Abstract
A European protocol for malignant CNS GCTs was initiated in 1996. The purpose was to compare patients with germinoma treated either with reduced craniospinal irradiation (CSI) (24 Gy craniospinal/16 Gy tumour boost) or with a combined therapy (2 courses Carbo PEI) and focal irradiation (40 Gy). In non-germinomatous malignant tumours (choriocarcinoma, yolk sac tumours, embryonal carcinoma) (sGCTs) the efficacy of intensive preoperative chemotherapy (4 courses PEI) followed by radiotherapy was investigated. Irradiation was either focal (54 Gy) if negative spinal MRI and negative CSF-cytology, or CSI in metastatic patients (30 Gy CSI/24 Gy tumour boost). Measurement of markers was mandatory. Elevated markers in serum or CSF (ß-HCG > 50 IU/1, AFP > 25 ng/ml) together with an intracranial primary suggested the clinical diagnosis of a sGCTs.
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© 2002 Springer-Verlag London Limited
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Calaminus, G. et al. (2002). Intracranial Malignant Germ Cell Tumours (CNS GCTs): Interim Results of the SIOP Trial. In: Harnden, P., Joffe, J.K., Jones, W.G. (eds) Germ Cell Tumours V. Springer, London. https://doi.org/10.1007/978-1-4471-3281-3_28
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DOI: https://doi.org/10.1007/978-1-4471-3281-3_28
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