Experimental Allergic Neuritis

  • Richard A. C. Hughes
Part of the Clinical Medicine and the Nervous System book series (CLIN.MED.NERV.)


Experimental allergic neuritis (EAN), an experimental model of GBS, developed as a by-product of research into experimental allergic encephalomyelitis (EAE). In 1895 Louis Pasteur had prepared the first rabies vaccines from dried formalin-treated rabbit brain. The vaccine provided some protection from rabies but also occasionally caused encephalomyelitis. Rivers and Schwentker (1935) showed that repeated injections of rabbit brain into monkeys would produce encephalomyelitis and Freund in 1949 showed that the same result could be achieved with a single injection provided that the nervous tissue was emulsified with an adjuvant. Early experiments were directed towards identifying the antigen. The encephalitogenic component of nervous tissue was found to reside largely in the major myelin basic protein (see Leibowitz and Hughes 1983 for review). More recently it has been demonstrated that highly purified proteolipid protein will also induce EAE (Yoshimura et al. 1985; Endoh et al. 1986). There is no theoretical reason why other CNS myelin antigens should not be capable of inducing EAE. Myelin basic protein (MBP), molecular weight 18 500, is rich in basic aminoacids, and its amino acid sequence is highly conserved from one species to another (Hashim 1980). However, there is great species variation in the part of the protein which is responsible for inducing EAE.


Dorsal Root Ganglion Sciatic Nerve Schwann Cell Myelin Basic Protein Experimental Allergic Encephalo 
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Copyright information

© Springer-Verlag London Limited 1990

Authors and Affiliations

  • Richard A. C. Hughes
    • 1
  1. 1.Department of Neurology, United Medical and Dental Schools of Guy’s and St Thomas’s HospitalsGuy’s HospitalLondonUK

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