Acute Pancreatitis

  • D. W. Rattner
  • A. L. Warshaw


While the precise etiology of acute pancreatitis is not known, a variety of inciting factors have been identified (Table 39.1). Alcoholism and biliary tract disease are the processes most commonly associated with pancreatitis. Together they account for 80% of cases of acute pancreatitis. The number of patients with idiopathic pancreatitis depends on the extent to which rarer causes are searched for.


Acute Pancreatitis Pancreatic Duct Pulmonary Capillary Wedge Pressure Severe Acute Pancreatitis Pancreatic Necrosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Abruzzo JL, Homa M, Houck JC et al. (1958) Significance of the serum amylase determination. Ann Surg 147: 921–928PubMedGoogle Scholar
  2. 2.
    Acosta JM, Ledersma CL, (1974) Gallstone migration as a cause of acute pancreatitis. N Engl J Med 290: 484–487PubMedCrossRefGoogle Scholar
  3. 3.
    Acosta JM, Pellegrini CA, Skinner DB, (1980) Etiology and pathogenesis of acute biliary pancreatitis. Surgery 88: 118–125PubMedGoogle Scholar
  4. 4.
    Allam BF, Imrie CW, (1977) Serum ionized calcium in acute pancreatitis. Br J Surg 64: 665–668PubMedCrossRefGoogle Scholar
  5. 5.
    Barrows D, Burke JE, Fridhandler L, (1972) Macroamy- lasemia: survey of prevalence in a mixed population. N Engl J Med 1972; 286: 1352CrossRefGoogle Scholar
  6. 6.
    Beger HG, Krautzberger W, Bittner R et al. (1985) Results of surgical treatment of necrotizing pancreatitis. World J Surg 59: 972–978CrossRefGoogle Scholar
  7. 7.
    Beger HG, Bittner R, Block S, Buchler M, (1986) Bacterial contamination of pancreatic necrosis: a prospective clinical study. Gastroenterology 91: 433–438PubMedGoogle Scholar
  8. 8.
    Beger HG, Bittner R, Buchler M et al. (1986) Hemodynamic data pattern in patients with acute pancreatitis. Gastroenterology 90: 74–79PubMedGoogle Scholar
  9. 9.
    Bradley EL, Fulenwider JT, (1984) Operative treatment of pancreatic abscess. Surg Gynecol Obstet 150: 509–513Google Scholar
  10. 10.
    Buchler M, Block S, Krautzberger W et al. (1984) Necrotizing pancreatitis: peritoneal lavage (PL) or local lavage ( LL) of the lesser sac. Dig Dis Sci 29: 944Google Scholar
  11. 11.
    Cobo JC, Abraham E, Bland RD, Shoemaker WC, (1984) Sequential hemodynamic and oxygen transport abnormalities in patients with acute pancreatitis. Surgery 95: 324–330PubMedGoogle Scholar
  12. 12.
    Condon JR, Ives D, Knight MJ, Day J, (1975) The etiology of hypocalcemia in acute pancreatitis. Br J Surg 62: 115–118PubMedCrossRefGoogle Scholar
  13. 13.
    Coppa GF, LeFleur R, Ranson JHC, (1981) The role of Chiba needle cholangiography in the diagnosis of possible acute pancreatitis with cholelithiasis. Ann Surg 193: 393–398PubMedCrossRefGoogle Scholar
  14. 14.
    Danker A, Herfitz CK, (1951) Interrelationship of blood and urine diastase during transient acute pancreatitis. Gastroenterology 18: 2077–83Google Scholar
  15. 15.
    DeTroyer A, Naeije R, Yernault JC, Englert M, (1978) Impairment of pulmonary function in acute pancreatitis. Chest 73: 360–363CrossRefGoogle Scholar
  16. 16.
    Ellis CT, Koehler DF, Eckfeldt JH, Levitt MD, (1982) Evaluation of an inhibitor assay to determine serum amylase distribution. Dig Dis Sci 27: 897–901PubMedCrossRefGoogle Scholar
  17. 17.
    Frey CF, (1972) Operative therapy in pancreatitis and its complications. U Mich Med J 38: 103–110Google Scholar
  18. 18.
    Gerzof SG, Banks PA, Robbins AH et al. (1987) Early diagnosis of pancreatic infection by CT-guided aspiration. Gastroenterology 93: 1315–20PubMedGoogle Scholar
  19. 19.
    Gerzof SG, Banks PA, Spechler SJ et al. (1984) Role of guided percutaneous aspiration in early diagnosis of pancreatic sepsis. Dig Dis Sci 29: 950Google Scholar
  20. 20.
    Gerzof SG, Robbins AH, Johnson WC et al. (1981) Percutaneous catheter drainage of abdominal abscess: a five year experience. N Engl J Med 305: 653–657PubMedCrossRefGoogle Scholar
  21. 21.
    Greenberg AG, Terlizzi L, Peskin GW, (1977) Oxyhe-moglobin affinity in acute pancreatitis. J Surg Res 22: 561–565CrossRefGoogle Scholar
  22. 22.
    Hollender LF, Meyer C, Marrie A et al. (1981) Role of surgery in the management of acute pancreatitis. World J Surg 5: 361–368PubMedCrossRefGoogle Scholar
  23. 23.
    Ihse I, Evander A, Holmberg JT, Gustafson I, (1986) Influence of peritoneal lavage on objective prognostic signs in acute pancreatitis. Ann Surg 204: 122–127PubMedCrossRefGoogle Scholar
  24. 24.
    Imrie CW, Whyte AS, (1975) A prospective study of acute pancreatitis. Br J Surg 62: 490–494PubMedCrossRefGoogle Scholar
  25. 25.
    Ito K, Ramirez-Schon G, Shah P et al. (1981) Myocardial function in acute pancreatitis. Ann Surg 194: 85–88PubMedCrossRefGoogle Scholar
  26. 26.
    Jacobs ML, Daggett WM, Civetta JM et al. (1977) Acute pancreatitis: analysis of factors influencing survival. Ann Surg 185: 43–51PubMedCrossRefGoogle Scholar
  27. 27.
    Kauste A, Hookersted EK, Ahonen J et al. (1983) Peritoneal lavage as a primary treatment in acute fulminant pancreatitis. Surg Gynecol Obstet 156: 458–463PubMedGoogle Scholar
  28. 28.
    Kelley TR, (1980) Gallstone pancreatitis: the timing of surgery. Surgery 88: 345–350Google Scholar
  29. 29.
    Kivilaakso E, Lempinen M, Makelarnen A et al. (1981) Pancreatic resection versus peritoneal lavation for acute fulminant pancreatitis. Surg Gynecol Obstet 152: 493–498PubMedGoogle Scholar
  30. 30.
    Lawson DW, Daggett WM, Civetta JM et al. (1970) Surgical treatment of acute necrotizing pancreatitis. Ann Surg 172: 605–617PubMedCrossRefGoogle Scholar
  31. 31.
    Lee BC, Malik AB, Bare PS, Minnear FL, (1981) Effect of acute pancreatitis on pulmonary transvascular fluid and protein exchange. Am Rev Resp Dis 123: 618–621PubMedGoogle Scholar
  32. 32.
    Lesser PB, Warshaw AL, (1975) Diagnosis of pancreatitis masked by hyperlipemia. Ann Intern Med 82: 795–798PubMedGoogle Scholar
  33. 33.
    Long WB, Kowlessar OD, (1972) A rapid thin layer test for macroamylase with observations on the nature of macroamylase in 6 patients. Gastroenterology 63: 564–571PubMedGoogle Scholar
  34. 34.
    Lorett WL, Wangensteen SL, Glenn TM, Lefer AM, (1971) Presence of a myocardial depressant factor in patients with circulatory shock. Surgery 70: 223–230Google Scholar
  35. 35.
    Lucas CE, Ledgerwood AM, (1982) Shock and renal failure. In: Bradley EL (ed) Complications of pancreatitis: medical and surgical management. WB Saunders and Co Philadelphia pp 51–71Google Scholar
  36. 36.
    Malangoni MA, Shallcross JC, Seiler JG et al. (1986) Factors contributing to fatal outcome after treatment of pancreatic abscess. Ann Surg 203: 606–611CrossRefGoogle Scholar
  37. 37.
    Mayer AD, McMahon MJ, (1984) Biochemical identification of patients with gallstones associated with acute pancreatitis the day of admission to the hospital. Ann Surg 201: 68–75Google Scholar
  38. 38.
    Mayer AD, McMahon MJ, Corfield AP et al. (1985) Controlled clinical trial of peritoneal lavage for the treat-ment of severe acute peritonitis. N Engl J Med 312: 399–403PubMedCrossRefGoogle Scholar
  39. 39.
    McMahon MJ, Playforth MJ, Pickford IR, (1980) A com-parative study of methods for the prediction of severity of attacks of acute pancreatitis. Br J Surg 67: 22–25PubMedCrossRefGoogle Scholar
  40. 40.
    Miller A, Lees RS, McCluskey MA, Warshaw AL, (1979) The natural history and surgical significance of hyperlipemic abdominal pain. Ann Surg 190: 401–405PubMedCrossRefGoogle Scholar
  41. 41.
    Morrisey R, Burke JE, Fridhandler L et al. (1974) The nature and significance of hyperamylasemia following operation. Ann Surg 180: 67–71CrossRefGoogle Scholar
  42. 42.
    Ofstad E, (1970) Formation and destruction of plasma kinins during experimental acute hemorrhagic pancreatitis in dogs. Scand J Gastroenterol 5 (Supplement): 1–3Google Scholar
  43. 43.
    Ranson JHC, (1979) The timing of biliary surgery in acute pancreatitis. Ann Surg 189: 654–661PubMedCrossRefGoogle Scholar
  44. 44.
    Ranson JH, Spencer FC, (1978) The role of peritoneal lavage in severe acute pancreatitis. Ann Surg 187: 565–573PubMedCrossRefGoogle Scholar
  45. 45.
    Ranson JHC, Rifkin KM, Roses DF et al. (1974) Prognostic signs and the role of operative management in acute pancreatitis. Surg Gynecol Obstet 139: 69–81PubMedGoogle Scholar
  46. 46.
    Ranson JHC, Turner JW, Roses DF, (1974) Respiratory complications in acute pancreatitis. Ann Surg 179: 557–565PubMedGoogle Scholar
  47. 47.
    Ranson JHC, Balthazar E, Caccavale R, Cooper M, (1985) Computed tomography and the predication of pancreatic abscess in acute pancreatitis. Ann Surg 201: 656–663PubMedCrossRefGoogle Scholar
  48. 48.
    Reber HA, (1986) Surgical intervention in necrotizing pancreatitis. Gastroenterology 91: 479–480PubMedGoogle Scholar
  49. 49.
    Rosseland AR, Solhaug JH, (1984) Early or delayed endoscopic papillotomy in gallstone pancreatitis. Ann Surg 199: 165–167PubMedCrossRefGoogle Scholar
  50. 50.
    Rutledge PL, Warshaw AL, (1988) Persistent pancreatitis: a variant treated by pancreaticoduodenectomy. Arch Surg 123: 597–600PubMedCrossRefGoogle Scholar
  51. 51.
    Ryan JW, Moffat JG, Thomason AC, (1965) The role of bradykinin in acute hemorrhagic pancreatitis. Arch Surg 91: 14–24CrossRefGoogle Scholar
  52. 52.
    Sanfray L, Cotton PB, (1981) A preliminary report: urgent duodenoscopic sphincterotomy for acute gallstone pancreatitis. Surgery 89: 424–428Google Scholar
  53. 53.
    Silverstein W, Isakoff MD, Hill MC, et al. (1981) Diagnostic imaging of acute pancreatitis: prospective study using CT and sonography. AJR 137: 497–502PubMedGoogle Scholar
  54. 54.
    Smith AC, Shapiro RH, Kelsey PB, Warshaw AL, (1986) Successful treatment of non-healing biliary-cutaneous fistulas with biliary stenting. Gastroenterology 90: 764–769PubMedGoogle Scholar
  55. 55.
    Steiner E, Mueller PR, Hahn PF et al. (1988) Complicated pancreatic abscesses: problems in interventional management. Radiology 167: 443–446PubMedGoogle Scholar
  56. 56.
    Thai AP, Kosold E, Hollenberg MJ, (1963) Release of vasoactive substances in acute pancreatitis. Am J Surg 105: 708–712CrossRefGoogle Scholar
  57. 57.
    Thomas FB, (1982) Drug induced pancreatitis: fact verses fiction drug therapy hospital. 7: 60–72Google Scholar
  58. 58.
    Van Gossam A, Seferian V, Rodzyneck JJ et al. (1984) Early detection of biliary pancreatitis. Dig Dis Sci 29: 97–101CrossRefGoogle Scholar
  59. 59.
    Van Sonnenberg E, Wittich GR, Casóla G et al. (1985) Complicated pancreatic inflammatory disease: diagnostic and therapeutic role of interventional radiology. Radiology 15: 335–340Google Scholar
  60. 60.
    Waltman AC, Luers PR, Athanasoulis CA, Warshaw AL, (1986) Massive arterial hemorrhage in patients with pancreatitis: complimentary roles of surgery and trans- catheter occlusive techniques. Arch Surg 121: 439–443PubMedCrossRefGoogle Scholar
  61. 61.
    Warshaw AL, Cambria RP, (1984) False pancreas divisimi: acquired pancreatic duct obstruction simulating the congenital anomaly. Ann Surg 200: 595–599PubMedCrossRefGoogle Scholar
  62. 62.
    Warshaw AL, Hawboldt M, (1988) Puzzling persistent hyperamylasemia is probably neither pancreatic nor pathological. Am J Surg 103: 328–334Google Scholar
  63. 63.
    Warshaw AL, Jin G, (1985) Improved survival in 45 patients with pancreatic abscess. Ann Surg 202: 408–415PubMedCrossRefGoogle Scholar
  64. 64.
    Warshaw AL, Imbembo AL, Civetta JM et al. (1974) Surgical intervention in acute necrotizing pancreatitis. Ann J Surg 127: 484–491CrossRefGoogle Scholar
  65. 65.
    Warshaw AL, Lesser PB, Rie M et al. (1975) The pathogenesis of pulmonary edema in acute pancreatitis. Ann Surg 182: 505–509PubMedCrossRefGoogle Scholar
  66. 66.
    Warshaw AL, Rattner DW, (1985) The timing of surgical drainage for pancreatic pseudocysts: clinical and chemical criteria. Ann Surg 202: 720–724PubMedCrossRefGoogle Scholar
  67. 67.
    Welch JP, White CE, (1982) Acute pancreatitis of biliary origin: is urgent operation necessary? Am J Surg 143: 120–125PubMedCrossRefGoogle Scholar

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© Springer-Verlag London Limited 1992

Authors and Affiliations

  • D. W. Rattner
  • A. L. Warshaw

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