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Childhood Obesity and the Environment

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Abstract

The rising rate of infant obesity presents the biggest challenge to diet- and lifestyle-based explanations for the obesity epidemic. Although the hypothesis that everyday exposure to chemicals may contribute to risk of obesity is controversial, there is pharmaceutical proof of concept from diabetes drugs in humans and diethylstilboestrol in a mouse model. Chemical exposure also complicates the role of obesity in the etiology of diabetes and cancer. Given that no chemical has been tested for obesogenicity before being brought to market, it is overly hasty to dismiss the obesogen hypothesis as a “green scare.”

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References

  1. Kim J, Peterson KE, Scanlon KS, Fitzmaurice GM, Must A, Oken E, et al. Trends in overweight from 1980 through 2001 among preschool-aged children enrolled in a health maintenance organization. Obesity (Silver Spring). 2006;14(7):1107–12.

    Article  Google Scholar 

  2. Heslehurst N, Ells LJ, Simpson H, Batterham A, Wilkinson J, Summerbell CD. Trends in maternal obesity incidence rates, demographic predictors, and health inequalities in 36,821 women over a 15-year period. BJOG. 2007;114(2):187–94.

    Article  PubMed  CAS  Google Scholar 

  3. Dennedy MC, Avalos G, O’Reilly MW, O’Sullivan EP, Dunne FP. The impact of maternal obesity on gestational outcomes. Ir Med J. 2012;105(5 Suppl):23–5.

    PubMed  CAS  Google Scholar 

  4. Johnson J, Tough S. Delayed child-bearing. J Obstet Gynaecol Can. 2012;34(1):80–93.

    PubMed  Google Scholar 

  5. White House Task Force on Childhood Obesity. Solving the problem of childhood obesity within a generation. United States. 2010. http://www.letsmove.gov/sites/letsmove.gov/files/TaskForce_on_Childhood_Obesity_May2010_FullReport.pdf.

  6. Finley A. Are plastics making us fat? Health gurus claim chemicals—not calories—are the cause of obesity. Wall Street Journal, United States 13/8/10. Cited 12/12/12. http://online.wsj.com/article/SB10001424052748703545604575407201305888876.html

  7. de Rooij SR, Painter RC, Holleman F, Bossuyt PM, Roseboom TJ. The metabolic syndrome in adults prenatally exposed to the Dutch famine. Am J Clin Nutr. 2007;86(4):1219–24.

    PubMed  Google Scholar 

  8. Li Y, Jaddoe VW, Qi L, He Y, Wang D, Lai J, et al. Exposure to the chinese famine in early life and the risk of metabolic syndrome in adulthood. Diabetes Care. 2011;34(4):1014–8.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Monasta L, Batty GD, Cattaneo A, Lutje V, Ronfani L, van Lenthe FJ, et al. Early-life determinants of overweight and obesity: a review of systematic reviews. Obes Rev. 2010;11(10):695–708.

    Article  PubMed  CAS  Google Scholar 

  10. Thayer KA, Heindel JJ, Bucher JR, Gallo MA. Role of environmental chemicals in diabetes and obesity: a National Toxicology Program workshop review. Environ Health Perspect. 2012;120(6):779–89.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  11. Grün F, Blumberg B. Perturbed nuclear receptor signaling by environmental obesogens as emerging factors in the obesity crisis. Rev Endocr Metab Disord. 2007;8(2):161–71.

    Article  PubMed  Google Scholar 

  12. Grün F. Obesogens. Curr Opin Endocrinol Diabetes Obes. 2010;17(5):453–9.

    Article  PubMed  Google Scholar 

  13. Newbold RR, Padilla-Banks E, Jefferson WN. Environmental estrogens and obesity. Mol Cell Endocrinol. 2009;304(1–2):84–9.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  14. International Maritime Organization. Anti-fouling systems. London; 2002.

    Google Scholar 

  15. Kirchner S, Kieu T, Chow C, Casey S, Blumberg B. Prenatal exposure to the environmental obesogen tributyltin predisposes multipotent stem cells to become adipocytes. Mol Endocrinol. 2010;24(3):526–39.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  16. Alonso-Magdalena P, Morimoto S, Ripoll C, Fuentes E, Nadal A. The estrogenic effect of bisphenol A disrupts pancreatic beta-cell function in vivo and induces insulin resistance. Environ Health Perspect. 2006;114(1):106–12.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  17. Somm E, Schwitzgebel VM, Toulotte A, Cederroth CR, Combescure C, Nef S, et al. Perinatal exposure to bisphenol a alters early adipogenesis in the rat. Environ Health Perspect. 2009;117(10):1549–55.

    PubMed  CAS  PubMed Central  Google Scholar 

  18. Wang H, Zhou Y, Tang C, Wu J, Chen Y, Jiang Q. Association between bisphenol a exposure and body mass index in Chinese school children: a cross-sectional study. Environ Health. 2012;11(1):79.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Trasande L, Attina TM, Blustein J. Association between urinary bisphenol A concentration and obesity prevalence in children and adolescents. JAMA. 2012;308(11):1113–21.

    Article  PubMed  CAS  Google Scholar 

  20. Stahlhut RW, van Wijngaarden E, Dye TD, Cook S, Swan SH. Concentrations of urinary phthalate metabolites are associated with increased waist circumference and insulin resistance in adult U.S. males. Environ Health Perspect. 2007;115(6):876–82.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  21. Vanden Heuvel JP, Thompson JT, Frame SR, Gillies PJ. Differential activation of nuclear receptors by perfluorinated fatty acid analogs and natural fatty acids: a comparison of human, mouse, and rat peroxisome proliferator-activated receptor-alpha, -beta, and -gamma, liver X receptor-beta, and retinoid X receptor-alpha. Toxicol Sci. 2006;92(2):476–89.

    Article  PubMed  CAS  Google Scholar 

  22. Carpenter DO. Environmental contaminants as risk factors for developing diabetes. Rev Environ Health. 2008;23(1):59–74.

    PubMed  CAS  Google Scholar 

  23. Longnecker MP, Klebanoff MA, Brock JW, Zhou H. Polychlorinated biphenyl serum levels in pregnant subjects with diabetes. Diabetes Care. 2001;24(6):1099–101.

    Article  PubMed  CAS  Google Scholar 

  24. Turyk M, Anderson H, Knobeloch L, Imm P, Persky V. Organochlorine exposure and incidence of diabetes in a cohort of Great Lakes sport fish consumers. Environ Health Perspect. 2009;117(7):1076–82.

    PubMed  CAS  PubMed Central  Google Scholar 

  25. Rignell-Hydbom A, Lidfeldt J, Kiviranta H, Rantakokko P, Samsioe G, Agardh C, et al. Exposure to p, p′-DDE: a risk factor for type 2 diabetes. PLoS One. 2009;4(10):e7503.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Lee D, Steffes MW, Sjödin A, Jones RS, Needham LL, Jacobs DR. Low dose of some persistent organic pollutants predicts type 2 diabetes: a nested case–control study. Environ Health Perspect. 2010;118(9):1235–42.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  27. Lee D, Jacobs DR, Porta M. Could low-level background exposure to persistent organic pollutants contribute to the social burden of type 2 diabetes? J Epidemiol Community Health. 2006;60(12):1006–8.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Markey CM, Luque EH, Munoz De Toro M, Sonnenschein C, Soto AM. In utero exposure to bisphenol A alters the development and tissue organization of the mouse mammary gland. Biol Reprod. 2001;65(4):1215–23.

    PubMed  CAS  Google Scholar 

  29. Weber Lozada K, Keri RA. Bisphenol A increases mammary cancer risk in two distinct mouse models of breast cancer. Biol Reprod. 2011;85(3):490–7.

    Article  PubMed  PubMed Central  Google Scholar 

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Correspondence to Paul A. Whaley BA, MLitt .

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© 2014 Springer-Verlag London

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Whaley, P.A. (2014). Childhood Obesity and the Environment. In: Haslam, D., Sharma, A., le Roux, C. (eds) Controversies in Obesity. Springer, London. https://doi.org/10.1007/978-1-4471-2834-2_12

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  • DOI: https://doi.org/10.1007/978-1-4471-2834-2_12

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  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-2833-5

  • Online ISBN: 978-1-4471-2834-2

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