Fibronectin-Substituted Gels for Treatment of Experimental Wound Infections in a Pig Model
Thermal injuries were induced on the back of young pigs. After two to three days each wound was inoculated with 109 to 5×109 Staphylococcus aureus cells. The wounds were covered by an occlusive wound dressing for 3 days and then treated for 5 days with daily changes of dressing. In wounds treated with fibronectin-substituted Sepharose 6B or DEAE-Sephadex there was a significant decrease in the bacterial count on the third day compared to wounds treated with unsubstituted gels. On the fourth day of treatment these wounds showed young granulation tissue throughout dermis whereas wounds treated with unsubstituted gels still presented as an acute inflammation. Macroscopically, wounds treated with fibronectin-substituted gels healed more rapidly than control wounds.
KeywordsBacterial Count Cell Surface Hydrophobicity Wound Dressing Epidermal Wound Healing Quantitative Bacterial Culture
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