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Experimental Allergic Neuritis

  • Richard A. C. Hughes
Part of the Clinical Medicine and the Nervous System book series (CLIN.MED.NERV.)

Abstract

Experimental allergic neuritis (EAN), an experimental model of GBS, developed as a by-product of research into experimental allergic encephalomyelitis (EAE). In 1895 Louis Pasteur had prepared the first rabies vaccines from dried formalin-treated rabbit brain. The vaccine provided some protection from rabies but also occasionally caused encephalomyelitis. Rivers and Schwentker (1935) showed that repeated injections of rabbit brain into monkeys would produce encephalomyelitis and Freund in 1949 showed that the same result could be achieved with a single injection provided that the nervous tissue was emulsified with an adjuvant. Early experiments were directed towards identifying the antigen. The encephalitogenic component of nervous tissue was found to reside largely in the major myelin basic protein (see Leibowitz and Hughes 1983 for review). More recently it has been demonstrated that highly purified proteolipid protein will also induce EAE (Yoshimura et al. 1985; Endoh et al. 1986). There is no theoretical reason why other CNS myelin antigens should not be capable of inducing EAE. Myelin basic protein (MBP), molecular weight 18 500, is rich in basic aminoacids, and its amino acid sequence is highly conserved from one species to another (Hashim 1980). However, there is great species variation in the part of the protein which is responsible for inducing EAE.

Keywords

Dorsal Root Ganglion Sciatic Nerve Schwann Cell Myelin Basic Protein Experimental Allergic Encephalo 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Abramsky O, London Y (1975) Purification and partial characterization of two basic proteins from human peripheral nerve. Biochim Biophys Acta 393:556–562PubMedGoogle Scholar
  2. Abramsky O, Teitelbaum D, Arnon R (1977) Experimental allergic neuritis induced by a basic neuritogenic protein (P1L) of human peripheral nerve origin. Eur J Immunol 7:213–217PubMedCrossRefGoogle Scholar
  3. Acha-Orbea H, Mitchell DJ, Timmermann L, et al. (1988) Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention. Cell 54:263–273PubMedCrossRefGoogle Scholar
  4. Adam AM, Atkinson PF, Hall SM, Hughes RAC, Taylor WA (1989) Chronic experimental allergic neuritis in Lewis rat. Neuropathol Appl Neurobiol 15:249–264PubMedCrossRefGoogle Scholar
  5. Alit G (1975) The node of Ranvier in experimental allergic neuritis. An electron microscopic study. J Neurocytol 4:63–76CrossRefGoogle Scholar
  6. Antony JH, Pollard JD, McLeod JG (1981) Effects of plasmapheresis on the course of experimental allergic neuritis in rabbits. J Neurol Neurosurg Psychiatry 44:1124–1128PubMedCrossRefGoogle Scholar
  7. Appenzeller O, Arnason BGW, Adams RD (1965) Experimental autonomic neuropathy: an immunologically induced disorder of reflex vasomotor function. J Neurol Neurosurg Psychiatry 28:510–515PubMedCrossRefGoogle Scholar
  8. Arnason BGW, Chelmicka-Szorc E (1972) Passive transfer of experimental allergic neuritis in Lewis rats by direct injection of sensitised lymphocytes into the sciatic nerve. Acta Neuropathol 22:1–6PubMedCrossRefGoogle Scholar
  9. Arnason BGW, Winkler GF, Hadler NM (1969) Cell-mediated demyelination of peripheral nerve in tissue culture. Lab Invest 21:1–10PubMedGoogle Scholar
  10. Asbury AK, Arnason BG, Adams RD (1969) The inflammatory lesion in idiopathic polyneuritis. Its role in pathogenesis. Medicine 48:173–215PubMedCrossRefGoogle Scholar
  11. Askenase PW, Bursztajn S, Gershon NID, Gershon RK (1980) T cell dependent mast cell de-granulation and release of serotonin in immune delayed-type hypersensitivity. J Exp Med 152: 1358–1374PubMedCrossRefGoogle Scholar
  12. Astrom KE, Waksman BH (1962) The passive transfer of experimental allergic encephalomyelitis and neuritis with living lymphoid cells. J Pathol Bacteriol 83:89–100PubMedCrossRefGoogle Scholar
  13. Ballin RHM, Thomas PK (1968) Electron microscopic observations on demyelination and remyelination in experimental allergic neuritis. Part 1 (Demyelination). J Neurol Sci 8:1–18CrossRefGoogle Scholar
  14. Behan PO, Lamarche JB, Behan WB, Feldman RG (1969) Immunopathological mechanisms of allergic neuritis in animals, primates and man. Trans Am Neurol Assoc 94:219–222PubMedGoogle Scholar
  15. Brosnan CF, Lyman WD, Tansey FA, Carter TH (1985) Quantitation of mast cells in experimental allergic neuritis. J Neuropathol Exp Neurol 44:196–203CrossRefGoogle Scholar
  16. Brosnan JV, Craggs RI, King RHM, Thomas PK (1984) Attempts to transfer experimental allergic neuritis with lymphocytes. J. Neuroimmunol 6:373–385PubMedCrossRefGoogle Scholar
  17. Brosnan JV, Fellowes R, Craggs RI, King RHM, Bowley TJ, Thomas PK (1985) Changes in lymphocyte subsets during the course of experimental allergic neuritis. Brain 108:315–334PubMedCrossRefGoogle Scholar
  18. Brosnan JV, Craggs RI, King RHM, Thomas PK (1987) Reduced susceptibility of T cell deficient rats to induction of experimental allergic neuritis. J Neuroimmunol 14:267–282PubMedCrossRefGoogle Scholar
  19. Brosnan JV, King RHM, Thomas PK, Craggs RI (1988) Disease patterns in EAN in the Lewis rat. J Neurol Sci 88:261–276PubMedCrossRefGoogle Scholar
  20. Brosnan SF, Tansey FA (1984) Delayed onset of experimental allergic neuritis in rats treated with reserpine. J. Neuropathol Exp Neurol 43:84–93PubMedCrossRefGoogle Scholar
  21. Brostoff S, Burnett S, Lampert P, Eylar E (1972) Isolation and characterisation of a protein from sciatic nerve myelin responsible for experimental allergic neuritis. Nature New Biol 235:210–212PubMedGoogle Scholar
  22. Brostoff SW, Levit S, Powers JM (1977) Induction of experimental allergic neuritis with a peptide from myelin P2 basic protein. Nature 268:752–753PubMedCrossRefGoogle Scholar
  23. Brostoff SW, Powers JM, Weise MJ (1980) Allergic encephalomyelitis induced in guinea pigs by a peptide from the NH2 terminus of bovine P2 protein. Nature 285:103–104PubMedCrossRefGoogle Scholar
  24. Caspary EA, Field FJ (1965) Antibody response to central and peripheral nerve antigens in rat and guinea pig. J Neurol Neurosurg Psychiatry 28:179–182PubMedCrossRefGoogle Scholar
  25. Cohen IR, Weiner HL (1988) T cell vaccination. Immunol Today 9:332–334PubMedCrossRefGoogle Scholar
  26. Cragg BG, Thomas PK (1964) Changes in nerve conduction in experimental allergic neuritis. J Neurol Neurosurg Psychiatry 27:106–115PubMedCrossRefGoogle Scholar
  27. Craggs R, Brosnan JV, King RHM, Thomas PK (1986) Chronic relapsing experimental allergic neuritis in Lewis rats: effects of thymectomy and splenectomy. Acta Neuropathol 70:22–29PubMedCrossRefGoogle Scholar
  28. Cunningham JM, Powers JM, Brostoff SW (1983) Prevention of experimental allergic neuritis in the Lewis rat with bovine P2 protein. Brain Res 258:285–289PubMedCrossRefGoogle Scholar
  29. Curtis BM, Forno LS, Smith PE (1979) Reactivation of neuritogenic activity of P2 protein from peripheral nervous system myelin. Brain Res 175:387–391PubMedCrossRefGoogle Scholar
  30. De Lisi G, Berzofsky JA (1985) T cell antigenic sites tend to be amphipathic structures. Proc Natl Acad Sci USA 82:7048–7052CrossRefGoogle Scholar
  31. Ellerman KE, Powers JM, Brostoff SW (1988) A suppressor T-lymphocyte cell line for autoimmune encephalomyelitis. Nature 331:256–267CrossRefGoogle Scholar
  32. Endoh M, Tabira T, Kunishita T, Sakai K, Yamamura T, Taketomi T (1986) DM-20, a proteolipid apoprotein, is an encephalitogen of acute and relapsing autoimmune encephalomyelitis in mice. J Immunol 137:3832–3835PubMedGoogle Scholar
  33. Feasby TE, Gilbert JJ, Hahn AF, Neilson M (1987) Complement depletion suppresses Lewis rat experimental allergic neuritis. Brain Res 419:97–103PubMedCrossRefGoogle Scholar
  34. Gilbert JJ, Feasby TE, Hahn AF (1983) Intraneural injection of lymphocytes in experimental allergic neuritis. Acta Neuropathol 61:61–64PubMedCrossRefGoogle Scholar
  35. Gross MLP, Craggs RI, King RHM, Thomas PK (1983) The treatment of experimental allergic neuritis by plasma exchange. J Neurol Sci 61:149–160PubMedCrossRefGoogle Scholar
  36. Hahn AF, Feasby TE, Gilbert JJ (1985) Blood—nerve barrier studies in experimental allergic neuritis. Acta Neuropathol 68:101–109PubMedCrossRefGoogle Scholar
  37. Happ MP, Kiraly AS, Offner H, Vandenbark A, Heber-Katz E (1988) The autoreactive T cell population in experimental allergic encephalomyelitis: T cell receptor B-chain rearrangements. J Neuroimmunol 19:191–204PubMedCrossRefGoogle Scholar
  38. Hartung HP, Schafer B, Heininger K, Stoll G, Toyka KV (1988) The role of macrophages and line-mediated experimental autoimmune neuritis in the rat. Neurosci Lett 83:195–200CrossRefGoogle Scholar
  39. Hartung H-P, Schafer B, Heininger K, Stoll G, Toyka KV (1988) The role of macrophages and eicosanoids in the pathogenesis of experimental allergic neuritis. Brain 111:1039–1059PubMedCrossRefGoogle Scholar
  40. Harvey GK, Pollard JD, Schindhelm K, Antony J (1987) Chronic experimental allergic neuritis. An electrophysiological and histological study in the rabbit. J Neurol Sci 81:215–226PubMedCrossRefGoogle Scholar
  41. Hashim GA (1980) T cell activation and suppression. In: Davison AN, Cuzner ML (eds) Experimental allergic encephalomyelitis and multiple sclerosis. Academic Press, New York, pp 79–104Google Scholar
  42. Heber-Katz E, Acha-Orbea H (1989) The V-region hypothesis: evidence from autoimmune encephalomyelitis. Immunol Today 10:164–169PubMedCrossRefGoogle Scholar
  43. Heininger K, Stoll G, Linington C, Toyka KV, Wekerle H (1986) Conduction failure and nerve conduction slowing in experimental allergic neuritis induced by P2-specific T cell lines. Ann Neurol 19:44–49Google Scholar
  44. Heininger K, Schafer B, Hartung HP, Fierz W, Linington C, Toyka KV (1988) The role of macrophages in experimental allergic neuritis induced by a P2 specific T cell line. Ann Neurol 23: 326–331PubMedCrossRefGoogle Scholar
  45. Heitman NR, Mannweiler KL (1956) Experimental animal studies on allergic polyneuroses. Dtsch Z Nervenheilk 177:28–47Google Scholar
  46. Hoffman PM, Powers JM, Weise MJ, Brostoff SW (1980) Experimental allergic neuritis I. Rat strain differences in the response to bovine myelin antigens. Brain Res 195:355–362PubMedCrossRefGoogle Scholar
  47. Hsieh DL, Weise MJ, Levit S, Powers JM, Brostoff SW (1981) Structure of bovine P2 basic protein: sequence of a carboxyterminal segment that is a neuritogen in rabbits. J Neurochem 36:913–916PubMedCrossRefGoogle Scholar
  48. Hughes RAC (1974) Protection of rats from experimental allergic encephalomyelitis with antiserum to guinea pig spinal cord. Immunology 26:703–711PubMedGoogle Scholar
  49. Hughes RAC, Kadlubowski M (1980) Experimental allergic neuritis in the rat. In: Rose FC, Behan, PO (eds) Animal models of neurological disease. Pitman Medical, Tunbridge Wells, pp 95–103Google Scholar
  50. Hughes RAC, Powell HC (1984) Experimental allergic neuritis: demyelination induced by P2 alone and non-specific enhancement by cerebroside. J Neuropathol Exp Neurol 43:154–161PubMedCrossRefGoogle Scholar
  51. Hughes RAC, Kadlubowski M, Gray IA, Leibowitz S (1981a) Immune responses in experimental allergic neuritis. J Neurol Neurosurg Psychiatry 44:565–569CrossRefGoogle Scholar
  52. Hughes RAC, Kadlubowski M, Hufschmidt A (1981b) Treatment of acute inflammatory polyneuropathy. Ann Neurol 9 Supp1:125–133CrossRefGoogle Scholar
  53. Hughes RAC, Powell HC, Braheny SL, Brostoff SW (1985) Endoneurial injection of antisera to myelin antigens. Muscle Nerve 8:516–522PubMedCrossRefGoogle Scholar
  54. Hughes RAC, Atkinson PF, Gray IA, Taylor WA (1987) Major histocompatibility antigens and lymphocyte subsets during experimental allergic neuritis in the Lewis rat. J Neurol 234:390–395PubMedCrossRefGoogle Scholar
  55. Ichijo K, Fujimoto Y, Okada K (1981) Ultrastructural study of experimental allergic neuritis in the chicken. I. Cell migration, granuloma formation and demyelination. Zentralbl Veterinarmed [B] 28:210–225CrossRefGoogle Scholar
  56. Ishaque A, Szymanska I, Ramwani J, Eylar EH (1981) Allergic neuritis: phospholipid requirement for the disease inducing conformation of the P2 protein. Biochim Biophys Acta 669:28–32PubMedGoogle Scholar
  57. Ishaque A, Hofmann T, Eylar EH (1982) The complete amino acid sequence of the rabbit P2 protein. JAMA 257:592–595Google Scholar
  58. Izumo S, Linington C, Wekerle H, Meyermann R (1985) Morphological study on EAN mediated by T cell line specific for bovine P2 protein in Lewis rats. Lab Invest 53:209–218PubMedGoogle Scholar
  59. Kadlubowski M, Hughes RAC (1979) Identification of the neuritogen responsible for experimental allergic neuritis. Nature 277:140–141PubMedCrossRefGoogle Scholar
  60. Kadlubowski M, Hughes RAC (1980) The neuritogenicity and encephalitogenicity of P2 in the rat, guinea pig and rabbit. J Neurol Sci 48:171–178PubMedCrossRefGoogle Scholar
  61. Kadlubowski M, Hughes RAC, Gregson NA (1980) Experimental allergic neuritis in the Lewis rat: characterisation of the activity of peripheral myelin and its major basic protein P2. Brain Res 184: 439–454PubMedCrossRefGoogle Scholar
  62. King RHM, Thomas PK, Pollard JD (1977) Axonal and dorsal root ganglion cell changes in experimental allergic neuritis. Neuropathol Appl Neurobiol 3:471–486CrossRefGoogle Scholar
  63. King RHM, Craggs RI, Gross MLP, Tompkins C, Thomas PK (1983) Suppression of experimental allergic neuritis by cyclosporin A. Acta Neuropathol 59:262–268PubMedCrossRefGoogle Scholar
  64. King RHM, Craggs RI, Gross MLP, Thomas PK (1985) Effects of glucocorticoids on experimental allergic neuritis. Exp Neurol 87:9–19PubMedCrossRefGoogle Scholar
  65. Kitamura K, Suzuki M, Suzuki A, Uyemura K (1980) The complete amino acid sequence of the P2 protein in bovine peripheral nerve myelin. FEBS Lett 115:27–30PubMedCrossRefGoogle Scholar
  66. Konovalov G, Korneva E, Khai L (1971) Effect of destruction of the posterior hypothalamic area on experimental allergic neuritis. Brain Res 29:383–386PubMedCrossRefGoogle Scholar
  67. Lampert PW (1967) Electron microscopic studies on ordinary and hyperacute experimental allergic encephalomyelitis. Acta Neuropathol 9:99–126PubMedCrossRefGoogle Scholar
  68. Lampert PW (1969) Mechanism of demyelination in experimental allergic neuritis. Electron microscopic studies. Lab Invest 20:127–138PubMedGoogle Scholar
  69. Lassmann H (1983) Comparative neuropathology of chronic experimental allergic encephalomyelitis and multiple sclerosis. Springer-Verlag, BerlinGoogle Scholar
  70. Lassmann H, Brunner C, Bradl M, Linington (1988) Experimental allergic encephalomyelitis: the balance between encephalitogenic T lymphocytes and demyelinating antibodies determines the size and structure of demyelinated lesions. Acta Neuropathol 75:566–576PubMedCrossRefGoogle Scholar
  71. Lehrich JR, Arnason BG (1971) Suppression of experimental allergic neuritis in rats by prior immunization with nerve in saline. Acta Neuropathol 18:144–155PubMedCrossRefGoogle Scholar
  72. Leibowitz S, Hughes RAC (1983) Immunology of the nervous system. Edward Arnold, London, pp 1–304Google Scholar
  73. Levine S, Wenk EJ (1963) Allergic neuritis induced in rats without the use of mycobacteria. Proc Soc Exp Biol Med 113:898–900PubMedGoogle Scholar
  74. Linington C, Izumo S, Suzuki M, Uyemura M, Meyermann R, Wekerle H (1984) A permanent rat T cell line that mediates experimental allergic neuritis in the rat in vitro. J Immunol 133: 1946–1950PubMedGoogle Scholar
  75. Linington C, Mann A, Izumo S et al. (1986) Induction of experimental allergic neuritis in the BN rat: P2 protein-specific T cells overcome resistance to actively induced disease. J Immunol 137: 3826–3831PubMedGoogle Scholar
  76. Linington C, Bradl M, Lassmann H, Brunner C, Vass K (1988) Augmentation of demyelination in rats: acute allergic encephalomyelitis directed against a myelin/oligodendrocyte glycoprotein. Am J Pathol 130:443–454PubMedGoogle Scholar
  77. London Y (1971) Ox peripheral nerve myelin membrane. Purification and partial characterization of two basic proteins. Biochim Biophys Acta 249:188–196PubMedCrossRefGoogle Scholar
  78. Madrid RE (1983) Chronic progressive and relapsing EAN in guinea pigs. In: Battistin L, Hashim GA, Lajtha A (eds) Clinical and biological aspects of peripheral nerve diseases. Alan R. Liss, New York, pp 265–276Google Scholar
  79. Madrid RE, Wisniewski HM (1977) Axonal degeneration in demyelinating disorders. J Neurocytol 6:103–117PubMedCrossRefGoogle Scholar
  80. McDermott JR, Keith AB (1979) Suppression of experimental allergic neuritis with P2 protein of peripheral nervous system myelin. Z Naturforsch [C] 34:641–643Google Scholar
  81. McDermott JR, Wisniewski HM (1977) Studies on the myelin protein changes and antigenic properties of rabbit sciatic nerves undergoing Wallerian degeneration. J Neurol Sci 33:81–94PubMedCrossRefGoogle Scholar
  82. Milek DJ, Cunningham JM, Powers JM, Brostoff SW (1983) Experimental allergic neuritis: Humoral and cellular responses to the cyanogen bromide peptides of the P2 protein. J Neuroimmunol 4:105–116PubMedCrossRefGoogle Scholar
  83. Milner P, Lovelidge GA, Taylor WA, Hughes RAC (1987) Po myelin protein produces experimental allergic neuritis in Lewis rats. J Neurol Sci 79:275–285PubMedCrossRefGoogle Scholar
  84. Morey MK, Hughes RAC, Powell HC (1985) Are Schwann cells involved in experimental allergic neuritis? Acta Neuropathol 67:75–80PubMedCrossRefGoogle Scholar
  85. Nagai Y, Uchida T, Takeda S, Ikuta F (1978) Restoration of activity for induction of experimental allergic peripheral neuritis by a combination of myelin basic protein P2 and gangliosides from peripheral nerve. Neurosci Lett 8:247–254PubMedCrossRefGoogle Scholar
  86. Nomura K, Hamaguchi K, Ohno R et al. (1987) Cell-mediated immunity to bovine P2 protein and neuritogenic synthetic peptide in experimental allergic neuritis. J Neuroimmunol 15:25–35PubMedCrossRefGoogle Scholar
  87. Ohno R, Hamaguchi K, Nomura K et al. (1988) Immune responses in experimental allergic neuritis treated with corticosteroids. Acta Neurol Scand 77:468–473PubMedCrossRefGoogle Scholar
  88. Olee T, Powers JM, Brostoff SW (1988) A T cell epitope for experimental allergic neuritis. J Neuroimmunol 19:167–173PubMedCrossRefGoogle Scholar
  89. Olee T, Weise M, Powers J, Brostoff SW (1989) A T cell epitope for experimental allergic neuritis is an amphipathic a-helical structure. J Neuroimmunol 21:235–240PubMedCrossRefGoogle Scholar
  90. Olsson T, Holdmahl R, Klareskog L, Forsum U, Kristinsson K (1984) Dynamics of Ia expressing cells and T lymphocytes of different subsets during experimental allergic neuritis in Lewis rats. J Neurol Sci 66:141–149PubMedCrossRefGoogle Scholar
  91. Ota K, Irie H, Takahashi K (1987) T cell subsets and Ia-positive cells in the sciatic nerve during the course of experimental allergic neuritis. J Neuroimmunol 13:283–292PubMedCrossRefGoogle Scholar
  92. Paraf A (1963) Polyradiculonévrite experimentale chez le mouton, ses rapports avec la syndrome de Guillain—Barré chez l’homme. Ann Inst Pasteur 104:208–218Google Scholar
  93. Paterson PY, Harwin SM (1963) Suppression of allergic encephalomyelitis in rats by means of anti-brain serum. J Exp Med 117:755–762PubMedCrossRefGoogle Scholar
  94. Paty DW (1971) An encephalitogenic basic protein from human peripheral nerve. Eur Neurol 5: 281–287PubMedCrossRefGoogle Scholar
  95. Pender MP, Sears TA (1984) The pathophysiology of acute experimental allergic encephalomyelitis in the rabbit. Brain 107:699–726PubMedCrossRefGoogle Scholar
  96. Peter M, Quaglio GL (1967) Experimental allergic neuritis in the chicken. Pathol Vet 4:464–476 Pollard JD, King RHM, Thomas PK (1975) Recurrent experimental allergic neuritis: an electron microscope study. J Neurol Sci 24:365–383Google Scholar
  97. Powell HC, Braheny SL, Myers RR, Rodriguez M, Lampert PW (1983) Early changes in experimental allergic neuritis. Lab Invest 83:332–338Google Scholar
  98. Raine CS, Bornstein MB (1979) Experimental allergic neuritis — ultrastructure of serum induced myelin aberrations in peripheral nervous system cultures. Lab Invest 40:423–432PubMedGoogle Scholar
  99. Raine CS, Johnson AB, Marcus DM, Suzuki A, Bornstein MB (1981) Demyelination in vitro — absorption studies demonstrate that galactocerebroside is a major target. J Neurol Sci 52:117–131PubMedCrossRefGoogle Scholar
  100. Rivers TM, Schwentker FF (1935) Encephalomyelitis accompanied by myelin destruction experimentally produced in monkeys. J Exp Med 61:689–703PubMedCrossRefGoogle Scholar
  101. Robinson HC, Alit G, Evans DHL (1972) A study of the capacity of myelinated and unmyelinated nerves to induce experimental allergic neuritis. Acta Neuropathol 21:99–108PubMedCrossRefGoogle Scholar
  102. Rostami A, Brown MJ, Lisak RP, Sumner AJ, Zweiman B, Pleasure DE (1984) The role of myelin P2 protein in the production of experimental allergic neuritis. Ann Neurol 16:680–685PubMedCrossRefGoogle Scholar
  103. Rostami A, Burns JB, Brown MJ et al. (1985) Transfer of experimental allergic neuritis with P2-reactive T cell lines. Cell Immunol 91:354–361PubMedCrossRefGoogle Scholar
  104. Rostami A, Rosen JL, Hickey WF, Brown MJ (1986a) Experimental allergic neuritis can occur in experimental allergic encephalomyelitis-resistant Lewis rats. Neurology 36:312Google Scholar
  105. Rostami A, Rosen JL, Cancro MP, Brown MJ, Pleasure DE (1986b) The variable susceptibility of inbred mice to experimental allergic neuritis. Neurology 36:304–305Google Scholar
  106. Rostami AM, Ventura E, Kimura H, Brown MJ, Pleasure DE (1988) Induction of severe experimental allergic neuritis with a synthetic peptide corresponding to the 53–78 amino acid sequence of the myelin P2 protein. Neurology 38:375Google Scholar
  107. Saida K, Saida T, Brown MJ (1979) In vitro demyelination induced by intraneural injection of antigalactocerebroside serum: a morphological study. Am J Pathol 95:99–116PubMedGoogle Scholar
  108. Saida T, Saida K, Silberberg DH, Brown MJ (1978) Transfer of demyelination by injection of experimental allergic neuritis serum. Nature 272:639–641PubMedCrossRefGoogle Scholar
  109. Saida T, Saida K, Dorfman SH (1979a) Experimental allergic neuritis induced by sensitisation with galactocerebroside. Science 204:1103–1106CrossRefGoogle Scholar
  110. Saida T, Saida K, Silberberg DH (1979b) Demyelination produced by experimental allergic neuritis serum and anti-galactocerebroside antiserum in CNS cultures. An ultrastructural study. Acta Neuropathol 48:18–25CrossRefGoogle Scholar
  111. Saida T, Saida K, Silberberg DH, Brown MK (1981) Experimental allergic neuritis induced by galactocerebroside. Ann Neurol 9 supp1:87–101PubMedCrossRefGoogle Scholar
  112. Seil FJ, Kies MW, Bacon ML (1981) A comparison of demyelinating and myelination inhibiting factor induction by whole peripheral nerve tissue and P2 protein. Brain Res 210:441–448PubMedCrossRefGoogle Scholar
  113. Sheremata WA, Behan PO (1973) Experimental allergic neuritis: a new experimental approach. J Neurol Neurosurg Psychiatry 36:139–145CrossRefGoogle Scholar
  114. Smith ME, Forno LS, Hoffman WW (1979) Experimental allergic neuritis in the Lewis rat. J Neuropathol Exp Neurol 38:377–391PubMedCrossRefGoogle Scholar
  115. Steinman L, Smith ME, Forno LS (1981) Genetic control of susceptibility to experimental allergic neuritis and the immune response to P2 protein. Neurology 31:950–954PubMedGoogle Scholar
  116. Stoll G, Schwendemann G, Heininger K et al. (1986) Relation of clinical, serological, morphological and electrophysiological findings in galactocerebroside induced experimental allergic neuritis. J Neurol Neurosurg Psychiatry 49:258–264PubMedCrossRefGoogle Scholar
  117. Strigard K, Olsson T, Larsson P, Holmdahl R, Klareskog L (1988) Modulation of experimental allergic neuritis in rats by in vivo treatment with monoclonal anti T cell antibodies. J Neurol Sci 83:283–291PubMedCrossRefGoogle Scholar
  118. Strigard K, Larsson P, Holmdahl R, Klareskog L, Olsson T (1989) In vivo monoclonal antibody treatment with Ox19 (anti-rat CD5) causes disease relapse and terminates P2-induced immunospecific tolerance on experimental allergic neuritis. J Neuroimmunol 23:11–18PubMedCrossRefGoogle Scholar
  119. Sumner AJ, Saida K, Saida T, Silberberg DH, Asbury AK (1982) Acute conduction block associated with experimental antiserum mediated demyelination of peripheral nerve. Ann Neurol 11:469–477PubMedCrossRefGoogle Scholar
  120. Suzuki M, Kitamura K, Uyemura K, Ogawa Y, Ishihara Y, Matsuyama H (1980) Neuritogenic activity of peripheral nerve proteins in Lewis rats. Neurosci Lett 19:353–358PubMedCrossRefGoogle Scholar
  121. Suzuki M, Kitamura K, Sakamoto T, Uyemura K (1982) The complete amino acid sequence of human P2 protein. J Neurochem 39:1759–1762PubMedCrossRefGoogle Scholar
  122. Suzuki M, Kitamura K, Uyemura K, Ogawa Y, Nozaki S, Marumatsu I (1984) Synthesis and neuritogenic activity of the peptides related to P2 protein. In: Alvord EC, Kies MW, Suckling AJ (ed) Experimental allergic encephalomyelitis — a useful model for multiple sclerosis. Alan R Liss, New York, pp 478–492Google Scholar
  123. Szymanska I, Ishaque A, Ramwani JAI, Eylar EH (1981) Allergic neuritis: a neuritogenic peptide from the P2 protein that induces disease in rats. J Immunol 126:1203–1206PubMedGoogle Scholar
  124. Tansey FA, Brosnan CF (1982) Protection against experimental allergic neuritis with silica quartz dust. J Neuroimmunol 3:169–179PubMedCrossRefGoogle Scholar
  125. Taylor WA, Hughes RAC (1985) Experimental allergic neuritis induced in SJL mice by bovine P2. J Neuroimmunol 8:153–157PubMedCrossRefGoogle Scholar
  126. Taylor WA, Hughes RAC (1988) Responsiveness to P2 of blood and cauda equina derived lymphocytes in experimental allergic neuritis: preliminary characterisation of a cauda equina derived P2 specific T cell line. J Neuroimmunol 19:279–289PubMedCrossRefGoogle Scholar
  127. Taylor WA, Hughes RAC, Lee T (1988) Lack of effect of fish oil enriched diet on experimental allergic neuritis in Lewis rats. J Neuroimmunol 17193–197Google Scholar
  128. Tuck RR, Pollard JD, McLeod JG (1981) Autonomic neuropathy: experimental allergic neuritis: an electrophysiological and histological study. Brain 104:187–208PubMedCrossRefGoogle Scholar
  129. Tuck RR, Antony JH, McLeod JG (1982) F-wave in experimental allergic neuritis. J Neurol Sci 56:173–184PubMedCrossRefGoogle Scholar
  130. Uyemura K, Suzuki M, Kitamura K et al. (1982) Neuritogenic determinant of bovine P2 protein in peripheral nerve myelin. J Neurochem 39:895–898PubMedCrossRefGoogle Scholar
  131. Waksman BH, Adams RD (1955) Allergic neuritis: experimental disease of rabbits induced by the injection of peripheral nervous tissue and adjuvants. J Exp Med 102:213–225PubMedCrossRefGoogle Scholar
  132. Waksman BH, Adams RD (1956) A comparative study of experimental allergic neuritis in the rabbit, guinea pig and mouse. J Neuropathol Exp Neurol 15:293–310PubMedCrossRefGoogle Scholar
  133. Watts PM, Taylor WA, Hughes RAC (1989) High-dose methylprednisolone suppresses experimental allergic neuritis in the Lewis rat. Exp Neurol 103:101–104PubMedCrossRefGoogle Scholar
  134. Weise MJ, Hsieh D, Hoffman PM, Powers JM, Brostoff SW (1980) Bovine peripheral nervous system myelin P2 protein: chemical and immunological characterization of the cyanogen bromide peptides. J Neurochem 35:393–400PubMedCrossRefGoogle Scholar
  135. Whitaker JN, Seyer JM (1984) Degradation of bovine P2 protein by bovine brain cathepsin D. Neurochem Res 9:1431–1443PubMedCrossRefGoogle Scholar
  136. Wisniewski H, Prineas J, Raine CS (1969) An ultrastructural study of experimental demyelination and remyelination. 1 Acute experimental allergic encephalomyelitis in the peripheral nervous system. Lab Invest 21:105–118PubMedGoogle Scholar
  137. Wisniewski HM, Brostoff SW, Carter H, Eylar EH (1974) Recurrent experimental allergic polyganglioradiculoneuritis. Arch Neurol 30:347–358PubMedGoogle Scholar
  138. Yonezawa T, Ishihara Y, Matsuyama H (1968) Studies on experimental allergic neuritis. I. Demyelinating patterns studied in vitro. J Neuropathol Exp Neurol 27:453–463CrossRefGoogle Scholar
  139. Yoshimura T, Kunishita T, Sakai K, Endoh M, Namikawa T, Tabira T (1985) Chronic experimental allergic encephalomyelitis in guinea pigs induced by proteolipid protein. J Neurol Sci 69:47–58PubMedCrossRefGoogle Scholar
  140. Zamvil SS, Mitchell DJ, Moore AC, Kitamura K, Steinman L, Rothbard JB (1986) T cell epitope of the autoantigen myelin basic protein that induces encephalomyelitis. Nature 324:258–260PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag London Limited 1990

Authors and Affiliations

  • Richard A. C. Hughes
    • 1
  1. 1.Department of Neurology, United Medical and Dental Schools of Guy’s and St Thomas’s HospitalsGuy’s HospitalLondonUK

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