Abstract
Relative overrepresentation of the short of chromosome 12, mostly as isochromosomes (i(12p)), is considered to be characteristic for testicular germ cell tumours (TGCTs). Here we show that gain of 12p is not one of the initiating events in the development of TGCTs, but is related to invasive growth.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Pottern ML, Morris Brwn L, Devesa SS. Epidemiology and pathogenesis of testicular cancer. In: Ernsthoff MS, Heaney JA, Peschel RE, editors. Testicular and Penile Cancer. Oxford: Blackwell Science, 1998:2–10
Møller H. Decreased testicular cancer risk in men born in wartime. J Natl Cancer Inst 1989; 81(21):1668–9
Gondos B. Ultrastructure of developing and malignant germ cells. Eur Urol 1993;23:68–75.
Jørgensen N, Giwercman A, Müller J, Skakkebæk NE. Immunohistochemical markers of carcinoma in situ of the testis also expressed in normal infantile germ cells. Histopathol 1993;22:373–378
Rajpert-De Meyts E, Skakkebæk NE. Expression of the c-kit protein product in carcinoma-in-situ and invasive testicular germ cell tumours. Int J Androl 1994;17:85–92
Jørgensen N, Rajpert-De Meyts E, Graem N, Müller J, Giwercman A, Skakkebæk NE. Expression of immunohistochemical markers for testicular carcinoma in situ by normal fetal germ cells. Lab Invest 1995;72:223–231
De Meyts ER, Jorgensen N, Muller J, Skakkebaek NE. Prolonged expression of the c-kit receptor in germ cells of intersex fetal testes. Journal of Pathology. 1996;178:166–169
Roelofs H, Manes T, Millan JL, Oosterhuis JW, Looijenga LHJ. Heterogeneity in alkaline phosphatase isozyme expression in human testicular germ cell tumours. An enzyme-/immunohistochemical and molecular analysis. J Pathol 1999;189:236–244
Skakkebæk NE. Possible carcinoma-in-situ of the testis. Lancet 1972:516–517
Oosterhuis JW, Castedo SMMJ, De Jong B et al. Ploidy of primary germ cell tumours of the testis. Pathogenetic and clinical relevance. Lab Invest 1989;60:14–20
De Graaff WE, Oosterhuis JW, De Jong B et al. Ploidy of testicular carcinoma in situ. Lab Invest 1992;66:166–168
Van Echten-Arends J, Oosterhuis JW, Looijenga LHJ et al. No recurrent structural abnormalities in germ cell tumours of the adult testis apart from i(12p). Genes Chromosom & Cancer 1995;14:133–144
Atkin NB, Baker MC. Specific chromosome change, i(12p), in testicular tumours? Lancet 1982;8311:1340
Van Echten-Arends J, Stoepker M, Leegte B, Looijenga LHJ, De Jong B, Oosterhuis JW. Cytogenetic evidence that carcinoma in situ is the precursor lesion for invasive testicular germ cell tumours. Cancer Genet Cytogenet 1994;77:194
Looijenga LHJ, Gillis AJM, Van Putten WLJ, Oosterhuis JW. In situ numeric analysis of centromeric regions of chromosomes 1, 12, and 15 of seminomas, nonseminomatous germ cell tumours, and carcinoma in situ of human testis. Lab Invest 1993;68:211–219
Looijenga LHJ, Rosenberg C, Van Gurp RJHLM et al. Comparative genomic hybridization of microdissected samples from different stages in the development of a seminoma and nonseminoma. J Pathol 2000;19:187–192
Mostofi FK, Sesterhenn IA. Histological typing of testis tumours. 2nd ed. Berlin: Springer, 1998
Mosselman S, Looijenga LHJ, Gillis AJM, et al. Aberrant platelet-derived growth factor a-receptor transcript as a diagnostic marker for early human germ cell tumours of the adult testis. Proc Natl Acad Sci USA 1996;93:2884–2888
Roelofs H, Mostert MC, Pompe K et al. Restricted 12p-amplification and RAS mutation in human germ cell tumours of the adult testis .Am J Pathol 2000;157(4):1155–1166
Rosenberg C, Van Gurp RJHLM, Geelen E, Oosterhuis JW, Looijenga LHJ. Overrepresentation of the short arm of chromosome 12 is related to invasive growth of human testicular seminomas and nonseminomas. Oncogene 2000;19:5858–5862
Stoop H, Van Gurp RHJLM, De Krijger R et al. Reactivity of germ cell maturation stage-specific markers in spermatocytic seminoma: diagnostic and etiological implications. Lab Invest 2001; 81:919–928
Scully RE. Gonadoblastoma/A review of 74 cases. Cancer 1970;25:1340–1356
Jørgensen N, Muller J, Jaubert F, Clausen OP, Skakkebaek NE. Heterogeneity of gonadoblastoma germ cells: similarities with immature germ cells, spermatogonia and testicular carcinoma in situ cells. Histopathol 1997;30(2):177–86
Mostert MC, Verkerk AJMH, Van de Pol M et al. Identification of the crucial region of 12p overrepresentation in testicular germ cell tumours of adolescents and adults. Oncogene 1998;16:2617–2627
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2002 Springer-Verlag London Limited
About this paper
Cite this paper
Oosterhuis, J.W., van Gurp, R.J.H.L.M., Rosenberg, C., Looijenga, L.H.J. (2002). Overrepresentation of the Short Arm of Chromosome 12 Is Related to Invasive Growth of Testicular Seminomas and Non-seminomas. In: Harnden, P., Joffe, J.K., Jones, W.G. (eds) Germ Cell Tumours V. Springer, London. https://doi.org/10.1007/978-1-4471-3281-3_5
Download citation
DOI: https://doi.org/10.1007/978-1-4471-3281-3_5
Publisher Name: Springer, London
Print ISBN: 978-1-4471-3283-7
Online ISBN: 978-1-4471-3281-3
eBook Packages: Springer Book Archive