Skip to main content
SpringerLink
Log in

Haemangiomas and Vascular Malformations

  • Chapter
Neonatal Tumours

  • 57 Accesses

Abstract

Haemangiomas are the most common benign tumour of infancy, occurring in approximately 10% of all infants during the first year of life1–6. Only 2% of haemangiomas are present at birth in full-term infants, but most appear during the first few weeks of life2. Haemangiomas are more common in premature infants weighing less than 1000 g, with a reported1 incidence as high as 30%. Some 20%–75% of newborns have some vascular mark present at birth7,8. Girls are affected two to three times more commonly than boys1,4–6. Functional complications occur in 20% of all haemangiomas, and life-threatening complications develop in 3%–5% of children with haemangioma3,9.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Low DW (1994) Haemangiomas and vascular malformations. Semin Pediatr Surg 3: 40–61.

    PubMed  CAS  Google Scholar 

  2. Enjolras O, Riche MC, Merland JJ et al. (1990) Management of alarming hemangiomas in infancy: a review of 25 cases. Pediatrics 85: 491–498.

    PubMed  CAS  Google Scholar 

  3. Weber TR, Connors RH, Tracy TF et al. (1990) Complex hemangiomas in infants and children. Individualized management in 22 cases. Arch Surg 125: 1017–1021.

    PubMed  CAS  Google Scholar 

  4. Fonkalsrud EW (1980) Malformations of the lymphatic system and hemangiomas. In: Holder TM, Ashworth KW, eds. Pediatric surgery. WB Saunders, Philadelphia, pp 1054–1060.

    Google Scholar 

  5. Handley GH (1987) Hemangiomas of the head and neck. Ear Nose Throat 66: 486–490.

    CAS  Google Scholar 

  6. Brown DA, Smith JD (1987) Late complications of congenital hemangioma of the tongue. Head Neck Surg 9: 299–304.

    Article  PubMed  CAS  Google Scholar 

  7. Rosen S, Smaller BR (1987) Port-wine stains: a new hypothesis. J Am Acad Dermatol 17: 164–166.

    Article  PubMed  CAS  Google Scholar 

  8. Benninson J, Hurley JP (1988) Hemolymphangioma in a neonate - a therapeutic problem - case history. Angiology 39: 1043–1047.

    Article  Google Scholar 

  9. Garfinkle TJ, Handlen SD (1980) Hemangiomas of the head and neck in children - a guide to management. J Otolaryngol 9: 439–450.

    PubMed  CAS  Google Scholar 

  10. Sweetser TH (1921) Hemangioma of the larynx. Laryngoscopy 31: 797–806.

    Google Scholar 

  11. Bartlett JA, Riding KH, Salkfeld LJ et al. (1988) Management of hemangiomas of the head and neck in children. J Otolaryngol 17: 111–120.

    PubMed  CAS  Google Scholar 

  12. Raffensperger JG (1990) Hemangiomas and vascular malformations. In: Raffensperger JG, ed. Swenson’s pediatric surgery. Appleton and Lange, pp 157–166.

    Google Scholar 

  13. Lofland GK, Filston HC (1987) Giant hemangioma anaerated with axillary anteriovenous fistula causing congestive heart failure in the newborn infant. J Pediatr Surg 22: 458–460.

    Article  PubMed  CAS  Google Scholar 

  14. Williams HB (1980) Vascular neoplasms. Clin Pediatr Surg 7: 397–411.

    CAS  Google Scholar 

  15. Apfelberg DB, Smith T, White J (1989) Preliminary study of the vascular dynamics of port wine stain hemangioma with therapeutic implications for argon laser treatment. Plast Reconstr Surg 83: 820–823.

    Article  PubMed  CAS  Google Scholar 

  16. Mulliken JB (1991) A plea for biological approach to hemangioma. Arch Dermatol 127: 243–244.

    Article  PubMed  CAS  Google Scholar 

  17. Mulliken JB, Glowacki J (1982) Hemangiomas and vascular malformations in infants and children: a classification based on endothelial characteristics. Plast Reconstr Surg 69: 412–420.

    Article  PubMed  CAS  Google Scholar 

  18. Robinson D, Segal M, Halperin N et al. (1992) Neuropeptidergic innervation of intramuscular haemangiomas. Exp Mol Pathol 56: 186–196.

    Article  PubMed  CAS  Google Scholar 

  19. Burrows PE, Lasjaunias PL, Ter Brugge KG et al. (1987) Urgent and emergent embolization of lesions of head and neck in children: indications and results. Pediatrics 80: 386–394.

    PubMed  CAS  Google Scholar 

  20. Sasaki GH, Pang CY, Wottliff JL (1984) Pathogenesis and treatment of infant skin strawberry hemangiomas: clinical and in vitro studies of hormonal effects. Plast Reconstr Surg 73: 359–367.

    Article  PubMed  CAS  Google Scholar 

  21. Edgerton MJ (1976) Treatment of hemangiomas: with special reference to the role of steroid therapy. Ann Surg 183: 517–532.

    Article  PubMed  CAS  Google Scholar 

  22. Cogen MS, Elsas FJ (1989) Eyelid depigmentation following corticosteroid injection for infantile ocular adnexal hemangioma. J Pediatr Ophthalmol Strabismus 26: 35–38.

    PubMed  CAS  Google Scholar 

  23. George CD, Ng YY, Hull-Crags MA et al. (1991) Parotid hemangioma in infants: MR imaging at 1.5T. Pediatr Radiol 21: 483–485.

    Article  PubMed  CAS  Google Scholar 

  24. Totsuka Y, Fukuda H, Tomitu K (1988) Compression therapy for parotid hemangioma in infants. A report of 3 cases. J Craniomaxillofac Surg 16: 366–370.

    Article  PubMed  CAS  Google Scholar 

  25. Sutula FC, Glover AT (1987) Eyelid necrosis following intralesional corticosteroid injection for capillary hemangioma. Ophthalmic Surg 18: 103–105.

    PubMed  CAS  Google Scholar 

  26. Boyd MZ, Callin JR (1991) Capillary hemangiomas: an approach to their management. Br J Ophthalmol 53: 298–300.

    Article  Google Scholar 

  27. Mensell A J, Willshaw HF (1991) Normalisation of refractive error after steroid injection for adnexal hemangiomas. Br J Ophthalmol 75: 301–305.

    Article  Google Scholar 

  28. Hollinger PH, Brown WT (1967) Congenital webs, cysts, laryngoceles and other anomalies of the larynx. Ann Otol Rhinol Laryngol 26: 744–752.

    Google Scholar 

  29. Litter ER (1963) Asphyxia due to hemangioma of the trachea. Thorac Cardiovasc Surg 45: 552–553.

    Google Scholar 

  30. Meeuwi SJ, Bos CE, Hoeve LJ et al. (1990) Subglottic hemangiomas in infants: treatment with intralesional corticosteroid injection and intubation. Int J Pediatr Otorolaryngol 19: 145–150.

    Article  Google Scholar 

  31. Rojiani AM, Elwott K, Dorovini-Zig K (1991) Extensive replacement of spinal cord and brainstem by hemangioblastoma in a case of Von Hippel - Lindau disease. Clin Neuropathol 10: 297–302.

    PubMed  CAS  Google Scholar 

  32. Rush C, Langleben D, Schlesinger RD et al. (1991) Lung scintigraphy in pulmonary capillary hemangiomatosis. A rare disorder causing pulmonary hypertension. Clin Nucl Med 16: 913–917.

    Google Scholar 

  33. Bowyer JJ, Sheppard M (1990) Capillary hemangioma presenting as lung pseudocyst. Arch Dis Child 65: 1162–1164.

    Article  PubMed  CAS  Google Scholar 

  34. Paul KP, Bonner C, Muller KM et al. (1991) Capillary hemangioma of the right main bronchus treated by sleeve resection in infancy. Am Rev Resp Dis 143: 867–869.

    Google Scholar 

  35. Hobbs KE (1990) Hepatic hemangiomas. World J Surg 14: 468–471.

    Article  PubMed  CAS  Google Scholar 

  36. Miller JH (1987) Technetium-99M-labelled red blood cells in the evaluation of hemangiomas of the liver in infants and children. J Nucl Med 28: 1412–1418.

    PubMed  CAS  Google Scholar 

  37. Hofhuis WJ, Orange A, Bouquet J et al. (1990) Blue rubberbleb naevus syndrome: report of a case with consumption coagulopathy complicated by manifest thrombosis. Eur J Pediatr 149: 526–528.

    Article  PubMed  CAS  Google Scholar 

  38. Levgliton DM, Benghanem T, Mantogne JP et al. (1990) A case of rectal bleeding in infancy. Australas Radiol 34: 89–90.

    Article  Google Scholar 

  39. Masterson J, Wood D, Lau G et al. (1991) Isolated colonic hemangioma in a child. Can Assoc Radiol J 42: 431–434.

    PubMed  CAS  Google Scholar 

  40. Pollack MS, Bound LM (1989) Hemangioma of the umbilical cord. J Ultrasound Med 8: 163–166.

    PubMed  CAS  Google Scholar 

  41. Mishriki YY, Vanyshelbaum Y, Epstein W et al. (1983) Hemangioma of the umbilical cord. Pediatrt Pathol 7: 43–49.

    Article  Google Scholar 

  42. Dombrowski MP, Budev H, Walfe HM et al. (1987) Fetal hemorrhage from umbilical cord hemangioma. Obstet Gynecol 70: 439–552.

    PubMed  CAS  Google Scholar 

  43. Fumera-Martin AM, Graubad Z, Holloway GA et al. (1990) Placental hemangioma associated with acute fetal anemia in labour. Acta Med Port 3: 187–189.

    Google Scholar 

  44. Achauer BM, Vander Kam VM (1991) Ulcerated anogenital hemangioma of infancy. Plast Reconstr Surg 87: 861–866.

    Article  PubMed  CAS  Google Scholar 

  45. Cunrie BG, Schell D, Bowring AC (1991) Giant hemangioma of the arm associated with cardiac failure and the Kasabach-Merritt syndrome in a neonate. J Pediatr Surg 26: 734–737.

    Article  Google Scholar 

  46. Malcom GP, Nicolaides K, Howard ER (1990) Giant cutaneous hemangioma with heart failure in a neonate: successful surgical treatment. Pediatr Surg Int 5: 71–73.

    Google Scholar 

  47. Kasabach H, Merritt K (1940) Capillary hemangioma with extensive purpura: report of a case. Am J Dis Child 59: 1063.

    Google Scholar 

  48. Martins A (1970) Hemangioma and thrombocytopenia. J Pediatr Surg 5: 641.

    Article  PubMed  CAS  Google Scholar 

  49. Stenninger E, Schollin J (1993) Diffuse neonatal hemangiomatosis in a newborn child. Acta Paediatr 82, 102–104.

    Article  PubMed  CAS  Google Scholar 

  50. Gozal D, Saad N, Bader D et al. (1990) Diffuse neonatal hemangiomata: successful management with high dose corticosteroids. Eur J Pediatr 149: 321–324.

    Article  PubMed  CAS  Google Scholar 

  51. Byard RW, Burrows PE, Izakawa T et al. (1991) Diffuse infantile hemangiomatosis: clinicopathological features and management problems in five fatal cases. Eur J Pediatr 150: 224–227.

    Article  PubMed  CAS  Google Scholar 

  52. Montgomery SP, Guillot AD, Burth RA (1990) MRI of disseminated neonatal hemangiomata: a case report. Pediatr Radiol 20: 204–205.

    Article  PubMed  CAS  Google Scholar 

  53. McShane MA, Finn JD, Hall-Craggs MA (1990) Neonatal hemangiomata presenting as infantile spasms. Neuropediatrics 21: 211–212.

    Article  PubMed  CAS  Google Scholar 

  54. Spiller JC, Sharma V, Woods GM et al. (1992) Diffuse neonatal haemangiomatosis treated successfully with interferon a2a- J Am Acad Dermatol 27: 102–104.

    CAS  Google Scholar 

  55. Christofenson LA, Gustofson NB, Peterson AG (1961) Von-Hippel-Lindau’s disease. JAMA 178: 280.

    Google Scholar 

  56. Nakasu S, Yoshida M, Nakajima M et al. (1991) Cystic carvernous angioma in an infant. J Comput Assist Tomogr 15: 163–165.

    Article  PubMed  CAS  Google Scholar 

  57. Fiore F, Califano L, Cortese A, Zupi A (1993) Haemangioma of the maxillofacial area. Usefulness of 99mTc-labelled red cell scintigraphy. Nucl Med Commun 14: 378–383.

    Article  PubMed  CAS  Google Scholar 

  58. Shulkin BL, Arqenta LC, Cho KJ (1990) Kasabach-Merritt syndrome: treatment with ε-amino caproic acid and assessment by indium III platelet scintigraphy. J Pediatr 117: 746–749.

    Article  PubMed  CAS  Google Scholar 

  59. Lister WA (1938) Natural history of strawberry naevi. Lancet i: 1429–1434.

    Google Scholar 

  60. Gunn T, Reece ER, Metrukos K et al. (1981) Depressed T cells following neonatal steroid treatment. Pediatrics 67: 61–67.

    PubMed  CAS  Google Scholar 

  61. White CW, Walfe SJ, Koras DN (1991) Treatment of childhood angiomatous disease with recombinant interferon α-24. J Pediatr 118: 59–66.

    Article  PubMed  CAS  Google Scholar 

  62. Ezekowitz RA, Mulliken JB, Folkman J (1992) Interferon a2a therapy for life-threatening hemangiomas of infancy. N Engl J Med 326: 1456–1463.

    Article  PubMed  CAS  Google Scholar 

  63. Ingben D, Fujitu T, Kishimoto S et al. (1990) Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth. Nature 348: 555–557.

    Article  Google Scholar 

  64. Townsend LM, Buckley EG (1990) Linear subcutaneous fat atrophy after a single corticosteroid injection for ocular adnexal hemangioma. Am J Ophthalmol 109: 102–103.

    Google Scholar 

  65. Sato Y, Freg EE, Kisker CT et al. (1987) Embolization therapy in the management of infantile hemangioma with Kasabach-Merritt syndrome. Pediatr Radiol 17: 503–504.

    Article  PubMed  CAS  Google Scholar 

  66. Milligan NS, Edwards JC, Monro JL et al. (1988) Excision of giant hemangioma in the newborn using hypothermia and cardiopulmonary bypass. Anesthesia 40: 875–878.

    Article  Google Scholar 

  67. Franks R, Rothera M (1990) Cardiopulmonary bypass for resection in low tracheal hemangioma. Arch Dis Child 65: 680–682.

    Article  Google Scholar 

  68. Ranse RD, Ashcraft KW, Haeden TM et al. (1988) Hepatic hemangioma: resection using hypothermic circulatory arrest in the newborn. J Pediatr Surg 23: 924–926.

    Article  Google Scholar 

  69. Lannigan SW, Cotterie JA (1990) The treatment of port wine stain with carbondioxide laser. Br J Dermatol 123: 229–235.

    Article  Google Scholar 

  70. Carruth JAS, Shakespeare P (1986) Towards ideal treatment for the port wine stain with the argon laser: better prediction and an “optimal” technique. Lasers Surg Med 6: 2–4.

    Article  PubMed  CAS  Google Scholar 

  71. Apfelberg DB, Maser MR, White DN et al. (1990) Benefits of contact and non contact YAG laser for periorbital hemangiomas. Ann Plasti Surg 24: 397–408.

    Article  CAS  Google Scholar 

  72. Achaeur BM, Victoria M, Vander Kam RN (1989) Capillary hemangioma (strawberry mark) of infancy: comparison of argon and ND:YAG laser treatment. Plast Reconstr Surg 84: 60–70.

    Article  Google Scholar 

  73. Garden JM, Polla LL, Tan OT (1988) The treatment of port wine stains by the pulsed dye laser. Arch Dermatol 124: 889–896.

    Article  PubMed  CAS  Google Scholar 

  74. Reyes BA, Geronemus R (1990) Treatment of port wine stain during childhood with the flash lamp - pumped pulsed dye laser. J Am Acad Dermatol 23: 1142–1148.

    Article  PubMed  CAS  Google Scholar 

  75. Achauer BM, Vander Kam VM, Miller SR (1990) Clinical experience with the pulsed-dye laser in the treatment of capillary malformations (port wine stain): a preliminary report. Ann Plast Surg 25: 344–352.

    Article  PubMed  CAS  Google Scholar 

  76. Holy A, Geronemus RG (1992) Treatment of periorbital port wine stains with the flashlamp-pumped dye laser. Arch Ophthalmol 110: 793–797.

    PubMed  CAS  Google Scholar 

  77. Garden JM, Bakus AD, Paller AS (1992) Treatment of cutaneous hemangiomas with flashlamp-pumped dye laser. Prospective analysis. J Pediatr 120: 555–560.

    Google Scholar 

  78. Strauss RP, Resnicke SD (1993) Pulse dye laser therapy for port wine stains in children: psychosocial and ethical issues. J Pediatr 122: 505–510.

    Article  PubMed  CAS  Google Scholar 

  79. Goldman MP, Fitzpatrick RE, Ruiz-Esparza J (1993) Treatment of port wine stains (capillary malformation) with the flashlamp-pumped pulsed dye laser. 122: 71–77.

    CAS  Google Scholar 

  80. Stingel S (1987) Giant hemangioma: treatment with intermittent pneumatic compression. J Pediatr Surg 1: 7–10.

    Article  Google Scholar 

  81. Totsuka Y, Fukuda H, Tomita K (1988) Compression therapy for parotid haemangioma in infants: a report of three cases. J Craniomaxillofac Surg 16: 366–370.

    Article  PubMed  CAS  Google Scholar 

  82. Furst CJ, Lundell M, Holm LE (1990) Tumours after radio-therapy for skin hemangioma in childhood. A case control study. Acta Oncol 29: 557–562.

    Google Scholar 

Download references

Authors
  1. Prem Puri
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. George Ninan
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Our Lady’s Hospital for Sick Children, National Children’s Hospital The Children’s Hospital, Dublin, Ireland

    Prem Puri MS, FACS (Consultant Paediatric Surgeon, Director of Research) (Consultant Paediatric Surgeon, Director of Research)

  2. Children’s Research Centre, Our Lady’s Hospital for Sick Children, Dublin, Ireland

    Prem Puri MS, FACS (Consultant Paediatric Surgeon, Director of Research) (Consultant Paediatric Surgeon, Director of Research)

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Springer-Verlag London Limited

About this chapter

Cite this chapter

Puri, P., Ninan, G. (1996). Haemangiomas and Vascular Malformations. In: Puri, P. (eds) Neonatal Tumours. Springer, London. https://doi.org/10.1007/978-1-4471-3028-4_13

Download citation

  • DOI: https://doi.org/10.1007/978-1-4471-3028-4_13

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-3030-7

  • Online ISBN: 978-1-4471-3028-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation