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Free Radicals and Antioxidants in Pancreatic Inflammation

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Pancreatic Disease

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Abstract

While many clinical situations are known to initiate acute pancreatitis, our understanding of the pathogenesis of this disorder is still incomplete, despite the accumulation of a considerable amount of experimental data. Therefore, the treatment of acute pancreatitis is non-specific and often does not alter the course of the disease. Many recent studies have suggested that the local and systemic effects of this disease may be mediated by a common pathway, irrespective of the initiating stimulus. Previous experimental work has demonstrated that an increase in capillary permeability is an early step in the development of acute pancreatitis in experimental models of ischaemic (Sanfey et al. 1985a), alcoholic (Sanfey and Cameron 1984), gallstone (Broe and Cameron 1982) and caerulein-induced pancreatitis (McEntee et al. 1989). This capillary injury is thought to be mediated by the action of oxygen-derived free radicals.

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References

  • Aho HJ, Nevelainen TJ (1980) Experimental pancreatitis in the rat. Ultrastructure of sodium taurocholate-induced pancreatic lesions. Scand J Gastroenterol 15: 417–424

    Article  PubMed  CAS  Google Scholar 

  • Anderson RL, Jeffrey IJ, Kay PM et al. (1986) Peroxidised linoleic acid and experimental pancreatitis. Int J Pancreatol 1: 237–248

    PubMed  CAS  Google Scholar 

  • Badwey J A, Curnotte JT, Karnovsky ML (1981) Polyunsaturated fatty acids induce high levels of superoxide production by human neutrophils. J Biol Chem 256: 640–653

    Google Scholar 

  • Badwey JA, Curnotte JT, Robinson JM et al. (1984) Effects of free fatty acid on release of superoxide and on change of shape by human neutrophils. J Biol Chem 259: 7870–7877

    PubMed  CAS  Google Scholar 

  • Bank S, Sandberg A, Aaron J et al. (1985) The effect of oxygen free radical scavengers on ethionine induced pancreatitis in mice. Dig Dis Sci 30: 962 (abstract)

    Google Scholar 

  • Batelli MG, Lorenzoni E, Stirpe F (1973) Milk xanthine oxidase type D (dehydrogenase) and type O (oxidase) purification, interconversion and some properties Biochem J 131: 191–198

    Google Scholar 

  • Blind JP, Marklund SL, Stenling R et al. (1988) Parenteral superoxide dismutase plus catalase diminish pancreatic oedema in sodium taurocholate-induced pancreatitis in the rat. Pancreas 3: 563–567

    Article  PubMed  CAS  Google Scholar 

  • Braganza JM (1988) Free radicals and pancreatitis. In: Rice-Evans C, Dormandy TL (eds) Free radicals chemistry, pathology and medicine. Richlieu Press, London, pp 357–381

    Google Scholar 

  • Braganza JM (1990) Experimental acute pancreatitis. Curr Op Gastroenterol 6: 763–768

    Article  Google Scholar 

  • Braganza JM, Rinderknecht H (1988) Free radicals and acute pancreatitis. Gastroenterology 94: 1111–1112

    PubMed  CAS  Google Scholar 

  • Braganza JM, Wickens DG, Cawood P et al. (1983) Lipid peroxidation (free radical oxidation) products in bile from patients with pancreatic disease. Lancet ii: 375–378

    Article  Google Scholar 

  • Braganza JM, Jeffrey IJM, Foster J et al. (1987) Recalcitrant pancreatitis: eventual control by antioxidants. Pancreas 4: 489–494

    Article  Google Scholar 

  • Broe PJ, Cameron JL (1982) Experimental gallstone pancreatitis: pathogenesis and response to different treatment modalities. Ann Surg 195: 566–573

    Article  PubMed  CAS  Google Scholar 

  • Degertekin K, Van Meter A, Ertan K et al. (1984) Effect of hyperbaric oxygen therapy and a xanthine oxidase inhibitor on diet induced acute pancreatitis in mice. Gastroenterology 84: A1059 (abstract)

    Google Scholar 

  • Del Maestro RF (1979) The influence of oxygen derived free radicals on in vitro and in vivo model systems. Acta Univ Upsal 340: 32–40

    Google Scholar 

  • Del Maestro RF, Thaw HH, Bjork J et al. (1980) Free radicals as mediators of tissue injury. Acta Physiol Scand 492: 153–168 (suppl)

    Google Scholar 

  • Fong KL, McKay PB, Poyer JL et al. (1973) Evidence that peroxidation of lysosomal membranes is initiated by hydroxyl free radicals produced during flavin enzyme activity. J Biol Chem 248: 7792–7797

    PubMed  CAS  Google Scholar 

  • Fox RB (1984) Prevention of granulocyte mediated oxidant lung injury in rats by a hydroxyl radical scavenger, dimethylthiourea. J Clin Invest 74: 1456–1464

    Article  PubMed  CAS  Google Scholar 

  • Fridovich I (1978) The biology of oxygen radicals. Science 201: 875–880

    Article  PubMed  CAS  Google Scholar 

  • Gardner TJ, Stewart JR, Casale AS et al. (1983) Reduction of myocardial ischaemic injury with oxygen derived free radical scavengers. Surgery 94: 423–432

    PubMed  CAS  Google Scholar 

  • Goldstein IM, Weissman G (1977) Effects of the generation of superoxide anion on permeability of liposomes. Biochem Biophys Res Commun 75: 604–609

    Article  PubMed  CAS  Google Scholar 

  • Gough D, Boyle B, Joyce WP et al. (1990) Free radical inhibition and serial chemiluminescence in evolving experimental pancreatitis. Br J Surg 77: 1256–1259

    Article  PubMed  CAS  Google Scholar 

  • Guice KS, Miller DE, Oldham KT et al. (1986) Superoxide dismutase and catalase. A possible role in established pancreatitis. Am J Surg 151: 163–167

    Article  PubMed  CAS  Google Scholar 

  • Guice KS, Oldham KT, Johnson KJ et al. (1987) Mechanisms of pancreatic capillary endothelial injury in acute pancreatitis. Surg Forum 34: 144–146

    Google Scholar 

  • Guyan PM, Braganza JM, Butler J (1988) The effect of oxygen metabolites on the zymogens of human pancreatic proteases. In: Rice-Evans C, Dormandy TL (eds) Free radicals, chemistry, pathology and medicine. Richlieu Press, London, pp 471–474

    Google Scholar 

  • Halliwell B (1978) Biochemical mechanisms accounting for the toxic action of oxygen on living organisms. The key role of superoxide. Cell Biol Int Rep 2: 113–128

    Article  PubMed  CAS  Google Scholar 

  • Im MJ, Shen WH, Pak CJ et al. (1984) Effect of allopurinol on the survival of hyperemic island skin grafts. Plast Reconstr Surg 73: 276–278

    Article  PubMed  CAS  Google Scholar 

  • Im MJ, Manson PN, Bulkley GB et al. (1985) Effects of superoxide dismutase and allopurinol on the survival of acute island skin flaps. Ann Surg 201: 357–359

    Article  PubMed  CAS  Google Scholar 

  • Kakinuma K (1974) Effects of fatty acids on the oxidative metabolism of leukocytes. Biochim Biophys Acta 348: 76–85

    PubMed  CAS  Google Scholar 

  • Kellogg EW, Fridovich I (1975) Superoxide, hydrogen peroxide and singlet oxygen in lipid peroxidation by a xanthine oxidase system. J Biol Chem 250: 8812–8817

    PubMed  CAS  Google Scholar 

  • Kelly D, McEntee GP, McGeeney KF et al. (1989) Comparison of pathological changes in the local microvasculature in caerulein induced experimental haemorrhagic and oedematous pancreatitis. Digestion 43: 152 (abstract)

    Article  Google Scholar 

  • Koiwai T, Oguchi H, Kawa S et al. (1989) The role of oxygen free radicals in experimental acute pancreatitis in the rat. Int J Pancreatol 5: 135–143

    PubMed  CAS  Google Scholar 

  • Koyama I, Bulkley GB, Williams GM et al. (1985) The role of oxygen free radicals in mediating the reperfusion injury of cold preserved ischemic kidneys. Transplantation 40: 590–595

    Article  PubMed  CAS  Google Scholar 

  • Lankisch PG, Pohl U, Otto J et al. (1989) Xanthine oxidase inhibitor in acute experimental pancreatitis in rats and mice. Pancreas 4: 436–440

    Article  PubMed  CAS  Google Scholar 

  • Lombardi B (1976) Influence of dietary factors on the pancreatoxicity of ethionine. Am J Pathol 84: 633–644

    PubMed  CAS  Google Scholar 

  • MacGowan S, Bouchier-Hayes DJ, Broe PJ (1987) Experimental pancreatitis: the effect of allopurinol. Gut 28: A368 (abstract)

    Google Scholar 

  • Martensson J, Bolin T (1986) Sulfur amino acid metabolism in chronic relapsing pancreatitis. Am J Gastroenterol 81: 1179–1184

    PubMed  CAS  Google Scholar 

  • McCord JM (1974) Free radicals in inflammation: Protection of synovial fluid by superoxide dismutase. Science 185: 529–531

    Article  PubMed  CAS  Google Scholar 

  • McCord JM (1983) The superoxide free radical: its biochemistry and pathophysiology. Surgery 94: 412–414

    PubMed  CAS  Google Scholar 

  • McCord JM, Fridovich I (1978) The biology and pathology of oxygen radicals. Ann Intern Med 89: 122–127

    PubMed  CAS  Google Scholar 

  • McEntee G, Leahy A, Cottell D et al. (1989) Three dimensional morphological study of the pancreatic microvasculature in caerulein induced experimental pancreatitis. Br J Surg 76: 853–855

    Article  PubMed  CAS  Google Scholar 

  • Morgan AR, Cone RL, Elgert TM (1976) The mechanism of DNA strand breakage by vitamin C and superoxide and the protective role of catalase and superoxide dismutase. Nucleic Acids Res 3: 1139–1149

    PubMed  CAS  Google Scholar 

  • Nonaka A, Manabe T, Tamura K et al. (1989a) Changes of xanthine oxidase, lipid peroxide and superoxide dismutase in mouse acute pancreatitis. Digestion 43: 41–46

    Article  PubMed  CAS  Google Scholar 

  • Nonaka A, Manabe T, Asano N et al. (1989b) Direct ESR measurement of free radicals in mouse pancreatic lesions. Int J Pancreatol 5: 203–211

    PubMed  CAS  Google Scholar 

  • Parker G, Branigan S, Houston JB et al. (1986) Potent induction of cytochromes P448 by corn oil in Syrian golden hamsters. Gut 27: A603 (abstract)

    Google Scholar 

  • Parks DA, Granger DN (1983) Ischemia-induced microvascular changes. Role of xanthine oxidase and hydroxyl radical. Am J Physiol 245: G285–G289

    PubMed  CAS  Google Scholar 

  • Parks DA, Bulkley GB, Granger DN (1983) Role of oxygen derived free radicals in digestive tract diseases. Surgery 94: 415–512

    PubMed  CAS  Google Scholar 

  • Ratych RE, Chuknyiska R, Bulkley GB (1987) The primary localisation of free radical generation after anoxia/reoxygenation in isolated endothelial ceils. Surgery 102: 122–131

    PubMed  CAS  Google Scholar 

  • Rutledge PL, Saluja AK, Powers RE et al. (1987) Role of oxygen derived free radicals in diet induced haemorrhagic pancreatitis in mice. Gastroenterology 93:41–47 Sacks T,

    Google Scholar 

  • Moldow CF, Craddock PR et al. (1978) Oxygen radicals mediate endothelial cell damage by complement stimulated granulocytes. J Clin Invest 61: 1161–1167

    Article  PubMed  Google Scholar 

  • Saluja A, Powers RE, Saluja M et al. (1986) The role of oxygen free radicals in caerulein-induced pancreatitis. Gastroenterology 90: 1613 (abstract)

    Google Scholar 

  • Sanfey H (1986) The pathogenesis of acute pancreatitis. MCh Thesis. Trinity College, Dublin Sanfey H, Cameron JL (1984) Increased capillary permeability: an early lesion in acute pancreatitis. Surgery 96: 485–491

    Google Scholar 

  • Sanfey H, Bulkley GB, Cameron JL (1984) The role of oxygen derived free radicals in the

    Google Scholar 

  • pathogenesis of acute pancreatitis. Ann Surg 200:405–413

    Google Scholar 

  • Sanfey H, Broe PJ, Cameron JL (1985a) Experimental ischemic pancreatitis: treatment with albumin. Am J Surg 150: 297–300

    Article  PubMed  CAS  Google Scholar 

  • Sanfey H, Bulkley GB, Cameron JL (1985b) The pathogenesis of acute pancreatitis: the source and role of oxygen derived free radicals in three different experimental models. Ann Surg 201: 633–639

    Article  PubMed  CAS  Google Scholar 

  • Sanfey H, Sarr MG, Bulkley GB et al. (1986) Oxygen derived free radicals and acute pancreatitis: a review. Acta Physiol Scand 548: 109–118 (suppl)

    CAS  Google Scholar 

  • Sarr MG, Bulkley GB, Cameron JL (1987a) Temporal efficacy of allopurinol during the induction of pancreatitis in the ex-vivo, perfused, canine pancreas. Surgery 101: 342–345

    PubMed  CAS  Google Scholar 

  • Sarr MG, Bulkley GB, Cameron JL (1987b) The role of leukocytes in the production of oxygen derived free radicals in acute experimental pancreatitis. Surgery 101: 292–296

    PubMed  CAS  Google Scholar 

  • Wisner JR, Renner IG (1988) Allopurinol attenuates caerulein induced acute pancreatitis in the rat. Gut 29: 926–929

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. Hilary Sanfey
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Editors and Affiliations

  1. Faculty of Medicine, University Surgical Unit, Southampton General Hospital, Tremona Road, SO1 6HU, Southampton, UK

    C. D. Johnson MChir, FRCS (Senior Lecturer and Honorary Consultant Surgeon) (Senior Lecturer and Honorary Consultant Surgeon)

  2. Surgical Unit, Royal Infirmary, G4 OSF, Glasgow, UK

    C. W. Imrie ChB, FRCS (Consultant Surgeon) (Consultant Surgeon)

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© 1991 Springer-Verlag London Limited

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Sanfey, H. (1991). Free Radicals and Antioxidants in Pancreatic Inflammation. In: Johnson, C.D., Imrie, C.W. (eds) Pancreatic Disease. Springer, London. https://doi.org/10.1007/978-1-4471-3356-8_22

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  • DOI: https://doi.org/10.1007/978-1-4471-3356-8_22

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-3358-2

  • Online ISBN: 978-1-4471-3356-8

  • eBook Packages: Springer Book Archive

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