Rheological Studies in Obstetrics and Gynaecology
Because of the strong connection between arterio-venous thrombo-embolism and oral contraception (Vessey and Mann, 1978) much interest has been focussed on the alterations in rheological parameters caused by hormonal ovulation suppression. A full understanding of these effects of oestrogens and progestagens must be based on a sound appreciation of the physiological background upon which they are imposed but little attention has been paid, as yet, to the rheological changes in the menstrual cycle and pregnancy. In common with most biological measurements rheological parameters vary in response to circadian (Seaman et al., 1965), menstrual (Dintenfass and Yu, 1968) and reproductive (Hamilton, 1950) cycles. This chapter is a review of the existing literature on rheological changes during ovulatory cycles, oral contraception and pregnancy, supplemented by our own data drawn from serial and cross-sectional studies of women in these various states.
KeywordsMenstrual Cycle Luteal Phase Fibrinogen Level Packed Cell Volume Plasma Fibrinogen
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- Esiaschwili 1 (1933) Blutgerinnung und Viskosität in der Schwangerschafts und Nachgeburtsperiode. Zentralbl Gynaekol 57: 2712–2728Google Scholar
- Lowe G D O, Reavey M M, Forbes C D, Prentice C R M (1979) Increased blood viscosity in young women taking oral contraceptives. Clin Sci Mol Med 56: 21 PGoogle Scholar
- Merke C, Lundh B (1976) Erythrocyte filterability and heure catabolism during the menstrual cycle. Ann Intern Med 85: 322–324Google Scholar
- Nygaard K K, Wilder M, Berkson J (1935) The relationship between viscosity of blood and the relative volume of erythrocytes (hematocrit value). Am J Physiol 114: 128–136Google Scholar
- Pellisier M P (1912) De la viscosité du sang total chez la femme enceinte et accouchée et de ses rapports avec la tension artérielle. Arch d’Obstet 11: 306–320Google Scholar
- Poller L (1978) Oral contraceptives, blood clotting and thrombosis. Br Med Bull 34: 151–156 Rampling M W, Sirs J A (1977) Fibrinogen, fibrinogen degradation products and erythrocyte flexibility. Thromb Haemostas 38: 668–676Google Scholar