Adherence of Staphylococcus aureus to Hep2 Monolayers and Fibronectin

  • J. Zoe Jordens


Clinical isolates of the “epidemic” methicillin-resistant Staphy-lococcus aureus (EMRSA-1) and methicillin-susceptible Staphylococcus aureus (MSSA) were compared for their ability to bind to human epithelial cells (HEp2) and fibronectin by radiometric assays. EMRSA-1 adhered significantly less to HEp2 monolayers and to fibronectin than MSSA (P<0.01). The decreased binding capacity of this MRSA strain may be an important factor in its virulence.


Staphylococcus Aureus HEp2 Cell Human Epithelial Cell Hosp Infection Radiometric Assay 
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  1. 1.
    Marples RR, Cooke EM. Current problems with methicillin-resistantStaphylococcus aureus. J Hosp Infection 11: 381 - 392, 1988.CrossRefGoogle Scholar
  2. 2.
    Duckworth GJ, Lothian JLE, Williams JD. Methicillinresistant Staphylococcus aureus: report of an outbreak in a London teaching hospital. J Hosp Infection 11: 1 - 15, 1988.CrossRefGoogle Scholar
  3. 3.
    Wadström T. Molecular aspects on pathogenesis of wound and foreign body infections due to staphylococci. Zbl Bakt Hyg A 266: 191 - 211, 1987.Google Scholar
  4. 4.
    Lee DA, Hoidal JR, Clawson CC, Quie PG, Peterson PK. Phagocytosis by polymorphonudear leukocytes of Staphylococcus aureus and Pseudomonas aeruginosa adherent to plastic, agar or glass. J Immunological Methods 63: 103 - 114, 1983.CrossRefGoogle Scholar

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© Springer-Verlag London Limited 1990

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  • J. Zoe Jordens

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