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Biomaterial-Centered Infections: Microbial Adhesion versus Tissue Integration

  • Chapter
Pathogenesis of Wound and Biomaterial-Associated Infections

Summary

Microorganisms in nature and disease are dependent on substra-tum attachment for optimal growth and development. Similarly, implanted biomaterials tend to potentiate bacteria on their surfaces so that normally friendly organisms become virulent pathogens. Virulence is also enhanced because both bacteria and biomaterials interfere with host defense mechanisms. Infections centered on biomaterials are difficult to eliminate and usually require removal of the device. The consequences of infection are catastrophic and costly. The specific nature of a biomaterial surface, which is not directly related to bulk characteristics, changes in bacterial behavior resulting in virulence.

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  1. Anthony G. Gristina
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  2. Paul T. Naylor
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  3. Quentin N. Myrvik
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Editors and Affiliations

  1. Department of Medical Microbiology, University of Lund, POB 117, S-22100, Lund, Sweden

    Torkel Wadström PhD (Professor) & Åsa Ljungh PhD (Assistant Professor) (Professor) &  (Assistant Professor)

  2. Department Medical Microbiology, Sölvegaten 23, S-23362, Lund, Sweden

    Ingvar Eliasson PhD

  3. Burns Institute, Shriners Hospital, Cincinnati, Ohio, USA

    Ian Holder PhD

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© 1990 Springer-Verlag London Limited

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Gristina, A.G., Naylor, P.T., Myrvik, Q.N. (1990). Biomaterial-Centered Infections: Microbial Adhesion versus Tissue Integration. In: Wadström, T., Eliasson, I., Holder, I., Ljungh, Å. (eds) Pathogenesis of Wound and Biomaterial-Associated Infections. Springer, London. https://doi.org/10.1007/978-1-4471-3454-1_25

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  • DOI: https://doi.org/10.1007/978-1-4471-3454-1_25

  • Publisher Name: Springer, London

  • Print ISBN: 978-3-540-19596-2

  • Online ISBN: 978-1-4471-3454-1

  • eBook Packages: Springer Book Archive

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