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Intermittent Hypoxia in Treatment of Bronchial Asthma in Childhood

  • Tatiana V. SerebrovskayaEmail author
  • Alexander N. Bakunovsky
  • Klaudia V. Nesvitailova
  • Iryna N. Mankovska
Chapter

Abstract

According to the World Health Organization, bronchial asthma (BA) is a serious public health problem with over 300 million sufferers of all ages. In this chapter, we demonstrate the possibility to treat BA in childhood with intermittent hypoxia treatment/training (IHT) programs and provide clinical evidence, adverse effects, and latest experience in IHT implementation. Particularly, it was shown that 2-week IHT resulted in a significant decline in breath shortness and feelings of chest congestion in BA children (aged 9–13 years). The cough was diminished or disappeared, and the amount of sputum was reduced and passed more easily. The attacks of asphyxia disappeared or became more occasional. Considerable augmentation of ventilatory response to hypoxic stimuli was observed as well as a diminution of heart rate (HR) reactions to increased hypoxia and an attenuated fall of SaO2 under hypoxic conditions. Mitochondrial enzymes activity of immune cells such as succinate dehydrogenase (SDG) and alpha-glycerophosphate dehydrogenase (GPDG) increased significantly under IHT. Strong correlation between individual hypoxic sensitivity and enzymes activities was found. In conclusion, IHT represents a promising approach in prevention and treatment of bronchial asthma in childhood. The proper choice of the hypoxic dosage depending on individual’s reactivity must be titrated for each patient in order to avoid negative effects of hypoxia and to augment the favorable ones.

Keywords

Bronchial Asthma Chronic Obstructive Pulmonary Disease Obstructive Sleep Apnea Syndrome Intermittent Hypoxia Hypoxic Ventilatory Response 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

BA

Bronchial asthma

CAT

Catalase

COPD

Chronic obstructive pulmonary disease

EPO

Erythropoietin

GPDG

Alpha-glycerophosphate dehydrogenase

GST

Glutathione-s-transferase

HIF

Hypoxia-inducible factor

HR

Heart rate

HVR

Hypoxic ventilatory response

IH

Intermittent hypoxia

IHT

Intermittent hypoxia training/treatment

MEAS

Method of expert assessing scales

NO

Nitric oxide

NOS

Nitric oxide synthase

OSAS

Obstructive sleep apnea syndrome

ROS

Reactive oxygen species

SaO2

Arterial oxygen saturation

SDG

Succinate dehydrogenase

Cu,Zn – SOD

Cu,Zn-superoxide dismutase

VE

Minute ventilation

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Copyright information

© Springer-Verlag London 2012

Authors and Affiliations

  • Tatiana V. Serebrovskaya
    • 1
    Email author
  • Alexander N. Bakunovsky
    • 1
  • Klaudia V. Nesvitailova
    • 1
  • Iryna N. Mankovska
    • 1
  1. 1.Department of HypoxiaBogomoletz Institute of Physiology, National Academy of Sciences of UkraineKievUkraine

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