Abstract
Most cystic neoplasms of the pancreas arise from the exocrine components of the gland. Such lesions are much less common than solid exocrine carcinomas. Cystic change in endocrine tumours of the pancreas is unusual (see p. 208), and cystic vascular tumours of the pancreas are even more unusual. The lesions to be considered in this chapter are:
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The serous cystadenomas, also known as microcystic, glycogen-rich cystadenomas. Such tumours are nearly always benign.
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A type of mucin-secreting cystic tumour with much larger loculi that may behave, even for years, as a benign cystadenoma, but which has, nevertheless, a malignant potential.
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A mucin-secreting cystadenocarcinoma that seems, in most cases, to be the result of malignant change in part, or parts, of the wall of a pre-existing mucinous cystic tumour.
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References
Albores-Saavedra J, Angeles-Angeles A, Nadji M, Henson DE, Alvarez L (1987) Mucinous cystadenocarcinoma of the pancreas: morphological and immunocytochemical observations. Am J Surg Pathol 11:11–20
Albores-Saavedra J, Nadji M, Henson DE, Angeles-Angeles A (1988) Entero-endocrine cell differentiation in carcinoma of the gall bladder and mucinous cystadenocarcinomas of the pancreas. Pathol Res Pract 183:169–175
Alpert LC, Truong LD, Bossart MI, Spjut HJ (1988) Microcystic adenoma (serous cystadenoma) of the pancreas: a study of 14 cases. Immunohistochemical and electronmicroscopic correlation. Am J Surg Pathol 12:251–263
Anderson GS, Peebles Brown DA (1959–1960) A case of hydatid cyst of the pancreas. Br J Surg 47:147–149
Becker WF, Welsh RA, Pratt HS (1965) Cystadenoma and cystadenocarcinoma of the pancreas. Ann Surg 161:845–863
Bogomoletz WV (1992) Cystic tumours of the exocrine pancreas. In: Anthony PP, MacSween RNM (eds) Recent advances in histopathology. Churchill Livingstone, Edinburgh, pp 141–155
Bogomoletz WV, Adnet JJ, Widegren S, Stavrou M, McLaughlin JE (1980) Cystadenoma of pancreas: a histological histochemical and ultrastructural study of seven cases. Histopathology 4:309–320
Bombi JA, Milla A, Badal JM, Piulachs J, Estape J, Cardesa A (1984) Papillary-cystic neoplasm of the pancreas. Cancer 54:780–784
Campbell JA, Cruickshank AH (1962) Cystadenoma and cystadenocarcinoma of the pancreas. J Clin Pathol 15:432–437
Cantrell BB, Cubilla AL, Erlandson RA, Fortner J, Fitzgerald PJ (1981) Acinar cell cystadenocarcinoma of human pancreas. Cancer 47:410–416
Cappellari JO, Geisinger KR, Albertson DA, Wolfman NT, Kute TE (1990) Malignant papillary cystic tumour of the pancreas. Cancer 66:193–198
Chen J, Baithun SI (1985) Morphological study of 391 cases of exocrine pancreatic tumours with special reference to the classification of exocrine pancreatic carcinoma. J Pathol 146:17–29
Cocco AE, Conway S (1975) Zollinger-Ellison syndrome associated with ovarian mucinous cystadenocarcinoma. N Engl J Med 293:485–486
Compagno J, Oertel JE (1978a) Microcystic adenomas of the pancreas (glycogen-rich cystadenomas): a clinicopathologic study of 34 cases. Am J Clin Pathol 69 : 289–298
Compagno J, Oertel JE (1978b) Mucinous cystic neoplasms of the pancreas with overt and latent malignancy (cystadenocarcinoma and cystadenoma): a clinicopathological study of 41 cases. Am J Clin Pathol 69:573–580
Compagno J, Oertel JE, Kremzar M (1979) Solid and papillary epithelial neoplasm of the pancreas, probably of small duct origin: a clinico-pathologic study of 52 cases. (International Academy of Pathology (United States — Canadian Division) 68th annual meeting, San Francisco, 5–9 March, 1979) Lab Invest 40:248–249
Cornes JS, Azzopardi JG (1959–1960) Papillary cystadenocarcinoma of the pancreas with report of two cases. Br J Surg 47:139–144
Corrente RF (1980) Cystadenocarcinoma of the pancreas. Am J Surg 139:265–267
Corrin B (1962) Cystadenoma of the liver. J Pathol Bacteriol 84:441–443
Cruickshank AH, Sparshott SM (1971) Malignancy in natural and experimental hepatic cysts: experiments with aflatoxin in rats and the malignant transformation of cysts in human livers. J Pathol 104:185–190
Cubilla AL, Fitzgerald PJ (1980) Cancer (non-endocrine) of the pancreas: a suggested classification. In: Fitzgerald PJ, Morrison AB (eds) The pancreas. Williams and Wilkins, Baltimore, pp 82–110
Cullen PK, ReMine WH, Dahlin DC (1963) A clinicopathological study of cystadenocarcinoma of the pancreas. Surg Gynecol Obstet 117:189–195
Davison C, Brock S, Dyke C (1936) Retinal and central nervous hemangiomatosis with visceral changes (von Hippel-Lindau’s disease). Bull Neurol Inst New York 5:72–93
Dennis WA (1923) Dermoid cyst of the pancreas. Surg Clin North Am 3:1319–1322
Doberstein C, Kirchner R, Gordon L, Silberman AW, Morgenstern L, Shapiro S (1990) Cystic neoplasms of the pancreas. Mt Sinai J Med 57:102–105
Dodds WJ, Margolin FR, Goldberg HI (1969) Cavernous lymphangioma of the pancreas. Radiol Clin Biol 38:267–270
Dreiling DA (1959) Cystadenocarcinoma of the pancreas in a patient with long-standing chronic relapsing pancreatitis and pancreatic calcinosis. J Mt Sinai Hosp 26:589–593
Dubois JD (1981) Lymphangioma of the pancreas masquerading as acute appendicitis and torsion of the left testis. Br J Surg 68:799–800
Edmondson HA (1958) Tumors of the liver and intrahepatic bile ducts. (Atlas of tumor pathology, Section 7, Fascicle 25) Armed Forces Insititute of Pathology, Washington, DC, pp 24–28
Epstein HS, Berman R (1975) Mesenteric and pancreatic lymphangioma presenting as a right adnexal mass. Am J Obstet Gynecol 121:1117–1118
Ferrer JP, Hensley G, Kalser MH, Zappa R (1978) Cystadenocarcinoma and carcinoembryonic antigen. Cancer 42:632–634
Fishman RS, Bartholomew LG (1979) Severe pancreatic involvement in three generations in von Hippel-Lindau disease. Mayo Clin Proc 54:329–331
Frantz VK (1959) Tumors of the pancreas. Armed Forces Institute of Pathology, Washington, DC, p 32 (Atlas of tumor pathology, section 7, fascicles 27, 28)
George DH, Murphy F, Michalski R, Ulmer BG (1989) Serous cystadenocarcinoma of the pancreas: a new entity? Am J Surg Pathol 13:61–66
Grosfield JL, Clatworthy HW, Hamoudi AB (1970) Pancreatic malignancy in childhood. Arch Surg 101:370–375
Grunberg A, Blair JL, St Hill CA (1952) Congestive splenomegaly due to pancreatic cystadenoma. Br Med J ii: 265–266
Ham WA (1974) Histology, 7th edn. Lippincott, Philadelphia, pp 682–683
Hamoudi AB, Misugi K, Grosfeld JL, Reiner CB (1970) Papillary epithelial neoplasm of pancreas in a child: report of a case with electron microscopy. Cancer 26:1126–1134
Hanelin LG, Schimmel DH (1977) Lymphangioma of the pancreas exhibiting an unusual pattern of calcification. Radiology 122:636
Haukohl RS, Melamed A (1950) Cystadenoma of the pancreas: a report of two cases showing calcification. AJR 63:234–245
Hernandez-Maldonado JJ, Rodriguez-Bigas MA, Gonzalez DePesante A, Vazquez-Quintana E (1989) Papillary cystic neoplasm of the pancreas: a report of a case presenting with carcinomatosis. Am Surg 55:552–559
Hodgkinson DJ, ReMine WH, Weiland LH (1978a) Pancreatic cystadenoma: a clinicopathological study of 45 cases. Arch Surg 113:512–519
Hodgkinson DJ, ReMine WH, Weiland LH (1978b) A clinicopathologic study of 21 cases of pancreatic cystadenocarcinoma. Ann Surg 188:679–684
Hoover E, Natesha R, Dao A, Adams CZ, Barnwell S (1991) Proliferative pancreatic cysts: pathogenesis and treatment options. Am J Surg 162:274–277
Hueper WC (1928) Cystadenoma of the pancreas. Arch Pathol 5:261–266
Itai Y, Ohhashi K, Nagai H et al. (1986) “Ductectatic” mucinous cystadenoma and cystadenocarcinoma of the pancreas. Radiology 161:697–700
Johnson CD, Stephens DH, Carboneau JW, Carpenter HA, Welch TJ (1988) Cystic pancreatic tumors — CT and sonographic assessment. AJR 151:1133–1138
Judd ES, Mattson H, Mahorner HR (1931) Pancreatic cysts: report of forty-seven cases. Arch Surg 22:838–849
Kattan YB (1975) Hydatid cysts in pancreas. Br Med J iv: 729–730
Kerlin DL, Frey CF, Bodai BI, Twomey PL, Ruebner B (1987) Cystic neoplasms of the pancreas. Surg Gynecol Obstet 165:475–478
Kerr AA (1918) Cysts and pseudocyst of the pancreas, with report of cases. Surg Gynecol Obstet 27:40–44
Kim YI, Seo JW, Suh JS, Lee KU, Choe KJ (1990) Microcystic adenomas of the pancreas: report of three cases with two of multicentric origin. Am J Clin Pathol 94:150–156
Klöppel G (1984) Pancreatic, non-endocrine tumours. In: Klöppel G, Heitz PU (eds) Pancreatic pathology. Churchill Livingstone, Edinburgh, pp 101–102
Klöppel G, Maurer R, Hofmann E et al. (1991) Solid-cystic (papillary-cystic) tumours within and outside the pancreas in men: report of two patients. Virchows Archiv [A] 418:179–183
Kuo T-T, Su I-J, Chien C-H (1984) Solid and papillary neoplasm of the pancreas: report of three cases from Taiwan. Cancer 54:1469–1474
Ladanyi M, Mulay S, Arseneau J, Bettez P (1987) Estrogen and progesterone receptor determination in the papillary cystic neoplasm of the pancreas with immunohistochemical and ultrastructural observations. Cancer 60:1604–1611
Lamiell JM, Salagar FG, Hsia YE (1989) Von Hippel-Lindau disease: affecting 43 members of a single kindred. Medicine 68:1–29
Learmonth GM, Price SK, Visser AE, Emms M (1985) Papillary and cystic neoplasm of the pancreas: an acinic cell tumour? Histopathology 9:63–79
Letoquart JP, Marcorolles P, Lancien G et al. (1989) Un nouveau cas de lymphangiome kistique du pancréas. J Chir (Paris) 126:650–658
Lo JW, Fung CHK, Yonan TN, Martinez N (1977) Cystadenoma of the pancreas: an ultrastructural study. Cancer 39:2470–2474
Maher ER, Yates JRW, Harries R et al. (1990) Clinical features and natural history of von Hippel-Lindau disease. Q J Med New Ser 77 (283) : 1151–1163
Mallory TB (1941) Case records of the Massachusetts General Hospital: Case 27262. N Engl J Med 224:1112–1114
Margolis RM, Jang N (1984) Zollinger-Ellison syndrome associated with pancreatic cystadenocarcinoma. N Engl J Med 311:1380–1381
Matsunou H, Konishi F (1990) Papillary-cystic neoplasm of the pancreas: a clinicopathologic study concerning the tumor aging and malignancy of nine cases. Cancer 65:283–291
Miettinen M, Partanen S, Fräki O, Kivilaskso E (1987) Papillary cystic tumor of the pancreas: an analysis of cellular differentiation by electron microscopy and immunohistochemistry. Am J Surg Pathol 11:855–865
Morohoshi T, Kanda M, Asanuma K, Klöppel G (1989) Intraductal papillary neoplasms of the pancreas: a clinicopathologic study of six patients. Cancer 64:1329–1335
Mozan AA (1951) Cystadenoma of the pancreas. Am J Surg 81:204–214
Neumann HPH, Dinkel E, Brambs H et al. (1991) Pancreatic lesions in the von Hippel-Lindau syndrome. Gastroenterology 101:465–471
Nyongo A, Huntrakoon M (1985) Microcystic adenoma of the pancreas with myoepithelial cells: a hitherto undescribed morphological feature. Am J Clin Pathol 84:114–120
Orlando CA, Bowman RL, Loose JH (1991) Multicentric papillary- cystic neoplasm of the pancreas. Arch Pathol Lab Med 115:958–960
Pack GT, Trinidad SS, Lisa JR (1958) Rare primary somatic tumors of the pancreas. Arch Surg 77:1000–1003
Padfield CJH, Ansell ID, Furness PN (1988) Mucinous biliary papillomatosis: a tumour in need of wider recognition. Histopathology 13:687–694
Persaud V, Walrond RE (1971) Carcinoid tumor and cystadenoma of the pancreas. Arch Pathol 92:28–30
Porter HW (1946) Case of lymphangioma in the region of the head of the pancreas causing an obstructive jaundice. Br J Surg 34:217–218
Pyke CM, van Heerden JA, Colby TV, Sarr MG, Weaver AL (1992) The spectrum of serous cystadenoma of the pancreas: clinical, pathologic, and surgical aspects. Ann Surg 215:132–139
Rego JAG, Ruvira LV, Garcia AA, Freijanes MPS, Penaranda JMS, Soto JMR (1991) Pancreatic mucinous cystadenocarcinoma with pseudosarcomatous mural nodules: a report of a case with immunohistochemical study. Cancer 67:494–498
ReMine SG, Frey D, Rossi RL, Munson JL, Braasch JW (1987) Cystic neoplasms of the pancreas. Arch Surg 122:443–446
Rickaert F, Cremer M, Devière J et al. (1991) Intraductal mucinhypersecreting neoplasms of the pancreas: a clinicopathologic study of eight patients. Gastroenterology 101:512–519
Rode J, Dhillon AP, Hamid Q, Polak JM, Moss E (1988) Solid and cystic tumour of the pancreas [abstract]. J Pathol 155:351A
Rood RP, DeLellis RA, Dayal Y, Donowitz M (1988) Pancreatic cholera syndrome due to a vasoactive intestinal polypeptide- producing tumor: further insights into the pathophysiology. Gastronterology 94:813–818
Sanfey H, Mendelsohn G, Cameron JL (1983) Solid and papillary neoplasm of the pancreas: a potentially curable surgical lesion. Ann Surg 197:272–275
Satake K, Uchima K, Yamashita K, Yashimoto T, Umeyama K (1979) Pancreatic cystadenoma of the spleen. Am J Surg 137:670–672
Schlosnagle D, Campbell WG (1981) The papillary and solid neoplasm of the pancreas. Cancer 47:2603–2610
Shorten SD, Hart WR, Petras RE (1986) Microcystic adenomas (serous cystadenomas) of pancreas: a clinicopathologic investigation of eight cases with immunohistochemical and ultra- structural studies. Am J Surg Pathol 10:365–372
Singh S, Baboo M, Pathak I (1971) Cystic lymphangioma in children: report of 32 cases including lesions at rare sites. Surgery 69:947–951
Soloway HB (1965) Constitutional abnormalities associated with pancreatic cystadenomas. Cancer 18:1297–1300
Speese JJ (1915) Cystadenoma of the pancreas with extension to the abdominal wall ten years after drainage of a pancreatic cyst. Ann Surg 61:759–761
Stamm B, Burger H, Hollinger A (1987) Acinar cell cystadenocarcinoma of the pancreas. Cancer 60:2542–2547
Stömmer P, Kraus J, Stolte M, Giedl J (1991) Solid and cystic pancreatic tumors: clinical, histochemical, and electron microscopic features in ten cases. Cancer 67:1635–1641
Todani T, Shimada K, Watanabe Y, Toki A, Fujii T, Kagawa NU (1988) Frantz’s tumor: a papillary and cystic tumor of the pancreas in girls. J Pediatr Surg 23:116–121
Veloso FT, Ribeiro AT, Teixeira AA, Ramalhão J, Saleiro J, Serrãs D (1983) Biliary papillomatosis: report of a case with five year follow-up. Am J Gastroenterol 78:645–648
Virchow R (1887) Ueber Ranula pancreatica and Uber Pleuritis retrahens. Berl Klin Wochenschr 24:248–250
Warren KW, Hardy KJ (1968) Cystadenocarcinoma of the pancreas. Surg Gynecol Obstet 127:734–736
Warshaw AL, Compton CC, Lewandrowski K, Cardenosa G, Mueller PR (1990) Cystic tumors of the pancreas: new clinical, radiologic, and pathologic observations in 67 patients. Ann Surg 212:432–445
White WH (1897) Diseases of the pancreas. Guy’s Hosp Reports 54 (39 3rd series): 17–63
Yagihashi S, Sato I, Kaimori M, Matsumoto J, Nagai K (1988) Papillary and cystic tumor of the pancreas: two cases indistinguishable from islet cell tumor. Cancer 61:1241–1247
Yamaguchi K, Enjoji M (1987) Cystic neoplasms of the pancreas. Gastroenterology 92:1934–1943
Young EL (1937) Pancreatic cyst: report of a case. N Engl J Med 216:334–339
Yu HC, Shetty Y (1985) Mucinous cystic neoplasm of the pancreas with high carcinoembryonic antigen. Arch Pathol Lab Med 109:375–377
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Cruickshank, A.H., Benbow, E.W. (1995). Cystic Pancreatic Neoplasms. In: Pathology of the Pancreas. Springer, London. https://doi.org/10.1007/978-1-4471-3005-5_8
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