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Summary

Animals models have been developed which seek to 1) investigate skin colonization with pathogens 2) mimic skin and wound infections 3) provide a mechanism for the study of virulence determinants in the infectious process 4) determine the efficacy of anti-infective agents and 5) investigate pathogens under in vivo conditions.

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References

  1. Kinsman O. Models for staphylococcal colonization and skin infections. In experimental models; in Antimicrobial Chemotherapy Vol 2: 133–46, Academic Press Inc (London) 1986.

    Google Scholar 

  2. James RC, MacLeod CJ. Induction of staphylococcal infections in mice with small inocula introduced on sutures. Br J Exp Pathol 42: 266 – 77, 1961.

    Google Scholar 

  3. Goldschmidt F. Reproducible topical staphylococcal infection in rats. Appl Microb 23: 130 – 34, 1972.

    Google Scholar 

  4. Boon RJ, Beale AS, Sutherland R. Efficacy of topical mupirocin against an experimental Staphylococcus aureus surgical wound infection. J Antimicrob Che-mother 16: 519 – 26, 1985.

    Article  Google Scholar 

  5. Noble WC. The production of subcutaneous staphylococcal lesions in mice. Br J Exp Pathol 46: 254 – 62, 1965.

    Google Scholar 

  6. Taubier JH, Kapral FA, Mudd S. Role of alpha toxin in lesion formation by Staphylococcus aureus on sutures subcutaneously implanted in mice. J Bacteriol 86: 51 – 57, 1963.

    Google Scholar 

  7. Kinsman O. A review of mouse models of staphylococcal colonization and infection. In: Experimental bacterial and parasitic infections 65–73, Elsevier, 1983.

    Google Scholar 

  8. Patel AH, Nowlan P, Weavers ED, Foster T. Virulence of protein A-deficient mutants of Staphylococcus aure-us by allele replacement. Infect Immun 12: 3103 – 10, 1987.

    Google Scholar 

  9. Shibl AM. Subcutaneous staphylococcal infections in mice: the influence of antibiotics on extracellular products. Chemother 28: 46 – 53, 1982.

    Article  Google Scholar 

  10. De Azavedo JCS, Russell RJ. A simple method for study of bacterial characteristics and growth in vivo. Immunochemical and molecular genetic analysis of bacterial pathogens. Ed. P Owen, TJ Foster, Elsevier, 1988.

    Google Scholar 

  11. Gladstone GP, Glencross EJG. Growth and toxin production of staphylococci in cellophane sacs in vivo. Br J Exp Pathol 41: 313 – 33, 1960.

    Google Scholar 

  12. Lam GT, Sweeney FJ, Witner CM, Wise RI. Abscess forming factors produced by Staphylococcus aureus I. Colloidin bag implantation technique. J Bacteriol 86: 611 – 15, 1963.

    Google Scholar 

  13. Veale DR, Smith H, Witt K, Marshall RB. Differential ability of colonial type of Neisseria gonorrhoea to pro-duce infection and an inflammatory response in subcutaneous perforated plastic chambers in guinea pigs and rabbits. J Med Microbiol 8: 325 – 35, 1975.

    Article  Google Scholar 

  14. Arko RJ. Neisseria gonorrhoeae experimental infection of laboratory animals. Sci 177: 1200 – 01, 1972.

    Article  Google Scholar 

  15. Knoll I-I, Holm SE, Gerlash D, Kuhnemund O, Kohler W. Tissue cages for study of experimental streptococcal infection in rabbits. II Humoral and cell mediated immune responses to erythrogenic toxins. Immunobiol 169: 116 – 27, 1985.

    Article  Google Scholar 

  16. Davey PG, Barza M, Stuart M. Tolerance of Pseudo-monas aeruginosa to killing by ciprofloxacin, gentamicin and imipenem in vitro and in vivo. J Antimicrob Chemother 21: 395 – 404, 1988.

    Article  Google Scholar 

  17. Day SEJ, Vasti KK, Russell RJ, Arbuthnott JP. A simple method for the study in vivo of bacterial growth and accompanying host response. J Infect 2: 39 – 51, 1980.

    Article  Google Scholar 

  18. De Azavedo JCS, Foster TJ, Hartigan PJ, Arbuthnott JP, O'Reilly M, Kneisworth B, Novick RP. Expression of the cloned toxic shock syndrome toxin I gene TST in vivo with a rabbit uterine model. Infect Immun 50: 304 – 9, 1985.

    Google Scholar 

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© 1990 Springer-Verlag London Limited

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Kinsman, O.S., Arbuthnott, J.P. (1990). Pathogenesis of skin and wound infections. Animal models. In: Wadström, T., Eliasson, I., Holder, I., Ljungh, Å. (eds) Pathogenesis of Wound and Biomaterial-Associated Infections. Springer, London. https://doi.org/10.1007/978-1-4471-3454-1_14

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  • DOI: https://doi.org/10.1007/978-1-4471-3454-1_14

  • Publisher Name: Springer, London

  • Print ISBN: 978-3-540-19596-2

  • Online ISBN: 978-1-4471-3454-1

  • eBook Packages: Springer Book Archive

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