Skip to main content
SpringerLink
Log in

Experimental Models of Acute Pancreatitis

  • Chapter
Pancreatic Disease

Abstract

Pancreatitis was first induced experimentally in dogs as early as the mid-19th century by the intraductal injection of bile and other substances (Bernard 1855). Since then numerous experimental models have been described which have furthered our understanding of the pathogenesis and pathophysiology of acute pancreatitis, both at a glandular and cellular level. Experimental models have also permitted study of the treatment of acute pancreatitis and its many complications. Various models of experimental pancreatitis are summarised in Table 1.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 74.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Aho HJ, Koskensalo SM-L, Nevalainen TJ (1980) Experimental pancreatitis in the rat. Sodium taurocholate-induced acute haemorrhagic pancreatitis. Scand J Gastroenterol 15: 411–416

    Article  PubMed  CAS  Google Scholar 

  • Armstrong CP, Taylor TV, Torrance HB (1985a) Pressure, volume and the pancreas. Gut 26: 615–624

    Article  PubMed  CAS  Google Scholar 

  • Armstrong CP, Taylor TV, Torrance HB (1985b) Effects of bile, infection and pressure on pancreatic duct integrity. Br J Surg 72: 792–795

    Article  PubMed  CAS  Google Scholar 

  • Bartholomew C (1970) Acute scorpion pancreatitis in Trinidad. Br Med J i: 666–668

    Google Scholar 

  • Bernard C (1855) Leçons de physiologie expérimentale appliquée à la médicine. J.B. Balliere, Paris. (Quoted by Frey CF (1986) Classification of pancreatitis: state of the art, 1986. Pancreas 1: 62–68

    Google Scholar 

  • Blenkinsopp WK (1978) The liver and pancreas in acute necrotising pancreatitis. J Clin Pathol 31: 791–793

    Article  PubMed  CAS  Google Scholar 

  • Chetty U, Gilmour HM, Taylor TV (1980) Experimental acute pancreatitis in the rat — a new model. Gut 21: 115–117

    Article  PubMed  CAS  Google Scholar 

  • Coelle EF, Adham N, Elashoff J, Lewin K, Taylor IL (1983) Effects of prostaglandin and indomethacin on diet-induced acute pancreatitis in mice. Gastroenterology 85: 1307–1312

    PubMed  CAS  Google Scholar 

  • Dickson AP, Foulis AK, Imrie CW (1986) Histology and bacteriology of closed duodenal loop models of experimental acute pancreatitis in the rat. Digestion 34: 15–21

    Article  PubMed  CAS  Google Scholar 

  • Dressel TD, Goodale RL, Arneson MA, Borner JW (1979) Pancreatitis as a complication of anticholinesterase insecticide intoxication. Ann Surg 189: 199–204

    Article  PubMed  CAS  Google Scholar 

  • Elliot DW, Williams RD, Zollinger RM (1957) Alterations in the pancreatic resistance to bile in the pathogenesis of acute pancreatitis. Ann Surg 146: 669–682

    Article  Google Scholar 

  • Emslie R, White TT, Magee DF (1966) The significance of reflux of trypsin and bile in the pathogenesis of human pancreatitis. Br J Surg 53: 809–816

    Article  Google Scholar 

  • Feiner H (1976) Pancreatitis after cardiac surgery. A morphologic study. Am J Surg 131: 684–688

    Article  PubMed  CAS  Google Scholar 

  • Foulis AK (1980) Histological evidence of initiating factors in acute necrotising pancreatitis in man. J Clin Pathol 33: 1125–1131

    Article  PubMed  CAS  Google Scholar 

  • Foulis AK (1982) Morphological study of the relation between accidental hypothermia and acute pancreatitis. J Clin Pathol 35: 1244–1248

    Article  PubMed  CAS  Google Scholar 

  • Gilliland L, Steer ML (1980) Effects of ethionine on digestive enzyme synthesis and discharge by mouse pancreas. Am J Physiol 239: G418–G426

    PubMed  CAS  Google Scholar 

  • Imrie CW, Mackenzie M (1981) Effective aprotinin therapy in canine experimental bile-trypsin pancreatitis. Digestion 22: 32–38

    Article  PubMed  CAS  Google Scholar 

  • Kloppel G, von Gerkan R, Dreyer T (1984) Pathomorphology of acute pancreatitis. Analysis of 367 autopsy cases and 3 surgical specimens. In: Gyr KE, Singer MV, Sarles H (eds) Pancreatitis. Concepts and classification. Elsevier, Amsterdam, pp 29–35

    Google Scholar 

  • Konok GP, Thompson AG (1969) Pancreatic ductal mucosa as a protective barrier in the pathogenesis of pancreatitis. Am J Surg 117: 18–23

    Article  PubMed  CAS  Google Scholar 

  • Lampel M, Kern HF (1977) Acute interstitial pancreatitis in the rat induced by excessive doses of a pancreatic secretagogue. Virchows Arch [A] 373: 97–117

    Article  CAS  Google Scholar 

  • Lankisch PG, Koop H, Winckler K, Kunze H, Vogt W (1978) Indomethacin treatment of acute experimental pancreatitis in the rat. Scand J Gastroenterol 13: 629–633

    Article  PubMed  CAS  Google Scholar 

  • Lankisch PG, Koop H, Winckler K, Schmidt H (1979) Continuous peritoneal dialysis as treatment of acute experimental pancreatitis in the rat. I. Effect on length and rate of survival. Dig Dis Sci 24: 111–116

    Article  PubMed  CAS  Google Scholar 

  • Lombardi B, Estes LW, Longnecker DS (1975) Acute hemorrhagic pancreatitis (massive necrosis) with fat necrosis induced in mice by DL-ethionine fed with a choline-deficient diet. Am J Pathol 79: 465–475

    PubMed  CAS  Google Scholar 

  • Manabe T, Steer ML (1979) Protease inhibitors and experimental acute hemorrhagic pancreatitis. Ann Surg 190: 13–17

    Article  PubMed  CAS  Google Scholar 

  • McCutcheon AD (1968) A fresh approach to the pathogenesis of acute pancreatitis. Gut 9: 296–310

    Article  PubMed  CAS  Google Scholar 

  • Menguy RB, Hallenbeck GA, Bollman JL, Grindlay JH (1957) Ductal and vascular factors in etiology of experimentally induced acute pancreatitis. Arch Surg 74: 881–889

    Article  CAS  Google Scholar 

  • Niederau C, Ferell LD, Grendell JH (1984) Onset, course and regression of caerulin-induced acute necrotizing pancreatitis in mice. Dig Dis Sci 29: 962

    Google Scholar 

  • Olazabal A (1983) Effect of prostaglandins E2 and I2 and of indomethacin on deoxycholic acid-induced damage to the rat bile-pancreatic duct. Gastroenterology 84: 928–934

    PubMed  CAS  Google Scholar 

  • Opie EL (1901) The aetiology of acute haemorrhagic pancreatitis. Bull Johns Hopkins Hosp 12: 182–188

    Google Scholar 

  • Papp M (1976) Pathogenesis of acute pancreatitis: pancreatic ductal-interstitial-vascular and lymphatic pathways. Acta Med Acad Sci Hung 33: 191–206

    PubMed  CAS  Google Scholar 

  • Paulino-Netto A, Dreiling DA (1960) Chronic duodenal obstruction: a mechano-vascular etiology of pancreatitis. Am J Dig Dis 5: 1006–1018

    Article  PubMed  CAS  Google Scholar 

  • Pfeffer RB, Stasior O, Hinton JW (1957) The clinical picture of the sequential development of acute hemorrhagic pancreatitis in the dog. Surg Forum 8: 248–251

    PubMed  CAS  Google Scholar 

  • Popper HL, Necheles H (1942) Edema of the pancreas. Surg Gynecol Obstet 74: 123–124

    Google Scholar 

  • Popper HL, Necheles H, Russell KC (1948) Transition of pancreatic edema into pancreatic necrosis. Surg Gynecol Obstet 87: 79–82

    PubMed  CAS  Google Scholar 

  • Radakovich M, Pearse HE, Strain WH (1952) Study of etiology of acute pancreatitis. Surg Gynecol Obstet 94: 749–754

    PubMed  CAS  Google Scholar 

  • Rao KN, Toma J, Lombardi B (1976) Acute hemorrhagic pancreatitis in mice: intraparenchymal activation of zymogens, and other enzyme changes in pancreas and serum. Gastroenterology 70: 720–726

    PubMed  CAS  Google Scholar 

  • Rao KN, Zuretti MF, Baccino FM, Lombardi B (1980) Acute hemorrhagic pancreatic necrosis in mice. The activity of lysosomal enzymes in the pancreas and the liver. Am J Pathol 98: 45–60

    PubMed  CAS  Google Scholar 

  • Rao KN, Eagon PK, Okamura K (1982) Acute hemorrhagic pancreatic necrosis in mice. Induction in male mice treated with estradiol. Am J Pathol 109: 8–14

    PubMed  CAS  Google Scholar 

  • Rao SS, Watt IA, Donaldson LA, Crocket A, Joffe SN (1981) A serial histologic study of the development and progression of acute pancreatitis in the rat. Am J Pathol 103: 39–46

    PubMed  CAS  Google Scholar 

  • Reber HA, Mosley JG (1980) The effect of bile salts on the pancreatic duct mucosal barrier. Br J Surg 67: 59–62

    Article  PubMed  CAS  Google Scholar 

  • Reber HA, Roberts C, Way LW (1979) The pancreatic duct mucosal barrier. Am J Surg 137: 128–134

    Article  PubMed  CAS  Google Scholar 

  • Renner IG, Wisner JR (1983) Exogenous secretin ameliorates ceruletide induced acute pancreatitis in the dog. Dig Dis Sci 28: 946

    Article  Google Scholar 

  • Rich AR, Duff EL (1936) Experimental and pathological studies on the pathogenesis of acute haemorrhagic pancreatitis. Bull Johns Hopkins Hosp 58: 212–259

    Google Scholar 

  • Saharia P, Margolis S, Zuidema GD, Cameron JL (1977) Acute pancreatitis with hyperlipemia: studies with an isolated perfused canine pancreas. Surgery 82: 60–67

    PubMed  CAS  Google Scholar 

  • Sanfey H, Bulkley GB, Cameron JL (1985) The pathogenesis of acute pancreatitis. The source and role of oxygen-derived free radicals in three different experimental models. Ann Surg 201: 633–639

    Article  PubMed  CAS  Google Scholar 

  • Schmidt H, Creutzfeldt W (1969) The possible role of phospholipase A in the pathogenesis of acute pancreatitis. Scand J Gastroenterol 4: 39–48

    Article  PubMed  CAS  Google Scholar 

  • Seelig R, Seelig HP (1975) The possible role of serum complement system in the formal pathogenesis of acute pancreatitis. Acta Hepatogastroenterol 22: 263–268

    CAS  Google Scholar 

  • Seidel H (1910) Bemerkungen zu meiner methode der experimentellen erzeugung der akuten haemorrhagischen Pankreatitis. Zentralbl Chir 37:1601–1604

    Google Scholar 

  • Steer ML, Meldolesi J, Figarella C (1984) Pancreatitis. The role of lysosomes. Dig Dis Sci 29: 934–938

    Google Scholar 

  • Thal A (1955) Studies on pancreatitis. II. Acute pancreatic necrosis produced experimentally by the Arthus sensitization reaction. Surgery 37: 911–917

    PubMed  CAS  Google Scholar 

  • Thai A, Brackney E (1954) Acute hemorrhagic pancreatic necrosis produced by local Schwartzman reaction. JAMA 155: 569–574

    Article  Google Scholar 

  • Watanabe O, Baccino MF, Steer ML, Meldolesi J (1984) Supramaximal caerulin stimulation and ultrastructure of rat pancreatic acinar cell: early morphological changes during development of experimental pancreatitis. Am J Physiol 246: G457–G467

    PubMed  CAS  Google Scholar 

  • White TT, Magee DF (1960) Perfusion of the dog pancreas with bile without production of pancreatitis. Ann Surg 151: 245–250

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. C. Wilson
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. C. W. Imrie
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Faculty of Medicine, University Surgical Unit, Southampton General Hospital, Tremona Road, SO1 6HU, Southampton, UK

    C. D. Johnson MChir, FRCS (Senior Lecturer and Honorary Consultant Surgeon) (Senior Lecturer and Honorary Consultant Surgeon)

  2. Surgical Unit, Royal Infirmary, G4 OSF, Glasgow, UK

    C. W. Imrie ChB, FRCS (Consultant Surgeon) (Consultant Surgeon)

Rights and permissions

Reprints and permissions

Copyright information

© 1991 Springer-Verlag London Limited

About this chapter

Cite this chapter

Wilson, C., Imrie, C.W. (1991). Experimental Models of Acute Pancreatitis. In: Johnson, C.D., Imrie, C.W. (eds) Pancreatic Disease. Springer, London. https://doi.org/10.1007/978-1-4471-3356-8_21

Download citation

  • DOI: https://doi.org/10.1007/978-1-4471-3356-8_21

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-3358-2

  • Online ISBN: 978-1-4471-3356-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation