Abstract
The flow behaviour of blood in general and within the microcirculation in particular critically depends upon the ability of erythrocytes to undergo deformation (change in their tridimensional configuration) when submitted to stresses. In this way the red blood cells (RBCs) are able to negotiate capillaries with diameters smaller than their own diameter at rest. Although a series of different procedures to quantitate this deformability has already been described, many of them fail to fulfil (in part or completely) the requirements to simulate the boundary conditions prevailing in the microcirculation, and specifically:
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1)
The small shear stresses (below 10 Pa), and
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the small geometrical dimensions which impose mechanical constraints upon the erythrocytes.
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References
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© 1981 Spring-Verlag Berling Heidelberg
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Kiesewetter, H., Mussler, K., Teitel, P., Dauer, U., Schmid-Schönbein, H., Spohr, R. (1981). New Methods for Red Cell Deformability Measurement. In: Lowe, G.D.O., Barbenel, J.C., Forbes, C.D. (eds) Clinical Aspects of Blood Viscosity and Cell Deformability. Springer, London. https://doi.org/10.1007/978-1-4471-3105-2_3
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DOI: https://doi.org/10.1007/978-1-4471-3105-2_3
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