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Endocrinology of Male Infertility and Fertility

Part of the Clinical Practice in Urology book series (PRACTICE UROLOG)

Abstract

The gonads are unique amongst endocrine glands in that they have two functions: steroid hormone synthesis and gamete production. Spermatogenesis takes place within the seminiferous tubules while the sex steroids are synthesised in the Leydig cells in the interstitial spaces. As well as anatomical proximity (Fig. 6.1) there is close functional interrelationship. It has recently become clear that high intratesticular androgen concentrations are necessary for normal spermatogenesis and this concept has influenced thinking about patient management and also determined the direction of recent research.

Keywords

Luteinising Hormone Sertoli Cell Leydig Cell Seminiferous Tubule Male Infertility 
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References

  1. Ahmad N, Haltemeyer C, Eik-Nes KB (1973) Maintenance of spermatogenesis in rats with intratesticular implants of testosterone or dihydrotestosterone. Biol Reprod 8: 411–419PubMedGoogle Scholar
  2. Aiman J, Griffen JE, Gazak JM, Wilson JD, MacDonald PC (1979a) Androgen insensitivity as a causeof male infertility in otherwise normal men. N Engl J Med 300: 223–227PubMedCrossRefGoogle Scholar
  3. Aiman J, Griffen JE, Gazak JM, Parker CR, Wilson JD, MacDonald PC (1979b) The frequency of androgen insensitivity in infertile but otherwise normal men. Presented at the 26th Annual Meeting of the Society for Gynecological Investigation, San DiegoGoogle Scholar
  4. Anderson DC (1974) Sex-hormone-binding globulin. Clin Endocrinol 3: 69–96CrossRefGoogle Scholar
  5. Baker HWG, Santen RJ, Bureger HG, de Kretser DM, Hudson B, Pepperell RJ, Bardin CW (1975) Rhythms in the secretion of gonadotrophins and gonadal steroids. J Steroid Biochem 6: 793–801PubMedCrossRefGoogle Scholar
  6. Baker HWG, Bremner WJ, Burger HG, de Kretser DM, Dulmanis A, Eddie LW, Hudson B, Keogh EJ, Lee VWK, Rennie GC (1976a) Testicular control of follicle-stimulating hormone secretion. Recent Prog Horm Res 32: 429–469PubMedGoogle Scholar
  7. Baker HWG, Burger HG, de Kretser DM, Hudson B, O’Conner A, Wang C, Mirovies A, Court J, Dunlop M, Rennie GC (1976b) Changes in the pituitarv testicular system with age. Clin Endocrinol 5: 349–372CrossRefGoogle Scholar
  8. Bartke A (1971) Effects of prolactin on spermatogenesis in hypophysectomized mice. J Endocrinol 49: 311–316PubMedCrossRefGoogle Scholar
  9. Bartke A, Hafiez AA, Bax FJ, Dalterior S (1978) Hormonal interactions in regulation of androgen secretion. Biol Reprod 18: 44–54PubMedCrossRefGoogle Scholar
  10. Blacker AC, Asfour M, Boutemy JJ, Gasnault JB, Fossati P, L’Hermite M (1977) Étude de la prolactinaemie basale dans le stérilité masculine. Nouv Presse Med 6: 3979PubMedGoogle Scholar
  11. Bramble FJ, Houghton AL, Eccles S, O’Shea A, Jacobs HS (1974) Reproductive and endocrine function after surgical treatment of bilateral cryptorchidism. Lancet ii: 311–314CrossRefGoogle Scholar
  12. Brown-Grant K (1977) Physiological aspects of the steroid hormone-gonadotrophin interrelationship. In: Green RO (ed) International Review of Physiology, Reproductive Physiology II. Vol 13. University Park Press, Baltimore, pp 57–83Google Scholar
  13. Bruchowsky N, Wilson JD (1968) The conversion of testosterone to 5-androstan-17-ol-3-one by rat prostate in vivo and in vitro. J Biol Chem 243: 2012–2021Google Scholar
  14. Carmel PW, Araki S, Ferin M (1976) Pituitary stalk portal blood collection in rhesus monkeys: Evidence for pulsatile release of gonadotrophin releasing hormone (GnRH). Endocrinology 99: 243–248PubMedCrossRefGoogle Scholar
  15. Catt KJ, Dufau ML (1976) Basic concepts of the mechanism of action of peptide hormones. Biol Reprod 14: 1–15PubMedCrossRefGoogle Scholar
  16. Chapman RM, Sutcliffe BB, Rees LH, Edwards CRW, Malpas JC (1979) Cyclical combination chemotherapy and gonadal function. Lancet 1: 285–289PubMedCrossRefGoogle Scholar
  17. Charreau EH, Attramadel A, Torjesen PA, Purvis K, Calandra R, Hansson V (1977) Prolactin binding in rat testis: specific receptors in interstitial cells. Mol Cell Endocrinol 6: 303–307PubMedCrossRefGoogle Scholar
  18. Clermont Y (1963) The cycles of the seminiferous epithelium in man. Am J Anat 112: 35–51PubMedCrossRefGoogle Scholar
  19. Clermont Y, Morgentaler H (1955) Quantitative study of spermatogenesis in the hypophysectomized rat. Endocrinology 57: 369–382PubMedCrossRefGoogle Scholar
  20. Comhaire F. Vermeulen A (1975) Plasma testosterone in patients with varicocele and sexual inadequacy. J Clin Endocrinol Metab 40: 824–829PubMedCrossRefGoogle Scholar
  21. Cunningham GR, Huckins C (1979) Persistence of complete spermatogenesis in the presence of low intratesticular concentrations of testosterone. Endocrinology 105: 177–186PubMedCrossRefGoogle Scholar
  22. Davies RV, Main SJ, Setchell BP (1978) Inhibin: evidence for its existence, methods of bioassay and nature of the active material. Int J Androl 2: 102–113CrossRefGoogle Scholar
  23. de Kretser DM (1979) Endocrinology of male infertility. Br Med Bull 35: 187–192PubMedGoogle Scholar
  24. de Kretser DM, Burger HG, Hudson B, Keogh EJ (1975) The hCG stimulation test in men with testicular disorders. Clin Endocrinol 4: 591–596CrossRefGoogle Scholar
  25. de Kretser DM, Burger HG, Hudson B (1974) The relationship between germinal cells and serum FSH levels in males with infertility. J Clin Endocrinol Metab 38: 787–793PubMedCrossRefGoogle Scholar
  26. de Kretser DM, Holstein AF (1976) Testicular biopsy and abnormal cells. In: Hafez ESE (ed) Human semen and fertility regulation in men. The CV Mosby Co., St. Louis, pp 337Google Scholar
  27. Dorrington JH, Armstrong DT (1975) Follicle-stimulating hormone stimulates estradiol-17 synthesis in cultured Sertoli cells. Proc Natl Acad Sci USA 72: 2677–2681PubMedCrossRefGoogle Scholar
  28. Dorrington JH (1980) Pituitary and placental hormones. In: Austin CA, Short RV (eds) Reproduction in mammals. Book T. Mechanism of hormone action. Cambridge University Press, Cambridge, pp: 53–80Google Scholar
  29. Dufau ML, Hsueh AJ, Cigorraga S, Baukel A, Catt KJ (1978) inhibition of Leydig cell function through hormone regulatory mechanisms. Int J Androl 2: 193–239CrossRefGoogle Scholar
  30. Elkington JCH, Sanborn BM, Steinberger E (1975) The effect of testosterone proprionate on the concentration of testicular and epididymal androgen binding protein. Mol Cell Endocrinol 2: 157–170PubMedCrossRefGoogle Scholar
  31. Foss GL, Lewis FJW (1971) A study of four cases with Klinefelter’s syndrome showing motile spermatozoa in their ejaculate J Reprod Fertil 25: 401–408PubMedCrossRefGoogle Scholar
  32. Foster DL, Michelson IH, Ryan KD, Coon GA, Drogowski RA, Holt JA (1978) Ontogeny of pulsatile luteinizing hormone and testosterone secretion in male lambs. Endocrinology 102: 1137–1146PubMedCrossRefGoogle Scholar
  33. Franchimont P, Millet D, Vendreley E, Letawe J, Legros JJ, Netter A (1972) Relationship between spermatogenesis and serum gonadotrophin levels in azoospermia and oligospermia. J Clin Endocrinol Metab 34: 1003–1008PubMedCrossRefGoogle Scholar
  34. Franchimont P, Verstralen-Proyard, J, Hazee-Hagelstein MT, Renard CH, Demoulin A, Bourguinon JP, Hustin J (1979) Inhibin: from concept to reality. Vitam Horm 37: 243–302PubMedCrossRefGoogle Scholar
  35. Fritz IB, Louis BG, Tung PS, Griswold M, Rommerts FG, Dorrington JH (1975) Biochemical responses of cultured Sertoli cell enriched preparations to follicle-stimulating hormone and dibutyryl cyclic AMP. In: French FS, Hansson V, Ritzen EM, Nayfeh SN (eds) Hormonal regulation of spermatogenesis. Plenum Press, New York, pp 367–382CrossRefGoogle Scholar
  36. Fritz IB, (1978) Sites of action of androgens and follicle-stimulating hormone on cells of the seminiferous tubule. In: Litwok G (ed) Biochemical action of hormones. Academic Press, New York, pp 249–281Google Scholar
  37. Hall PF (1970) Endocrinology of the testis. In: Johnson AD, Gomes WR, Van Demark NL (eds) The Testis, Vol. 2. Academic Press, New York, pp 1–71Google Scholar
  38. Hargreave TB, Richmond JD, Liakatas J, Elton RA, Brown NS (1981) Searching for the infertile man with hyperprolactinaemia. Fertil Steril 36: 630–632PubMedGoogle Scholar
  39. Hashimoto T, Miyai K, Onishi T, Matsumato K, Kumahara Y (1975) Comparison of short and long term treatment with synthetic LHRH and clomiphene citrate in male hypothalamic hypogonadism. J Clin Endocrinol Metab 41: 905–910PubMedCrossRefGoogle Scholar
  40. Hermabessiere J, Boucher D, Gaillard J (1977) Hyperprolactinemie chez l’homme stérile. Action de la bromocriptine. Nouv Presse Med 6: 853–854PubMedGoogle Scholar
  41. Holmes GE, Holmes FH (1978) Pregnancy outcome of patients treated for Hodgkin’s disease. Cancer 41: 1317–1322PubMedCrossRefGoogle Scholar
  42. Hunter WM, Bennie JG (1979) Minimization of non-specific serum responses in human pituitary gonadotrophin radioimmunoassays. J Endocrinol 80: 59–68PubMedCrossRefGoogle Scholar
  43. Kallmann F, Schonfeld WA, Barrera SE (1944) Genetic aspects of primary eununchoidism. Am J Ment Defic 48: 203–236Google Scholar
  44. Kerr JB, Rich KA, de Kretser DM (1979) Alterations of the fine structure and androgen secretion of the interstitial cells in the experimentally cryptorchid rat testis. Biol Reprod 20: 409–422PubMedCrossRefGoogle Scholar
  45. Kingsley TR, Bogdanove EM (1973) Direct feedback of androgens: localized effects of intrapituitary implants of androgens on gonadotrophic cells and hormone stores. Endocrinology 93: 1398–1409PubMedCrossRefGoogle Scholar
  46. Krieger DT, Ossowski R, Fogel M, Allen W (1972) Lack of circadian periodicity of human serum FSH and LH levels. J Clin Endocrinol Metab 35: 619–623PubMedCrossRefGoogle Scholar
  47. Lendon M. Hann IM, Palmer MK, Shalet SM, Morris-Jones PH (1978) Testicular histology after combination chemotherapy in childhood for acute lymphoblastic leukaemia. Lancet 2: 439–441PubMedCrossRefGoogle Scholar
  48. Lincoln GA, Short RV (1980) Seasonal breeding: nature’s contraceptive. Recent Prog Horm Res 36: 1–52PubMedGoogle Scholar
  49. McCullagh DR (1932) Dual endocrine activity of testes. Science 76: 19–20PubMedCrossRefGoogle Scholar
  50. McCullagh EP, Beck JC, Schaffenberg CA (1953) A syndrome of eunuchoidism with spermatogenesis, normal urinary FSH and low or normal ICSH (‘fertile eunuch’). J Clin Endocrinol Metab 13: 489–509PubMedCrossRefGoogle Scholar
  51. McIlree M, Price W, Court Brown WM, Selby Tulloch W. Newsam JE, Maclean N (1966) Chromosome studies on testicular cells from 50 subfertile men. Lancet ii: 69–71CrossRefGoogle Scholar
  52. Mancini RE, Vilar O, Donini P, Perez Lloret A (1971) Effect of human urinary FSH and LH on the recovery of spermatogenesis in hypophysectomized patients. J Clin Endocrinol Metab 33: 888–895PubMedCrossRefGoogle Scholar
  53. Means AR, Dedman JR, Tindall DJ, Welsh MT (1978) Hormonal regulation of Sertoli cells. Int J Androl 2: 403–421CrossRefGoogle Scholar
  54. Means AR, Fakunding JL, Huckins C, Tindall DJ, Vitale R (1976) Follicle-stimulating hormone, the Sertoli cell and spermatogenesis. Recent Prog Horm Res 32: 477–527PubMedGoogle Scholar
  55. Mecklenburg RS, Sherins RJ (1974) Gonadotrophin response to luteinizing hormone-releasing hormone in men with germinal aplasia. J Clin Endocrinol Metab 38: 1005–1008PubMedCrossRefGoogle Scholar
  56. Mortimer CH, McNeilly AS, Fisher RA, Murray MAF, Besser GM (1974) Gonadotrophin-releasing hormone therapy in hypogonadal males with hypothalamic or pituitarv dysfunction. Br Med J 4: 617–621PubMedCrossRefGoogle Scholar
  57. Moyle WR. Jungas RL, Greep RO (1973) Influence of luteinising hormone and adenosine 3’: 5’-cyclic monophosphate on the metabolism of free and esterified cholesterol in mouse Levdig-cell tumour. Biochem J 134: 407–413Google Scholar
  58. Mulder E, Peters MJ, van Beurden WMO, Galdini M, Rommerts FFG, Janszen FHA, Van der Molen HJ (1976) Androgen receptors in isolated cell preparations obtained from rat testicular tissue. J Endocrinol 70: 331–332PubMedCrossRefGoogle Scholar
  59. Nieschlag E, Wickings EJ, Mauss J (1978) Endocrine testicular function in infertility. In: Fabbrini A, Steinberger E (eds) Recent progress in andrology. Proceedings of Serono Symposium Vol 14. Academic Press, London, pp: 101–113Google Scholar
  60. Nieschlag E, Wickings EJ, Mauss J (1979) Endocrine testicular function in vivo and in vitro in infertile men. Acta Endocrinol 90: 544–551PubMedGoogle Scholar
  61. Orth J, Christensen AK (1977) Localization of 125I-labelled FSH in the testes of hypophysectomized rats by autoradiography at the light and electron microscope levels. Endocrinology 101: 262–278PubMedCrossRefGoogle Scholar
  62. Paulsen CA (1974) in: Williams RH (ed) The testis. Textbook of endocrinology 5th Edn. Saunders, Philadelphia, pp 335–341Google Scholar
  63. Pierrepoint CG, John BM, Groom GV, Wilson DW, Gow JC (1978) Prolactin and testosterone levels in the plasma of fertile and infertile men. J Endocrinol 76: 171–172PubMedCrossRefGoogle Scholar
  64. Purvis K, Bremner PF, Landgren BM, Cekan Z, Diczfalusy E (1975a) Indices of gonadal function in the human male. I. Plasma levels of unconjugated steroids and gonadotrophins under normal and pathological conditions. Clin Endocrinol 4: 237–246CrossRefGoogle Scholar
  65. Purvis K, Langren BM, Cekan Z, Diczfaluzy E (1975b) Indices of gonadal function in the human male. II. Seminal plasma levels of steroids in normal and pathological conditions. Clin Endocrinol 4: 247–258CrossRefGoogle Scholar
  66. Raj HGM, Dym M (1976) The effects of selective withdrawal of FSH on LH on spermatogenesis in the immature rat. Biol Reprod 14: 489–494Google Scholar
  67. Rabinowitz D, Cohen M, Rosenman S, Segal S, Bell J (1974) Germinal aplasia of the testis associated with FSH deficiency of hypothalamic origin. Clin Res 22: 346AGoogle Scholar
  68. Rodriguez-Rigau LJ, Weiss PB, Smith KD, Steinberger E (1978) Suggestion of abnormal testicular steroidogenesis in some Oligospermic men. Acta Endocrinol 87: 400–412PubMedGoogle Scholar
  69. Roesen JP, Stacks AE, Smith AJ (1978) Testicular damage due to cytotoxic drugs and recovery after cessation of therapy. Aust NZ J Med 8: 250–254CrossRefGoogle Scholar
  70. Ross GT (1970) Plasma FSH and LH measured by radioimmunoassay in normal and pathological conditions in men. In: Rosemberg R. Paulsen CA (eds) The human testis. Plenum Press, New York, pp 289–296Google Scholar
  71. Roulier R, Mattei A, Reuter A, Franchimont P (1976) Plasma prolactin levels in male sterility and hypogonadism. Ann Endocrinol (Paris) 37: 285–286Google Scholar
  72. Rogol AD, Mittal KK, White BJ, McGinniss MH, Lieblich JM, Rosen SW (1980) HLA compatible paternity in two ‘fertile eunuchs’ with congenital hypogonadotrophic hypogonadism and anosmia (the Kallmann’s syndrome). J Clin Endocrinol Metab 57: 275–279CrossRefGoogle Scholar
  73. Rubin TR, Gouin PR, Lubin A, Poland RE, Pirke KM (1975) Nocturnal increase of plasma testosterone in men: relation to gonadotropins and prolactin. J Clin Endocrinol Metab 40: 1027PubMedCrossRefGoogle Scholar
  74. Rubin RT, Poland RE, Tower BB (1976) Prolactin-related testosterone secretion in normal adult men. J Clin Endocrinol Metab 42: 112–116PubMedCrossRefGoogle Scholar
  75. Saidi K, Wenn RW, Sharif F (1977) Bromocriptine for male infertility. Lancet 1: 250–251PubMedCrossRefGoogle Scholar
  76. Sanborn BM, Elkington SH, Chowdhury M, Tcholakian RK, Steinberger E (1975) Hormonal influences on the level of testicular androgen binding activity: effect of FSH following hypophysectomy. Endocrinology 96: 304–312PubMedCrossRefGoogle Scholar
  77. Santen RJ (1977) Independent effects of testosterone and oestradiol on the secretion of gonadotrophins in man. In: Nankin HR, Troen P (eds) The testis in normal and infertile men. Raven Press, New York, pp 197–211Google Scholar
  78. Santen RJ, Bardin CW (1973) Episodic luteinizing hormone secretion in man. J Clin Invest 52: 2617–2628PubMedCrossRefGoogle Scholar
  79. Santen RJ, Paulsen CA (1973) Hypogonadotropic hypogonadism. I. Clinical study of inheritance. J Clin Endocrinol Metab 36: 47–54PubMedCrossRefGoogle Scholar
  80. Santen RJ, Ruby EB (1979) Enhanced frequency and magnitude of episodic luteinizing hormone-releasing hormone discharge as a hypothalamic mechanism for increased luteinizing hormone secretion. J Clin Endocrinol Metab 48: 315–319PubMedCrossRefGoogle Scholar
  81. Schally AV, Arimura A, Kastin AJ, Matsuo H, Baba Y, Redding TW, Nair RMG, Debeljuk L, White WF (1971) The gonadotrophin-releasing hormone: a single hypothalamic polypeptide regulates the secretion of both LH and FSH. Science 173: 1036–1038PubMedCrossRefGoogle Scholar
  82. Schilsky RL, Lewis BJ, Sherins RJ, Young RC (1980) Gonadal dysfunction in patients receiving chemotherapy for cancer. Ann Intern Med 93: 109–114PubMedGoogle Scholar
  83. Scott RS, Burger HG (1980) Inhibin is absent from azoospermic semen of infertile men. Nature 285: 246–247PubMedCrossRefGoogle Scholar
  84. Segal S, Polishuk WZ, Ben-David M (1976) Hyperprolactinaemic male infertility. Fertil Steril 27: 1425–1427PubMedGoogle Scholar
  85. Setchell BP, Waites GMH (1975) The blood-testis barrier. In: Hamilton DW, Greep RO (eds) Male reproductive system, Section 7, Endocrinology. Handbook of Physiology, Vol V. American Physiological Society, Washington DC, pp 143–172Google Scholar
  86. Setchell BP (1980a) The functional significance of the blood-testis barrier. J Androl 1: 3–10Google Scholar
  87. Setchell BP, Davies RV, Main SJ (1977) Inhibin. In: Johnson AD, Gomes WR, Van Demark NL (eds) The testis, Vol 4. Academic Press, New York, pp: 190–237Google Scholar
  88. Shah GV, Desai RB, Sheth A (1976) Effect of prolactin on metabolism of human spermatozoa. Fertil Steril 27: 1292–1294PubMedGoogle Scholar
  89. Sherins RJ, Olweny CLM, Ziegler JL (1978) Gynaecomastia and gonadal dysfunction in adolescent boys treated with combination chemotherapy for Hodgkin’s disease. N Engl J Med 299: 12–16PubMedCrossRefGoogle Scholar
  90. Sheth AR, Mugatwala PP, Shah GV, Rao SS (1975) Occurrence of prolactin in human semen. Fertil Steril 26: 905–907PubMedGoogle Scholar
  91. Sitterii PK, MacDonald PC (1973) Role of extraglandular oestrogen in human endocrinology. In: Greep RO, Astwood EB (eds) Handbook of Physiology, Section 7, Vol II. American Physiological Society, Washington DC, pp 615–630Google Scholar
  92. Sjöberg В, de la Torre В, Hedman M, Falkay G, Diczfalusy E (1979) Circadian variation in systemic hormone levels in healthy men. J Endocrinol Invest 2: 131–137PubMedGoogle Scholar
  93. Steinberger E (1971) Hormonal control of mammalian spermatogenesis. Physiol Rev 51: 1–51Google Scholar
  94. Steinberger A (1979) Inhibin production by Sertoli cells in culture. J Reprod Fertil 2: 31–45Google Scholar
  95. Steinberger E, Smith KD, Tcholakian RK, Chowdhury AK, Steinberger A, Fischer M, Paulsen CA (1974a) Steroidogenesis in human testes. In: Mancini RE, Martini L (eds) Male fertility and sterility, Proceedings of the Serono symposium, Vol 5. Academic Press. New York. pp 149–174Google Scholar
  96. Stewart-Bentley M, Horton R (1973) Leydig cell function in Klinefelter’s syndrome. Metabolism 22: 875–884PubMedCrossRefGoogle Scholar
  97. Stewart-Bentley M, Wallack M (1975) Isolated FSH deficiency in a male. Clin Res 23: 96AGoogle Scholar
  98. Swerdloff RS, Walsh PC (1975) Pituitary and gonadal hormones in patients with varicocele. Fertil Steril 26: 1006–1012PubMedGoogle Scholar
  99. Thorner MO, Edwards CRW, Hanker JP, Abraham G, Besser GM (1977) Prolactin and gonadotrophin interaction in the male. In: Troen P, Nankin HR (eds) The testis in normal and infertile men. Raven Press, New York, pp 351–366Google Scholar
  100. Valk TW, Corby KP, Kelch RP, Marshall JC (1980) Hypogonadotrophic hypogonadism. Hormonal responses to low dose pulsatile administration of gonadotrophin-releasing hormone. J Clin Endocrinol Metab 51: 730–738PubMedCrossRefGoogle Scholar
  101. Van Zyl JA, Menkveld R, Kotze JJ van W, Retief AE, van Niekerk WA (1975) Oligozoospermia: a seven year survey of the incidence, chromosomal aberrations, treatment and pregnancy rate. Int J Fertil 20: 129–132PubMedGoogle Scholar
  102. Vermeulen A (1979) Decline in sexual activity in ageing men: correlation with sex hormone levels and testicular changes. J Biosoc Sci 6: 5–18CrossRefGoogle Scholar
  103. Vigersky RA, Loriaux DL, Howards SS, Hodgen GD, Lipsett MB, Chrambach A (1976) Androgenbinding proteins of testis epididymis and plasma in man and monkey. J Clin Invest 58: 1061–1068PubMedCrossRefGoogle Scholar
  104. Wang C, Baker HWG, Burger HG, de Kretser DM, Hudson В (1975) Hormonal studies in Klinefelter’s syndrome. Clin Endocrinol 4: 399–414CrossRefGoogle Scholar
  105. Weddington SC, Hansson V, Ritzen EM, Hagenas L, French FS, Nayfeh SN (1975) Sertoli cell secretory function after hypophysectomy. Nature (Lond) 254: 145–146CrossRefGoogle Scholar
  106. Weiss DB, Rodriguez-Rigau LJ, Smith KD, Steinberger E (1978) Leydig cell function in Oligospermic men with varicocele. J Urol 120: 427–430PubMedGoogle Scholar
  107. Wickings EJ, Usadel KH, Dathe G, Nieschlag E (1980) The role of follicle-stimulating hormone in testicular function of the mature rhesus monkey. Acta Endocrinol 95: 117–128PubMedGoogle Scholar
  108. Wu FCW, Borrow SM, Farquhar JW, Hunter WM (1980) Nocturnal sleep-related LHRH secretion in male puberty—a mechanism for the initiation of puberty. Proceedings of the One Hundred and Sixty-First Meeting of the Society for Endocrinology, London, Abstract 69, p 35Google Scholar
  109. Wu FCW, Edmond P, Raab G, Hunter WM (1981) Endocrine assessment of the subfertile male. Clin Endocrinol 14: 493–507CrossRefGoogle Scholar
  110. Wu FCW, Swanston IA, Baird DT (1982a) Raised plasma oestrogens in infertile men with elevated levels of FSH. Clin Endocrinol, 16: 39–48CrossRefGoogle Scholar
  111. Wu FCW, Swanston IA, Hargreave TB, Baird DT (1982b) Evidence that the human testis does not secrete oestrone sulphate. J Endocrinol, 92: 185–194PubMedCrossRefGoogle Scholar
  112. Wu FCW, Bancroft JHJ, Davidson DW, Nicol K (1982c) The behavioural effects of testosterone undecanoate in adult men with Klinefelter’s syndrome: a controlled study. Clin Endocrinol 16: 489–514CrossRefGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 1983

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  • F. Wu

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