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Pulmonary Hemorrhage Syndromes

  • Chapter
Diffuse Lung Disorders

Abstract

Diffuse pulmonary hemorrhage (DPH) is a syndrome defined by the clinical triad of hemoptysis, iron-deficiency anemia and transient diffuse acinar infiltrates on chest radiography [1–3]. Widespread damage of the alveolar-capillary lining leads to extensive hemorrhage from the pulmonary vasculature. DPH is caused by a heterogeneous group of disorders including Goodpasture’s syndrome, idiopathic pulmonary hemosiderosis, rapidly progressive glomerulonephritis, chemical-and drug-induced lung injury, coagulopathies, mitral stenosis and necrotizing pulmonary infections. This syndrome must be distinguished from localized alveolar hemorrhage with secondary spread of blood as seen with thromboembolism, chronic bronchitis, bronchiectasis, pneumonia and tumor [2].

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References

  1. Muller NL, Miller RR (1991) Diffuse pulmonary hemorrhage. Radiol Clin North Am 29: 965–71.

    PubMed  CAS  Google Scholar 

  2. Primack SL, Miller RR, Muller NL (1995) Diffuse pulmonary hemorrhage: Clinical, pathologic, and imaging features. AJR 164: 295–300.

    Google Scholar 

  3. Green RJ, Ruoss SJ, Kraft SA et al. (1996) Pulmonary capillaritis and alveolar hemorrhage. Chest 110: 1305–16.

    Article  PubMed  CAS  Google Scholar 

  4. Schwarz MI, Cherniack RM, King TE (1994) Diffuse alveolar hemorrhage and other rare infiltrative dis-orders. In: Murray JF, Nadel JA (eds) Textbook of respiratory medicine, 2nd edn. WB Saunders Co., Philadelphia, pp. 1889–912.

    Google Scholar 

  5. Greening AP, Hughes JMB (1981) Serial estimations of carbon monoxide diffusing capacity in intrapul- monary haemorrhage. Clin Sei 60: 507–12.

    CAS  Google Scholar 

  6. Perez-Arellano JL, Garcia JEL, Macias MCG et al. (1992) Hemosiderin-laden macrophages in bronchoalveolar lavage fluid. Acta Cytologica 36: 26–30.

    PubMed  CAS  Google Scholar 

  7. Abelda SM, Gefter WB, Epstein DM et al. (1985) Diffuse pulmonary hemorrhage: A review and classification. Radiology 154: 289–97.

    Google Scholar 

  8. Marasco WJ, Fishman EK, Kuhlman JE et al. (1993) Acute pulmonary hemorrhage. CT evaluation. Clin Imaging 17: 77–80.

    Article  PubMed  CAS  Google Scholar 

  9. Kelly PT, Haponik EF (1994) Goodpasture’s syndrome: molecular and clinical advances. Medicine 73: 171–85.

    Article  PubMed  CAS  Google Scholar 

  10. Gunwar S, Bejarano PA, Kalluri R et al. (1991) Alveolar basement membrane: molecular properties of the noncollagenous domain (hexamer) of colla-gen IV and its reactivity with Goodpasture autoantibodies. Am J Respir Cell Mol Biol 5: 107–12.

    PubMed  CAS  Google Scholar 

  11. Kalluri R, Melendez E, Rumpf KW et al. (1996) Specificity of circulating and tissue-bound autoantibodies in Goodpasture’s syndrome. Proc Assoc Am Physicians 108: 134–9.

    PubMed  CAS  Google Scholar 

  12. Turner N, Mason PJ, Brown R et al. (1992) Molecular cloning of the human Goodpasture antigen demonstrates it to be the 3 chain of type IV collagen. J Clin Invest 89: 592–601.

    Article  PubMed  CAS  Google Scholar 

  13. Hudson BG, Kalluri R, Gunwar S et al. (1993) Molecular characteristics of the Goodpasture autoantigen. Kidney Int 43: 135–9.

    Article  PubMed  CAS  Google Scholar 

  14. Jennings L, Roholt OA, Pressman D et al. (1981) Experimental anti-alveolar basement membrane antibody-mediated pneumonitis. The role of increased permeability of the alveolar capillary wall induced by oxygen. J Immunol 127: 129–34.

    PubMed  CAS  Google Scholar 

  15. McPhaul JJ, Mullins JD (1976) Glomerulonephritis mediated by antibody to glomerular basement membrane: Immunologic, clinical and histopathological characteristics. J Clin Invest 57: 351–61.

    Article  PubMed  Google Scholar 

  16. Peces R, Riera JR, Arboleya LR et al. (1997) Goodpasture’s syndrome in a patient receiving penicillamine and Carbimazole. Nephron 45: 316–20.

    Article  Google Scholar 

  17. Sternlieb I, Bennett B, Scheinberg IH (1975) D- penicillamine induced Goodpasture’s syndrome in Wilson’s disease. Ann Intern Med 82: 673–6.

    PubMed  CAS  Google Scholar 

  18. Beirne GJ, Brennan JT (1972) Glomerulonephritis associated with hydrocarbon solvents. Arch Environ Health 25: 365–9.

    PubMed  CAS  Google Scholar 

  19. Bombassei GJ, Kaplan AA (1992) The association between hydrocarbon exposure and anti-glomerular basement membrane antibody-mediated disease (Goodpasture’s syndrome). Am J Ind Med 21: 141–53.

    Article  PubMed  CAS  Google Scholar 

  20. Prakash UBS (1994) Renal diseases. In Baum GL, Wolinsky E (eds) Textbook of pulmonary diseases, 5th edn. Little, Brown and Company, Boston, pp. 1591–614.

    Google Scholar 

  21. Donaghy M, Rees AJ (1983) Cigarette smoking and hemorrhage in glomerulonephritis caused by auto antibodies to glomerular basement membrane. Lancet 1: 1390–2.

    Article  Google Scholar 

  22. Teague CA, Doak PB, Simpson IJ et al. (1978) Goodpasture’s syndrome: An analysis of 29 cases. Kidney Int 13: 492–504.

    Article  PubMed  CAS  Google Scholar 

  23. Rees AJ, Peters DK, Compston DA et al. (1978) Strong association between HLA-DRW2 and antibody-mediated Goodpasture’s syndrome. Lancet 1: 966–78.

    Article  PubMed  CAS  Google Scholar 

  24. Perl SI, Pussell BA, Charlesworth JA et al. (1981) Goodpasture’s (Anti-GBM) disease and HLA-DRw2. N Engl J Med 305: 463–4.

    PubMed  CAS  Google Scholar 

  25. Wilson CB, Dixon FJ (1973) Anti-glomerular basement membrane antibody-induced glomerulonephritis. Kidney Int 3: 74–89.

    Article  PubMed  CAS  Google Scholar 

  26. Ploner F, Lunger J, Lanthaler T (1993) Adult respiratory distress as first sign of Goodpasture’s syndrome. Lancet 341: 1472.

    Article  PubMed  CAS  Google Scholar 

  27. Mahieu P, Lambert PH, Miescher PA (1974) Detection of anti-glomerular basement membrane antibodies by a radioimmunological technique. J Clin Invest 54: 128–37.

    Article  PubMed  CAS  Google Scholar 

  28. Fish AJ, Kleppel M, Jeraj K et al. (1985) Enzyme immunoassay of anti-glomerular basement mem-brane antibodies. J Lab Clin Med 105: 700–5.

    PubMed  CAS  Google Scholar 

  29. Bell DD, Moffatt SL, Singer M et al. (1990) Antibasement membrane antibody disease without clinical evidence of renal disease. Am Rev Respir Dis 142: 234–7.

    PubMed  CAS  Google Scholar 

  30. Donald KJ, Edwards RL, McEvoy JDS (1975) Alveolar capillary basement membrane lesions in Goodpasture’s syndrome and idiopathic pulmonary hemosiderosis. Am J Med 59: 642–9.

    Article  PubMed  CAS  Google Scholar 

  31. Sisson S, Dysart NK, Fish AJ et al. (1982) Localization of the Goodpasture antigen by immunoelectron microscopy. Clin Immunol Immunopathol 23: 414–24.

    Article  PubMed  CAS  Google Scholar 

  32. McCormack JR, Kass J, Skewes M (1987) Goodpasture’s syndrome. Compr Ther 13: 25–32.

    Google Scholar 

  33. Balow JE (1986) Plasmapheresis: development and application in treatment of renal disorders. Artif Organs 10: 324–30.

    Article  PubMed  CAS  Google Scholar 

  34. Keller F, Offerman G, Schultze G et al. (1984) Membrane plasma exchange in Goodpasture’s syn-drome. Am J Med Sci 287: 32–6.

    Article  PubMed  CAS  Google Scholar 

  35. Baumgartner I, Gmur J, Fontana A et al. (1995) Recovery from life threatening pulmonary hemor-rhage in Goodpasture’s syndrome after plasmapheresis and subsequent pulse dose cyclophosphamide. Clin Nephrol 43: 68–70.

    PubMed  CAS  Google Scholar 

  36. Johnson JP, Moore J Jr, Austin HA III et al. (1985) Therapy of antiglomerular basement membrane antibody disease: analysis of prognostic significance of clinical, pathologic and treatment factors. Medicine 64: 219–27.

    PubMed  CAS  Google Scholar 

  37. Keller F, Nekarda H (1985) Fatal relapse in Goodpasture’s syndrome 3 years after plasma exchange. Respiration 48: 62–6.

    Article  PubMed  CAS  Google Scholar 

  38. Rees AJ, Peters DK, Amos N et al. (1984) The influence of HLA-linked genes on the severity of anti-GBM antibody-mediated nephritis. Kidney Int 26: 444–50.

    Article  Google Scholar 

  39. Walker RG, Scheinkestel C, Becker GJ et al. (1985) Clinical and morphological aspects of the manage-ment of crescentic anti-glomerular basement membrane antibody (Anti-GMB) nephritis/ Goodpasture’s syndrome. Q J Med 54: 75–89.

    PubMed  CAS  Google Scholar 

  40. Herody M, Bobrie G, Govarin C et al. (1993) Anti- GBM disease: predictive value of clinical, histolo-gical and serologic data. Clin Nephrol 40: 249–55.

    PubMed  CAS  Google Scholar 

  41. Merkel F, Pullig O, Marx M et al. (1994) Course and prognosis of anti-basement membrane antibody (anti-BM-Ab)-mediated disease: report of 35 cases. Nephrol Dial Transplant 9: 372–6.

    PubMed  CAS  Google Scholar 

  42. Conlon PJ, Walshe J J, Daly C et al. (1994) Antiglomerular basement membrane disease: The long-term pulmonary outcome. Am J Kidney Dis 23: 794–6.

    PubMed  Google Scholar 

  43. Repetto G, Lisbon C, Emparanza E et al. (1967) Idiopathic pulmonary hemosiderosis. Clinical, radiological and respiratory function studies. Pediatrics 40: 24–32.

    PubMed  CAS  Google Scholar 

  44. Pacheco A, Casanova C, Fogue et al. (1991) Long- term clinical follow-up of adult idiopathic pul-monary hemosiderosis and celiac disease. Chest 99: 1525–6.

    Article  PubMed  CAS  Google Scholar 

  45. Bouros D, Panagon P, Rokkas T et al. (1994) Bronchoalveolar lavage findings in a young adult with idiopathic pulmonary hemosiderosis and coeliac disease. Eur Respir J 7: 1009–12.

    PubMed  CAS  Google Scholar 

  46. Rafferty JR, Cook MK (1984) Idiopathic pulmonary haemosiderosis with autoimmune hemolytic anemia. Br J Dis Chest 78: 282–5.

    Article  PubMed  CAS  Google Scholar 

  47. Buchanan GR, Moore GC (1981) Pulmonary hemo-siderosis and immune thrombocytopenia. Initial manifestations of collagen-vascular disease. JAMA 246: 861–4.

    Google Scholar 

  48. van der Ent CK, Walenkamp MJ, Donckerwolcke RAMG et al. (1995) Pulmonary hemosiderosis and immune complex glomerulonephritis. Clin Nephrol 43: 339–41.

    PubMed  Google Scholar 

  49. Leaker B, Cambridge G, du Bois RM et al. (1992) Idiopathic pulmonary haemosiderosis: a form of microscopic polyarteritis? Thorax 47: 988–90.

    Article  PubMed  CAS  Google Scholar 

  50. Valassi-Adam H, Rovaska A, Karpousaz J et al. (1976) Raised IqA in idiopathic pulmonary haemosiderosis. Arch Dis Child 50: 320–2.

    Article  Google Scholar 

  51. Ognibene AJ, Johnson DE (1963) Idiopathic pul-monary hemosiderosis in adults. Arch Intern Med 111: 503–10.

    Article  PubMed  CAS  Google Scholar 

  52. Soergel KH, Sommers SC (1962) Idiopathic pulmonary hemosiderosis and related syndromes. Am J Med 32: 499–511.

    Article  Google Scholar 

  53. Bruwer AJ, Kennedy RLJ, Edwards JE (1956) Recurrent pulmonary hemorrhage with hemosiderosis: so-called idiopathic pulmonary hemo-siderosis. AJR 76: 98–107.

    Google Scholar 

  54. Bronson SM (1960) Idiopathic pulmonary hemosiderosis in adults: report of a case and review of the literature. AJR 83: 260–73.

    Google Scholar 

  55. Thaell JR, Greipp PR, Stubbs SE et al. (1978) Idiopathic pulmonary hemosiderosis. Two cases in a family. Mayo Clin Proc 53: 113–18.

    PubMed  CAS  Google Scholar 

  56. Breckenridge RL, Ross JS (1979) Idiopathic pul-monary hemosiderosis. A report of familial occur-rence. Chest 75: 636–9.

    Article  PubMed  Google Scholar 

  57. Bowley NH, Hughes JBM, Steiner RE (1979) The chest x-ray in pulmonary capillary hemorrhage: Correlation with carbon monoxide uptake. Clin Radiol 30: 413–17.

    Article  PubMed  CAS  Google Scholar 

  58. Akyar S, Ozbek SS (1993) Computed tomography findings in idiopathic pulmonary hemosiderosis. Respiration 60: 63–4.

    Article  PubMed  CAS  Google Scholar 

  59. Buschman DL, Ballard R (1993) Progressive massive fibrosis associated with idiopathic pulmonary hemosiderosis. Chest 104: 293–5.

    Article  PubMed  CAS  Google Scholar 

  60. Creah FK, Sheppard MN, Hansell DM (1993) Computed tomography of diffuse pulmonary hemorrhage with pathological correlation. Clin Radiol 48: 89–93.

    Article  Google Scholar 

  61. Rubin GD, Edwards DK, Reicher MA etal. (1989) Diagnosis of pulmonary hemosiderosis by MR imaging. AJR 152: 573–4.

    Google Scholar 

  62. Donlan CJ, Srodes CH, Duffy FD (1975) Idiopathic pulmonary hemosiderosis. Electron microscopic, immunofluorescent, and iron kinetic studies. Chest 68: 577–80.

    Article  Google Scholar 

  63. Rossi GA, Balzano E, Battistini E et al. (1992) Long- term prednisone and azathioprine treatment of a patient with idiopathic pulmonary hemosiderosis. Pediatr Pulmonol 13: 176–80.

    Article  PubMed  CAS  Google Scholar 

  64. Colombo JL, Stolz SM (1992) Treatment of life- threatening primary pulmonary hemosiderosis with cyclophosphamide. Chest 102: 959–60.

    Article  PubMed  CAS  Google Scholar 

  65. Ohga S, Nomura A, Suga N et al. (1994) Liposteroid against refractory pulmonary hemorrhage in idiopathic pulmonary hemosiderosis. Eur J Pediatr 153: 687–90.

    Article  PubMed  CAS  Google Scholar 

  66. Byrd RB, Gracey DR (1973) Immunosuppressive treatment of idiopathic pulmonary hemosiderosis. JAMA 226: 458–9.

    Google Scholar 

  67. Yeager H, Powell D, Weinberg RM et al. (1976) Idiopathic pulmonary hemosiderosis. Arch Intern Med 136: 1145–9.

    Article  PubMed  Google Scholar 

  68. Zaki M, Saleh QA, Mutari GA (1995) Effectiveness of chloroquine therapy in idiopathic pulmonary hemosiderosis. Pediatr Pulmonol 20: 125–6.

    Article  PubMed  CAS  Google Scholar 

  69. Tutor JD, Eid NS (1995) Treatment of idiopathic pulmonary hemosiderosis with inhaled flunisolide. South Med J 88: 984–6.

    Article  PubMed  CAS  Google Scholar 

  70. Elinder G (1985) Budesonide inhalation to treat idiopathic pulmonary haemosiderosis. Lancet 1: 981–2.

    Article  PubMed  CAS  Google Scholar 

  71. Dolan J, McGuire S, Sweeny E (1984) Mast cells in pulmonary hemosiderosis. Arch Dis Child 59: 276–8.

    Article  PubMed  CAS  Google Scholar 

  72. Andrassy K, Küster S, Waldherr R et al. (1991) Rapidly progressive glomerulonephritis: Analysis of prevalence and clinical course. Nephron 59: 206–12.

    Article  PubMed  CAS  Google Scholar 

  73. Boyce NW, Holdsworth SR (1986) Pulmonary mani-festations of the clinical syndrome of acute glomerulonephritis and lung hemorrhage. Am J Kidney Dis 8: 31–6.

    PubMed  CAS  Google Scholar 

  74. Leatherman JW, Davies SF, Hoidal JR (1984) Alveolar hemorrhage syndromes: Diffuse microvascular lung hemorrhage in immune and idiopathic disorders. Medicine 63: 343–61.

    Article  PubMed  CAS  Google Scholar 

  75. Jones DA, Jennette JC, Falk RJ (1990) Goodpasture’s syndrome revisited: A new perspective on glomeru-lonephritis and alveolar hemorrhage. N C Med J 51: 411–15.

    PubMed  CAS  Google Scholar 

  76. Jennette JC, Wilkman AS, Falk RJ (1989) Anti- neutrophil cytoplasmic autoantibody-associated glomerulonephritis and vasculitis. Am J Pathol 135: 921–30.

    PubMed  CAS  Google Scholar 

  77. Rollino C, Roccatello D, Coppo R et al. (1991) Classic and perinuclear anti-neutrophilic cytoplasm antibodies and antimyeloperoxidase antibodies in rapidly progressive glomerulonephritis. Am J Nephrol 11: 318–24.

    Article  PubMed  CAS  Google Scholar 

  78. Murray RJ, Albin RJ, Mergner W et al. (1988) Diffuse alveolar hemorrhage temporally related to cocaine smoking. Chest 93: 427–9.

    Article  PubMed  CAS  Google Scholar 

  79. Tapper DP, Taylor JR (1989) Diffuse pulmonary infiltrates following lymphography. Chest 96: 915–16.

    Article  PubMed  CAS  Google Scholar 

  80. Patterson R, Nugent KM, Harris KE et al. (1990) Immunologic hemorrhagic pneumonia caused by isocyanates. Am Rev Respir Dis 141: 226–30.

    PubMed  CAS  Google Scholar 

  81. Zeiss CR, Wolkonsky P, Chacon R et al. (1983) Syndromes in workers exposed to trimellitic anhydride. A longitudinal clinical and immunologic study. Ann Intern Med 98: 8–12.

    PubMed  CAS  Google Scholar 

  82. Kaplan V, Baur X, Czuppon A et al. (1993) Pulmonary hemorrhage due to inhalation of vapor containing pyromellitic dianhydride. Chest 104: 644–5.

    Article  PubMed  CAS  Google Scholar 

  83. Herbert FA, Orford R (1979) Pulmonary hemorrhage and edema due to inhalation of resins containing trimellitic anhydride. Chest 76: 546–51.

    Article  PubMed  CAS  Google Scholar 

  84. Ahmad D, Morgan WKC, Patterson R et al. (1979) Pulmonary hemorrhage and haemolytic anaemia due to trimellitic anhydride. Lancet 2: 328–30.

    Article  PubMed  CAS  Google Scholar 

  85. Sternlieb I, Bennett B, Scheinberg IH (1975) D- penicillamine induced Goodpasture’s syndrome in Wilson’s disease. Am Intern Med 82: 673–6.

    CAS  Google Scholar 

  86. Louie S, Gamble CN, Cross CE (1986) Penicillamine associated pulmonary hemorrhage. J Rheumatol 13: 963–6.

    PubMed  CAS  Google Scholar 

  87. Fireman Z, Yust I, Abramov AL (1981) Lethal occult pulmonary hemorrhage in drug-induced thrombocytopenia. Chest 79: 358–9.

    Article  PubMed  CAS  Google Scholar 

  88. Barnett VT, Bergamann F, Humphrey H et al. (1992) Diffuse alveolar hemorrhage secondary to super- warfarin ingestion. Chest 102: 1301–2.

    Article  PubMed  CAS  Google Scholar 

  89. Finley TN, Aronow A, Cosentino AM et al. (1975) Occult pulmonary hemorrhage in anticoagulated patients. Am Rev Respir Dis 112: 23–9.

    PubMed  CAS  Google Scholar 

  90. Robboy SJ, Minna JD, Colman RW et al. (1973) Pulmonary hemorrhage syndrome as a manifestation of disseminated intravascular coagulation: Analysis of 10 cases. Chest 63: 718–21.

    Article  PubMed  CAS  Google Scholar 

  91. Colman RW, Robboy SJ, Minna JD (1972) Disseminated intravascular coagulation (DIC): an approach. Am J Med 52: 679–89.

    Article  PubMed  CAS  Google Scholar 

  92. Drew WL, Finley TN, Golde DW (1977) Diagnostic lavage and occult pulmonary hemorrhage in thrombocytopenic immunocompromised patients. Am Rev Respir Dis 116: 215–21.

    PubMed  CAS  Google Scholar 

  93. Bodey GP, Powell RD Jr, Hersh EM et al. (1966) Pulmonary complications of acute leukemia. Cancer 19: 781–93.

    Article  PubMed  CAS  Google Scholar 

  94. Leach WB (1961) Acute leukemia: A pathologic study of the causes of death in 157 proved cases. Can Med Assoc J 85: 345–93.

    PubMed  CAS  Google Scholar 

  95. Smith LJ, Katzenstein ALA (1982) Pathogenesis of massive pulmonary hemorrhage in acute leukemia. Arch Intern Med 142: 2149–52.

    Article  PubMed  CAS  Google Scholar 

  96. Hildebrand FL, Rosenow EC III, Habermann TM et al. (1990) Pulmonary complications of leukemia. Chest 98: 1233–9.

    Article  PubMed  Google Scholar 

  97. Tenholder MF, Hooper RG (1980) Pulmonary infiltrates in leukemia. Chest 78: 468–73.

    Article  PubMed  CAS  Google Scholar 

  98. Golde DW, Drew WL, Klein HZ et al. (1975) Occult pulmonary haemorrhage in leukemia. Br Med J 2: 166–8.

    Article  PubMed  CAS  Google Scholar 

  99. West JB, Mathieu-Costello O (1995) Vulnerability of pulmonary capillaries in heart disease. Circulation 92: 622–31.

    PubMed  CAS  Google Scholar 

  100. Wood P (1954) An appreciation of mitral stenosis: I-Clinical features. Br Med J 1: 1051–63.

    Article  PubMed  CAS  Google Scholar 

  101. Diamond MA, Genovese PD (1971) Life-threatening hemoptysis in mitral stenosis. Emergency mitral valve replacement resulting in rapid, sustained cessation of pulmonary bleeding. JAMA 215: 441–4.

    Google Scholar 

  102. Fergusson FC, Kobilak RE, Deitrick JE (1944) Varices of the bronchial veins as a source of hemop-tysis in mitral stenosis. Am Heart J 28: 445–56.

    Article  Google Scholar 

  103. Gilroy JC, Marchand P, Wilson VH (1952) The role of the bronchial veins in mitral stenosis. Lancet 2: 957–9.

    Article  PubMed  CAS  Google Scholar 

  104. West JB, Mathieu-Costello 0 (1992) Strength of the pulmonary blood-gas barrier. Respir Physiol 88: 141–8.

    CAS  Google Scholar 

  105. Scarlat A, Bodner G, Liron M (1986) Massive haemoptysis as the presenting symptom in mitral stenosis. Thorax 41: 413–14.

    Article  PubMed  CAS  Google Scholar 

  106. Nennhaus HP, Hunter JA (1967) Massive hemor-rhage from bronchial varices in mitral stenosis. Surgery 61: 556–60.

    PubMed  CAS  Google Scholar 

  107. Abdallah PS, Mark JBD, Merigan TC (1976) Diagnosis of cytomegalovirus pneumonia in com-promised hosts. Am J Med 61: 326–32.

    Article  PubMed  CAS  Google Scholar 

  108. Janzen DL, Padley SPG, Adler BD et al. (1993) Acute pulmonary complications in immunocompromised non-AIDS patients: comparison of diagnostic accuracy of CT and chest radiography. Clin Radiol 47: 159–65.

    Article  PubMed  CAS  Google Scholar 

  109. Buff SJ, McLelland R, Gallis HA etal. (1982) Candida albicans pneumonia: radiographic appearance. AJR 138: 645–8.

    Google Scholar 

  110. Pagani JJ, Libshitz HI (1981) Opportunistic fungal pneumonias in cancer patients. AJR 137: 1033–9.

    Google Scholar 

  111. Orr DP, Myerowitz RL, Dubois PJ (1978) Patho-radio- logic correlation of invasive pulmonary aspergillosis in the compromised host. Cancer 41: 2028–39.

    Article  PubMed  CAS  Google Scholar 

  112. Kuhlman JE, Fishman EK, Siegelman SS (1985) Invasive pulmonary aspergillosis in acute leukemia: Characteristic findings on CT, the CT halo sign, and the role of CT in early diagnosis. Radiology 157: 611–14.

    PubMed  CAS  Google Scholar 

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Lee-Chiong, T.L., Curtis, A.M., Matthay, R.A. (1999). Pulmonary Hemorrhage Syndromes. In: Sperber, M. (eds) Diffuse Lung Disorders. Springer, London. https://doi.org/10.1007/978-1-4471-3440-4_17

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