Prediction of carcinogenic potential of a new medicine

  • Peter I. Folb

Abstract

A chemical carcinogen is a substance which induces in mammalian species tumours that are not normally encountered, or which increases the incidence of naturally occurring tumours, or which causes the appearance of naturally occurring tumour types earlier than would be expected.

Keywords

Arsenic Methotrexate Progesterone Alkaloid Dextran 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Selective Bibliography

  1. Berenblum I (ed) (1969) Carcinogenicity testing. International Union Against Cancer; Technical Report Series, 2Google Scholar
  2. Clayson DB (1962) Chemical carcinogenesis. Churchill, LondonGoogle Scholar
  3. National Cancer Institute (1976) Guidelines for carcinogen bioassay in small rodents. Technical Report Series, 1. U. S. Department of Health, Education and Welfare, National Institutes of HealthGoogle Scholar
  4. Roe FJC (1966) The relevance of preclinical assessment of carcinogenesis. Clin Pharmacol Ther 7: 77PubMedGoogle Scholar
  5. Salsburg D (1978) Lifetime carcinogenic studies in rodents, viewed from the standpoint of experimental design: Weaknesses and alternatives. In: Dayan AD, Brimblecombe RW (eds) Carcinogenicity testing: Principles and problems. MTP Press, Lancaster, England, p 89Google Scholar
  6. Schmahl D, Thomas C, Auer R (1977) Iatrogenic carcinogenesis. Springer, Berlin Heidelberg New YorkCrossRefGoogle Scholar
  7. World Health Organisation (1969) Principles for the testing and evaluation of drugs for carcinogenicity. WHO Tech Rep Ser 426Google Scholar
  8. World Health Organisation (1971) Evaluation and testing of drugs for mutagenicity: Principles and problems. WHO Tech Rep Ser 482Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1980

Authors and Affiliations

  • Peter I. Folb
    • 1
    • 2
  1. 1.University of Cape TownSouth Africa
  2. 2.Groote Schuur HospitalCape TownSouth Africa

Personalised recommendations