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Mast Cells and Interstitial Cystitis

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Interstitial Cystitis

Abstract

Mast cells are widely distributed throughout the connective tissue of most organs. They are numerous in the skin and in mucosal membranes, areas that are exposed to the exterior environment. Mast cells contain potent, pharmacologically active mediators and express plasma membrane receptors with a high affinity to the Fc portion of the IgE antibody (Ishizaka and Ishizaka 1969). The cell is the main tissue repository for histamine, which is stored in cytoplasmic granules together with proteoglycan and several proteins such as neutral proteases, acid hydrolases and chemotactic factors. Upon appropriate immunologic or nonimmunologic stimulation the mast cells release their preformed mediators and also generate and release metabolites of arachiodonic acid (see Katz et al. 1985).

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Authors
  1. F. Aldenborg
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  2. M. Fall
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  3. L. Enerbäck
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Editor information

Editors and Affiliations

  1. Department of Urology, Temple University School of Medicine, Broad and Tioga Street, Philadelphia, Pennsylvania, 19140, USA

    Philip M. Hanno MD (Professor and Chairman) (Professor and Chairman)

  2. Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts, 02215, USA

    David R. Staskin MD (Assistant Professor of Urology) (Assistant Professor of Urology)

  3. Department of Urology, Boston University School of Medicine, 720 Harrison Avenue, Boston, Massachusetts, 02118, USA

    Robert J. Krane MD (Professor and Chairman) (Professor and Chairman)

  4. Division of Urology, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, Pennsylvania, 19104, USA

    Alan J. Wein MD (Professor and Chairman) (Professor and Chairman)

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© 1990 Springer-Verlag London Limited

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Aldenborg, F., Fall, M., Enerbäck, L. (1990). Mast Cells and Interstitial Cystitis. In: Hanno, P.M., Staskin, D.R., Krane, R.J., Wein, A.J. (eds) Interstitial Cystitis. Springer, London. https://doi.org/10.1007/978-1-4471-3293-6_10

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  • DOI: https://doi.org/10.1007/978-1-4471-3293-6_10

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-3295-0

  • Online ISBN: 978-1-4471-3293-6

  • eBook Packages: Springer Book Archive

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