Abstract
Peripheral nerves have unique properties which govern the outcome of inflammatory and immunological disorders affecting them. Nerve cells are in danger of being affected by inflammatory disorders anywhere along their extremely lengthy processes. Some motor neurons and dorsal root ganglion cell axons are more than a metre long. Fortunately the axons are wrapped and protected by myelin or Schwann cell cytoplasm. The integrity of the nerve terminals depends on uninterrupted axonal transport which occurs both at slow and fast (over 400 mm/day) rates. RNA is transcribed and protein and membrane materials are synthesised in the cell body and then transported down the axons. However, the traffic is two-way and for instance IgG (Fabian and Petroff 1987) and viruses, including rabies virus, may be carried from the periphery to the central nervous system via a retrograde axonal transport system. Inflammatory disorders have a particular tendency to affect the proximal ventral and dorsal roots. Vulnerable sites are the spinal cord entry zones, the dorsal root ganglia, and the junction of the ventral and dorsal roots where they become tightly invested by collagenous tissue. This junction is a point at which the nerve fibres might be expected to be particularly prone to compression by an oedematous inflammatory process.
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References
Baba H, Daune GC, Ilyas AA et al. (1989) Anti GM1 ganglioside antibodies with differing fine specificities in patients with multifocal motor neuropathy. J Neuroimmunol 25: 143–150
Beuche W, Friede RL (1984) The role of non-resident cells in Wallerian degeneration. J Neurocytol 13: 767–796
Brosnan CF, Stoner GL, Bloom BR, Wisniewski HM (1977) Studies in demyelination by activated lymphocytes in the rabbit eye. J Immunol 118: 2103–2110
Brosnan CF, Selmaj K, Raine CS (1988) Hypothesis: a role for tumor necrosis factor in immune-mediated demyelination and its relevance to multiple sclerosis. J Neuroimmunol 18: 87–94
Brostoff SW (1984) Antigens of peripheral nervous system myelin. In: Dyck PJ, Thomas PK, Lambert EH, Bunge R (eds) Peripheral neuropathy. WB Saunders, Philadelphia, pp 562–576
Carroll WM, Jennings AR, Mastaglia FL (1984) Experimental demyelinating optic neuropathy induced by intra-neural injection of galactocerebroside antiserum. J Neurol Sci 85: 125–135
Deibler GE, Driscoll BF, Kies MW (1978) Immunochemical and biochemical studies demonstrating the identity of a bovine spinal cord protein (SCP) and a basic protein of bovine peripheral nerve myelin ( BF ). J Neurochem 30: 401–412
Fabian RH, Petroff G (1987) Intraneuronal IgG in the central nervous system: uptake by retrograde axonal transport. Neurology 37: 1780–1784
Goban Y, Saida T, Saida K, Nishitkani H, Kameyana M (1986) Role of non-specific myelin destruction by delayed type hypersensitivity in primary demyelination. J Neurol Sci 74: 97–109
Gregson NA, Leibowitz S (1985) IgM paraproteinaemia, polyneuropathy and MAG. Neuropathol Appl Neurobiol 11: 329–347
Gregson NA, Kennedy MC, Leibowitz S (1971) Immunological reactions with lysolecithinsolubilised myelin. Immunology 20: 501–512
Hall SM, Gregson NA (1971) The in vivo and ultrastructural effects of injection of lysophosphatidyl choline into myelinated peripheral nerve fibres. J Cell Sci 9: 769–789
Hays AP, Latov N, Takatsu M, Sherman WH (1987) Experimental demyelination of nerve induced by serum of patients with neuropathy and an anti MAG M protein. Neurology 37: 242–246
Hughes RAC, Powell HC (1984) Experimental allergic neuritis: demyelination induced by P2 alone and non-specific enhancement by cerebroside. J Neuropathol Exp Neurol 43: 154–161
Hughes RAC, Powell HC, Braheny SL, Brostoff SW (1985) Endoneurial injection of antisera to myelin antigens. Muscle Nerve 8: 516–522
Hughes RAC, Atkinson PF, Gray IA, Taylor WA (1987) Major histocompatibility antigens and lymphocyte subsets during experimental allergic neuritis in the Lewis rat. J Neurol 234: 390–395
Izumo S, Linington C, Wekerle H, Meyermann R (1985) Morphological study on EAN mediated by T-cell line specific for bovine P2 protein in Lewis rats. Lab Invest 53: 209–218
Jacobs JM, MacFarlane RM, Cavanagh JB (1976) Vascular leakage in the dorsal root ganglia of the rat, studied with horseradish peroxidase. J Neurol Sci 29: 95–107
Jones TA, Bergfors T, Sedzik J, Unge T (1988) The three-dimensional structure of P2 myelin protein. EMBO 7: 1597–1604
Kadlubowski M, Hughes RAC, Gregson NA (1984) Spontaneous and experimental neuritis and the distribution of the myelin protein P2 in the nervous system. J Neurochem 42: 123–129
Koski CL, Vanguri P, Shin ML (1985) Activation of the alternative pathway of complement by human peripheral nerve myelin. J Immunol 134: 1810–1814
Lassmann H, Brunner C, Bradl M, Linington C (1988) Experimental allergic encephalomyelitis: the balance between encephalitogenic T lymphocytes and demyelinating antibodies determines the size and structure of demyelinated lesions. Acta Neuropathol 75: 566–576
Linington C, Izumo S, Suzuki M, Uyemura M, Meyermann R, Wekerle H (1984) A permanent rat T cell line that mediates experimental allergic neuritis in the rat in vitro. J Immunol 133: 1946–1950
Linington C, Bradl M, Lassmann H, Brunner C, Vass K (1988) Augmentation of demyelination in rats: acute allergic encephalomyelitis directed against a myelin/oligodendrocyte glycoprotein. Am J Pathol 130: 443–454
Low PA (1984) Endoneurial fluid pressure and microenvironment of the nerve, In: Dyck PJ, Thomas PK, Lambert EH, Bunge R (eds) Peripheral neuropathy. WB Saunders, Philadelphia, pp 599–617
Marcus DM, Latov N, Hsi BP, Gillard BK (1989) Measurement and significance of antibodies against GM1 ganglioside. Report of a Workshop, 18 April 1989, Chicago, IL, USA. J Neuroimmunol 25: 255–259
Milner P, Lovelidge CA, Taylor WA, Hughes RAC (1987) Po myelin protein produces experimental allergic neuritis in Lewis rats. J Neurol Sci 79: 275–285
Mizisin AP, Wiley CA, Hughes RAC, Powell HC (1987) Peripheral nerve demyelination in rabbits after inoculation with Freund’s complete adjuvant alone or in combination with lipid hapten. J Neuroimmunol 16: 381–395
Myers RR, Powell HC, Heckman HM, Costello ML, Katz J (1981) Biophysical and pathological effects of cryogenic nerve lesion. Ann Neurol 10: 478–485
Nagai Y, Momoi T, Saito M, Mitsuzawa E, Ohtani S (1976) Ganglioside syndrome, a new autoimmune neurologic disorder, experimentally induced with brain gangliosides. Neurosci Lett 2: 107–111
Norton WT, Cammer W (1984) Isolation and characterisation of myelin. In: Morell P (ed) Myelin, 2nd edn. Plenum Press, New York
Norton WT (1985) Recent advances in myelin biochemistry. Ann NY Acad Sci 436: 5–10
Olsson Y (1984) Vascular permeability in the peripheral nervous system. In: Dyck PJ, Thomas PK, Lambert EH, Bunge R (eds) Peripheral neuropathy. WB Saunders, Philadelphia, pp 579–597
Perlmann P, Perlmann H, Muller-Eberhard HJ (1975) Cytolytic lymphocytic cells with complement receptor in human blood. Induction of cytolysis by Igh antibody but not by target cell-bound C3.J Exp Med 141: 287–296
Powell HC, Hughes RAC (1987) Role of non-specific myelin destruction by delayed type hypersensitivity in primary demyelination. J Neurol Sci 74: 97
Powell HC, Myers RR, Costello ML, Lampert PW (1979) Endoneural fluid pressure in Wallerian degeneration. Ann Neurol 5: 550–573
Powell HC, Myers RR, Costello ML (1980) Increased endoneurial fluid pressure following injection of histamine and compound 48/80 into rat peripheral nerves. Lab Invest 43: 564–573
Powell HC, Braheny SL, Hughes RAC, Lampert PW (1984) Antigen-specific demyelination and significance of the bystander effect in peripheral nerves. Am J Pathol 114: 443–453
Quarles RH (1984) Myelin-associated glycoprotein in development and disease. Dev Neurosci 6: 285–303
Quarles RH, Ilyas AA, Willison HJ (1986) Antibodies to glycolipids in demyelinating diseases of the human peripheral nervous system. Chem Phys Lipids 42: 235–248
Raine CS, Bornstein MB (1979) Experimental allergic neuritis — ultrastructure of serum induced myelin aberrations in peripheral nervous system cultures. Lab Invest 40:423–432
Raine CS, Johnson AB, Marcus DM, Suzuki A, Bornstein MB (1981) Demyelination in vitro — absorption studies demonstrate that galactocerebroside is a major target. J Neurol Sci 52: 117–131
Rostami A, Brown MJ, Lisak RP, Sumner AJ, Zweiman B, Pleasure DE (1984) The role of myelin 112 protein in the production of experimental allergic neuritis. Ann Neurol 16: 680–685
Saida T, Saida K, Dorfman SH (1979) Experimental allergic neuritis induced by sensitisation with galactocerebroside. Science 204: 1103–1106
Saida T, Saida K, Silberberg DH, Brown MK (1981) Experimental allergic neuritis induced by galactocerebroside. Ann Neurol 9 supp1: 87–101
Saida T, Saida K, Olawa K, Goban Y, Kawanishi T (1987) Experimental models of immune-mediated demyelination in peripheral nerve. In: Aarli JA, Behan WMH, Behan PO (eds) Clinical Neuroimmunology. Blackwell Scientific Publications, Oxford, pp 102–113
Schwartz M, Sela BA, Eshhar N (1982) Antibodies to gangliosides and myelin autoantigens are produced in mice following sciatic nerve injury. J Neurochem 38: 1192–1195
Seil FJ (1977) Tissue culture studies of demyelinating disease: a critical review. Ann Neurol 2: 345–355
Seil FJ, Kies MW, Bacon ML (1981) A comparison of demyelinating and myelination inhibiting factor induction by whole peripheral nerve tissue and P2 protein. Brain Res 210: 441–448
Sergott RC, Brown MJ, Silberberg DH, Lisak RP (1984) Antigalactocerebroside serum demye-linates optic nerve in vitro. J Neurol Sci 64: 297–303
Smith KJ, Hall SM (1988) Peripheral demyelination and remyelination initiated by the calcium-selective ionophore ionomycin: in vivo observations. J Neurol Sci 83: 37–53
Stoner GL, Brosnan CF, Wisniewski HM, Bloom BR (1977) Studies on demyelination by activated lymphocytes in the rabbit eye. Effects of a monuclear cell infiltrate induced by products of activated lymphocytes. J Immunol 118: 2094–2102
Thomas PK, Olsson Y (1984) Microscopic anatomy and function of the connective tissue components of peripheral nerve. In: Dyck PJ, Thomas PK, Lambert EH, Bunge R (eds) Peripheral neuropathy. WB Saunders, Philadelphia, pp 97–120
Vedeler CA (1987) Demonstration of Fc gamma receptors on human peripheral nerve fibres. J Neuroimmunol 15: 207–216
Ward RHR, Lachmann PJ (1985) Monoclonal antibodies which react with lymphocyte-lysed target cells and which cross-react with complement-lysed ghosts. Immunology 56: 179–188
Wekerle H, Linington C, Lassmann H, Meyermann R (1986a) Cellular immune reactivity within the CNS. Trends in Neurol Sci 9: 271–277
Wekerle H, Schwab M, Linington C, Meyermann R (1986b) Antigen presentation in the peripheral nervous system: Schwann cells present endogenous myelin autoantigens to lymphocytes. Eur J Immunol 16: 1551–1557
Westland K, Pollard JD (1987) Proteinase induced demyelination. An electrophysiological and histological study. J Neurol Sci 82: 41–53
Wisniewski HM, Bloom BR (1975) Primary demyelination as a non-specific consequence of circulating immunocytes in Guillan—Barré syndrome. A cell-mediated immune reaction. J Exp Med 141: 346–359
Yonezawa T, Hasegawa M, Arizona N, Okabe H (1981) Antigenicity of galactocerebroside in experimental allergic demyelinating diseases. Acta Neuropathol suppl. 7: 162–164
Young JD-E, Liu C-C (1988) Multiple mechanisms of lymphocyte-mediated toxicity. Immunol Today 9: 140–144
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Hughes, R.A.C. (1990). Immunobiology of the Peripheral Nervous System. In: Guillain-Barré Syndrome. Clinical Medicine and the Nervous System. Springer, London. https://doi.org/10.1007/978-1-4471-3175-5_2
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DOI: https://doi.org/10.1007/978-1-4471-3175-5_2
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