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Hypobaric Interval Hypoxia as a Nonmedication Method for Improving the Functional State of Aerospace Pilots and Astronauts

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Intermittent Hypoxia and Human Diseases

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Abstract

Maintenance of health of risky profession workers (such as aerospace pilots and astronauts) and rendering them rehabilitative procedures remains to be one of the major medical issues. There is an apparent necessity to seek and adopt effective methods of rehabilitating the workers of risky professions who usually suffer with fatigue, impairment of body tolerance to negative factors, deadaptation, and asthenization (a condition experienced by astronauts with symptoms such as fatigue, irritability, lack of appetite, and sleep disorders) following stressful situations of aerospace flights. These adverse effects could potentially lead to functional and organic diseases in the pilots and astronauts. A method of hypobaric interval hypoxia (HIH) was devised and test validated for the needs of aviation, space, military, preventive, and rehabilitation medicine. The course of HIH treatment consists of ten 1-h daily sessions of exposure to HIH in a hypobaric chamber simulating high altitude of 3,000–5,000 m. In each of the 10-min periods, 7-min hypoxic air breathing alternates with 3-min hyperoxic air mixture breathing with air pressure simulating same altitude. In the first session, the subjects “climb” to 3,000 m; in sessions 2–4, the altitude increases in 500 m steps; and finally the sessions 5–10 are performed at the altitude of 5,000 m. HIH has showed high effectiveness in improving human organism functionality and tolerance to the environmental adverse factors, that is, hypoxia, flight accelerations, and motion sickness, as well as in preventing and correcting the impaired functional states.

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Abbreviations

BP:

Blood pressure

CCCA:

Continuous cumulation of Coriolis accelerations

FR:

Physiological reserve

HIH:

Hypobaric interval hypoxia

ICCA:

Intermittent cumulation of Coriolis accelerations

MS:

Motion sickness

SET:

Statoergometric test

SV:

Systolic volume

TPR:

Total peripheral resistance

VBV:

Volumetric blood flow velocity

VVR:

Vestibulovegetative reactions

References

  1. Ushakov IB, Cherniakov IN, Shishov AA. Physiology of high-altitude flight. Moscow: Istoki; 2007 [In Russian].

    Google Scholar 

  2. Shishov AA, Cherniakov IN, Nizky AM. Hyperbaric oxygenation as a method of normalizing reduced functional state of human operator. Problems of prophylaxis and rehabilitation in aviation and space medicine. 1994;3:19–20 [In Russian].

    Google Scholar 

  3. Bodrov VA. On the problem of performance rehabilitation in flying personnel. Voenno-Med J. 1982;8:46–8 [In Russian].

    Google Scholar 

  4. Ponomarenko VA, Belinsky AV. Substantiation of differential assessment of mental health of flying personnel. Aviakosmich Ekologich Med. 1995;4:67c [In Russian].

    Google Scholar 

  5. Stupakov GP, Ushakov IB, Lapa VV. Aviation medicine to military science and practice. Voenno-Med J. 1995;7:76–9 [In Russian].

    Google Scholar 

  6. Kovalenko EA. Hypoxic training in medicine. Hypoxia Med J. 1993;1:3–5 [In Russian].

    Google Scholar 

  7. Kovalenko EA. Problems of hypoxia in space medicine. Hypoxia Med J. 1994;2:53–4 [In Russian].

    Google Scholar 

  8. Kolchinskaya AZ, Tkachuk EN, Tsyganova TN. Interval hypoxic training of sportsmen. In: Interval hypoxic training. Kiev; 1992 [In Russian].

    Google Scholar 

  9. Mirrakhimov MM. Treatment of internal diseases with mountain climate. Moscow: Meditsina; 1977 [In Russian].

    Google Scholar 

  10. Truijens MJ, Rodríguez FA, Townsend NE, et al. The effect of intermittent low-pressure hypoxic exposure and sea level training on submaximal economy in well-trained swimmers and runners. J Appl Physiol. 2008;104:328–37.

    Article  PubMed  Google Scholar 

  11. Rodríguez FA, Truijens MJ, Townsend NE, et al. Performance of runners and swimmers after four weeks of intermittent low-pressure hypoxic exposure plus sea level training. J Appl Physiol. 2007;103:1523–35.

    Article  PubMed  Google Scholar 

  12. Barbashova ZI. Acclimation to hypoxia and its physiological mechanisms. Moscow: AN SSSR; 1960 [In Russian].

    Google Scholar 

  13. Meerson FZ, Tverdokhlib VP, Boev VM, et al. Adaptation to periodic hypoxia in therapy and prophylaxis. Moscow: Nauka; 1989 [In Russian].

    Google Scholar 

  14. Pshennikova MG, Meerson FZ. Mechanisms of protective effects of adaptation to hypoxia. In: Hypoxia: mechanisms, adaptation, correction. Moscow; 1997 [In Russian].

    Google Scholar 

  15. Kovalenko EA, Cherniakov IN. Tissue oxygen and extreme flight factors. Probl Space Biol. 1972;21:263 [In Russian].

    Google Scholar 

  16. Fedorov VP, Ushakov IB, Saurina OS. Hypoxia as a type neuropathological process under the action of flight factors. In: Hypoxia: mechanisms, adaptation, correction. Moscow; 2002 [In Russian].

    Google Scholar 

  17. Meerson FZ. Adaptation, stress and prophylaxis. Moscow: Meditsina; 1981 [In Russian].

    Google Scholar 

  18. Meerson FZ. Adaptation medicine: concept of long-term adaptation. Moscow: Meditsina; 1993 [In Russian].

    Google Scholar 

  19. Meerson FZ, Malyshev IYu. Phenomenon of adaptive stabilization of the heart structures and protection. Moscow: Meditsina; 1993 [In Russian].

    Google Scholar 

  20. Burton RR, Smith AH. Induction of cardiac hypertrophy and polycythemia in the developing chick at high altitude. Fed Proc. 1969;28:1170–7.

    PubMed  CAS  Google Scholar 

  21. Hurtado A. Studies of myohemoglobin at high altitudes. Am J Med Sci. 1937;194:708.

    Article  CAS  Google Scholar 

  22. Meerson FZ. General mechanisms of adaptation and prophylaxis. Moscow: Meditsina; 1973 [In Russian].

    Google Scholar 

  23. Fradette C, Du Souich P. Effect of hypoxia on cytochrome P450 activity and expression. Curr Drug Metab. 2004;5:257–71.

    Article  PubMed  CAS  Google Scholar 

  24. Grek OP, Sharapov VI, Grek OO. Effect of hypoxic stress on xenobiotic metabolism and activities of various isoforms of cytochrome P-450. Eksp Klin Farmakol. 2001;64:42–4 [In Russian].

    PubMed  CAS  Google Scholar 

  25. Bayanov AA, Brunt AR. Role of hypoxia and constitutionally different resistance to hypoxia/stress as the determiners of individual profile of cytochrome P450 isozyme activity. Gen Pharmacol. 1999;33:355–61.

    Article  PubMed  CAS  Google Scholar 

  26. Agadzhanyan NA. Organism and gas environment. Moscow: Meditsina; 1972 [In Russian].

    Google Scholar 

  27. Agadzhanian NA, Gnevushev VV, Katkov AYu. Adaptation to hypoxia and bioeconomy of external respiration. Moscow: UDN; 1987 [In Russian].

    Google Scholar 

  28. Goranchuk VV, Novikov LA, Kalinina SN. Methodological aspects of hypoxic therapy. In: Barotherapy in complex treatment and rehabilitation of the wounded, sick, and damaged. 1997 [In Russian].

    Google Scholar 

  29. Vasiliev PV, Uglova NN. Effects of adaptation to reduced partial pressure of oxygen on g-tolerance. Probl Space Biol. 1967;6:215c [In Russian].

    Google Scholar 

  30. Haldane JS. Acclimatization to high altitudes. Physiol Rev. 1927;7:363.

    Google Scholar 

  31. Voitkevich VI. Chronic hypoxia: adaptive reactions of organism. Leningrad: Nauka; 1973.

    Google Scholar 

  32. Domontovich EN. Material on the problem of organism adjustment to hypoxic form of oxygen deficiency. Dissertation, Moscow; 1957 [In Russian].

    Google Scholar 

  33. Kolchinskaya AZ. Peculiarities of the mechanisms of effectiveness of using hypoxia adaptation in interval hypoxic training in medicine and sport. In: Hypoxia: mechanisms, adaptation, correction. Moscow; 2002. p. 63–4 [In Russian].

    Google Scholar 

  34. Vasiliev PV, Malkin VB, Babchinsky FV. Comparative evaluation of effectiveness of different regimes of adaptation to hypoxia. Probl Space Biol. 1968;8:122–9 [In Russian].

    Google Scholar 

  35. Bruner H, Klein KE. Hypoxia as stressor. Aerosp Med. 1960;1:1009–19.

    Google Scholar 

  36. Vasilenko ME, Gazenko OG, Gramenitsky PM, et al. Changes in altitude tolerance during chamber training. In: Functions of organism in the conditions of altered gas environment. Moscow: AN SSSR; 1958. p. 137–52 [In Russian].

    Google Scholar 

  37. Malkin VB, Cherniakov IN. Altitude hypoxia. In: Aviation Med. 1986:25–42 [In Russian].

    Google Scholar 

  38. Malkin VB. Barometric pressure and gas composition. Found Space Biol Med. 1975;2:11–73 [In Russian].

    Google Scholar 

  39. Lustin S.I. Physiological substantiation of increasing tolerance to hypoxia for correction of the functional state of organism. Dissertation, St. Petersburg; 1994.

    Google Scholar 

  40. Vasiliev PV, Kotovskaya AR. Long-term linear and radial accelerations. Found Space Biol Med. 1975;2:177–231 [In Russian].

    Google Scholar 

  41. Aliev MA. Adaptation to mountain climate in the event of arterial hypertension. Frunze: Ilim; 1978 [In Russian].

    Google Scholar 

  42. Bannikov VK. Application of low-pressure hypoxia to treatment and rehabilitation of patients with atopic neurodermatitis. Hypoxia Med J. 1994;2:74–5 [In Russian].

    Google Scholar 

  43. Berry LJ, Mitchell RB, Rubenstein D. Effect of acclimatization to altitude on susceptibility of mice to influenza virus infection. Proc Soc Exp Biol Med. 1957;96:501–6.

    Google Scholar 

  44. Malkin VB, Guippenreiter EB. Acute and chronic hypoxia. Probl Kosm Biol. 1977;35:320S [In Russian].

    Google Scholar 

  45. Lukyanova LD, Kharadurov SV, Romanova VE. Physiological and clinical issues of adaptation of human and animal organism to hypoxia, hyperthermia, hypodynamia and nonspecific methods of recovery. Moscow; 1978 [In Russian].

    Google Scholar 

  46. Katkov AYu, Kovalenko EA, Davydov GA, et al. Antihypoxic effectiveness of the “impulse” regime of chamber training of human. Kosmicheskaia Biologiya i Meditsina. 1981;5:56–8 [In Russian].

    Google Scholar 

  47. Tverdokhlib VP, Tkachuk EN. Organization of adaptation therapy in patient care institutions of the Russian Federation. Hypoxia in medicine; 1996. p. 110–1 [In Russian].

    Google Scholar 

  48. Tsyganova TN. Interval hypoxic training during sanatorium-­and-spa treatment. Yalta. 1993;6:90 [In Russian].

    Google Scholar 

  49. Ushakov IB, Usov VM, Dvornikov MV et al. Modern aspects of the problem of hypoxia in theory and practice of altitude physiology and aviation medicine. In: Lukyanova LD, Ushakov IB, editors. Problems of hypoxia. Moscow; 2004. p. 170–200 [In Russian].

    Google Scholar 

  50. Cherniakov IN. Stress-factors in altitude flight and homeostasis. In: Humanization and humanization of education. Pikalevo. 2002:40–7 [In Russian].

    Google Scholar 

  51. Tkachuk EN. Prevention of post-operation complications in gynaecological patients as a result of interval hypoxic training. Hypoxia Med. 1994;26:50–1 [In Russian].

    Google Scholar 

  52. Chizhov AYa, Strelkov RB, Potievskaya VI, et al. Normobaric hypoxic therapy. Moscow: RUDN; 1994 [In Russian].

    Google Scholar 

  53. Kolchinskaya AZ. Interval hypoxic training. effectiveness, action mechanisms. Kiev; 1992 [In Russian].

    Google Scholar 

  54. Ushakov IB, Cherniakov IN, Shishov AA. Low-pressure modification of interval hypoxic training in aerospace medicine. Voenno-Med J. 2003;2:54–7 [In Russian].

    Google Scholar 

  55. Belyi YuN, Kazennyi YuB. Methods of increasing work ability of opera­tor profile ship specialists. Voenno-Med J. 1987;11:52–3 [In Russian].

    Google Scholar 

  56. Zakoshchikov KF. Adaptation, hypoxia, and health. Moscow; 1996 [In Russian].

    Google Scholar 

  57. Marianovich AT. Comparative characteristics of the regimes of smooth and fractional adaptation. Dissertation, Leningrad; 1981 [In Russian].

    Google Scholar 

  58. Ushakov IB. Special psychophysiological and physical training of flying personnel for increasing tolerance of flight g-loads and hypoxia. Moscow; 2006 [In Russian].

    Google Scholar 

  59. Glod GD, Migachev SD, Plakhotnyuk LS, et al. Reactions of the cardiovascular system to graded static and dynamic physical tests. Space Biol Aerosp Med. 1982;1:234S [In Russian].

    Google Scholar 

  60. Krylov YuV, Lapaev EV, Kuznetsov VS. Function of the auditory and vestibular analyzers under the action of aerospace flight factors. Probl Space Biol. 1983;47:241S [In Russian].

    Google Scholar 

  61. Sidelnikov IA, Pavlov GI. Methodical guidelines on determination of vestibular tolerance and vestibular training of aviation schools students for use by LAM, KAM doctors. Moscow; 1976 [In Russian].

    Google Scholar 

  62. Ushakov IB, Cherniakov IN, Shishov AA et al. Russian patent #2098867 for invention “Method of improving human organism tolerance of exposure to flight stress-factors”. 1997 [In Russian].

    Google Scholar 

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Authors and Affiliations

  1. Russian Federation State Scientific Center, Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Russia

    Igor B. Ushakov, Anatoli A. Shishov, Vladimir N. Komarevtsev & Vladimir N. Filatov

Authors
  1. Igor B. Ushakov
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  2. Anatoli A. Shishov
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  3. Vladimir N. Komarevtsev
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  4. Vladimir N. Filatov
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Corresponding author

Correspondence to Igor B. Ushakov .

Editor information

Editors and Affiliations

  1. , Division of Cardiology, Virginia Commonwealth University, Richmond, 23298, Virginia, USA

    Lei Xi

  2. Bogomoletz Institute of Physiology, Kiev, 01601, Ukraine

    Tatiana V. Serebrovskaya

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Ushakov, I.B., Shishov, A.A., Komarevtsev, V.N., Filatov, V.N. (2012). Hypobaric Interval Hypoxia as a Nonmedication Method for Improving the Functional State of Aerospace Pilots and Astronauts. In: Xi, L., Serebrovskaya, T. (eds) Intermittent Hypoxia and Human Diseases. Springer, London. https://doi.org/10.1007/978-1-4471-2906-6_17

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  • DOI: https://doi.org/10.1007/978-1-4471-2906-6_17

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  • Online ISBN: 978-1-4471-2906-6

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