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Genetic Counselling and Its Role in PGD

Chapter

Abstract

Best practice recommends that counselling should be offered to all couples requesting PGD and is provided in a nondirective manner by an appropriately qualified professional. However, the process of PGD is by nature complex and requires a high level of clinical and laboratory understanding, including the practicalities of assisted reproduction treatment, some aspects of which may be unfamiliar to even experienced geneticists and general genetic counsellors. This chapter discusses some issues particular and peculiar to counselling patients considering PGD.

Keywords

Genetic Counselling Prenatal Diagnosis Embryo Transfer Umbilical Cord Blood Huntington Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Further Reading

  1. Ad Hoc Committee on Genetic Counseling American Society for Human Genetics. Genetic counselling. Am J Hum Genet. 1975;27:240–2.Google Scholar
  2. Banerjee I, Shevlin M, Taranissi M, Thornhill A, Abdalla H, Ozturk O, et al. Health of children conceived after preimplantation genetic diagnosis: a preliminary outcome study. Reprod Biomed Online. 2008;16:376–81.PubMedCrossRefGoogle Scholar
  3. British Medical Association. Human genetics: choice and responsibility. Oxford: Oxford University Press; 1998.Google Scholar
  4. Desmyttere S, De Schepper J, Nekkebroeck J, De Vos A, De Rycke M, Staessen C, et al. Two-year auxological and medical outcome of singletons born after embryo biopsy applied in preimplantation genetic diagnosis or preimplantation genetic screening. Hum Reprod. 2009;24:470–6.PubMedCrossRefGoogle Scholar
  5. Kessler S. Psychological aspects of genetic counselling. XI. Nondirectiveness revisited. Am J Med Genet. 1997;72(2):164–71.PubMedCrossRefGoogle Scholar
  6. Lashwood A, Kanabar D, El-Toukhy T, Kavalier F. Paediatric outcome from birth onwards after preimplantation genetic diagnosis. J Med Genet. 2007;44 Suppl 1:S28.Google Scholar
  7. Nekkebroeck J, Bonduelle M, Desmyttere S, Van den Broeck W, Ponjaert-Kristoffersen I. Mental and psychomotor development of 2-year-old children born after preimplantation genetic diagnosis/screening. Hum Reprod. 2008;23:1560–6.PubMedCrossRefGoogle Scholar
  8. Nekkebroeck J, Bonduelle M, Desmyttere S, Van den Broeck W, Ponjaert-Kristoffersen I. Socioemotional and language development of 2-year-old children born after PGD/PGS, and parental well-being. Hum Reprod. 2008;23:1849–57.PubMedCrossRefGoogle Scholar
  9. Palomba ML, Monni G, Lai R, Cau G, Olla G, Cao A. Psychological implications and acceptability of preimplantation diagnosis. Hum Reprod. 1994;9:360–2.PubMedGoogle Scholar
  10. Preimplantation Genetic Diagnosis International Society (PGDIS). Guidelines for good practice in PGD: programme requirements and laboratory quality assurance. RBM Online. 2008;16:134–47.Google Scholar
  11. Thornhill AR, deDie-Smulders CE, Geraedts JP, Harper JC, Harton GL, Lavery SA, Moutou C, Robinson MD, Schmutzler AG, Scriven PS, Sermon KD, Wilton L. ESHRE PGD consortium “best practice guidelines for clinical preimplantation genetic diagnosis (PGD) and preimplantation genetic screening (PGS)”. Hum Reprod. 2005;20:35–48.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag London 2014

Authors and Affiliations

  1. 1.Clinical Genetics DepartmentGuy’s and St. Thomas’ Hospital NHS Foundation TrustLondonUK

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