Skip to main content
SpringerLink
Log in

Diagnostic Histopathology

  • Chapter
Introduction to Biopsy Interpretation and Surgical Pathology

  • 79 Accesses

Abstract

The twentieth century has seen histopathology develop into a major branch of clinical medicine. While surgeons and physicians continue to bear direct responsibility for the provision of clinical services, investigative and diagnostic specialists are now an integral part of the team that cares for patients. Histopathologists are increasingly involved in work that has a fundamental bearing on the immediate management of patients and are frequently party to therapeutic decisions. The modern histopathologist therefore requires both an intimate knowledge of biopsy appearances and the ability to interpret biopsies in the context of contemporary clinical practice. Before examining the various ways in which the histopathological interpretation of biopsies and surgical resections contributes to clinical practice, the origins of the discipline merit brief recapitulation.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 74.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Bamforth J, Osborn GR (1958) Diagnosis from cells. J Clin Pathol 11:473–482

    Article  PubMed  CAS  Google Scholar 

  • Bartels P, Bibbo M, Wied G (1976) Modeling of histologic images by computer. Acta Cytol (Baltimore) 20:62–67

    PubMed  CAS  Google Scholar 

  • Beale LS (1854) The microscope in medicine. Churchill, London

    Google Scholar 

  • Bennett JH (1845) Introductory address to a course of lectures on histology and the use of the microscope. Lancet 1:517–522

    Article  Google Scholar 

  • Bohrod MG (1971) What is a pathologic diagnosis? Pathol Annu 6:197–208

    PubMed  CAS  Google Scholar 

  • Britton M (1974a) Diagnostic errors discovered at autopsy. Acta Med Scand 196:203–210

    Article  PubMed  CAS  Google Scholar 

  • Britton M (1974b) Clinical diagnostics: experience from 383 autopsied cases. Acta Med Scand 196:211–219

    Article  PubMed  CAS  Google Scholar 

  • Coppleson LW, Factor RM, Strum SB, Graff PW, Rappaport H (1970) Observer disagreement in the classification and histology of Hodgkin’s disease. J Natl Cancer Inst 45:731–740

    PubMed  CAS  Google Scholar 

  • Desjardins AU (1960) Is the pathologist infallible? Arch Intern Med 106:596–602

    Article  PubMed  CAS  Google Scholar 

  • Donaldson F (1853) The practical application of the microscope to the diagnosis of cancer. Am J Med Sci 25:43–70

    Article  Google Scholar 

  • Feinstein AR (1967) Clinical judgement. Williams and Wilkins, Baltimore, p 80

    Google Scholar 

  • Feinstein AR, Gelfman NA, Yesner R (1970) Observer variability in the histopathologic diagnosis of lung cancer. Am Rev Respir Dis 101:671–684

    PubMed  CAS  Google Scholar 

  • Garceau AJ (1964) The natural history of cirrhosis. II The influence of alcohol and prior hepatitis on pathology and prognosis. N Engl J Med 271:1173–1179

    Article  PubMed  CAS  Google Scholar 

  • Garland LH (1959) Studies on the accuracy of diagnostic procedures. Am J Roentgenol 82:25–38

    CAS  Google Scholar 

  • Higginson J (1977) The role of the pathologist in environmental medicine and public health. Am J Pathol 86:460–484

    PubMed  CAS  Google Scholar 

  • Iversen OH, Sandnes K (1971) The reliability of pathologists. A study of some cases of lymph node biopsies showing giant follicular hyperplasia or lymphoma. Acta Pathol Microbiol Scand [A] 79:330–334

    CAS  Google Scholar 

  • King LS (1967a) What is a diagnosis? JAMA 202:154–157

    Article  Google Scholar 

  • King LS (1967b) How does a pathologist make a diagnosis? Arch Pathol 84:331–333

    PubMed  CAS  Google Scholar 

  • King LS, Meehan MC (1973) A history of the autopsy: A review. Am J Pathol 73:514–544

    PubMed  CAS  Google Scholar 

  • Komberg A (1977) Pathology, pathologists and the new biology. Arch Pathol Lab Med 101:397–399

    Google Scholar 

  • Kramer IRH (1975) Computer-aided analyses in diagnostic histopathology. Postgrad Med J 51:690–694

    Article  PubMed  CAS  Google Scholar 

  • Kramer IRH, El-Labban NG, Sonkodi S (1974) Further studies on lesions of the oral mucosa using computer-aided analysis of histological features. Br J Cancer 29:223–231

    Article  PubMed  CAS  Google Scholar 

  • Langley FA (1978) Quality control in histopathology and diagnostic cytology. Histopathology 2:3–18

    Article  PubMed  CAS  Google Scholar 

  • Lusted LB, Ledley RS (1960) Mathematical models in medical diagnosis. J Med Educ 35:214–222

    PubMed  CAS  Google Scholar 

  • Morson BC (1979) Prevention of colorectal cancer. Proc R Soc Med 27:83–85

    Google Scholar 

  • Ober WB (1970) The case of the Kaiser’s cancer. Pathol Annu 5:207–216

    PubMed  CAS  Google Scholar 

  • Owen DA, Tighe JR (1975) Quality evaluation in histopathology. Br Med J i:149–150

    Article  Google Scholar 

  • Papanicolaou GN (1928) New cancer diagnosis. In: Proceedings of the 3rd Race Betterment Conference, Battle Creek, Michigan. Race Betterment Foundation, pp 528–534

    Google Scholar 

  • Pearse AGE (1975) The role of histochemistry in increasing objectivity in histopathology. Postgrad Med J51:708–710

    Article  PubMed  CAS  Google Scholar 

  • Penner DW (1973) Quality control and quality evaluation in histopathology and cytology. Pathol Annu 8:1–19

    PubMed  CAS  Google Scholar 

  • Sissons HA (1975) Agreement and disagreement between pathologists in histological diagnosis. Postgrad Med J 51:685–689

    Article  PubMed  CAS  Google Scholar 

  • Sissons HA (1978) On seeking a second opinion. J Clin Pathol 31:1121–1124

    Article  PubMed  CAS  Google Scholar 

  • Soloway RD, Bagenstoss AH, Schoenfield LJ, Summerskill WHJ (1971) Observer error and sampling variability in evaluation of hepatitis and cirrhosis by liver biopsy. Am J Dig Dis 16:1082–1086

    Article  PubMed  CAS  Google Scholar 

  • Symmers WStC (1968) Survey of the eventual diagnosis in 600 cases referred for a second histological opinion after an initial biopsy diagnosis of Hodgkin’s disease. J Clin Pathol 21:650–653

    Article  PubMed  Google Scholar 

  • Theodossi A, Knill-Jones RP, Silk DBA, Williams R (1977) Study of interobserver variation between liver histopathologists. Gut 18:953

    Google Scholar 

  • Virchow R (1887) Professor Virchow’s report on the portion of growth removed from the larynx of H.I.H. the Crown Prince of Germany by Dr. M. Mackenzie on June 28th. Br Med J ii:199

    Google Scholar 

  • Zajicek G, Maayan C, Rosenmann E (1977) The application of cluster analysis to glomerular histopathology. Comput Biomed Res 10:471–481

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. University of Sheffield Medical School, Sheffield, S10 2RX, England

    J. C. E. Underwood MD, MRCPath. (Senior Lecturer in Pathology, Honorary Consultant Histopathologist)

  2. Royal Hallamshire Hospital, Sheffield, S10 2RX, England

    J. C. E. Underwood MD, MRCPath. (Senior Lecturer in Pathology, Honorary Consultant Histopathologist)

Authors
  1. J. C. E. Underwood MD, MRCPath.
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 1981 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Underwood, J.C.E. (1981). Diagnostic Histopathology. In: Introduction to Biopsy Interpretation and Surgical Pathology. Springer, London. https://doi.org/10.1007/978-1-4471-3301-8_1

Download citation

  • DOI: https://doi.org/10.1007/978-1-4471-3301-8_1

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-3303-2

  • Online ISBN: 978-1-4471-3301-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation