Anatomy of the Myocardium in the Normal Left Ventricle

  • V Rao Parachuri
  • Srilakshmi M. Adhyapak


There are several limitations in the understanding of the pathophysiology of heart failure and in defining therapeutic strategies for the same. This is a result of existing lacunae in the understanding of the normal structure and function of the heart in vivo, as well as the molecular and genetic factors influencing crucial steps toward altered geometry and function. Despite the presence of regional inhomogeneity in the normal left ventricle during systole and diastole, a highly effective global function is maintained. This is due to its structural and functional anisotropy.


Tricuspid Valve Pulmonary Valve Helix Angle Embryonic Heart Left Ventricular Free Wall 
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  1. 1.
    Rankin JS, McHale PA, Arentzen CE, Ling D, Greenfield Jr JC, Andersen RW. The three dimensional dynamic geometry of the left ventricle in the conscious dog. Circ Res. 1976;39:304–13.PubMedCrossRefGoogle Scholar
  2. 2.
    Hutchins GM, Brawley RK. Shape of the human cardiac ventricles. Am J Cardiol. 1978;41:646–54.PubMedCrossRefGoogle Scholar
  3. 3.
    Burton AC. The importance of the shape and size of the heart. Am Heart J. 1957;54:801–10.PubMedCrossRefGoogle Scholar
  4. 4.
    Wong YK, Rautaharju PM. Stress distribution within the left ventricular wall approximated as a thick ellipsoid shell. Am Heart J. 1968;5:649–62.CrossRefGoogle Scholar
  5. 5.
    Flett RL. The musculature of the heart, with its application to physiology, and a note on heart rupture. J Anat. 1928;62:439–75.PubMedGoogle Scholar
  6. 6.
    Torrent-Guasp FF, Ballester M, Buckberg GD. Spatial orientation of the ventricular muscle band: physiologic contribution and surgical implications. J Thorac Cardiovasc Surg. 2001;122:389–92.PubMedCrossRefGoogle Scholar
  7. 7.
    Sedemera D. Form follows function: developmental and physiological view on ventricular myocardial architecture. Eur J Cardiothorac Surg. 2005;28:526–8.CrossRefGoogle Scholar
  8. 8.
    Criscione JC, Rodrigues F, Miller DC. The myocardial band: simplicity can be a weakness. Eur J Cardiothorac Surg. 2005;28:363–4.PubMedCrossRefGoogle Scholar
  9. 9.
    Andersen RH, Ho SY, Redmann K, Sanchez-Quintana D, Lunkenheimer PP. The anatomical arrangement of the myocardial cells making up the ventricular mass. Eur J Cardiothorac Surg. 2005;28:517–25.CrossRefGoogle Scholar
  10. 10.
    Chen J, Liu W, Zhang H. Regional ventricular wall thickening reflects changes in cardiac fiber and sheet structure during contraction: quantification with diffusion tensor MRI. Am J Physiol Heart Circ Physiol. 2005;289:H1898–907.PubMedCrossRefGoogle Scholar
  11. 11.
    Vendelin M, Bovedeerd PH, Engelbrechet J, Arts T. Optimising ventricular fibers: uniform strain or stress, but not ATP consumption, leads to high efficiency. Am J Physiol Heart Circ Physiol. 2002;283:H1072–81.PubMedGoogle Scholar
  12. 12.
    Nielsen PM, Le Grice IJ, Smaill BH, Hunter PJ. Mathematical model of geometry and fibrous structure of the heart. Am J Physiol. 1991;260:H1365–78.PubMedGoogle Scholar
  13. 13.
    Grider JR. Reciprocal activity of longitudinal and circular muscle during intestinal peristaltic reflex. Am J Physiol Gastrointest Liver Physiol. 2003;284:G768–75.PubMedGoogle Scholar
  14. 14.
    Streeter Jr DD, Spotniz HM, Patel DP, Ross Jr J, Sonnenblick EH. Fiber orientation in the canine left ventricle during diastole and systole. Circ Res. 1969;24:339–47.PubMedCrossRefGoogle Scholar
  15. 15.
    Geertz L, Bovendeerd P, Nicolay K, Arts T. Characterisation of the normal cardiac myofiber in goat measured with MR diffusion tensor imaging. Am J Physiol Heart Circ Physiol. 2002;283:H139–45.Google Scholar
  16. 16.
    Greenbaum RA, Ho SY, Gibson DG, Becker AE, Andersen RH. Left ventricular fiber architecture in man. Br Heart J. 1981;45:248–63.PubMedCrossRefGoogle Scholar
  17. 17.
    Grant RP. Notes on the muscular architecture of the left ventricle. Circulation. 1965;32:301–8.PubMedCrossRefGoogle Scholar
  18. 18.
    Gilbert HS, Benson AP, Li P, Holden AV. Regional localization of left ventricular sheet structure: integration with current models of cardiac fiber, sheet and band structure. Eur J Cardiothorac Surg. 2007;32:231–49.PubMedCrossRefGoogle Scholar
  19. 19.
    Weiss P. Mechanical tension and fiber orientation in cultures of fibroblasts. Arch Entwicklungsmech Organ. 1929;116:438.CrossRefGoogle Scholar
  20. 20.
    Takayama Y, Costa KD, Covell JW. Contribution of laminar myofiber architecture to load dependent changes in mechanics of LV myocardium. Am J Physiol Heart Circ Physiol. 2002;282:H1510–20.PubMedGoogle Scholar
  21. 21.
    Costa KD, Takayama Y, McCulloch AD, Covell JW. Laminar fiber architecture and three dimensional systolic mechanics in canine ventricular myocardium. Am J Physiol Heart Circ Physiol. 1999;276:H595–607.Google Scholar
  22. 22.
    Moore CC, McVeigh ER, Elias A. Quantitative tagged magnetic resonance imaging of the normal human ventricle. Top Magn Reson Imaging. 2000;11(6):359–71.PubMedCrossRefGoogle Scholar
  23. 23.
    Coghlan C, Hoffman J. Leonardo da Vinci’s flights of the mind must continue: cardiac architecture and the fundamental relation of form and function revisited. Eur J Cardiothorac Surg. 2006;29:S4–17.PubMedCrossRefGoogle Scholar
  24. 24.
    Sengupta PP, Korinek J, Belohlavek M. Left ventricular structure and function basic science for cardiac imaging. J Am Coll Cardiol. 2006;48:1988–2001.PubMedCrossRefGoogle Scholar
  25. 25.
    Francisco Torrent-Guasp, Manel Ballester, Gerald D. Buckberg, Francesc Carreras, Albert Flotats, Ignasi Carrió, Ana Ferreira, Louis E. Samuels, Jagat Narula. Spatial orientation of the ventricular muscle band: Physiologic contribution and surgical implications. J Thorac Cardiovasc Surg. 2001;122:389–392.Google Scholar

Copyright information

© Springer-Verlag London 2012

Authors and Affiliations

  • V Rao Parachuri
    • 1
  • Srilakshmi M. Adhyapak
    • 2
  1. 1.Department of Cardiothoracic SurgeryNarayana HrudayalayaBangaloreIndia
  2. 2.Department of CardiologySt. John’s Medical College HospitalBangaloreIndia

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