Skip to main content

Liver Tumours

  • Chapter
Neonatal Tumours

Abstract

Neonatal primary hepatic tumours are rare, and few cases are reported in both small and large series1–4. Benign tumours, including haemangioendothelioma and mesenchymal hamartoma, account for the majority of hepatic lesions; hepatic malignancies are extremely rare5–7. This low incidence of malignancy in the neonatal period is different from that of infancy and childhood in which two-thirds of patients present with hepatoblastoma and hepatocarcinoma1. Liver tumours of the newborn pose a challenge to all disciplines of paediatric practice. The benign vascular lesions can reach a large size before discovery, and may present with a life-threatening complication such as congestive heart failure, whereas the malignant tumours are unresectable in half the patients at the time of diagnosis8,9. A combined management plan by surgeons, neonatologists, oncologists and anaesthetists have minimized morbidity and mortality rates in both patient groups, although the prognosis for patients with malignant disease is still poor1,9.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Exelby PR, Filler RM, Grosfeld JL (1975) Liver tumors in children in the particular reference for hepatoblastoma and hepatocellular carcinoma: American Academy of Pediatrics, Surgical Section Survey - 1974. J Pediatr Surg 10: 329–337.

    PubMed  CAS  Google Scholar 

  2. Dehner LP, Ishak KG (1971) Vascular tumours of the liver in infants and children. A study of 30 cases and review of the literature. Arch Pathol 92: 101–111.

    PubMed  CAS  Google Scholar 

  3. Ehren H, Mahour GH, Isaacs H (1983) Benign liver tumors in infancy and childhood: report of 48 cases. Am J Surg 145: 325–329.

    PubMed  CAS  Google Scholar 

  4. Thomas BL, Krummel TM, Parker GA et al. (1989) Use of intraoperative ultrasound during hepatic resection in pediatric patients. J Pediatr Surg 24: 690–693.

    PubMed  CAS  Google Scholar 

  5. Campbell AN, Chan HSL, O’Brien A et al. (1987) Malignant tumours in the neonate. Arch Dis Child 62: 19–23.

    PubMed  Google Scholar 

  6. Isaacs H (1987) Congenital neonatal malignant tumours. A 28 year experience at Children’s Hospital of Los Angeles. Am J Pediatr Hematol Oncol 9: 121–129.

    PubMed  Google Scholar 

  7. Hartman GE, Shochat SJ (1989) Abdominal mass lesions in the newborn’s diagnosis and treatment. Clin Perinatol 16: 123–135.

    PubMed  CAS  Google Scholar 

  8. Becker JM, Heitler MS (1989) Hepatic hemangioendothe-liomas in infancy - collective review. Surg Gynecol Obstet 168: 189–200.

    PubMed  CAS  Google Scholar 

  9. Giacomantonio M, Ein SH, Mancer K et al. (1984) Thirty years of experience with pediatric primary malignant liver tunors. J Pediatr Surg 19: 523–526.

    PubMed  CAS  Google Scholar 

  10. King DR, Ortega J, Campbell J et al. (1991) The surgical management of children with incompletely resected hepatic cancer is facilitated by intensive chemotherapy. J Pediatr Surg 26: 1074–1081.

    PubMed  CAS  Google Scholar 

  11. Black CT, Cangir A, Choroszy M, Andrassy RJ (1991) Marked response to preoperative high dose cis-platinum in children with unresectable hepatoblastoma. J Pediatr Surg 26: 1070–1073.

    PubMed  CAS  Google Scholar 

  12. Pazder R, Bready B, Langir A (1993) Pediatric hepatic tumours: clinical trials conducted in the United States. J Surg Oncol 3: 127–130.

    Google Scholar 

  13. Tugge EP, Tugge DU, Reyes J et al. (1992) Resection including transplantation for hepatoblastoma and hepatocellular carcinoma: impact on survival. J Pediatr Surg 27: 292–296.

    Google Scholar 

  14. Romero R (1988) Hepatomegaly. In: Romero R, Pilu G, Jeahthy P, Ghidiri A, Hobbins JC, eds. Prenatal diagnosis of congenital anomalies. Appleton and Lange, East Norwalk, Connecticut, pp 249–251.

    Google Scholar 

  15. Petrikovsky BM, Cohen HL, Scimeca P, Belluci E (1994) Prenatal diagnosis of focal nodular hyperplasia of the liver. Prenat Diagn 14: 406–409.

    PubMed  CAS  Google Scholar 

  16. Berdon WE, Baker DH (1969) Giant hepatic hemangioma with cardiac failure in the newborn infant. Radiology 62: 1523–1528.

    Google Scholar 

  17. Cremin BJ, Nuss D (1974) Calcified hepatoblastoma in a newborn. J Pediatr Surg 9: 913–915.

    PubMed  CAS  Google Scholar 

  18. Hirata GI, Matsunaga ML, Medeari AL et al. (1990) Ultrasonographic diagnosis of a fetal abdominal mass: a case of a mesenchymal liver hamartoma and a review of the literature. Prenat Diagn 10: 507–512.

    PubMed  CAS  Google Scholar 

  19. Alcalay M, Dan U, Kessler A et al. (1991) Prenatal ultrasonic diagnosis of hepatic cyst. Pediatr Surg Int 6: 146–147.

    Google Scholar 

  20. Flagg RS, Robinson DW (1967) Solitary nonparasitic hepatic cysts. Arch Surg 95: 964–973.

    PubMed  CAS  Google Scholar 

  21. Abramson SJ, Lack EF, Teele RL (1982) Benign vascular tumors of the liver in infants: sonographic appearance. AJR Am J Roentgenol 138: 629–632.

    PubMed  CAS  Google Scholar 

  22. Shackelford GD, Kirks DR (1977) Neonatal hepatic calcification secondary to transplacental infection. Radiology 122: 753–757.

    PubMed  CAS  Google Scholar 

  23. Hawass ND, El Badawi MG, Fatani JA et al. (1990) Fetal hepatic calcification. Pediatr Radiol 20: 528–535.

    PubMed  CAS  Google Scholar 

  24. Howell CG, Templeton JM, Weiner S et al. (1983) Antenatal diagnosis and early surgery for choledochal cyst. J Pediatr Surg 18: 387–393.

    PubMed  CAS  Google Scholar 

  25. Holcomb GW, O’Neill JA, Mahboubi S (1988) Experience with hepatic hemangioendothelioma in infancy and childhood. J Pediatr Surg 23: 661–666.

    PubMed  Google Scholar 

  26. Jackson C, Greene HL, O’Neill JA et al. (1977) Hepatic hemangioendothelioma. Am J Dis Child 131: 74–77.

    PubMed  CAS  Google Scholar 

  27. McLean RH, Moller JH, Warwick WJ et al. (1972) Multinodular hemangiomatosis of the liver in infancy. Pediatrics 49: 563–573.

    PubMed  CAS  Google Scholar 

  28. Pereyra R, Andrassy CRJ, Mahour GH (1982) Management of massive hepatic hemangiomas in infants and children: a review of 13 cases. Pediatrics 70: 254–258.

    PubMed  CAS  Google Scholar 

  29. Guzzetta PC, Randolph JG (1989) Pediatric hepatic surgery. Surg Clin North Am 69: 251–257.

    PubMed  CAS  Google Scholar 

  30. Weinberg AG, Finegold MJ (1986) Primary hepatic tumours in childhood. In: Finegold MJ, ed. Pathology of neoplasia in childhood and adolescence. WB Saunders, Philadelphia, pp 333–372.

    Google Scholar 

  31. Falk H, Herbert JT, Edmonds L et al. (1981) Review of four cases of childhood hepatic angiosarcoma - elevated environmental arsenic exposure in one case. Cancer 47: 382–391.

    PubMed  CAS  Google Scholar 

  32. Strate SM, Rutledge JC, Weinberg AC (1984) Delayed development of angiosarcoma in multinodular infantile hepatic hemangioendothelioma. Arch Pathol Lab Med 108: 943–944.

    PubMed  CAS  Google Scholar 

  33. Lampe I, Latourette HB (1959) Management of hemangiomas in infants. Pediatr Clin North Am 6: 511–521.

    Google Scholar 

  34. DeLorimier AA, Simpson EB, Baum RS et al. (1967) Hepatic artery ligation for hepatic hemangiomatosis. N Engl J Med 277: 333–337.

    PubMed  CAS  Google Scholar 

  35. Touloukian RJ (1970) Hepatic hemangioendothelioma during infancy: pathology diagnosis and therapy with prednisone. Pediatrics 45: 71–76.

    PubMed  CAS  Google Scholar 

  36. Dachman DH, Lichtenstein JE, Friedman AC et al. (1983) Infantile hemangioendothelioma of the liver: a radiologic-pathologic-clinical correlation. Am J Radiol 140: 1091–1096.

    CAS  Google Scholar 

  37. Leonidas JC, Staus L, Beck AR (1973) Vascular tumours of the liver in newborns. Am J Dis Child 125: 507–510.

    PubMed  CAS  Google Scholar 

  38. Shim WKT (1968) Hemangiomas of infancy complicated by thrombocytopenia. Am J Surg 116: 869–906.

    Google Scholar 

  39. Ezekowitz RAB, Phil D, Mulliken JB et al. (1992) Interferon Alfa-2a therapy for life-threatening hemangiomas of infancy. N Engl J Med 326: 1456–1463.

    PubMed  CAS  Google Scholar 

  40. Cohen RC, Myers NA (1986) Diagnosis and management of massive hemangiomas in childhood. J Pediatr Surg 21: 6–9.

    PubMed  CAS  Google Scholar 

  41. Cornelius AS, Womer RB, Jakacki R (1989) Multiple hemangioendotheliomas of the liver. Med Pediatr Oncol 17: 501–504.

    PubMed  CAS  Google Scholar 

  42. Yohannan MD, Abdulla AMA, Patel PJ (1990) Neonatal hepatic hemangioendothelioma: presentation with jaundice and microangiopathic haemolytic anaemia. Eur J Pediatr 149: 804–805.

    PubMed  CAS  Google Scholar 

  43. Linderkamp O, Hopner F, Klose H et al. (1976) Solitary hepatic hemangioma in a newborn infant complicated by cardiac failure, consumptive coagulopathy, microangiopathic hemolytic anemia and obstructive jaundice. Eur J Pediatr 124: 23–29.

    PubMed  CAS  Google Scholar 

  44. Margileth AM, Muceles M (1965) Cutaneous hemangiomas in children: diagnosis and conservation management. JAMA 194: 523–526.

    PubMed  CAS  Google Scholar 

  45. Chitayat D, Schwartz KO, Daniels-Phillips E (1979) Fatal bleeding due to spontaneous rupture of a cavernous hepatic hemangioma. Harefuah 97: 75–76.

    PubMed  CAS  Google Scholar 

  46. Sewell JH, Weiss K (1961) Spontaneous rupture of hemangioma of the liver: a review of the literature and presentation of illustrative case. Arch Surg 83: 729–733.

    PubMed  CAS  Google Scholar 

  47. Moss AA, Clark RF, Palubinskas AJ et al. (1971) Angiographic appearance of benign and malignant hepatic tumours in infants and children. AJR Am J Roentgenol 113: 61–69.

    CAS  Google Scholar 

  48. Abramson SJ, Lack EE, Teele RL (1982) Benign vascular tumours of the liver in infants: sonographic appearance. AJR Am J Roentgenol 138: 629–632.

    PubMed  CAS  Google Scholar 

  49. Front D, Royal HD, Israel O et al. (1981) Scintigraphy of hepatic hemangiomas: the value of Tc-99m labelled red blood cells. J Nucl Med 22: 684–687.

    Google Scholar 

  50. Montgomery SP, Guillot AP, Barth RA (1990) MRI of disseminated neonatal hemangiomatosis: case report. Pediatr Radiol 20: 204–205.

    PubMed  CAS  Google Scholar 

  51. Rummeny E, Weissleder R, Stark DD et al. (1989) Primary liver tumors: diagnosis by MR imaging. AJR Am J Roentgenol 152: 63–72.

    PubMed  CAS  Google Scholar 

  52. McFarland EG, Mayo-Smith WW, Saini S, Hahn PF, Goldberg MA, Lee MJ (1994) Hepatic hemangiomas and malignant tumours: improved differentiation with heavily T-2 weighted conventional spin-ECHO MR imaging. Radiology 193: 43–47.

    PubMed  CAS  Google Scholar 

  53. Stewart B, Mulker MF, Foley M, Weilopolski PA, Finn JP (1994) Fast MR imaging of the liver: quantitative comparison of techniques. Radiology 193: 37–42.

    Google Scholar 

  54. Goldberg SJ, Fonkalsrud E (1969) Successful treatment of hepatic hemangioma with corticosteroids. JAMA 208: 2473–2474.

    PubMed  CAS  Google Scholar 

  55. Nguyen B, Shandling B, Ein S et al. (1982) Hepatic hemangioma in childhood: medical management or surgical management. J Pediatr Surg 17: 576–579.

    PubMed  CAS  Google Scholar 

  56. Davenport M, Hansen L, Heaton ND et al. (1995) Hemangioendothelioma of the liver in infants. J Pediatr Surg 30: 44–48.

    PubMed  CAS  Google Scholar 

  57. Hurvitz CH, Alkally AL, Sloninsky L et al. (1985) Cyclophosphamide therapy in life-threatening vascular tumors. J Pediatr 109: 360–363.

    Google Scholar 

  58. Johnson DH, Vinson AM, Wirth FH et al. (1984) Management of hepatic hemangioendothelioma of infancy by transarterial embolization: a report of two cases. Pediatrics 73: 546–549.

    PubMed  CAS  Google Scholar 

  59. Burrows PE, Rosenberg HC, Chuang HS (1985) Diffuse hepatic hemangiomas: percutaneous transcatheter embolization with detachable silicone balloons. Radiology 156: 85–88.

    PubMed  CAS  Google Scholar 

  60. Davenport M, Hansen L, Heaton ND, Howard ER (1995) Hemangioendothelioma of the liver in infants. J Pediatr Surg 30: 44–48.

    PubMed  CAS  Google Scholar 

  61. Haselow RE, Nesbit M, Dehner LP et al. (1978) Second neoplasms following megavoltage radiation in a pediatric population. Cancer 42: 1185–1191.

    PubMed  CAS  Google Scholar 

  62. Irving IM (1990) Abdominal tumors. In: Lister J, Irving IM, eds. Neonatal surgery. Butterworths, London, pp 122–141.

    Google Scholar 

  63. Stanley P, Grinell VS, Staunton RE et al. (1983) Therapeutic embolization of infantile hepatic hemangioma with polyvinyl alcohol. AJR Am J Roentgenol 141: 1047–1051.

    PubMed  CAS  Google Scholar 

  64. Stocker JT, Ishak KG (1983) Mesenchymal hamartoma of the liver: report of 30 cases and a review of the literature. Pediatr Pathol 1: 245–267.

    PubMed  CAS  Google Scholar 

  65. DeMaioribus CA, Lally KP, Sim K et al. (1990) Mesenchymal hamartoma of the liver. A 35 year review. Arch Surg 125: 598–600.

    PubMed  CAS  Google Scholar 

  66. Maresh R (1903) Uber ein Lymphangiom der Leber. Z Heilk 24: 39–50.

    Google Scholar 

  67. Edmondson HA (1956) Differential diagnosis of tumors and tumor-like lesions of liver in infancy and childhood. Am J Dis Child 91: 168–186.

    CAS  Google Scholar 

  68. Raffensperger JG, Gonzalez-Crussi F, Skeehan T (1983) Mesenchymal hamartoma of the liver. J Pediatr Surg 18: 585–587.

    PubMed  CAS  Google Scholar 

  69. Lanuza A, Perez-Candela V, Ceres L et al. (1980) Hepatic hamartoma in a newborn. Pediatr Radiol 9: 111–112.

    PubMed  CAS  Google Scholar 

  70. Smith WL, Ballantine TVN, Gonzalez-Crussi F (1978) Hepatic mesenchymal hamartoma causing heart failure in the neonate. J Pediatr Surg 13: 183–185.

    PubMed  CAS  Google Scholar 

  71. Dehner LP, Ewing SL, Saumer HW (1975) Infantile mes-enchymal hamartoma of the liver. Arch Pathol 99: 379–382.

    PubMed  CAS  Google Scholar 

  72. Srouji MN, Chatten J, Schulman WM et al. (1978) Mesenchymal hamartoma of the liver in infants. Cancer 42: 2483–2489.

    PubMed  CAS  Google Scholar 

  73. Ishida M, Tsuchida Y, Saito S et al. (1966) Mesenchymal hamartoma of the liver. Case report and literature review. Ann Surg 164: 175–182.

    Google Scholar 

  74. Silber DL, Soper RT, Kent T (1970) Life threatening mesenchymal hamartoma of the liver. J Pediatr Surg 5: 471–472.

    PubMed  CAS  Google Scholar 

  75. Ito H, Kishikawa T, Toda T et al. (1984) Hepatic mesenchymal hamartoma of an infant. J Pediatr Surg 19: 315–317.

    PubMed  CAS  Google Scholar 

  76. Alkalay AL, Puri AR, Pomerance JJ et al. (1985) Mesenchymal hamartoma of the liver responsive to cyclophosphamide therapy: therapeutic approach. J Pediatr Surg 20: 125–128.

    PubMed  CAS  Google Scholar 

  77. Rosenbaum DM, Mindell HJ (1980) Ultrasonographic findings in mesenchymal hamartoma of the liver. Radiology 138: 425–427.

    Google Scholar 

  78. Ros PR, Goodman ZD, Ishak KG et al. (1986) Mesenchymal hamartoma of the liver: radiologic-pathologic correlation. Radiology 158: 619–623.

    PubMed  CAS  Google Scholar 

  79. Stanley RJ, Dehner LP, Hesker AE (1973) Primary malignant mesenchymal tumors (mesenchymoma) of the liver in childhood: an angiographic-pathologic study of three cases. Cancer 32: 973–984.

    PubMed  CAS  Google Scholar 

  80. Stocker JT, Ishak KG (1978) Undifferentiated (embryonal) sarcoma of the liver. Cancer 42: 336–348.

    PubMed  CAS  Google Scholar 

  81. Newman KD, Schisgall R, Reaman G, Guzzetta PC (1989) Malignant mesenchymoma of the liver in children. J Pediatr Surg 24: 781–783.

    PubMed  CAS  Google Scholar 

  82. Randolph JG, Altman RP, Arensman RM et al. (1978) Liver resection in children with hepatic neoplasms. Ann Surg 187: 599–605.

    PubMed  CAS  Google Scholar 

  83. Yandza T, Valayer J (1986) Benign tumors of the liver in children: analysis of a series of 20 cases. J Pediatr Surg 21: 419–423.

    PubMed  CAS  Google Scholar 

  84. Clatworthy HW, Schiller M, Grosfeld JL (1974) Primary liver tumours in infancy and childhood. Arch Surg 109: 143–147.

    PubMed  Google Scholar 

  85. Valayer J, Lemerle J (1986) Tumeurs du foie. In: Alagille D, Odieure M, eds. Maladies du foie et des voies biliaries chez l’enfant. Flammarion, Paris, pp 239–259. Cited by Gauthier F, Valayer J, LeThai B et al. (1986) Hepatoblastoma and hepatocarcinoma in children: analysis of a series of 29 cases. J Pediatr Surg 21: 424–429.

    Google Scholar 

  86. Ishak K, Glunz PR (1967) Hepatoblastoma and hepatocarcinoma in infancy and childhood: report of 47 cases. Cancer 20: 396–422.

    PubMed  CAS  Google Scholar 

  87. Lack EE, Neave C, Vawter GF (1983) Hepatocellular carcinoma. Cancer 52: 1510–1515.

    PubMed  CAS  Google Scholar 

  88. Alpert ME, Seeler RA (1970) Alpha-fetoprotein in embryonal hepatoblastoma. J Pediatr 77: 1058.

    PubMed  CAS  Google Scholar 

  89. Foster JH, Berman MM (1977) Solid liver tumors. WB Saunders, Philadelphia.

    Google Scholar 

  90. Misugi K, Okajima H, Misugi N et al. (1967) Classification of primary malignant tumors of the liver in infancy and childhood. Cancer 20: 1760–1771.

    PubMed  CAS  Google Scholar 

  91. Surendran N, Radhakrishna K, Chellam VG (1989) Hepatoblastoma in siblings. J Pediatr Surg 24: 1169–1171.

    PubMed  CAS  Google Scholar 

  92. Napoli VM, Campbell WG Jr (1977) Hepatoblastoma in infant sister and brother. Cancer 39: 2647–2650.

    PubMed  CAS  Google Scholar 

  93. Parkin DM, Stiller CA, Drager GJ et al. (1988) The international incidence of childhood cancer. Int J Cancer 42: 511–520.

    PubMed  CAS  Google Scholar 

  94. Chen WJC, Lee JC, Hung WT (1988) Primary malignant tumor of liver in infants and children in Taiwan. J Pediatr Surg 23: 457–461.

    PubMed  CAS  Google Scholar 

  95. Mann JR, Kasthuri N, Raafat F et al. (1990) Malignant hepatic tumours in children: incidence, clinical features and aetiology. Paediatr Perinat Epidemiol 4: 276–289.

    PubMed  CAS  Google Scholar 

  96. Weinberg AG, Mize CE, Worthen HG (1976) The occurrence of hepatoma in the chronic form of hereditary tyrosinaemia. J Pediatr Surg 88: 434–438.

    CAS  Google Scholar 

  97. Filler RM, Hagen J (1981) Liver tumors. Surg Clin North Am 61: 1209–1217.

    CAS  Google Scholar 

  98. Altman RP, Schwartz AD (1983) Malignant disease of infancy, childhood and adolescence, 2nd edn. WB Saunders, Philadelphia, p 524.

    Google Scholar 

  99. Green DM (1985) Diagnosis and management of malignant solid tumors in infants and children. Martinus Nijhoff, Boston, pp 410–438.

    Google Scholar 

  100. Kasai M, Watanabe I (1970) Histologic classification of liver cell carcinoma in infancy and childhood and its clinical evaluation. A study of 70 cases collected in Japan. Cancer 25: 551–553.

    PubMed  CAS  Google Scholar 

  101. Gonzalez-Crussi F, Upton MP, Maurer HS (1982) Hepatoblastoma. Attempt at characterization of histologic subtypes. Am J Surg Pathol 6: 599–612.

    Google Scholar 

  102. Craig JR, Peters RL, Edmondson HA et al. (1980) Fibrolamellar carcinoma of the liver. A tumor of adolescents and young adults with distinctive clinicopathologic features. Cancer 46: 372–379.

    Google Scholar 

  103. Joyce AD, Howard ER (1989) Hepatobiliary tumours of childhood: investigation and management. In: Spitz L, Wurnig P, Angerpointner TA, eds. Progress in pediatric surgery 22. Springer-Verlag, Berlin, pp 69–93.

    Google Scholar 

  104. Nakagawara A, Ikeda K, Hayashida Y et al. (1982) Immunocytochemical identification of human chorionic gonadotropin and α-fetoprotein producing cells of hepatoblastoma associated with precocious puberty. Virchows Arch A Pathol Anat 398: 45–51.

    CAS  Google Scholar 

  105. Behrle FC, Mantz FA, Olsen RL (1963) Virilization accompanying hepatoblastoma. Pediatrics 32: 265–271.

    PubMed  CAS  Google Scholar 

  106. Hirota M, Iwafuchi M, Oshawa Y et al. (1982) Gonadotropin producing hepatoblastoma. J Jpn Soc Pediatr Surg 18: 1147–1152.

    Google Scholar 

  107. Galifer RB, Sultan C, Margueritte G et al. (1985) Testosterone-producing hepatoblastoma in a 3 year old boy with precocious puberty. J Pediatr Surg 20: 713–714.

    PubMed  CAS  Google Scholar 

  108. Nickerson HJ, Silberman TL, McDonald TP (1980) Hepatoblastoma, thrombocytosis and increased thrombopoietin. Cancer 45: 315–317.

    PubMed  CAS  Google Scholar 

  109. Tsuchida Y, Endo Y, Saito S et al. (1978) Evaluation of α-fetoprotein in early infancy. J Pediatr Surg 13: 155–156.

    PubMed  CAS  Google Scholar 

  110. Davidson PM, Waters KD, Brown TCK, Auldist AW (1988) Liver tumors in children. Pediatr Surg Int 3: 377–381.

    Google Scholar 

  111. Mclntyre KR, Vogel CL, Primack A et al. (1976) Effect of surgical and chemotherapeutic treatment on α-fetoprotein levels in patients with hepatocellular carcinoma. Cancer 37: 677–683.

    Google Scholar 

  112. Purves LR (1976) Alpha fetoprotein and the diagnosis of liver cell cancer. In: Cameron HM, Linsell DA, Warwick GP, eds. Liver cell cancer. Elsevier, Amsterdam, pp 61–79.

    Google Scholar 

  113. Black CT, Luck SR, Musemeche CA, Andrassy RJ (1991) Aggressive excision of pulmonary metastases is warranted in the management of childhood hepatic tumors. J Pediatr Surg 26: 1082–1086.

    PubMed  CAS  Google Scholar 

  114. DeCampo M, DeCampo JF (1988) Ultrasound of primary hepatic tumours in childhood. Pediatr Radiol 19: 19–24.

    CAS  Google Scholar 

  115. Plumky DA, Grosfeld JL, Kopecky KK, Buckwalter KA, Glaze Vaughan W (1994) The role of spiral (helical) computerized tomography with three dimensional reconstruction in pediatric solid tumours. J Pediatr Surg 30: 317–321.

    Google Scholar 

  116. Korobkin M, Kirks DR, Sullivan DC et al. (1981) Computed tomography of primary liver tumours in children. Radiology 139: 431–435.

    PubMed  CAS  Google Scholar 

  117. LeBerge JM, Laing FC, Federle MP et al. (1984) Hepatocellular carcinoma: assessment of resectability by computed tomography and ultrasound. Radiology 152: 485–490.

    Google Scholar 

  118. Miller JH, Gates GF, Stanley P (1977) The radiologic investigation of hepatic tumors in childhood. Radiology 124: 451–458.

    PubMed  CAS  Google Scholar 

  119. Miller JH (1981) The ultrasonographic appearance of cystic hepatoblastoma. Radiology 138: 141–143.

    PubMed  CAS  Google Scholar 

  120. Brunelle F, Chaumont P (1984) Hepatic tumors in children: ultrasonic differentiation of malignant from benign lesions. Radiology 150: 695–699.

    PubMed  CAS  Google Scholar 

  121. Foley DW, Stewart ET, Milbrath JA et al. (1983) Digital subtraction angiography of the portal venous system. AJR Am J Roentgenol 140: 497–499.

    PubMed  CAS  Google Scholar 

  122. Takayama T, Makuuchi M, Kosuge T et al. (1991) A hepatoblastoma originating in the caudate lobe radically resected with the inferior vena cava. Surgery 109: 208–213.

    PubMed  CAS  Google Scholar 

  123. Ohtomo K, Itai Y, Yoshirawa K et al. (1987) Hepatic tumours: dynamic MR imaging. Radiology 163: 27–31.

    PubMed  CAS  Google Scholar 

  124. Randolph JG, Altman RP, Arensman RM et al. (1978) Liver resection in children with hepatic neoplasms. Ann Surg 187: 599–605.

    PubMed  CAS  Google Scholar 

  125. Weinblatt ME, Siegal SE, Siegal MM et al. (1982) Preoperative chemotherapy for unresectable primary hepatic malignancies in children Cancer 50: 1061–1064.

    CAS  Google Scholar 

  126. Quinn JJ, Altman AJ, Robinson HT et al. (1985) Adriamycin and cisplatin for hepatoblastoma. Cancer 56: 1926–1929.

    PubMed  CAS  Google Scholar 

  127. Langevin AM, Pierro A, Liu P et al. (1990) Adriamycin and cis-platinum administered by continuous infusion preoperatively in hepatoblastoma unresectable at presentation. Med Pediatr Oncol 18: 181–184.

    PubMed  CAS  Google Scholar 

  128. Tsuchida Y, Bastos JC, Honna T et al. (1990) Treatment of disseminated hepatoblastoma involving bilateral lobes. J Pediatr Surg 25: 1253–1255.

    PubMed  CAS  Google Scholar 

  129. Filler RM, Ehrlich PF, Greenberg ML et al. (1991) Preoperative chemotherapy in hepatoblastoma. Surgery 110: 591–597.

    PubMed  CAS  Google Scholar 

  130. Ogita S, Tokiwa K, Taniguchi H, Takahashi T (1987) Intraarterial injection of antitumor drugs dispersed in lipid contrast medium: a choice for initially unresectable hepatoblastoma in infants. J Pediatr Surg 22: 412–414.

    PubMed  CAS  Google Scholar 

  131. Perilongo G, Uni A (1989) Hepatoblastoma. Med Pediatr Oncol 17: 144–148.

    CAS  Google Scholar 

  132. Goldsmith NA, Woodburne RT (1957) The surgical anatomy pertaining to liver resection. Surg Gynecol Obstet 105: 310–318.

    PubMed  CAS  Google Scholar 

  133. Tsuchida Y, Hashimoto H, Iwanaka T et al. (1989) Left hepatic trisegmentectomy for intralobar hepatoblastoma located close to the hepatic hilum. J Pediatr Surg 24: 1167–1168.

    PubMed  CAS  Google Scholar 

  134. Bismuth H (1982) Surgical anatomy and anatomical surgery of the liver. World J Surg 6: 3–9.

    PubMed  CAS  Google Scholar 

  135. Estrin JA, Belani KG, Karnavas AG et al. (1986) A new approach to massive blood transfusions during pediatric liver resection. Surgery 99: 664–670.

    PubMed  CAS  Google Scholar 

  136. Stone HH (1975) Major hepatic resections in children. J Pediatr Surg 10: 127–135.

    PubMed  CAS  Google Scholar 

  137. Putnam CW (1989) Techniques of ultrasonic dissection in resection of the liver. Surg Gynecol Obstet 157: 474–478.

    Google Scholar 

  138. Price JB, Schullinger JN, Sontulli NV (1982) Major hepatic resections for neoplasia in children. Arch Surg 117: 1139–1141.

    PubMed  Google Scholar 

  139. Huguet CH, Nordliner B, Galopin JJ et al. (1978) Normothermic hepatic vascular exclusion for extensive hepatectomy. Surg Gynecol Obstet 147: 689–693.

    PubMed  CAS  Google Scholar 

  140. Nordlinger B, Douvin D, Javardin L et al. (1980) An experimental study of survival after two hours of normothermic hepatic ischemia. Surg Gynecol Obstet 150: 859–864.

    PubMed  CAS  Google Scholar 

  141. Fortner JG, Shiy MH, Kinne DW et al. (1974) Major hepatic resection using vascular isolation and hypothermic perfusion. Ann Surg 180: 644–652.

    PubMed  CAS  Google Scholar 

  142. Schaller RT, Schaller JJ, Furman EB (1984) The advantages of hemodilution anesthesia for major liver resection in children. J Pediatr Surg 19: 705–710.

    PubMed  Google Scholar 

  143. Ein SH, Shandling B, Williams WG et al. (1981) Major hepatic tumour resection using profound hypothermia and circulation arrest. J Pediatr Surg 16: 339–342.

    PubMed  CAS  Google Scholar 

  144. Chang JHT, Janik JS, Burrington JD et al. (1988) Extensive tumor resection under deep hypothermia and circulatory arrest. J Pediatr Surg 23: 254–258.

    PubMed  CAS  Google Scholar 

  145. Brown KB, Auldist AW, Davidson PM (1988) Anaesthetic considerations in liver tumor resection in children. Pediatr Surg Int 4: 11–15.

    Google Scholar 

  146. McDermott WV Jr (1967) Major hepatic resection in diagnostic techniques and metabolic problems. Surgery 54: 56–66.

    Google Scholar 

  147. Balasegaram M (1979) Hepatic resection for malignant tumours. Surg Rounds 2: 14–44.

    Google Scholar 

  148. Bar-Maor JA, Kam I, Sweed Y, Shashony G (1988) Resection of primary liver tumours in children. Harefuah 114: 594–598.

    PubMed  CAS  Google Scholar 

  149. Pitchard J, Da Curha A, Cornbleet MA, Carter CJ (1982) Alpha-fetoprotein monitoring of response to adriamycin in hepatoblastoma. J Pediatr Surg 17: 429–430.

    Google Scholar 

  150. Kasai M, Watanabe I (1986) Liver tumurs. In: Voute PA, Barrett A, Bloom HL et al., eds. Cancer in children. Springer-Verlag, Berlin.

    Google Scholar 

  151. Whitington PF (1990) Advances in pediatric liver transplantation. Adv Pediatr 37: 357–379.

    PubMed  CAS  Google Scholar 

  152. Iwatsuki S, Starzl TE, Sheahan DG et al. (1991) Hepatic resection versus transplantation for hepatocellular carcinoma. Ann Surg 214: 221–229.

    PubMed  CAS  Google Scholar 

  153. Iwatsuki S, Gordon RD, Shaw BW et al. (1985) Role of liver transplantation in cancer therapy. Ann Surg 202: 401–407.

    PubMed  CAS  Google Scholar 

  154. Colonna JO II, Ray RA, Goldstein Li et al. (1986) Orthotopic liver transplantation for hepatobiliary malignancy. Transplantation 42: 561–562.

    PubMed  Google Scholar 

  155. Evans AE, Land VS, Newton WA et al. (1982) Combination chemotherapy (vincristine, adriamycin, cyclophosphamide, and 5-fluorouracil) in the treatment of children with malignant hepatoma. Cancer 50: 821–826.

    PubMed  CAS  Google Scholar 

  156. Haas J, Maczynski A, Krailo M et al. (1984) Histopathology and prognosis in childhood hepatoblastoma and hepatocarcinoma. Cancer 64: 1082–1095.

    Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Springer-Verlag London Limited

About this chapter

Cite this chapter

Sweed, Y., Bar-Maor, J.A. (1996). Liver Tumours. In: Puri, P. (eds) Neonatal Tumours. Springer, London. https://doi.org/10.1007/978-1-4471-3028-4_6

Download citation

  • DOI: https://doi.org/10.1007/978-1-4471-3028-4_6

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-3030-7

  • Online ISBN: 978-1-4471-3028-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics