Abstract
ECP has been isolated from human eosinophils and constitutes 30% of the protein of the eosinophil granules (Olsson and Venge 1974). It is a highly cationic zinc containing single-chained protein with a molecular weight of about 20 000 (Venge et al. 1980; Lose et al. 1987). ECP seems to be involved in the regulation of the humoral part of inflammation by modulation of coagulation, fibrinolysis and the kallikrein-kinin system (Venge et al. 1980). It has also proven toxic against many cells and tissues (Frigas et al. 1980; Tai et al. 1982, 1984).
Hitherto, no blood or urine analyses have been encountered which provide specific diagnostic information to classify patients with painful bladder disease. However, we have observed an increased level of eosinophil cationic protein in urine (U-ECP) in patients with interstitial cystitis (IC) (Lose et al. 1983, 1988) and recently it has been shown that these patients also have elevated urinary excretion of metabolites of histamine (Holm-Bentzen et al. 1987).
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Lose, G., Fransden, B. (1990). Urine Eosinophil Cationic Protein in Painful Bladder Disease. In: Hanno, P.M., Staskin, D.R., Krane, R.J., Wein, A.J. (eds) Interstitial Cystitis. Springer, London. https://doi.org/10.1007/978-1-4471-3293-6_19
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DOI: https://doi.org/10.1007/978-1-4471-3293-6_19
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