Abstract
Family and cytogenetic studies of testicular germ cell tumours (TGCT) suggest a strong genetic component in the aetiology of these tumours. We have focused upon genes that may play a key regulatory role in the development of germ cells. Following studies in the nematode worm, Caenorhabditis elegans [1], we have investigated the Notch gene family. Initial results indicate that members of the Notch family are expressed by primordial germ cells, and by seminoma and intratubular germ cell neoplasia, consistent with a possible role in tumour development (unpublished results).
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© 2002 Springer-Verlag London Limited
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Adamah, D., Gokhale, P.J., Walsh, J., Andrews, P.W. (2002). A Notch-related Gene Located on the Long Arm of Human Chromosome 12. In: Harnden, P., Joffe, J.K., Jones, W.G. (eds) Germ Cell Tumours V. Springer, London. https://doi.org/10.1007/978-1-4471-3281-3_3
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DOI: https://doi.org/10.1007/978-1-4471-3281-3_3
Publisher Name: Springer, London
Print ISBN: 978-1-4471-3283-7
Online ISBN: 978-1-4471-3281-3
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