ. Deep infections following total hip replacement. In: Remington JS, Swartz MS (ed). Current clinical topics in infectious diseases, Mc Graw-Hill Book Co, New York: 206–217, 1982.
Inman RD, Gallegos KV, Brause BD, Redecha PD, Christian CL. Clinical and microbial features of prosthetic joint infection. Am J Med 77: 47–53, 1984.
Waldvogel FA, Vasey H. Osteomyelitis: the past decade. New Engl J Med 303: 360–370, 1980.
Salvati EA, Brause BD. Infection of Orthopaedic Prostheses. In: Schlossberg D (ed). Orthopaedic Infection, Springer-Verlag, New-York: 133–144, 1988.
Zimmerli W, Waldvogel FA, Vaudaux P, Nydegger UE. Pathogenesis of foreign body infection: description and characteristics of an animal model. J Infect Dis 146: 487–497, 1982.
Vaudaux P, Suzuki R, Waldvogel FA, Morgenthaler JJ, Nydegger UE. Foreign body infection: role of fibronectin as a ligand for the adherence of Staphylococcus aureus. J Infect Dis 150: 546–553, 1984.
Vaudaux P, Waldvogel FA, Morgenthaler JJ, Nydegger UE. Adsorption of fibronectin onto polymethylmethacrylate and promotion of Staphylococcus aureus adherence. Infect Immun 45: 768–774, 1984.
Falcieri E, Vaudaux P, Huggler E, Lew PD, Waldvogel FA. Role of bacterial exopolymers and host factors on adherence and phagocytosis of Staphylococcus aureus in foreign body infection. J Infect Dis 155: 524–531, 1987.
Collins WE, Mosher DF, Diwan AR, Murthy KD, Simmons SR, Albrecht RM, Cooper SL. Ex vivo platelet deposition on fibronectin-preadsorbed surfaces. Scanning Microscopy 1: 1669–1676, 1987.
Descouts P, Emch R, Niedermann Ph, Fischer O. Scanning Tunneling Microscopy at the University of Geneva. H.P.A. 61: 579–587, 1988.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Springer-Verlag London Limited
About this chapter
Cite this chapter
Delmi, M., Vaudaux, P., Descouts, P., Lew, P.D., Vasey, H. (1990). Role of Fibronectin on Staphylococcal Adherence to Metallic Surfaces Used as Models of Orthopaedic Devices. In: Wadström, T., Eliasson, I., Holder, I., Ljungh, Å. (eds) Pathogenesis of Wound and Biomaterial-Associated Infections. Springer, London. https://doi.org/10.1007/978-1-4471-3454-1_42
Download citation
DOI: https://doi.org/10.1007/978-1-4471-3454-1_42
Publisher Name: Springer, London
Print ISBN: 978-3-540-19596-2
Online ISBN: 978-1-4471-3454-1
eBook Packages: Springer Book Archive