Treatment of Multiple Sclerosis with Cyclophosphamide
Multiple sclerosis (MS) is an inflammatory disease of the central nervous system of presumed autoimmune etiology. A number of immune abnormalities have been described in the disease including loss of suppressor influences and activated T- and B-cells both in the central nervous system and the periphery (Hafler and Weiner 1989). The majority of immunotherapeutic approaches studied over the past 20 years have been designed to suppress the immune system in MS. This has included attempts at both antigen-specific and antigen non-specific suppression (Weiner and Hafler 1988).
KeywordsPlacebo Toxicity Leukemia Corticosteroid Amide
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