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Beneficial Effects of Intermittent Normobaric Hypoxic Training on Respiratory Function in Patients with Chronic Pulmonary Diseases

  • Mikhail I. LevashovEmail author
Chapter

Abstract

In this chapter, we present the results of our studies regarding the INHT effects on respiratory functions in 103 high-risk chronic obstructive pulmonary disease (COPD) patients, 157 bronchial asthma (BA) patients, and 36 healthy individuals. Patients ranged in age from 21 to 59 years (women – 52.1%, men – 47.9%). INHT was carried out in “Orotron” chamber under such environmental parameters: PO2 – 147–160 hPa, relative humidity – 60–70%, ambient temperature – 16–18°C, and content of light negative ions – up to 6,000/cm3. All patients received daily 90 min of INHT alone or INHT in combination with conventional therapy for 2–4 weeks. Total time of hypoxic gas mixture breathing for the whole INHT course ranged from 21 to 42 h. We performed pulmonary function tests in all patients before, during, and after INHT. Results of our studies indicated that INHT increased reserves of lung ventilation and restored the physiological level of alveolar ventilation in 78% of patients with COPD, optimized regional air distribution in lung, and decreased by 25–30% the lung ventilation unevenness. INHT reduced the bronchial resistivity by 31–37% in BA patients and changed the respiratory regulation in COPD patients and healthy individuals. It contributed to more complete restoration of the optimal structure of respiratory pattern. Further investigations will allow INHT to emerge as an important nonpharmacological therapy for care and rehabilitation of patients with pulmonary diseases.

Keywords

Chronic Obstructive Pulmonary Disease Chronic Obstructive Pulmonary Disease Patient Bronchial Asthma Patient Functional Residual Capacity Inspiratory Flow 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

BA

Bronchial asthma

CIA

Central inspiratory activity

COPD

Chronic obstructive pulmonary diseases

f

Respiratory rate

ERV

Expiratory reserve volume

FEV1

Volume at the end of the first second of forced expiration

FEFmax

Maximum instantaneous flow achieved during FVC maneuver

FEF25%

Average flow from the point were 25% of the FVC has been exhaled

FEF50%

Average flow from the point were 50% of the FVC has been exhaled

FEF75%

Average flow from the point were 75% of the FVC has been exhaled

FRC

Functional residual capacity

FVC

Forced vital capacity

Gaw

Airway conductance

INHT

Intermittent normobaric hypoxic training

IRV

Inspiratory reserve volume

MVV

Maximal voluntary ventilation

MVV/VE

Ratio of respiratory reserve

PO2

Partial pressure of oxygen

PImax

Maximal inspiratory pressure

Raw

Airway resistance

tI

Inspiratory time of one respiratory cycle

tE

Expiratory time of one respiratory cycle

ttot

Total duration of respiratory cycle

tI/ttot

Proportion of inspiration phase in total duration of respiratory cycle or “useful cycle” of breathing

tE/tI

Time respiratory quotient

VA

Alveolar ventilation/min

VC

Vital capacity

VE

Expired volume/min

VT

Tidal volume

VI/tI

Mean rate of inspiratory flow of one breath

VE/tE

Mean rate of expiratory flow of one breath

VI max/tI

Maximum rate of inspiratory flow of one breath

VE max/tE

Maximum rate of expiratory flow of one breath

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Copyright information

© Springer-Verlag London 2012

Authors and Affiliations

  1. 1.National Academy of Sciences of UkraineA.A. Bogomoletz Institute of PhysiologyKievUkraine

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