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Treatment of Multiple Sclerosis pp 267–279Cite as

Total Lymphoid Irradiation in Multiple Sclerosis

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Part of the book series: Clinical Medicine and the Nervous System ((CLIN.MED.NERV.))

Abstract

Immunosuppressive drugs have been increasingly used in both uncontrolled and controlled studies in an attempt to modify the relentless deterioration in neurologic function which commonly occurs in patients with chronic/progressive multiple sclerosis (CPMS) (The Multiple Sclerosis Study Group 1990; Rudge et al. 1989; Hauser et al. 1983; British and Dutch Multiple Sclerosis Azathioprine Trial Group 1988; Ellison et al. 1988). Unfortunately, no unequivocal long-term clinical benefits have been documented with immunosuppressive drugs in carefully controlled trials of CPMS. Further, many immunosuppressive drugs must be given at frequent intervals or even daily to sustain remissions in autoimmune disorders, which obviously increases their potential for toxic side effects including infection and neoplasia.

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Authors
  1. Stuart D. Cook
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  2. Corinne Devereux
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  3. Raymond Troiano
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  4. Christine Rohowsky-Kochan
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  5. Amiram Sheffet
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  6. Annette Jotkowitz
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  7. George Zito
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  8. Peter C. Dowling
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Editor information

Editors and Affiliations

  1. Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic Foundation, 9500 Euclid Avenue, 44195-5244, Cleveland, OH, USA

    Richard A. Rudick MD  & Donald E. Goodkin MD  & 

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© 1992 Springer-Verlag London Limited

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Cook, S.D. et al. (1992). Total Lymphoid Irradiation in Multiple Sclerosis. In: Rudick, R.A., Goodkin, D.E. (eds) Treatment of Multiple Sclerosis. Clinical Medicine and the Nervous System. Springer, London. https://doi.org/10.1007/978-1-4471-3184-7_13

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  • DOI: https://doi.org/10.1007/978-1-4471-3184-7_13

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-3186-1

  • Online ISBN: 978-1-4471-3184-7

  • eBook Packages: Springer Book Archive

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