Skip to main content
SpringerLink
Log in

Systemic Effects of Acute Pancreatitis

  • Chapter
Pancreatic Disease

Abstract

Moynihan (1925) went on to describe the characteristic distribution of the pain and the collapse and shock that may occur. This classical picture of acute pancreatitis associated with pallor, sweating, cyanosis, low blood pressure and oliguria with tenderness and rigidity of the abdomen describes the characteristic systemic effects but was observed in only half the patients studied by Pollock (1959). Cyanosis is indeed very unusual, whereas tachypnoea is the normal systemic effect of hypoxaemia.

Acute pancreatitis is the most terrible of all the calamities that occur in connection with the abdominal viscera. The suddenness of its onset, the illimitable agony which accompanies it, and the mortality attendant upon it, all render it the most formidable of catastrophies. Moynihan (1925)

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 74.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Albo R, Silen W, Goldman L (1963) A critical analysis of acute pancreatitis. Arch Surg 86: 1032–1038

    Article  PubMed  CAS  Google Scholar 

  • Anderson MC, Schoenfeld FB, Iams WB, Suwa M (1967) Circulatory changes in acute pancreatitis. Surg Clin North Am 47: 127–140

    PubMed  CAS  Google Scholar 

  • Balsov JT, Jorgensen HE, Nielsen R (1962) Acute renal failure complicating severe acute pancreatitis. Acta Chir Scand 124: 348–354

    Google Scholar 

  • Beger HG, Bittner R, Buchler M, Hess W, Schmitz JE (1986) Hemodynamic data patterns in patients with acute pancreatitis. Gastroenterology 90: 74–79

    PubMed  CAS  Google Scholar 

  • Beger HG, Buchler M, Bittner R et al. (1988) Necrosectomy and postoperative local lavage in necrotizing pancreatitis. Br J Surg 75: 207–212

    Article  PubMed  CAS  Google Scholar 

  • Beisel WR, Herndon EG, Myers JE, Stones L (1959) Acute renal failure as a complication of acute pancreatitis. Arch Intern Med 104: 539–543

    Article  PubMed  CAS  Google Scholar 

  • Blauvelt H (1946) A case of acute pancreatitis with subcutaneous fat necrosis. Br J Surg 34: 207–208

    Article  PubMed  CAS  Google Scholar 

  • Bockus HL, Kaiser MH, Roth JLA, Bogoch AL, Stein G (1955) Clinical features of acute inflammation of the pancreas. Arch Intern Med 96: 308–321

    Article  CAS  Google Scholar 

  • Bradley EL, Hall JR, Lutz J, Hamner L, Lattouf O (1983) Hemodynamic consequences of severe pancreatitis. Ann Surg 198: 130–133

    Article  PubMed  Google Scholar 

  • Cameron JL (1978) Chronic pancreatic ascites and pancreatic pleural effusions. Gastroenterology 74: 134–140

    PubMed  CAS  Google Scholar 

  • Carey LC (1979) Extra-abdominal manifestations of acute pancreatitis. Surgery 86: 337–342

    PubMed  CAS  Google Scholar 

  • Carey LC, Rodgers RE (1966) Pathophysiologic alterations in experimental pancreatitis. Surgery 60: 171–178

    Google Scholar 

  • Cobo JC, Abraham E, Bland RD, Shoemaker WC (1984) Sequential hemodynamic and oxygen transport abnormalities in patients with acute pancreatitis. Surgery 95: 324–330

    PubMed  CAS  Google Scholar 

  • Corfield AP, Cooper MJ, Williamson RCN et al. (1985) Prediction of severity in acute pancreatitis: prospective comparison of three prognostic indices. Lancet ii: 403–407

    Article  Google Scholar 

  • Di Carlo V, Nespoli A, Chiesa R et al. (1981) Hemodynamic and metabolic impairment in acute pancreatitis. World J Surg 5: 329–339

    Article  PubMed  Google Scholar 

  • Durr GH-K (1979) Acute pancreatitis. In: Howat HT, Sarles H (eds) The exocrine pancreas. WB Saunders, London, pp 352–401

    Google Scholar 

  • Ellison EC, Pappas TN, Johnson JA, Fabri PJ, Carey LC (1981) Demonstration and characterization of the hemoconcentrating effect of ascitic fluid that accumulates during hemorrhagic pancreatitis. J Surg Res 30: 241–248

    Article  PubMed  CAS  Google Scholar 

  • Estrada RV, Moreno J, Martinez E et al. (1979) Pancreatic encephalopathy. Acta Neurol Scand 59: 135–139

    Article  PubMed  CAS  Google Scholar 

  • Foster PD, Ziffren SE (1962) Severe acute pancreatitis. Arch Surg 85: 252–259

    Article  PubMed  CAS  Google Scholar 

  • Frey CF, Brody GL (1966) Relationship of azotemia and survival in bile pancreatitis in the dog. Arch Surg 93: 295–300

    Article  PubMed  CAS  Google Scholar 

  • Gerzof SG, Banks PA, Robbins AH et al. (1987) Early diagnosis of pancreatic infection by computed tomography-guided aspiration. Gastroenterology 93: 1315–1320

    PubMed  CAS  Google Scholar 

  • Goldstein DA, Llach F, Massry SG (1976) Acute renal failure in patients with acute pancreatitis. Arch Intern Med 136: 1363–1365

    Article  PubMed  CAS  Google Scholar 

  • Greipp PR, Brown JA, Gralnick HR (1972) Defibrination in acute pancreatitis. Ann Intern Med 76: 73–76

    PubMed  CAS  Google Scholar 

  • Gupta RK (1971) Immunohistological study of glomerular lesions in acute pancreatitis. Arch Pathol 2: 267–272

    Google Scholar 

  • Hernandez IA, Powers SR, Frawley TF (1961) The role of the parathyroid glands in calcium and magnesium metabolism in acute hemorrhagic pancreatitis. Surgery 50: 143–150

    PubMed  CAS  Google Scholar 

  • Imrie CW (1974) Observations on acute pancreatitis. Br J Surg 61: 539–544

    Article  PubMed  CAS  Google Scholar 

  • Imrie CW, Blumgart LH (1975) Acute pancreatitis: a prospective study on some factors in mortality. Bull Soc Int Chir 6: 601–603

    Google Scholar 

  • Imrie CW, Allam BF, Ferguson JC (1976) Hypocalcaemia of acute pancreatitis: the effect of hypoalbuminaemia. Curr Med Res Opin 4: 101–116

    Article  PubMed  CAS  Google Scholar 

  • Imrie CW, Ferguson JC, Murphy D, Blumgart LH (1977) Arterial hypoxia in acute pancreatitis. Br J Surg 64: 185–188

    Article  PubMed  CAS  Google Scholar 

  • Imrie CW, Benjamin IS, Ferguson JC et al. (1978a) A single-centre double-blind trial of Trasylol therapy in primary acute pancreatitis. Br J Surg 65: 337–341

    Article  PubMed  CAS  Google Scholar 

  • Imrie CW, Beastall GH, Allam BF et al. (1978b) Parathyroid hormone and calcium homeostasis in acute pancreatitis. Br J Surg 65: 717–720

    Article  PubMed  CAS  Google Scholar 

  • Imrie CW, Shearer MG, Wilson C (1988) Glycoproteins as markers of pancreatic damage in acute pancreatitis. Int J Pancreatol 3: S43–S52

    PubMed  Google Scholar 

  • Interiano B, Stuard ID, Hyde RW (1972) Acute respiratory distress syndrome in pancreatitis. Ann Intern Med 77: 923–926

    PubMed  CAS  Google Scholar 

  • Ito K, Ramirez-Schon G, Shah PM et al. (1981) Myocardial function in acute pancreatitis. Ann Surg 194: 85–88

    Article  PubMed  CAS  Google Scholar 

  • Jacobs ML, Daggett WM, Civetta JM et al. (1977) Acute pancreatitis: analysis of factors influencing survival. Ann Surg 185: 43–51

    Article  PubMed  CAS  Google Scholar 

  • Keating JP, Shackelford GD, Shackelford PG, Ternberg JL (1972) Pancreatitis and osteolytic lesions. J Pediatr 81: 350–353

    Article  PubMed  CAS  Google Scholar 

  • Kwaan HC, Anderson MC, Gramatica L (1971) A study of pancreatic enzymes as a factor in the pathogenesis of disseminated intravascular coagulation during acute pancreatitis. Surgery 69: 663–672

    PubMed  CAS  Google Scholar 

  • Lankisch PG, Rahlf G, Koop H (1983) Pulmonary complications in fatal acute hemorrhagic pancreatitis. Dig Dis Sci 28: 111–116

    Article  Google Scholar 

  • Lefer AM, Glenn TM, O’Neill TJ, Lovett WL (1971) Inotropic influence of endogenous peptides in experimental hemorrhagic pancreatitis. Surgery 69: 220–228

    PubMed  CAS  Google Scholar 

  • Lovett WL, Wangensteen SL, Glenn TM, Lefer AM (1971) Presence of a myocardial depressant factor in patients in circulatory shock. Surgery 70: 223–231

    PubMed  CAS  Google Scholar 

  • McKenna JM, Craig RM, Chandrasekhar AJ, Cugell DW, Skorton D (1977) The pleuropulmonary complications of pancreatitis. Chest 71: 197–204

    Article  PubMed  CAS  Google Scholar 

  • McMahon MJ, Playforth MJ, Pickford IR (1980) A comparative study of methods for the prediction of severity of attacks of acute pancreatitis. Br J Surg 67: 22–25

    Article  PubMed  CAS  Google Scholar 

  • Moynihan B (1925) Acute pancreatitis. Ann Surg 81: 132–134

    Article  PubMed  CAS  Google Scholar 

  • Murphy D, Imrie CW, Davidson JF (1977) Haematological abnormalities in acute pancreatitis. Postgrad Med J 53: 310–314

    Article  PubMed  CAS  Google Scholar 

  • Murphy D, Pack AI, Imrie CW (1980) The mechanism of arterial hypoxia occurring in acute pancreatitis. Q J Med 49: 151–163

    PubMed  CAS  Google Scholar 

  • Neoptolemos JP, Carr-Locke DL, Leese T, James D (1987) Acute cholangitis in association with acute pancreatitis: incidence, clinical features, outcome and the role of ERCP and endoscopic sphincterotomy. Br J Surg 74: 1103–1106

    Article  PubMed  CAS  Google Scholar 

  • Pollock AV (1959) Acute pancreatitis. Analysis of 100 patients. Br Med J i: 6–14

    Google Scholar 

  • Ranson JHC, Turner JW, Roses DF, Rifkind KM, Spencer FC (1974) Respiratory complication in acute pancreatitis. Ann Surg 179: 557–566

    PubMed  CAS  Google Scholar 

  • Ranson JHC, Lackner H, Berman IR, Schinella R (1977) The relationship of coagulation factors to clinical complications of acute pancreatitis. Surgery 81: 502–511

    PubMed  CAS  Google Scholar 

  • Read G, Braganza JM, Howat HT (1976) Pancreatitis — a retrospective study. Gut 17: 945–952

    Article  PubMed  CAS  Google Scholar 

  • Renner IG, Savage WT, Pantoja JL, Renner VJ (1985) Death due to acute pancreatitis. A retrospective analysis of 405 autopsy cases. Dig Dis Sci 30: 1005–1018

    Article  PubMed  CAS  Google Scholar 

  • Romer JF, Carey LC (1966) Pancreatitis. A clinical review. Am J Surg 111: 795–798

    Article  PubMed  CAS  Google Scholar 

  • Scarpelli DG (1956) Fat necrosis of bone marrows in acute pancreatitis. Am J Pathol 32: 1077–1087

    PubMed  CAS  Google Scholar 

  • Shader AE, Paxton JR (1966) Fatal pancreatitis. Am J Surg 111: 369–373

    Article  PubMed  CAS  Google Scholar 

  • Storck G, Pettersson G, Edlund Y (1976) A study of autopsies upon 116 patients with acute pancreatitis. Surg Gynecol Obstet 143: 241–245

    PubMed  CAS  Google Scholar 

  • Tahamont MV, Barie PS, Blumenstock FA, Hussain MH, Malik AB (1982) Increased lung vascular permeability after pancreatitis and trypsin infusion. Am J Pathol 109: 15–26

    PubMed  CAS  Google Scholar 

  • Takada Y, Appert HE, Howard JM (1976) Vascular permeability induced by pancreatic exudate formed during acute pancreatitis in dogs. Surg Gynecol Obstet 143: 779–783

    PubMed  CAS  Google Scholar 

  • Trapnell JE (1966) The natural history and prognosis of acute pancreatitis. Ann R Coll Surg Engl 38: 265–287

    PubMed  CAS  Google Scholar 

  • Werner MH, Hayes DF, Lucas CE, Rosenberg IK (1974) Renal vasoconstriction in association with acute pancreatitis. Am J Surg 127: 185–190

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. C. Wilson
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. C. W. Imrie
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Faculty of Medicine, University Surgical Unit, Southampton General Hospital, Tremona Road, SO1 6HU, Southampton, UK

    C. D. Johnson MChir, FRCS (Senior Lecturer and Honorary Consultant Surgeon) (Senior Lecturer and Honorary Consultant Surgeon)

  2. Surgical Unit, Royal Infirmary, G4 OSF, Glasgow, UK

    C. W. Imrie ChB, FRCS (Consultant Surgeon) (Consultant Surgeon)

Rights and permissions

Reprints and permissions

Copyright information

© 1991 Springer-Verlag London Limited

About this chapter

Cite this chapter

Wilson, C., Imrie, C.W. (1991). Systemic Effects of Acute Pancreatitis. In: Johnson, C.D., Imrie, C.W. (eds) Pancreatic Disease. Springer, London. https://doi.org/10.1007/978-1-4471-3356-8_25

Download citation

  • DOI: https://doi.org/10.1007/978-1-4471-3356-8_25

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-3358-2

  • Online ISBN: 978-1-4471-3356-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation