Abstract
A group of diseases, fast expanding, are marked by the deposition in tissue of crystals which appear to produce tissue destruction by a common mechanism. Either they are ingested by, or nucleation occurs within the cytoplasm of, polymorphonuclear leucocytes. There is abundant evidence that the white cell responds by trying to digest or destroy these crystals. The rate of all measured metabolic processes of these cells increases, neutral and acidic proteinases are formed within the primary and secondary lysosomes of these cells and these and other products of the cells leak into the extracellular fluid, reducing the local pH. Potentially toxic products of oxygen metabolism and products of cell membrane lysis such as prostaglandins, leukotrienes, interleukins and superoxides are released and an acute inflammatory reaction ensues which may limit or promote further destruction according to local circumstances. In the past individual crystals have been linked to different diseases. Recently it has been appreciated that the position may be considerably more complex.
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Abramson S, Hoffstein ST, Weissman G (1982) Superoxide anion generation by human neutrophils exposed to monosodium urate. Arthritis Rheum 25: 174–180
Dieppe PA (1978) Crystal arthritis. In: Dick WC, Buchanan WW (eds) Recent advances in rheumatology, 2nd edn. Churchill Livingstone, Edinburgh London New York
Dieppe PA, Calvert PR (in press) A practical guide to polarising light microscopy. In: Dieppe PA, Calvert PR (eds) Crystal induced arthritis and related diseases. Chapman and Hall, London
Dieppe PA, Crocker PR, Corke CF, Doyle DV, Huskisson EC, Willoughby DA (1979) Synovial fluid crystals. J Med, New Series XLVIII (192): 533–553
Fessel WJ (1972) Hyperuricaemia in health and disease. Semin Arthritis Rheum 1: 275 – 299
Hesselbacher P (1979) C3 activation by monosodium urate monohydrate and other crystalline material. Arthritis Rheum 22: 571–578
Howell DS (1981) Diseases due to the deposition of calcium pyrophosphate and hydroxyapatite. In: Kelly W, Harris ED Jr, Ruddy S, Sledge CB (eds) Textbook of rheumatology, 1st edn. Saunders, Philadelphia London Toronto, Chap 87
Kelly WN (1981) Gout and related disorders of purine metabolism. In: Kelly W, Harris ED Jr, Ruddy S, Sledge CB (eds) Textbook of rheumatology, 1st edn. Saunders, Philadelphia London Toronto, Chap 86
McCarty DJ Jr, Hogan JM, Gatter RE, Grossman M (1966) Studies on pathological calcifications in human cartilage. J Bone Joint Surg 48A (2): 309–325
McGuire MKB, Hearn PR, Russell RCG (1980) Calcium pyrophosphate crystals (their relevance to C.P.P.D., pseudogout, chondrocalcinosis and pyrophosphate arthropathy); biochemical and physicochemical aspects. In: Maroudas A, Hoborrow EJ (eds) Studies in joint disease—1. Pitman Medical, Tunbridge Wells, pp 117–156
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© 1983 Springer-Verlag Berlin Heidelberg
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Capell, H.A., Daymond, T.J., Dick, W.C. (1983). Crystal Arthropathies. In: Rheumatic Disease. Treatment in Clinical Medicine. Springer, London. https://doi.org/10.1007/978-1-4471-3113-7_6
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DOI: https://doi.org/10.1007/978-1-4471-3113-7_6
Publisher Name: Springer, London
Print ISBN: 978-3-540-12622-5
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