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Pulmonary Disease in the Immunocompromised Host

  • G. Simonetti
  • L. Bonomo
  • P. Rossi
  • G. L. Sergiacomi
  • L. Migliorato
  • A. Moscone

Abstract

Immunodeficiency develops when one or more natural defence mechanisms of the human body are compromised [1–3]; the immunocompromised host is at a greater risk to acquire infections. Pulmonary complications are a common cause of morbidity and mortality in the immunocompromised host. In these patients, the lung is the organ most frequently involved by pathologic manifestations (70%), most of which are infectious (70–90%) and burdened with a high mortality [4].

Keywords

Invasive Aspergillosis Invasive Pulmonary Aspergillosis High Resolution Compute Tomography Immunocompromised Host Halo Sign 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Rubin TR, Lotze MT (1992) Immune function and disfunction. Radiol Clin North Am 40: 507–523.Google Scholar
  2. 2.
    McLoud TC, Naidich DP (1992) Thoracic disease in the immunocompromised patient. Radiol Clin North Am 30: 525–54.PubMedGoogle Scholar
  3. 3.
    Mc Loud TC (1989) Pulmonary infections in the immunocompromised host. Radiol Clin North Am 27: 1059.Google Scholar
  4. 4.
    Rosenow III EC, Wilson WR, Cockerill III FR (1985) Pulmonary disease in the immunocompromised host (first of two parts). Mayo Clin Proc 60: 473–87.PubMedGoogle Scholar
  5. 5.
    Zompatori M, Canini R, Gavelli G et al. (1991) Le infezioni polmonari del paziente immunodepresso (P. I. D. ). Atti Congresso Nazionale Italiano Sezione Radiologia Toracica.Google Scholar
  6. 6.
    Wilson WR, Cockerill III FR, Rosenow III EC (1985) Pulmonary disease in the immunocompromised host (second of two parts). Mayo Clin Proc 60: 610–31.PubMedGoogle Scholar
  7. 7.
    Graham NJ, Muller NL, Miller RR et al. (1991) Intrathoracic complications following allogenic bone marrow transplantation: CT findings. Radiology 181: 153–6.PubMedGoogle Scholar
  8. 8.
    Jules-Elise K, Stover DE, Yahalom J et al. (1992) Pulmonary complications in lymphoma patients treated with high-dose therapy and autologous bone marrow transplantation. Am Rev Resp Dis 146: 485–91.Google Scholar
  9. 9.
    Letendre L, Hoagland HC, Moore SB et al. (1992) Mayo clinic experience with allogenic and syngenic bone marrow transplantation, 1982 through 1990. Mayo Clin Proc 67: 109–16.PubMedGoogle Scholar
  10. 10.
    Bonomo L, Guidotti A, Bartelli F et al. (1994) Diagnostic imaging in the immunocompromised hematologic patient. Rays 19: 444–59.PubMedGoogle Scholar
  11. 11.
    Primack SL, Muller NL (1994) High-resolution com-puted tomography in acute diffuse lung disease in the immunocompromised patient. Radiol Clin North Am 32: 731–44.PubMedGoogle Scholar
  12. 12.
    Bonomo L, Ciccotosto C, Gavelli G et al. (1996) TAC ad alta risoluzione del torace. Gnocchi Eds, Napoli.Google Scholar
  13. 13.
    Webb WR, Muller NR, Naidich DP (1996) High- resolution CT of the lung. Lippincott-Raven, Philadelphia.Google Scholar
  14. 14.
    Ettinger NA, Trulock EP (1991) Pulmonary consider-ation of organ transplantation, part 1. Am Rev Resp Dis 143: 1386–404.PubMedGoogle Scholar
  15. 15.
    Ettinger NA, Trulock EP (1991) Pulmonary consideration of organ transplantation, part 2. Am Rev Resp Dis 144: 213–23.PubMedCrossRefGoogle Scholar
  16. 16.
    Grebski E, Hess T, Hold G et al. (1992) Diagnostic value of hemosiderin-containing macrophages in bronchoalveolar lavage. Chest 102: 1794–9.PubMedCrossRefGoogle Scholar
  17. 17.
    Kang EY, Staples CA, McGuinness G etal. (1996) Detection and differential diagnosis of pulmonary infections and tumors in patients with AIDS: value of chest radiography versus CT. AJR 166: 15–19.Google Scholar
  18. 18.
    Bianco R, Arborio G, Mariani P et al. (1996) Infezioni polmonari da Pneumocystis Carinii nei pazienti affetti da AIDS: studio con Tomografia Computerizzata ad alta risoluzione (HRCT). Radiol Med 91: 370–6.PubMedGoogle Scholar
  19. 19.
    Pennington GE, Feldman NT (1973) Pulmonary infiltrates and fever in patients with hematologic malignancies: assessment of transbronchial biopsy. Am J Med 55: 155.PubMedCrossRefGoogle Scholar
  20. 20.
    Sickles EA, Young UM, Greene WH et al. (1973) Ann Inter Med 79: 528.Google Scholar
  21. 21.
    Valdiveso M, Gil-Extremera B, Zornoza J et al. (1977) Gram-negative bacillary pneumonia in the compromised host. Medicine 46: 241.CrossRefGoogle Scholar
  22. 22.
    Ikezoe J, Takeuchi N, Johkoh T etal. (1992) CT appearance of pulmonary tuberculosis in diabetic and immunocompromised patients. AJR 159: 1175–9.Google Scholar
  23. 23.
    Conant EF, Wechsler RJ (1992) Actinomycosis and nocardiosis of the lung. J Thorac Imaging 7: 75–84.PubMedCrossRefGoogle Scholar
  24. 24.
    Haque AK (1992) Pathology of common pulmonary fungal infections. J Thorac Imaging 7: 1–11.PubMedCrossRefGoogle Scholar
  25. 25.
    Boyars MC, Zwischenberger JB, Cox CS (1992) Clinical manifestations of pulmonary fungal infections. J Thorac Imaging 7: 12–22.PubMedCrossRefGoogle Scholar
  26. 26.
    Patz EF, Goodman PC (1992) Pulmonary cryptococ-cosis. J Thorac Imaging 7: 51–5.PubMedCrossRefGoogle Scholar
  27. 27.
    Sergiacomi G, Tomiselli A, Grimaldi P et al. (1996) Aspetti dell–aspergillosi invasiva nel paziente ematologico: utilità dello studio mediante Tomografia Computerizzata e Tomografia Computerizzata ad alta risoluzione. Radiol Med 91: 377–84.PubMedGoogle Scholar
  28. 28.
    Staples CA, Kang EY, Wright JL et al. (1996) Invasive pulmonary aspergillosis in AIDS: radiographic, CT and pathologic findings. Radiology 196: 409–14.Google Scholar
  29. 29.
    Kuhlman JE, Fishman EK, Siegelman SS (1985) Invasive pulmonary aspergillosis in acute leukemia: characteristic findings on CT, the halo sign, and role of CT in early diagnosis. Radiology 157: 611–14.PubMedGoogle Scholar
  30. 30.
    Gefter WB, Albelda SM, Talbot JH et al. (1985) Invasive pulmonary aspergillosis and acute leukemia. Radiology 157: 605–10.PubMedGoogle Scholar
  31. 31.
    Mori M, Galvin JR, Barloon TJ et al. (1991) Fungal pulmonary infections after bone marrow transplan-tation: evaluation with radiography and CT. Radiology 178: 721–8.PubMedGoogle Scholar
  32. 32.
    Gefter WB (1992) The spectrum of pulmonary aspergillosis. J Thorac Imaging 7: 56–74.PubMedCrossRefGoogle Scholar
  33. 33.
    H ruban RH, Meziane MA, Zerhouni EA et al. (1987) Radiologie-pathologie correlation of the halo sign in invasive aspergillosis. J Comput Assist Tomogr 11: 534.PubMedCrossRefGoogle Scholar
  34. 34.
    Kuhlman JE, Fishman EK, Teigen C (1990) Pulmonary septic emboli: diagnosis with CT. Radiology 174: 211–13.PubMedGoogle Scholar
  35. 35.
    Krowka MJ, Rosenow EC, Hoagland HC (1985) Pulmonary complications of bone marrow trans-plantation. Chest 87: 237–46.PubMedCrossRefGoogle Scholar
  36. 36.
    Cordonnier C, Bernaudin JF, Bierling P et al. (1986) Pulmonary complications occurring after allogenic bone marrow transplantation. Cancer 58: 1047–54.PubMedCrossRefGoogle Scholar
  37. 37.
    Ruutu P, Ruutu T, Volin R et al. (1990) Cyto-megalovirus is frequently isolated in bronchoalveolar lavage fluid of bone marrow transplant recipients without pneumonia. Ann Intern Med 112: 913–16.PubMedGoogle Scholar
  38. 38.
    Crawford SW, Hackman RC, Clark JG (1988) Open lung biopsy diagnosis of diffuse pulmonary infiltrates after marrow transplantation. Chest 94: 949–53.PubMedCrossRefGoogle Scholar
  39. 39.
    Hamilton PJ, Pearson ADJ (1986) Bone marrow transplantation and the lung. Thorax 41: 497–502.PubMedCrossRefGoogle Scholar
  40. 40.
    Kang EY, Patz EF Jr, Muller NL (1996) Cyto-megalovirus pneumonia in transplant patients: CT findings. J Comput Assist Tomogr 20: 295–9.PubMedCrossRefGoogle Scholar
  41. 41.
    Stern EJ, Swensen SJ (1996) High-resolution CT of the chest. Lippincott-Raven, Philadelphia.Google Scholar
  42. 42.
    Bergin CJ, Wirth RL, Berry GJ et al. (1990) Pneumocystis carinii pneumonia: CT and HRCT observations. J Comput Assist Tomogr 14: 756–9.PubMedCrossRefGoogle Scholar
  43. 43.
    Barloon TJ, Galvin JR, Mori M et al. (1991) High-resolution ultrafast chest CT in the clinical management of febrile bone marrow transplant patients with normal or nonspecific chest roentgenograms. Chest 99: 928–33.PubMedCrossRefGoogle Scholar
  44. 44.
    Leung AN, Brauner MW, Gamsu G et al. (1996) Pulmonary tubercolosis: comparison of CT findings in HIV-seropositive and HIV-seronegative patients. Radiology 198: 687–91.PubMedGoogle Scholar
  45. 45.
    Epstein DM, Glickstein MF (1989) Pulmonary lym- phoproliferative disorders. Radiol Clin North Am 27: 1077.PubMedGoogle Scholar
  46. 46.
    Harris K, Schwartz ML, Slasky SB et al. (1987) Posttransplantation Cyclosporine-induced lympho- proliferative disorders: clinical and radiologic manifestations. Radiology 162: 697–700.PubMedGoogle Scholar
  47. 47.
    Dodd III GD, Ledesma-Medina J, Baron LR et al. (1992) Post-transplant lymphoproliferative disor-ders: intrathoracic manifestations. Radiology 184: 65–9.PubMedGoogle Scholar
  48. 48.
    Honda H, Barloon TJ, Franken Jr. EA etal. (1990) Clinical and radiologic features of malignant neo-plasm in organ transplant recipients. AJR 154: 271–4.Google Scholar
  49. 49.
    Eisner MD, Kaplan LD, Herndier B et al. (1996) The pulmonary manifestations of AIDS-related non- Hodgkin’s lymphoma. Chest 110: 729–36.PubMedCrossRefGoogle Scholar
  50. 50.
    Carignan S, Staples CA, Muller NL (1995) Intrathoracic lymphoproliferative disorders in the immunocompromised patient: CT findings. Radiology 197: 53–8.PubMedGoogle Scholar
  51. 51.
    McGuinness G, Scholes JV, Jagirdar JS et al. (1995) Unusual lymphoproliferative disorders in nine adults with HIV or AIDS: CT and pathologic findings. Radiology 197: 59–65.PubMedGoogle Scholar

Copyright information

© Springer-Verlag London Limited 1999

Authors and Affiliations

  • G. Simonetti
  • L. Bonomo
  • P. Rossi
  • G. L. Sergiacomi
  • L. Migliorato
  • A. Moscone

There are no affiliations available

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