Prostate cancer is the most common non-skin cancer in American men and accounts for greater than 200,000 new cancer cases each year in the United States . Although prostate cancer is the second leading cause of cancer death, survival is favorable for most men. Currently, a number of different effective treatment modalities are used to manage prostate cancer, including surgery, external radiation therapy, interstitial radiation therapy, and ablative therapy such as cryotherapy. Outcomes following treatment vary according to disease factors (e.g., Gleason grade, pretreatment PSA levels, and disease stage) as well as treatment modality; however, most cancers are cured or controlled with local therapy. Other outcomes, such as functional outcomes, vary more substantially. Because survival is typically favorable regardless of therapy, greater focus has been placed on treatment-related morbidity and health-related quality of life (HRQOL). Several population-based studies have been used to assess these outcomes and arguably provide more accurate, real-world estimates of outcomes experienced by most patients when compared to results reported in single-surgeon or institutional case series. As a result, these population-based studies are applicable to the majority of patients treated for clinically localized prostate cancer because of the heterogeneity and community-based nature of the pooled population. This chapter will focus on several studies from three of the largest and most commonly used data sources: the Surveillance, Epidemiology, and End Results (SEER) program (and SEER-Medicare), the Prostate Cancer Outcomes Study (PCOS), and the Cancer of the Prostate Strategic Urologic Research Endeavor (CaPSURE) database.
Sexual Function Localize Prostate Cancer Anastomotic Stricture Urinary Function Open Radical Prostatectomy
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access.
Guillonneau B, Rozet F, Barret E, et al. Laparoscopic radical prostatectomy: assessment after 240 procedures. Urol Clin North Am. 2001;28:189–202.PubMedCrossRefGoogle Scholar
Herrell S, Smith Jr J. Robotic-assisted laparoscopic prostatectomy: what is the learning curve? Urology. 2005;66(suppl):105–7.PubMedCrossRefGoogle Scholar
Hu J, Wang Q, Pashos C, et al. Utilization and outcomes of minimally invasive radical prostatectomy. J Clin Oncol. 2008;26:2278–84.PubMedCrossRefGoogle Scholar
Potosky A, Harlan L, Stanford J, et al. Prostate cancer practice patterns and quality of life: the prostate cancer outcomes study. J Natl Cancer Inst. 1999;91:1719–24.PubMedCrossRefGoogle Scholar
Stanford J, Feng Z, Hamilton A, et al. Urinary and sexual function after radical prostatectomy for clinically localized prostate cancer: the prostate cancer outcomes study. JAMA. 2000;283:354–60.PubMedCrossRefGoogle Scholar
Penson D, McLerran D, Feng Z, et al. Five-year urinary and sexual outcomes after radical prostatectomy: results from the prostate cancer outcomes study. J Urol. 2005;173:1701–5.PubMedCrossRefGoogle Scholar
Potosky A, Legler J, Albertsen P, et al. Health outcomes after prostatectomy or radiotherapy for prostate cancer: results from the prostate cancer outcomes study. J Natl Cancer Inst. 2000;92:1582–92.PubMedCrossRefGoogle Scholar
Postosky A, Davis W, Hoffman R, et al. Five-year outcomes after prostatectomy or radiotherapy for prostate cancer: the prostate cancer outcomes study. J Natl Cancer Inst. 2004;96:1358–67.CrossRefGoogle Scholar
Huang G, Sadetsky N, Penson D. Health related quality of life for men treated for localized prostate cancer with long-term followup. J Urol. 2010;183:2206–12.PubMedCrossRefGoogle Scholar
Litwin M, Pasta D, Yu J, et al. Urinary function and bother after radical prostatectomy or radiation for prostate cancer: a longitudinal multivariate quality of life analysis from the Cancer of the Prostate Strategic Urologic Research Endeavor. J Urol. 2000;164:1973–7.PubMedCrossRefGoogle Scholar
Le J, Cooperberg M, Sadetsky N, et al. Changes in specific domains of sexual function and sexual bother after radical prostatectomy. BJU Int. 2010;106:1022–9.PubMedCrossRefGoogle Scholar
Litwin M, Flanders S, Pasta D, et al. Sexual function and bother after radical prostatectomy or radiation for prostate cancer: multivariate quality-of-life analysis from CaPSURE. Urology. 1999;54:503–8.PubMedCrossRefGoogle Scholar
Lubeck D, Litwin M, Henning J, et al. Changes in health-related quality of life in the first year after treatment for prostate cancer: results from CaPSURE. Urology. 1999;53:180–6.PubMedCrossRefGoogle Scholar
Sanda MG, et al. Quality of life and satisfaction with outcome among prostate-cancer survivors. N Engl J Med. 2008;358(12):1250–61.PubMedCrossRefGoogle Scholar