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Cardiac Arrest: Who Should Be Cooled?

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Book cover Therapeutic Hypothermia After Cardiac Arrest

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Abstract

Approximately 300,000 out-of-hospital and 20,000 in-hospital cardiac arrests occur annually in the United States [1], and an estimated 92–189 out-of-hospital cardiac arrests per 100,000 population occur annually in industrialized nations [2, 3]. The use of therapeutic hypothermia (TH) in cardiac arrest survivors has been advocated in order to mitigate the neurologic injury that transpires as a result of hypoxia and reperfusion [4]. The precise mechanisms how mild hypothermia is beneficial in these patients is unclear at present but the supposition is that mild hypothermia modifies various chemical and cellular pathways that cause necrosis and apoptosis of neurons [4] (see Chap. 2). Moreover, it has beneficial effects on various other organ systems which bear the brunt of the post-cardiac arrest state [5]. With the rising popularity of mild therapeutic hypothermia (32–34°C) in cardiac arrest patients, there is a continuing need to appropriately select patients who will benefit from its use. This chapter attempts to interpret the available information and provide direction on selecting appropriate adult cardiac arrest patients who may benefit from the use of therapeutic hypothermia (TH).

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Authors and Affiliations

  1. Division of Cardiology, Henry Low Heart Center, Hartford Hospital, Hartford, CT, USA

    Sanjeev U. Nair MBBS, M.D., FACP & Justin B. Lundbye M.D., FACC

  2. University of Connecticut School of Medicine, Farmington, CT, USA

    Sanjeev U. Nair MBBS, M.D., FACP & Justin B. Lundbye M.D., FACC

Authors
  1. Sanjeev U. Nair MBBS, M.D., FACP
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  2. Justin B. Lundbye M.D., FACC
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Correspondence to Sanjeev U. Nair MBBS, M.D., FACP .

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Editors and Affiliations

  1. , School of Medicine, University of Connecticut, Hartford, 06102-5037, Connecticut, USA

    Justin B. Lundbye

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© 2012 Springer-Verlag London

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Nair, S.U., Lundbye, J.B. (2012). Cardiac Arrest: Who Should Be Cooled?. In: Lundbye, J. (eds) Therapeutic Hypothermia After Cardiac Arrest. Springer, London. https://doi.org/10.1007/978-1-4471-2951-6_4

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  • DOI: https://doi.org/10.1007/978-1-4471-2951-6_4

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  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-2950-9

  • Online ISBN: 978-1-4471-2951-6

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