Skip to main content
SpringerLink
Log in

Experimental Orthopaedic Infections

  • Chapter
Pathogenesis of Wound and Biomaterial-Associated Infections

  • 358 Accesses

Summary

Staphylococcus aureus is the most common known microorganism to cause osteomyelitis, and also the most widely used microorganism in experimental animal models to study these infections. However Pseudomonasaeruginosa, Escherichia coli, and Bacteroidesfragilis have been used as well. In general, results obtained from the animal models, i.e., mainly the rabbit model, using a sclerosing agent, have contributed to our present knowledge of these diseases. In spite of this, further studies of the pathomechanisms of various bacteria and anatomic locations in relation to treatment need to be performed in order to understand better how osteomyelitis developes and how treatment can be improved.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Andriole VT, Nagel DA, Southwick WO. A paradigm for human chronic osteomyelitis. J Bone Joint Surg 55A: 1511–15, 1973.

    Google Scholar 

  2. Blomgren G, Lindgren U. The susceptibility of total joint replacement to hematogenous infection in the early postoperative period: An experimental study in the rabbit. Clin Orthop 151: 308–312, 1980.

    Google Scholar 

  3. Blomgren G, Lundquist H, Nord CE, Lindgren U. Late anaerobic hematogenous infection of experimental total joint replacement. A study in the rabbit using Propionibacterium aines. J Bone Joint Surg 63B: 614–8, 1981.

    Google Scholar 

  4. Blomgren G, Lindgren U. Late hematogenous infection in total joint replacement: Studies of gentamicin and bone cement in the rabbit. Clin Orthop 155: 244–48, 1981.

    Google Scholar 

  5. Dekel S, Francis MJO. The treatment of osteomyelitis of the tibia with sodium salicylate: an experimental study in rabbits. J Bone Joint Surg 63B: 178–84, 1981.

    Google Scholar 

  6. Desplaces N, Acar JF. New quin ol ones in the treatment of joint and bone infections. Rev Infect Dis 10 (suppl 1): S179–83, 1988.

    Article  Google Scholar 

  7. Deysine M. Acute hematogenous osteomyelitis: An experimental model. Surg 79: 97–99, 1976.

    Google Scholar 

  8. Deysine M, Rafkin H, Russell R, Teicher I, Aufses AH. The detection of acute experimental osteomyelitis with 67Ga citrate scannings. Surg Gynecol Obstet 141: 40–42, 1975.

    Google Scholar 

  9. Eitenmiiller J, Schmidt KH, Peters G, Gellissen G, Weltin R, Reichmann W. Experimental and preliminary clinical experience with absorbable calcium phosphate granules containing an antibiotic or antiseptic for the local treatment of osteomyelitis. J Hosp Inf 6 (suppl): 177–84, 1985.

    Article  Google Scholar 

  10. Emslie KR, Nade S. Pathogenesis and treatment of acute hematogenous osteomyelitis: Evaluation of current views with reference to an animal model. Rev Infect Dis 8: 841–49, 1986.

    Article  Google Scholar 

  11. Fitzgerald RH. Experimental osteomyelitis: Description of a canine model and the role of depot administration of antibiotics in the prevention and treatment of sepsis. J Bone Joint Surg 65A: 371–80, 1983.

    Google Scholar 

  12. Jacob E, Arendt DM, Brook I, Durham LC, Falk MC, Schaberg SJ. Enzyme-linked immunosorbent assay for detection of antibodies to Staphylococcus aureus cell walls in experimental osteomyelitis. J Clin Microbiol 22: 547–52, 1985.

    Google Scholar 

  13. Johansson A, Svensson O, Blomgren G, Nord CE. Anaerobic osteomyelitis. A novel experimental rabbit model. Annual Meeting, Swedish Orthopaedic Society, May, 1989.

    Google Scholar 

  14. Kamme C, Lidgren L, Lindberg L, Mârdh P-A. Anaerobic bacteria in late infections after total hip arthroplasty. Scand J Infect Dis 6: 161–165, 1974.

    Google Scholar 

  15. Kam me C, Lindberg L. Aerobic and anaerobic bacteria in deep infections after total hip arthroplasty. Differential diagnosis between infectious and non-infectious loosening. Clin Orthop 154: 201–07, 1981.

    Google Scholar 

  16. Kaps HP, Georgi P. Die Leukocytenszintigraphie mit I1llndium bei akuter and chronischer Osteomyelitis im Tiermodell–Eine experimentelle Studie. Nud Med 25: 61–70, 1986.

    Google Scholar 

  17. Köndell PA, Granström M, Heimdahl A, Möllby R, Nord CE. Experimental mandibular Staphylococcus aureus osteomyelitis; antibody response and treatment with dicloxacillin Int J Oral Maxillofac Surg 15: 620–28, 1986.

    Google Scholar 

  18. LaMont JT, Sonnenblick EB, Rothman S. Role of clostridial toxin in the pathogenesis of clindamydn colitis in rabbits. Gastroenterology 70: 356–61, 1979.

    Google Scholar 

  19. Lexer E. Zur experimentellen Erzeugung osteomyelitischer Herde. Arch Klin Chir 48: 181–200, 1894.

    Google Scholar 

  20. Lexer E. Experimente uber Osteomyelitis. Arch Klin Chir 53: 266–77, 1896.

    Google Scholar 

  21. Mader JT. Animal models of osteomyelitis. Am J Med 78: 213–17, 1985.

    Article  Google Scholar 

  22. Norden CW, Kennedy E. Experimental osteomyelitis I. A description of the model. J Infect Dis 122: 410–18, 1970.

    Article  Google Scholar 

  23. Norden CW. Lessons learned from animal models of osteomyelitis. Rev Infect Dis 10: 103–10, 1988.

    Article  Google Scholar 

  24. Passl R, Muller C, Zielinski CC, Eibl MM. A model of experimental post-traumatic osteomyelitis in guinea pigs. J Trauma 24: 323–26, 1984.

    Article  Google Scholar 

  25. Rissing JP, Buxton TB, Weinstein RS, Shockley RK. Model of experimental chronic osteomyelitis in rats. Infect Immun 47: 581–86, 1985.

    Google Scholar 

  26. Rissing JP, Buxton TB, Fisher J, Harris R, Shockley RK. Arachidonic acid facilitates experimental chronic osteomyelitis in rats. Infect Immun 49: 141–44, 1985.

    Google Scholar 

  27. Rissing JP, Buxton TB, Horner JA, Shockley RK, Fisher JF, and Harris R. Synergism between Bacteroides fragilis and Staphylococcus aureus in experimental tibial osteomyelitis. Journal of Lab Clin Med 110: 433–438, 1987.

    Google Scholar 

  28. Rissing JP, Buxton TB. Effect of ibuprofen on gross pathology, bacterial count, and levels of prostaglandin E2 in experimental staphylococcal osteomyelitis. J Infect Dis 154: 627–30, 1986.

    Article  Google Scholar 

  29. Rodet A. Étude expérimentale sur l’ostéomyélite infectieuse. Compt rend Acad sci 99: 569–71, 1884.

    Google Scholar 

  30. Scheman L, Janota M, Lewin P. The production of experimental osteomyelitis. JAMA 117: 1525–29, 1941.

    Article  Google Scholar 

  31. Wakahara K. Studies on bone infections induced by non-spore-forming anaerobic bacteria. Clinical investigation and an experimental osteomyelitis. Nippon Sekeigeka Gakkai Zasshi 55: 665–79, 1981.

    Google Scholar 

  32. Whalen JL, Fitzgerald RH, Morrissy RT. A histological study of acute hematogenous osteomyelitis following physeal injuries in rabbits. J bone Joint Surg 70A: 138–392, 1988.

    Google Scholar 

  33. Worlock P, Slack R, Harvey L, Mawhinney R. An experimental model of post-traumatic osteomyelitis in rabbits. B J Exp Path 69: 235–44, 1988.

    Google Scholar 

  34. Zak O, Zak F, Rich R, Tosch W, Kradolfer F, Scheld WM. Experimental staphylococcal osteomyelitis in rats: Therapy with rifampicin and cloxacillin alone or in combination. In: Periti P, Grassi GG, eds. Current chemotherapy and immunotherapy. Washington: American Society for Microbiology 973–4, 1982.

    Google Scholar 

Download references

Authors
  1. Åke Johansson
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Olle Svensson
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Carl Erik Nord
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Medical Microbiology, University of Lund, POB 117, S-22100, Lund, Sweden

    Torkel Wadström PhD (Professor) & Åsa Ljungh PhD (Assistant Professor) (Professor) &  (Assistant Professor)

  2. Department Medical Microbiology, Sölvegaten 23, S-23362, Lund, Sweden

    Ingvar Eliasson PhD

  3. Burns Institute, Shriners Hospital, Cincinnati, Ohio, USA

    Ian Holder PhD

Rights and permissions

Reprints and permissions

Copyright information

© 1990 Springer-Verlag London Limited

About this chapter

Cite this chapter

Johansson, Å., Svensson, O., Nord, C.E. (1990). Experimental Orthopaedic Infections. In: Wadström, T., Eliasson, I., Holder, I., Ljungh, Å. (eds) Pathogenesis of Wound and Biomaterial-Associated Infections. Springer, London. https://doi.org/10.1007/978-1-4471-3454-1_31

Download citation

  • DOI: https://doi.org/10.1007/978-1-4471-3454-1_31

  • Publisher Name: Springer, London

  • Print ISBN: 978-3-540-19596-2

  • Online ISBN: 978-1-4471-3454-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation