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The 4-Quinolones: Anti Bacterial Agents in Vitro pp 115–146Cite as

Structure-Activity Relationships of Fluoro-4-Quinolones

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Part of the book series: Springer Series in Applied Biology ((SSAPPL.BIOLOGY))

Abstract

The quinolone anti-infective field is now more than twenty years old and several thousand agents have been prepared from which to assemble generalizations connecting structure and activity. This is still a somewhat risky activity as this field all too often throws up an analog which does not fit the classic pattern and yet has excellent activity. Successfully rationalizing such a discovery often teaches us more than the addition of several more typical examples. The establishment of an incorrect orthodoxy by over interpretation of evidence inhibits such liberating discovery and narrows the scope of investigation. Nonetheless, a periodic critical examination of the cumulative experience in the field is essential in planning new work. In this review the primary emphasis will be on the fluoroquinolones of greatest contemporary interest and on the analogs which do not fit comfortably with the rest.

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Authors
  1. L. A. Mitscher
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  2. P. V. Devasthale
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  3. R. M. Zavod
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Editor information

Editors and Affiliations

  1. Department of Biology, University of York, York, YO1 5DD, UK

    Geoff C. Crumplin

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© 1990 Springer-Verlag London Limited

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Mitscher, L.A., Devasthale, P.V., Zavod, R.M. (1990). Structure-Activity Relationships of Fluoro-4-Quinolones. In: Crumplin, G.C. (eds) The 4-Quinolones: Anti Bacterial Agents in Vitro. Springer Series in Applied Biology. Springer, London. https://doi.org/10.1007/978-1-4471-3449-7_9

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  • DOI: https://doi.org/10.1007/978-1-4471-3449-7_9

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-3451-0

  • Online ISBN: 978-1-4471-3449-7

  • eBook Packages: Springer Book Archive

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