Abstract
Superficial vein thrombosis (SVT), also known as superficial thrombophlebitis, is historically thought of as a benign condition that can always be treated symptomatically with nonsteroidal antiinflammatory drugs (NSAIDs) and elastic compression. However, many studies have reported an association of SVT with venous thromboembolism (VTE), with rates of concomitant deep vein thrombosis (DVT) as high as 53% and pulmonary embolism (PE) as high as 33% with lung scanning. In addition, SVT recurrence and extension is often reported. Although well-designed, randomized, controlled trials are few in this patient population, data suggest that anticoagulation in general and low-molecular-weight heparins specifically are the most effective treatment for SVT for resolving symptoms, preventing SVT recurrence or extension, and preventing VTE. When the significant morbidity and mortality associated with VTE is considered, it is reasonable that anticoagulation be used in all patients with SVT.
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Coon WW, Willis 3rd PW, Keller JB. Venous thromboembolism and other venous disease in the Tecumseh community health study. Circulation. 1973;48:839–46.
Blumenberg RM, Barton E, Gelfand ML, Skudder P, Brennan J. Occult deep venous thrombosis complicating superficial thrombophlebitis. J Vasc Surg. 1998;27:338–43.
Decousus H, Epinat M, Guillot K, Quenet S, Boissier C, Tardy B. Superficial vein thrombosis: risk factors, diagnosis, and treatment. Curr Opin Pulm Med. 2003;9:393–7.
Superficial Thrombophlebitis Treated by Enoxaparin Study Group. A pilot randomized double-blind comparison of a low-molecular-weight heparin, a nonsteroidal anti-inflammatory agent, and placebo in the treatment of superficial vein thrombosis. Arch Intern Med. 2003;163:1657–63.
Heit JA, Silverstein MD, Mohr DN, Petterson TM, O’Fallon WM, Melton 3rd LJ. Predictors of survival after deep vein thrombosis and pulmonary embolism: a population-based, cohort study. Arch Intern Med. 1999;159:445–53.
Marchiori A, Mosena L, Prandoni P. Superficial vein thrombosis: risk factors, diagnosis, and treatment. Semin Thromb Hemost. 2006;32:737–43.
Leon L, Giannoukas AD, Dodd D, Chan P, Labropoulos N. Clinical significance of superficial vein thrombosis. Eur J Vasc Endovasc Surg. 2005;29:10–7.
Lutter KS, Kerr TM, Roedersheimer LR, Lohr JM, Sampson MG, Cranley JJ. Superficial thrombophlebitis diagnosed by duplex scanning. Surgery. 1991;110:42–6.
Husni EA, Williams WA. Superficial thrombophlebitis of lower limbs. Surgery. 1982;91:70–4.
Subramaniam P, Van Doornum S. Superficial thrombophlebitis: underlying hypercoagulable states. Aust N Z J Surg. 1999;69:461–3.
Unno N, Mitsuoka H, Uchiyama T, Yamamoto N, Saito T, Ishimaru K, et al. Superficial thrombophlebitis of the lower limbs in patients with varicose veins. Surg Today. 2002;32:397–401.
De Maeseneer MG. Superficial thrombophlebitis of the lower limb: practical recommendations for diagnosis and treatment. Acta Chir Belg. 2005;105:145–7.
Martinelli I, Cattaneo M, Taioli E, De Stefano V, Chiusolo P, Mannucci PM. Genetic risk factors for superficial vein thrombosis. Thromb Haemost. 1999;82:1215–7.
Mozes G, Kalra M, Carmo M, Swenson L, Gloviczki P. Extension of saphenous thrombus into the femoral vein: a potential complication of new endovenous ablation techniques. J Vasc Surg. 2005;41:130–5.
Hanson JN, Ascher E, DePippo P, Lorensen E, Scheinman M, Yorkovich W, et al. Saphenous vein thrombophlebitis (SVT): a deceptively benign disease. J Vasc Surg. 1998;27:677–80.
Caprini JA, Goldshteyn S, Glase CJ, Hathaway K. Thrombophilia testing in patients with venous thrombosis. Eur J Vasc Endovasc Surg. 2005;30:550–5.
Leon Jr LR, Labropoulos N. Superficial vein thrombosis and hypercoagulable states: the evidence. Perspect Vasc Surg Endovasc Ther. 2005;17:43–6.
de Godoy JM, Braile DM. Protein S deficiency in repetitive superficial thrombophlebitis. Clin Appl Thromb Hemost. 2003;9:61–2.
de Moerloose P, Wutschert R, Heinzmann M, Perneger T, Reber G, Bounameaux H. Superficial vein thrombosis of lower limbs: influence of factor V Leiden, factor II G20210A and overweight. Thromb Haemost. 1998;80:239–41.
Vaya A, Llopis I, Trenor R, Mira Y, Estelles A, Aznar J. Spontaneous superficial vein thrombosis in a young patient double heterozygous for factor V Leiden and the prothrombin G20210A mutation: a case report. Haematologica. 2000;85:E11.
Lofgren EP, Lofgren KA. The surgical treatment of superficial thrombophlebitis. Surgery. 1981;90:49–54.
Heit JA, Silverstein MD, Mohr DN, Petterson TM, Lohse CM, O’Fallon WM, et al. The epidemiology of venous thromboembolism in the community. Thromb Haemost. 2001;86:452–63.
Verlato F, Zucchetta P, Prandoni P, Camporese G, Marzola MC, Salmistraro G, et al. An unexpectedly high rate of pulmonary embolism in patients with superficial thrombophlebitis of the thigh. J Vasc Surg. 1999;30:1113–5.
Porter JM, Moneta GL. Reporting standards in venous disease: an update. International Consensus Committee on Chronic Venous Disease. J Vasc Surg. 1995;21:635–45.
Quenet S, Laporte S, Decousus H, Leizorovicz A, Epinat M, Mismetti P. Factors predictive of venous thrombotic complications in patients with isolated superficial vein thrombosis. J Vasc Surg. 2003;38:944–9.
Hafner CD, Cranley JJ, Krause RJ, Strasser ES. A method of managing superficial thrombophlebitis. Surgery. 1964;55:201–6.
Partsch H. Compression therapy of the legs. A review. J Dermatol Surg Oncol. 1991;17:799–805.
Partsch H, Blattler W. Compression and walking versus bed rest in the treatment of proximal deep venous thrombosis with low molecular weight heparin. J Vasc Surg. 2000;32:861–9.
Belcaro G, Nicolaides AN, Errichi BM, Cesarone MR, De Sanctis MT, Incandela L, et al. Superficial thrombophlebitis of the legs: a randomized, controlled, follow-up study. Angiology. 1999;50:523–9.
Titon JP, Auger D, Grange P, Hecquet JP, Remond A, Ulliac P, et al. Therapeutic management of superficial venous thrombosis with calcium nadroparin. Dosage testing and comparison with a non-steroidal anti-inflammatory agent. Ann Cardiol Angeiol (Paris). 1994;43:160–6.
Geerts WH, Pineo GF, Heit JA, Bergqvist D, Lassen MR, Colwell CW, et al. Prevention of venous thromboembolism: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest. 2004;126:338S–400.
Marchiori A, Verlato F, Sabbion P, Camporese G, Rosso F, Mosena L, et al. High versus low doses of unfractionated heparin for the treatment of superficial thrombophlebitis of the leg. A prospective, controlled, randomized study. Haematologica. 2002;87:523–7.
Ascher E, Lorensen E, Pollina RM, Gennaro M. Preliminary results of a nonoperative approach to saphenofemoral junction thrombophlebitis. J Vasc Surg. 1995;22:616–21.
Ascher E, Hanson JN, Salles-Cunha S, Hingorani A. Lesser saphenous vein thrombophlebitis: its natural history and implications for management. Vasc Endovascular Surg. 2003;37:421–7.
Lozano FS, Almazan A. Low-molecular-weight heparin versus saphenofemoral disconnection for the treatment of above-knee greater saphenous thrombophlebitis: a prospective study. Vasc Endovascular Surg. 2003;37:415–20.
Di Nisio M, Middeldorp S, Wichers IM. Treatment for superficial thrombophlebitis of the leg. Cochrane Database Syst Rev. 2007;(1):CD004982.
Turpie AG, Bauer KA, Eriksson BI, Lassen MR. Fondaparinux vs enoxaparin for the prevention of venous thromboembolism in major orthopedic surgery: a meta-analysis of 4 randomized double-blind studies. Arch Intern Med. 2002;162:1833–40.
Decousus H, Leizorovicz A, Prandoni P. Haemostasis; “Fondaparinux 2.5 mg for the treatment of symptomatic, isolated superficial vein thrombosis (SVT): Preliminary data from the randomized placebo-controlled CALISTO Trial (on behalf of the CALISTO Investigators)”. ASH 2009; Abstract 171.
Beatty J, Fitridge R, Benveniste G, Greenstein D. Acute superficial venous thrombophlebitis: does emergency surgery have a role? Int Angiol. 2002;21:93–5.
Lohr JM, McDevitt DT, Lutter KS, Roedersheimer LR, Sampson MG. Operative management of greater saphenous thrombophlebitis involving the saphenofemoral junction. Am J Surg. 1992;164:269–75.
Plate G, Eklof B, Jensen R, Ohlin P. Deep venous thrombosis, pulmonary embolism and acute surgery in thrombophlebitis of the long saphenous vein. Acta Chir Scand. 1985;151:241–4.
Gjores JE. Surgical therapy of ascending thrombophlebitis in the saphenous system. Angiology. 1962;13:241–3.
Sullivan V, Denk PM, Sonnad SS, Eagleton MJ, Wakefield TW. Ligation versus anticoagulation: treatment of above-knee superficial thrombophlebitis not involving the deep venous system. J Am Coll Surg. 2001;193:556–62.
Yamaki T, Nozaki M, Sasaki K. Acute massive pulmonary embolism following high ligation combined with compression sclerotherapy for varicose veins report of a case. Dermatol Surg. 1999;25:321–5.
Ikeda M, Kambayashi J, Iwamoto S, Shinoki N, Nakamura T, Okahara K, et al. Hemostasis activation during sclerotherapy of lower extremity varices. Thromb Res. 1996;82:87–95.
Neglen P, Einarsson E, Eklof B. High tie sclerotherapy for saphenous vein insufficiency. Phlebology. 1986;1:105–11.
Rutherford RB, Sawyer JD, Jones DN. The fate of residual saphenous vein after partial removal or ligation. J Vasc Surg. 1990;12:422–6; discussion 426–8.
Bishop CC, Fronek HS, Fronek A, Dilley RB, Bernstein EF. Real-time color duplex scanning after sclerotherapy of the greater saphenous vein. J Vasc Surg. 1991;14:505–8; discussion 508–10.
Goren G. Real-time color duplex scanning after sclerotherapy of the greater saphenous vein. J Vasc Surg. 1992;16:497–8.
Prandoni P, Tormene D, Pesavento R. High vs. low doses of low-molecular-weight heparin for the treatment of superficial vein thrombosis of the legs: a double-blind, randomized trial. J Thromb Haemost. 2005;3:1152–7.
Gervais M. Les Thromboses veineuses superficielles. Lyon Chir. 1956;52:89–96.
Zollinger R, Williams RD, Briggs DO. Problems in the diagnosis and treatment of thrombophlebitis. Arch Surg. 1962;85:34–40.
Bergqvist D, Jaroszewski H. Deep vein thrombosis in patients with superficial thrombophlebitis of the leg. Br Med J (Clin Res Ed). 1986;292:658–9.
Skillman JJ, Kent KC, Porter DH, Kim D. Simultaneous occurrence of superficial and deep thrombophlebitis in the lower extremity. J Vasc Surg. 1990;11:818–23.
Prountjos P, Bastounis E, Hadjinikolaou L, Felekuras E, Balas P. Superficial venous thrombosis of the lower extremities co-existing with deep venous thrombosis. A phlebographic study on 57 cases. Int Angiol. 1991;10:63–5.
Pulliam CW, Barr SL, Ewing AB. Venous duplex scanning in the diagnosis and treatment of progressive superficial thrombophlebitis. Ann Vasc Surg. 1991;5:190–5.
Jorgensen JO, Hanel KC, Morgan AM, Hunt JM. The incidence of deep venous thrombosis in patients with superficial thrombophlebitis of the lower limbs. J Vasc Surg. 1993;18:70–3.
Chengelis DL, Bendick PJ, Glover JL, Brown OW, Ranval TJ. Progression of superficial venous thrombosis to deep vein thrombosis. J Vasc Surg. 1996;24:745–9.
Somjen GM, Donlan J, Hurse J, Bartholomew J, Weir E, Johnston AH, et al. Duplex ultrasound examination of the acutely painful and swollen leg. Dermatol Surg. 1996;22:383–7.
Bounameaux H, Reber-Wasem MA. Superficial thrombophlebitis and deep vein thrombosis. A controversial association. Arch Intern Med. 1997;157:1822–4.
Murgia AP, Cisno C, Pansini GC, Manfredini R, Liboni A, Zamboni P. Surgical management of ascending saphenous thrombophlebitis. Int Angiol. 1999;18:343–7.
Gorty S, Patton-Adkins J, DaLanno M, Starr J, Dean S, Satiani B. Superficial venous thrombosis of the lower extremities: analysis of risk factors, and recurrence and role of anticoagulation. Vasc Med. 2004;9:1–6.
De Sanctis MT, Cesarone MR, Incandela L, Belcaro G, Griffin M. Treatment of superficial vein thrombophlebitis of the arm with Essaven gel – a placebo-controlled, randomized study. Angiology. 2001;52 suppl 3:S63–7.
Agus GB, de Angelis R, Mondani P, Moia R. Double-blind comparison of nimesulide and diclofenac in the treatment of superficial thrombophlebitis with telethermographic assessment. Drugs. 1993;46 suppl 1:200–3.
Williams RD, Zollinger RW. Surgical treatment of superficial thrombophlebitis. Surg Gynecol Obstet. 1964;118:745–7.
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The authors would like to acknowledge the editorial assistance of Holly Capasso-Harris, Ph.D. in the preparation of this chapter.
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Caprini, J.A., Verta, M.J. (2013). Superficial Vein Thrombosis. In: Sadick, N., Khilnani, N., Morrison, N. (eds) Practical Approach to the Management and Treatment of Venous Disorders. Springer, London. https://doi.org/10.1007/978-1-4471-2891-5_15
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