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Kidney Cancer

  • Lee E. Moore
  • Patricia A. Stewart
  • Sara Karami
Chapter

Abstract

Malignant tumors of the kidney account for approximately 2 % of all new primary cancer cases diagnosed in the United States (US) and worldwide. Renal cell carcinoma (RCC) of the renal parenchyma accounts for over 80 % of all kidney cancers, the majority of which are adenocarcinomas that arise from the renal parenchyma. RCC is divided into distinct histological subtypes, clear cell being the most prevalent (80–85 %) followed by papillary RCC (10 %). Less common subtypes of kidney cancer include oncocytoma and chromophobe tumors. Another histological subtype of kidney cancer is transitional cell carcinoma (TCC) which is most often located in the renal pelvis. Histologically, these tumors are considered more similar to TCC of the bladder. In RCC, the major etiologic risk factors that are thought to explain approximately 50 % of cases include cigarette smoking, obesity (high body mass index or BMI), hypertension, and diabetes. The increasing prevalence of these risk factors may explain temporal variations in renal cancer incidence rates by country/region and within particular subpopulations. While the etiologic factors associated with the remaining 50 % of renal cancer cases are for the most part unexplained, other risk factors that have been described in the literature include analgesic use, long-term hemodialysis, hormonal/reproductive factors, variations in diet, family history of renal cancer, and genetic factors. Although not generally considered an occupationally related cancer, several studies have pointed towards occupational and environmental exposures; many associations, however, remain inconclusive. The current review will focus upon renal cancer risk associated with exposure to various agents in the workplace that are suspected of being renal carcinogens. Initial studies we present will evaluate historical exposures using job and industry titles, in which exposures to carcinogens were “likely” to be encountered in the workplace. Subsequently, to reduce speculation and exposure misclassification, higher-quality studies that used more sophisticated exposure assessment techniques (i.e., expert-assessed or actual industrial hygiene measurements) will be presented.

Keywords

Kidney cancer Occupation Solvents Trichloroethylene Metals Cadmium Lead Pesticides Diesel auto fumes Asbestos Ultraviolet (UV) exposure 

References

  1. 1.
    Naito S, Tomita Y, Rha SY, et al. Kidney Cancer Working Group report. Jpn J Clin Oncol. 2010;40 Suppl 1:i51–6.PubMedGoogle Scholar
  2. 2.
    Linehan JA, Nguyen MM. Kidney cancer: the new landscape. Curr Opin Urol. 2009;19(2):133–7.PubMedGoogle Scholar
  3. 3.
    Gago-Dominguez M, Yuan JM, Castelao JE, Ross RK, Yu MC. Regular use of analgesics is a risk factor for renal cell carcinoma. Br J Cancer. 1999;81(3):542–8.PubMedCentralPubMedGoogle Scholar
  4. 4.
    Moore LE, Wilson RT. Lifestyle factors, exposures, genetic susceptibility, and renal cell cancer risk: a review. Cancer Invest. 2005;23(3):240–52.PubMedGoogle Scholar
  5. 5.
    Chow WH, Dong LM, Devesa SS. Epidemiology and risk factors for kidney cancer. Nat Rev Urol. 2010;7(5):245–57.PubMedCentralPubMedGoogle Scholar
  6. 6.
    Chow WH, Devesa SS. Contemporary epidemiology of renal cell cancer. Cancer J. 2008;14(5):288–301.PubMedCentralPubMedGoogle Scholar
  7. 7.
    MedlinePlus Cancer-renal pelvis or ureter. http://www.nlm.nih.gov/medlineplus/ency/article/000525.htm. Accessed 7 Dec 2011.
  8. 8.
    Sasco AJ, Secretan MB, Straif K. Tobacco smoking and cancer: a brief review of recent epidemiological evidence. Lung Cancer. 2004;45 Suppl 2:S3–9.PubMedGoogle Scholar
  9. 9.
    Benichou J, Chow WH, McLaughlin JK, Mandel JS, Fraumeni Jr JF. Population attributable risk of renal cell cancer in Minnesota. Am J Epidemiol. 1998;148:424–30.PubMedGoogle Scholar
  10. 10.
    Hurst FP, Jindal RM, Fletcher JJ, et al. Incidence, predictors and associated outcomes of renal cell carcinoma in long-term dialysis patients. Urology. 2011;77(6):1271–6.PubMedGoogle Scholar
  11. 11.
    Lee JE, Hankinson SE, Cho E. Reproductive factors and risk of renal cell cancer: the Nurses’ Health Study. Am J Epidemiol. 2009;169(10):1243–50.PubMedCentralPubMedGoogle Scholar
  12. 12.
    Alexander DD, Cushing CA. Quantitative assessment of red meat or processed meat consumption and kidney cancer. Cancer Detect Prev. 2009;32(5–6):340–51.PubMedGoogle Scholar
  13. 13.
    Vainio H, Weiderpass E. Fruit and vegetables in cancer prevention. Nutr Cancer. 2006;54(1):111–42.PubMedGoogle Scholar
  14. 14.
    Karami S, Schwartz K, Purdue MP, et al. Family history of cancer and renal cell cancer risk in Caucasians and African Americans. Br J Cancer. 2010;102(11):1676–80.PubMedCentralPubMedGoogle Scholar
  15. 15.
    Linehan WM, Srinivasan R, Schmidt LS. The genetic basis of kidney cancer: a metabolic disease. Nat Rev Urol. 2010;7(5):277–85.PubMedCentralPubMedGoogle Scholar
  16. 16.
    Golka K, Wiese A, Assennato G, Bolt HM. Occupational exposure and urological cancer. World J Urol. 2004;21(6):382–91.PubMedGoogle Scholar
  17. 17.
    Boffetta P, Jourenkova N, Gustavsson P. Cancer risk from occupational and environmental exposure to polycyclic aromatic hydrocarbons. Cancer Causes Control. 1997;8(3):444–72.PubMedGoogle Scholar
  18. 18.
    Parent ME, Hua Y, Siemiatycki J. Occupational risk factors for renal cell carcinoma in Montreal. Am J Ind Med. 2000;38:609–18.PubMedGoogle Scholar
  19. 19.
    Asal NR, Geyer JR, Risser DR, Lee ET, Kadamani S, Cherng N. Risk factors in renal cell carcinoma. II. Medical history, occupation, multivariate analysis, and conclusions. Cancer Detect Prev. 1988;13:263–79.PubMedGoogle Scholar
  20. 20.
    Heck JE, Charbotel B, Moore LE, et al. Occupation and renal cell cancer in Central and Eastern Europe. Occup Environ Med. 2010;67:47–53.PubMedCentralPubMedGoogle Scholar
  21. 21.
    Laakkonen A, Kauppinen T, Pukkala E. Cancer risk among Finnish food industry workers. Int J Cancer. 2006;118(10):2567–71.PubMedGoogle Scholar
  22. 22.
    Zhang Y, Cantor KP, Lynch CF, Zheng T. A population-based case-control study of occupation and renal cell carcinoma risk in Iowa. J Occup Environ Med. 2004;46(3):235–40.PubMedGoogle Scholar
  23. 23.
    Mandel JS, McLaughlin JK, Schlehofer B, et al. International renal-cell cancer study. IV. Occupation. Int J Cancer. 1995;61(5):601–5.PubMedGoogle Scholar
  24. 24.
    Hu J, Mao Y, White K. Renal cell carcinoma and occupational exposure to chemicals in Canada. Occup Med (Lond). 2002;52(3):157–64.Google Scholar
  25. 25.
    Mellemgaard A, Engholm G, McLaughlin JK, Olsen JH. Occupational risk factors for renal-cell carcinoma in Denmark. Scand J Work Environ Health. 1994;20:160–5.PubMedGoogle Scholar
  26. 26.
    Weikert S, Ljungberg B. Contemporary epidemiology of renal cell carcinoma: perspectives of primary prevention. World J Urol. 2010;28:247–52.PubMedGoogle Scholar
  27. 27.
    Vena JE, Sultz HA, Fiedler RC, Barnes RE. Mortality of workers in an automobile engine and parts manufacturing complex. Br J Ind Med. 1985;42(2):85–93.PubMedCentralPubMedGoogle Scholar
  28. 28.
    McLaughlin JK, Malker HS, Stone BJ, et al. Occupational risks for renal cancer in Sweden. Br J Ind Med. 1987;44(2):119–23.PubMedCentralPubMedGoogle Scholar
  29. 29.
    Pesch B, Haerting J, Ranft U, Klimpel A, Oelschlägel B, Schill W. Occupational risk factors for renal cell carcinoma: agent-specific results from a case-control study in Germany. MURC Study Group. Multicenter urothelial and renal cancer study. Int J Epidemiol. 2000;29(6):1014–24.PubMedGoogle Scholar
  30. 30.
    Delahunt B, Bethwaite PB, Nacey JN. Occupational risk for renal cell carcinoma. A case-control study based on the New Zealand Cancer Registry. Br J Urol. 1995;75(5):578–82.PubMedGoogle Scholar
  31. 31.
    Youakim S. Risk of cancer among firefighters: a quantitative review of selected malignancies. Arch Environ Occup Health. 2006;61(5):223–31.PubMedGoogle Scholar
  32. 32.
    Lowery JT, Peters JM, Deapen D, London SJ. Renal cell carcinoma among architects. Am J Ind Med. 1991;20(1):123–5.PubMedGoogle Scholar
  33. 33.
    Magnani C, Coggon D, Osmond C, Acheson ED. Occupation and five cancers: a case-control study using death certificates. Br J Ind Med. 1987;44(11):769–76.PubMedCentralPubMedGoogle Scholar
  34. 34.
    Brownson RC. A case-control study of renal cell carcinoma in relation to occupation, smoking, and alcohol consumption. Arch Environ Health. 1988;43:238–41.PubMedGoogle Scholar
  35. 35.
    Lohi J, Kyyrönen P, Kauppinen T, Kujala V, Pukkala E. Occupational exposure to solvents and gasoline and risk of cancers in the urinary tract among Finnish workers. Am J Ind Med. 2008;51(9):668–72.PubMedGoogle Scholar
  36. 36.
    Schlehofer B, Heuer C, Blettner M, Niehoff D, Wahrendorf J. Occupation, smoking and demographic factors, and renal cell carcinoma in Germany. Int J Epidemiol. 1995;24(1):51–7.PubMedGoogle Scholar
  37. 37.
    Mattioli S, Truffelli D, Baldasseroni A, et al. Occupational risk factors for renal cell cancer: a case-control study in northern Italy. J Occup Environ Med. 2002;44(11):1028–36.PubMedGoogle Scholar
  38. 38.
    Karami S, Boffetta P, Rothman N, et al. Renal cell carcinoma, occupational pesticide exposure and modification by glutathione S-transferase polymorphisms. Carcinogenesis. 2008;29(8):1567–71.PubMedCentralPubMedGoogle Scholar
  39. 39.
    Hansen J, Raaschou-Nielsen O, Christensen JM, et al. Cancer incidence among Danish workers exposed to trichloroethylene. J Occup Environ Med. 2001;43(2):133–9.PubMedGoogle Scholar
  40. 40.
    Jacob S, Hery M, Protois JC, Rossert J, Stengel B. New insight into solvent-related end stage renal disease: occupations, products and types of solvents at risk. Occup Environ Med. 2007;64(12):843–8.PubMedCentralPubMedGoogle Scholar
  41. 41.
    Stewart PA, Lee JS, Marano DE, Spirtas R, Forbes CD, Blair A. Retrospective cohort mortality study of workers at an aircraft maintenance facility. II. Exposures and their assessment. Br J Ind Med. 1991;48(8):531–7.PubMedCentralPubMedGoogle Scholar
  42. 42.
    Spirtas R, Stewart PA, Lee JS, et al. Retrospective cohort mortality study of workers at an aircraft maintenance facility. I. Epidemiological results. Br J Ind Med. 1991;48(8):515–30.PubMedCentralPubMedGoogle Scholar
  43. 43.
    Moore LE, Boffetta P, Karami S, et al. Occupational trichloroethylene exposure and renal carcinoma risk: evidence of genetic susceptibility by reductive metabolism gene variants. Cancer Res. 2010;70(16):6527–36.PubMedCentralPubMedGoogle Scholar
  44. 44.
    Poole C, Dreyer NA, Satterfield MH, Levin L, Rothman KJ. Kidney cancer and hydrocarbon exposures among petroleum refinery workers. Environ Health Perspect. 1993;101 Suppl 6:53–62.PubMedCentralPubMedGoogle Scholar
  45. 45.
    Dosemeci M, Cocco P, Chow WH. Gender differences in risk of renal cell carcinoma and occupational exposures to chlorinated aliphatic hydrocarbons. Am J Ind Med. 1999;36(1):54–9.PubMedGoogle Scholar
  46. 46.
    McLean D, Pearce N, Langseth H, et al. Cancer mortality in workers exposed to organochlorine compounds in the pulp and paper industry: an international collaborative study. Environ Health Perspect. 2006;114(7):1007–12.PubMedCentralPubMedGoogle Scholar
  47. 47.
    IARC (International Agency for Research on Cancer). Trichloroethylene. IARC Monogr Eval Carcinog Risks Hum. 1995;63:75–158.Google Scholar
  48. 48.
    United States Environmental Protection Agency. EPA releases final health assessment for TCE. http://yosemite.epa.gov/opa/admpress.nsf/03dd877d6f1726c28525735900404443/b8d0e4d8489ad991852579190058d6c3!OpenDocument. Accessed 7 Dec 2011.
  49. 49.
    Guha N, Loomis D, Grosse Y, Lauby-Secretan B, El Ghissassi F, Bouvard V, Benbrahim-Tallaa L, Baan R, Mattock H, Straif K, International Agency for Research on Cancer Monograph Working Group. Carcinogenicity of trichloroethylene, tetrachloroethylene, some other chlorinated solvents, and their metabolites. Lancet Oncol. 2012;13(12):1192–3.PubMedGoogle Scholar
  50. 50.
    Agency for Toxic Substances and Disease Registry. Trichloroethylene. 4. Production, import/export, use and disposal. http://www.atsdr.cdc.gov/toxprofiles/tp19-c4.pdf. Accessed 7 Dec 2011.
  51. 51.
    Humphries JA, Ashe AM, Smiley JA, Johnston CG. Microbial community structure and trichloroethylene degradation in groundwater. Can J Microbiol. 2005;51(6):433–9.PubMedGoogle Scholar
  52. 52.
    Axelson O, Seldén A, Andersson K, Hogstedt C. Updated and expanded Swedish cohort study on trichloroethylene and cancer risk. J Occup Med. 1994;36(5):556–62.PubMedGoogle Scholar
  53. 53.
    Anttila A, Pukkala E, Sallmén M, Hernberg S, Hemminki K. Cancer incidence among Finnish workers exposed to halogenated hydrocarbons. J Occup Environ Med. 1995;37(7):797–806.PubMedGoogle Scholar
  54. 54.
    Henschler D, Vamvakas S, Lammert M, et al. Increased incidence of renal cell tumors in a cohort of cardboard workers exposed to trichloroethene. Arch Toxicol. 1995;69(5):291–9.PubMedGoogle Scholar
  55. 55.
    Morgan RW, Kelsh MA, Zhao K, Heringer S. Mortality of aerospace workers exposed to trichloroethylene. Epidemiology. 1998;9(4):424–31.PubMedGoogle Scholar
  56. 56.
    Ritz B. Cancer mortality among workers exposed to chemicals during uranium processing. J Occup Environ Med. 1999;41(7):556–66.PubMedGoogle Scholar
  57. 57.
    Boice Jr JD, Marano DE, Fryzek JP, Sadler CJ, McLaughlin JK. Mortality among aircraft manufacturing workers. Occup Environ Med. 1999;56(9):581–97.PubMedCentralPubMedGoogle Scholar
  58. 58.
    Raaschou-Nielsen O, Hansen J, McLaughlin JK, et al. Cancer risk among workers at Danish companies using trichloroethylene: a cohort study. Am J Epidemiol. 2003;158(12):1182–92.PubMedGoogle Scholar
  59. 59.
    Boice Jr JD, Marano DE, Cohen SS, et al. Mortality among Rocketdyne workers who tested rocket engines, 1948–1999. J Occup Environ Med. 2006;48(10):1070–92.PubMedGoogle Scholar
  60. 60.
    Radican L, Blair A, Stewart P, Wartenberg D. Mortality of aircraft maintenance workers exposed to trichloroethylene and other hydrocarbons and chemicals: extended follow up. J Occup Environ Med. 2008;50(11):1306–19.PubMedCentralPubMedGoogle Scholar
  61. 61.
    Harrington JM, Whitby H, Gray CN, Reid FJ, Aw TC, Waterhouse JA. Renal disease and occupational exposure to organic solvents: a case referent approach. Br J Ind Med. 1989;46(9):643–50.PubMedCentralPubMedGoogle Scholar
  62. 62.
    Sharpe CR, Rochon JE, Adam JM, Suissa S. Case-control study of hydrocarbon exposures in patients with renal cell carcinoma. Can Med Assoc J. 1989;140(11):1309–18.Google Scholar
  63. 63.
    Greenland S, Salvan A, Wegman DH, Hallock MF, Smith TJ. A case-control study of cancer mortality at a transformer-assembly facility. Int Arch Occup Environ Health. 1994;66(1):49–54.PubMedGoogle Scholar
  64. 64.
    Vamvakas S, Brüning T, Thomasson B, et al. Renal cell cancer correlated with occupational exposure to trichloroethene. J Cancer Res Clin Oncol. 1998;124(7):374–82.PubMedGoogle Scholar
  65. 65.
    Brüning T, Pesch B, Wiesenhütter B, et al. Renal cell cancer risk and occupational exposure to trichloroethylene: results of a consecutive case-control study in Arnsberg, Germany. Am J Ind Med. 2003;43(3):274–85.PubMedGoogle Scholar
  66. 66.
    Charbotel B, Fevotte J, Hours M, Martin JL, Bergeret A. Case-control study on renal cell cancer and occupational exposure to trichloroethylene. Part II: Epidemiological aspects. Ann Occup Hyg. 2006;50(8):777–87.PubMedGoogle Scholar
  67. 67.
    Siemiatycki J. Risk factors for cancer in the workplace. Boca Raton: CRC Press; 1991. p. 30–167.Google Scholar
  68. 68.
    Lash LH, Parker JC, Scott CS. Modes of action of trichloroethylene for kidney tumorigenesis. Environ Health Perspect. 2000;108 Suppl 2:225–40.PubMedCentralPubMedGoogle Scholar
  69. 69.
    Rudén C. Science and transscience in carcinogen risk assessment – the European Union regulatory process for trichloroethylene. J Toxicol Environ Health B Crit Rev. 2003;6(3):257–77.PubMedGoogle Scholar
  70. 70.
    Brüning T, Bolt HM. Renal toxicity and carcinogenicity of trichloroethylene: key results, mechanisms, and controversies. Crit Rev Toxicol. 2000;30(3):253–85.PubMedGoogle Scholar
  71. 71.
    Nakagawa Y, Kitahori Y, Cho M, et al. Effect of hexachloro-1,3-butadiene on renal carcinogenesis in male rats pretreated with N-ethyl-N-hydroxyethyl-nitrosamine. Toxicol Pathol. 1998;26:361–6.PubMedGoogle Scholar
  72. 72.
    Kelsh AM, Alexander DD, Mink PJ, Mandel JH. Occupational Trichloroethylene exposure and kidney cancer. Epidemiology. 2010;21:95–102.PubMedGoogle Scholar
  73. 73.
    Wartenberg D, Reyner D, Scott CS. Trichloroethylene and cancer: epidemiologic evidence. Environ Health Perspect. 2000;108 Suppl 2:161–76.PubMedCentralPubMedGoogle Scholar
  74. 74.
    Scott CS, Jinot J. Trichloroethylene and cancer: systematic and quantitative review of epidemiologic evidence for identifying hazards. Int J Environ Res Public Health. 2011;8(11):4238–72.PubMedCentralPubMedGoogle Scholar
  75. 75.
    Karami S, Lan Q, Rothman N, Stewart PA, Lee KM, Vermeulen R, Moore LE. Occupational trichloroethylene exposure and kidney cancer risk: a meta-analysis. Occup Environ Med. 2012;69(12):858–67.PubMedGoogle Scholar
  76. 76.
    Bruning T, Lammert M, Kempkes M, Thier R, Golka K, Bolt HM. Influence of polymorphisms of GSTM1 and GSTT1 for risk of renal cell cancer in workers with long-term high occupational exposure to trichloroethylene. Arch Toxicol. 1997;71:596–9.PubMedGoogle Scholar
  77. 77.
    Wiesenhütter B, Selinski S, Golka K, Brüning T, Bolt HM. Re-assessment of the influence of polymorphisms of phase-II metabolic enzymes on renal cell cancer risk of trichloroethylene-exposed workers. Int Arch Occup Environ Health. 2007;81(2):247–51.PubMedGoogle Scholar
  78. 78.
    Fischer W, Wirkner K, Weber M, et al. Characterization of P2X3, P2Y1 and P2Y4 receptors in cultured HEK293-hP2X3 cells and their inhibition by ethanol and trichloroethanol. J Neurochem. 2003;85(3):779–90.PubMedGoogle Scholar
  79. 79.
    Waggoner JK, Kullman GJ, Henneberger PK, et al. Mortality in the agricultural health study, 1993–2007. Am J Epidemiol. 2011;173(1):71–83.PubMedCentralPubMedGoogle Scholar
  80. 80.
    Faustini A, Forastiere F, Di Betta L, Magliola EM, Perucci CA. Cohort study of mortality among farmers and agricultural workers. Med Lav. 1993;84(1):31–41.PubMedGoogle Scholar
  81. 81.
    Wiklund K, Dich J. Cancer risks among female farmers in Sweden. Cancer Causes Control. 1994;5(5):449–57.PubMedGoogle Scholar
  82. 82.
    Buzio L, Tondel M, De Palma G, et al. Occupational risk factors for renal cell cancer. An Italian case-control study. Med Lav. 2002;93(4):303–9.PubMedGoogle Scholar
  83. 83.
    McLaughlin JK, Mandel JS, Blot WJ, Schuman LM, Mehl ES, Fraumeni Jr JF. A population – based case-control study of renal cell carcinoma. J Natl Cancer Inst. 1984;72(2):275–84.PubMedGoogle Scholar
  84. 84.
    Forastiere F, Quercia A, Miceli M, et al. Cancer among farmers in central Italy. Scand J Work Environ Health. 1993;19(6):382–9.PubMedGoogle Scholar
  85. 85.
    Davis DL, Blair A, Hoel DG. Agricultural exposures and cancer trends in developed countries. Environ Health Perspect. 1993;100:39–44.PubMedCentralPubMedGoogle Scholar
  86. 86.
    McCredie M, Stewart JH. Risk factors for kidney cancer in New South Wales. IV. Occupation. Br J Ind Med. 1993;50(4):349–54.PubMedCentralPubMedGoogle Scholar
  87. 87.
    Sweeney C, Farrow DC, Schwartz SM, Eaton DL, Checkoway H, Vaughan TL. Glutathione S-transferase M1, T1, and P1 polymorphisms as risk factors for renal cell carcinoma: a case-control study. Cancer Epidemiol Biomarkers Prev. 2000;9(4):449–54.PubMedGoogle Scholar
  88. 88.
    Buzio L, De Palma G, Mozzoni P, et al. Glutathione S-transferases M1-1 and T1-1 as risk modifiers for renal cell cancer associated with occupational exposure to chemicals. Occup Environ Med. 2003;60(10):789–93.PubMedCentralPubMedGoogle Scholar
  89. 89.
    Longuemaux S, Deloménie C, Gallou C, et al. Candidate genetic modifiers of individual susceptibility to renal cell carcinoma: a study of polymorphic human xenobiotic-metabolizing enzymes. Cancer Res. 1999;59(12):2903–8.PubMedGoogle Scholar
  90. 90.
    IARC (International Agency for Research on Cancer). Occupational exposures in insecticide application, and some pesticides. IARC Working Group on the evaluation of carcinogenic risks to humans. IARC Monogr Eval Carcinog Risks Hum. 1991;53:5–586. Lyon, 16–23 October 1990.Google Scholar
  91. 91.
    IARC (International Agency for Research on Cancer). Working Group the evaluation of carcinogenic risks to humans. Inorganic and organic lead compounds. IARC Monogr Eval Carcinog Risks Hum. 2006;87:1–471.Google Scholar
  92. 92.
    National Toxicology Program. Lead and lead compounds. http://ntp.niehs.nih.gov/ntp/newhomeroc/roc11/Lead-Public.pdf. Accessed 7 Dec 2011.
  93. 93.
    Steenland K, Boffetta P. Lead and cancer in humans: where are we now? Am J Ind Med. 2000;38(3):295–9.PubMedGoogle Scholar
  94. 94.
    Centers for Disease Control and Prevention. Morbidity and mortality weekly report. Adult blood lead epidemiology and surveillance – United States, 2005–2007. http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5814a3.htm. Accessed 7 Dec 2011.
  95. 95.
    Fowler BA. Mechanisms of kidney cell injury from metals. Environ Health Perspect. 1993;100:57–63.PubMedCentralPubMedGoogle Scholar
  96. 96.
    Boffetta P, Fontana L, Stewart P, et al. Occupational exposure to arsenic, cadmium, chromium, lead and nickel, and renal cell carcinoma: a case-control study from Central and Eastern Europe. Occup Environ Med. 2011;68(10):723–8.PubMedGoogle Scholar
  97. 97.
    Simonato L, Fletcher AC, Andersen A, et al. A historical prospective study of European stainless steel, mild steel, and shipyard welders. Br J Ind Med. 1991;48(3):145–54.PubMedCentralPubMedGoogle Scholar
  98. 98.
    Steenland K, Selevan S, Landrigan P. The mortality of lead smelter workers: an update. Am J Public Health. 1992;82(12):1641–4.PubMedCentralPubMedGoogle Scholar
  99. 99.
    Selevan SG, Landrigan PJ, Stern FB, Jones JH. Mortality of lead smelter workers. Am J Epidemiol. 1985;122(4):673–83.PubMedGoogle Scholar
  100. 100.
    Cocco P, Hua F, Boffetta P, et al. Mortality of Italian lead smelter workers. Scand J Work Environ Health. 1997;23(1):15–23.PubMedGoogle Scholar
  101. 101.
    Cooper WC, Wong O, Kheifets L. Mortality among employees of lead battery plants and lead-producing plants, 1947–1980. Scand J Work Environ Health. 1985;11(5):331–45.PubMedGoogle Scholar
  102. 102.
    Lundström NG, Nordberg G, Englyst V, et al. Cumulative lead exposure in relation to mortality and lung cancer morbidity in a cohort of primary smelter workers. Scand J Work Environ Health. 1997;23(1):24–30.PubMedGoogle Scholar
  103. 103.
    Sankila R, Kajalainen S, Pukkala E, et al. Cancer risk among glass factory workers: an excess of lung cancer? Br J Ind Med. 1990;47:815–8.PubMedCentralPubMedGoogle Scholar
  104. 104.
    Partanen T, Heikkilä P, Hernberg S, Kauppinen T, Moneta G, Ojajärvi A. Renal cell cancer and occupational exposure to chemical agents. Scand J Work Environ Health. 1991;17(4):231–9.PubMedGoogle Scholar
  105. 105.
    van Bemmel DM, Boffetta P, Liao LM, et al. Comprehensive analysis of 5-aminolevulinic acid dehydrogenase (ALAD) variants and renal cell carcinoma risk among individuals exposed to lead. PLoS One. 2011;6(7):e20432.PubMedCentralPubMedGoogle Scholar
  106. 106.
    Bhatti P, Stewart PA, Linet MS, Blair A, Inskip PD, Rajaraman P. Comparison of occupational exposure assessment methods in a case-control study of lead, genetic susceptibility and risk of adult brain tumours. Occup Environ Med. 2011;68(1):4–9.PubMedGoogle Scholar
  107. 107.
    Rajaraman P, Stewart PA, Samet JM, et al. Lead, genetic susceptibility, and risk of adult brain tumors. Cancer Epidemiol Biomarkers Prev. 2006;15(12):2514–20.PubMedGoogle Scholar
  108. 108.
    Onalaja AO, Claudio L. Genetic susceptibility to lead poisoning. Environ Health Perspect. 2000;108 Suppl 1:23–8.PubMedCentralPubMedGoogle Scholar
  109. 109.
    Wetmur JG, Kaya AH, Plewinska M, Desnick RJ. Molecular characterization of the human delta-aminolevulinate dehydratase 2 (ALAD2) allele: implications for molecular screening of individuals for genetic susceptibility to lead poisoning. Am J Hum Genet. 1991;49:757–63.PubMedCentralPubMedGoogle Scholar
  110. 110.
    IARC (International Agency for Research on Cancer). Agents classified by the IARC monographs, vols. 1–102. http://monographs.iarc.fr/ENG/Classification/index.php. Accessed 7 Dec 2011.
  111. 111.
    Armstrong BG, Kazantzis G. Prostatic cancer and chronic respiratory and renal disease in British cadmium workers: a case control study. Br J Ind Med. 1985;42(8):540–5.PubMedCentralPubMedGoogle Scholar
  112. 112.
    Il’yasova D, Schwartz GG. Cadmium and renal cancer. Toxicol Appl Pharmacol. 2005;207(2):179–86.PubMedGoogle Scholar
  113. 113.
    Satarug S, Moore MR. Adverse health effects of chronic exposure to low-level cadmium in foodstuffs and cigarette smoke. Environ Health Perspect. 2004;112(1099):e103.Google Scholar
  114. 114.
    Bernard A. Renal dysfunction induced by cadmium: biomarkers of critical effects. Biometals. 2004;17(519).Google Scholar
  115. 115.
    Fishbein L. Sources, transport and alterations of metal compounds: an overview. I. Arsenic, beryllium, cadmium, chromium, and nickel. Environ Health Perspect. 1981;40:43–64.PubMedCentralPubMedGoogle Scholar
  116. 116.
    Kolonel LN. Association of cadmium with renal cancer. Cancer. 1976;37(4):1782–7.PubMedGoogle Scholar
  117. 117.
    Cole P, Rodu B. Epidemiologic studies of chrome and cancer mortality: a series of meta-analyses. Regul Toxicol Pharmacol. 2005;43(225):e31.Google Scholar
  118. 118.
    Arena VC, Sussman NB, Redmond CK, Costantino JP, Trauth JM. Using alternative comparison populations to assess occupation-related mortality risk. Results for the high nickel alloys workers cohort. J Occup Environ Med. 1998;40(10):907–16.PubMedGoogle Scholar
  119. 119.
    Gerin M, Siemiatycki J, Richardson L, Pellerin J, Lakhani R, Dewar R. Nickel and cancer associations from a multicancer occupation exposure case-referent study: preliminary findings. IARC Sci Publ. 1984;53:105–15.PubMedGoogle Scholar
  120. 120.
    IARC (International Agency for Research on Cancer). Chromium, nickel and welding. IARC Monogr Eval Carcinog Risks Hum. 1990;49:1–648.Google Scholar
  121. 121.
    National Research Council: Subcommittee to Update the 1999 Arsenic in Drinking Water Report. Arsenic in drinking water: 2001 update. Washington, DC: National Academy Press; 2001.Google Scholar
  122. 122.
    Enterline PE, Day R, Marsh GM. Cancers related to exposure to arsenic at a copper smelter. Occup Environ Med. 1995;52(1):28–32.PubMedCentralPubMedGoogle Scholar
  123. 123.
    Macfarland HN, Ulrich CE, Holdsworth CE, Kitchen DN, Halliwell NH, Blum SC. A chronic inhalation study with unleaded gasoline. J Am CON Toxicol. 1984;3:23l–48.Google Scholar
  124. 124.
    McLaughlin JK, Blot WJ, Mehl ES, Stewart PA, Venable FS, Fraumeni Jr JF. Petroleum-related employment and renal cell cancer. J Occup Med. 1985;27(9):672–4.PubMedGoogle Scholar
  125. 125.
    Lynge E, Andersen A, Nilsson R, et al. Risk of cancer and exposure to gasoline vapors. Am J Epidemiol. 1997;145(5):449–58.PubMedGoogle Scholar
  126. 126.
    Schnatter AR, Katz AM, Nicolich MJ, Thériault G. A retrospective mortality study among Canadian petroleum marketing and distribution workers. Environ Health Perspect. 1993;101 Suppl 6:85–99.PubMedCentralPubMedGoogle Scholar
  127. 127.
    Soll-Johanning H, Bach E, Olsen JH, Tuchsen F. Cancer incidence in urban bus drivers and tramway employees: a retrospective cohort study. Occup Environ Med. 1998;55(9):594–8.PubMedCentralPubMedGoogle Scholar
  128. 128.
    Boffetta P, Dosemeci M, Gridley G, Bath H, Moradi T, Silverman D. Occupational exposure to diesel engine emissions and risk of cancer in Swedish men and women. Cancer Causes Control. 2001;12(4):365–74.PubMedGoogle Scholar
  129. 129.
    IARC (International Agency for Research on Cancer). IARC monographs on the evaluation of carcinogenic risks to humans. Diesel and gasoline engine exhausts and some nitroarenes. IARC Monogr Eval Carcinog Risks Hum. 1989;46:1–458.Google Scholar
  130. 130.
    Guo J, Kauppinen T, Kyyrönen P, Heikkilä P, Lindbohm ML, Pukkala E. Risk of esophageal, ovarian, testicular, kidney and bladder cancers and leukemia among Finnish workers exposed to diesel or gasoline engine exhaust. Int J Cancer. 2004;111(2):286–92.PubMedGoogle Scholar
  131. 131.
    Schenker MB, Smith T, Muñoz A, Woskie S, Speizer FE. Diesel exposure and mortality among railway workers: results of a pilot study. Br J Ind Med. 1984;41(3):320–7.PubMedCentralPubMedGoogle Scholar
  132. 132.
    Howe GR, Fraser D, Lindsay J, Presnal B, Yu SZ. Cancer mortality (1965–77) in relation to diesel fume and coal exposure in a cohort of retired railway workers. J Natl Cancer Inst. 1983;70(6):1015–9.PubMedGoogle Scholar
  133. 133.
    Siemiatycki J, Gérin M, Stewart P, Nadon L, Dewar R, Richardson L. Associations between several sites of cancer and ten types of exhaust and combustion products. Results from a case-referent study in Montreal. Scand J Work Environ Health. 1988;14(2):79–90.PubMedGoogle Scholar
  134. 134.
    Wong O, Morgan RW, Kheifets L, Larson SR, Whorton MD. Mortality among members of a heavy construction equipment operators union with potential exposure to diesel exhaust emissions. Br J Ind Med. 1985;42(7):435–48.PubMedCentralPubMedGoogle Scholar
  135. 135.
    Gustavsson P, Reuterwall C. Mortality and incidence of cancer among Swedish gas workers. Br J Ind Med. 1990;47(3):169–74.PubMedCentralPubMedGoogle Scholar
  136. 136.
    Boffetta P, Stellman SD, Garfinkel L. Diesel exhaust exposure and mortality among males in the American Cancer Society prospective study. Am J Ind Med. 1988;14(4):403–15.PubMedGoogle Scholar
  137. 137.
    Wong O, Harris F, Smith TJ. Health effects of gasoline exposure. II. Mortality patterns of distribution workers in the United States. Environ Health Perspect. 1993;101 Suppl 6:63–76.PubMedCentralPubMedGoogle Scholar
  138. 138.
    Agency for Toxic Substances and Disease Registry. Toxicological profile for polycyclic aromatic hydrocarbons. http://www.atsdr.cdc.gov/toxpro2.html. Accessed 7 Dec 2011.
  139. 139.
    Jacob J, Seidel A. Biomonitoring of polycyclic aromatic hydrocarbons in human urine. J Chromatogr B Analyt Technol Biomed Life Sci. 2002;778:31–47.PubMedGoogle Scholar
  140. 140.
    IARC (International Agency for Research on Cancer). Polynuclear aromatic compounds, part 1, chemical, environmental and experimental data. IARC Monogr Eval Carcinog Risk Chem Hum. 1983;32:1–453.Google Scholar
  141. 141.
    Redmond CK. Cancer mortality among coke oven workers. Environ Health Perspect. 1983;52:67–73.PubMedCentralPubMedGoogle Scholar
  142. 142.
    Bosetti C, Boffetta P, La Vecchia C. Occupational exposures to polycyclic aromatic hydrocarbons, and respiratory and urinary tract cancers: a quantitative review to 2005. Ann Oncol. 2007;18:431–46.PubMedGoogle Scholar
  143. 143.
    Mason TJ. Geographic patterns of cancer risk: a means for identifying possible occupational factors. Ann NY Acad Sci. 1976;271:370–6.PubMedGoogle Scholar
  144. 144.
    Karami S, Boffetta P, Brennan P, et al. Renal cancer risk and occupational exposure to polycyclic aromatic hydrocarbons and plastics. J Occup Environ Med. 2011;53(2):218–23.PubMedCentralPubMedGoogle Scholar
  145. 145.
    Butkiewicz D, Grzybowska E, Phillips DH, Hemminki K, Chorazy M. Polymorphisms of the GSTP1 and GSTM1 genes and PAH-DNA adducts in human mononuclear white blood cells. Environ Mol Mutagen. 2000;35(2):99–105.PubMedGoogle Scholar
  146. 146.
    Falahatpisheh M, Kerzee J, Metz R, Donnelly K, Ramos K. Inducible cytochrome P450 activities in renal glomerular mesangial cells: biochemical basis for antagonistic interactions among nephrocarcinogenic polycyclic aromatic hydrocarbons. J Carcinog. 2004;3(1):12.PubMedCentralPubMedGoogle Scholar
  147. 147.
    Smith AH, Shearn VI, Wood R. Asbestos and kidney cancer: the evidence supports a causal association. Am J Ind Med. 1989;16(2):159–66.PubMedGoogle Scholar
  148. 148.
    Patel-Mandlik KJ. Asbestos fibers in normal and cancerous human kidneys. Arch Environ Contam Toxicol. 1981;10(1):47–54.PubMedGoogle Scholar
  149. 149.
    Huang J, Hisanaga N, Sakai K, et al. Asbestos fibers in human pulmonary and extrapulmonary tissues. Am J Ind Med. 1988;14(3):331–9.PubMedGoogle Scholar
  150. 150.
    Selikoff IJ, Lilis R, Nicholson WJ. Asbestos disease in United States shipyards. Ann N Y Acad Sci. 1979;330:295–311.PubMedGoogle Scholar
  151. 151.
    Maclure M. Asbestos and renal adenocarcinoma: a case-control study. Environ Res. 1987;42(2):353–61.PubMedGoogle Scholar
  152. 152.
    Enterline PE, Hartley J, Henderson V. Asbestos and cancer: a cohort followed up to death. Br J Ind Med. 1987;44(6):396–401.PubMedCentralPubMedGoogle Scholar
  153. 153.
    Saarni H, Pentti J, Pukkala E. Cancer at sea: a case-control study among male Finnish seafarers. Occup Environ Med. 2002;59(9):613–9.PubMedCentralPubMedGoogle Scholar
  154. 154.
    Sali D, Boffetta P. Kidney cancer and occupational exposure to asbestos: a meta-analysis of occupational cohort studies. Cancer Causes Control. 2000;11(1):37–47.PubMedGoogle Scholar
  155. 155.
    Goodman M, Morgan RW, Ray R, Malloy CD, Zhao K. Cancer in asbestos-exposed occupational cohorts: a meta-analysis. Cancer Causes Control. 1999;10(5):453–65.PubMedGoogle Scholar
  156. 156.
    Selikoff IJ, Seidman H. Asbestos-associated deaths among insulation workers in the United States and Canada, 1967–1987. Ann N Y Acad Sci. 1991;643:1–14.PubMedGoogle Scholar
  157. 157.
    Karami S, Boffetta P, Stewart PS, et al. Occupational exposure to dusts and risk of renal cell carcinoma. Br J Cancer. 2011;104(11):1797–803.PubMedCentralPubMedGoogle Scholar
  158. 158.
    Shannon H, Muir A, Haines T, Verma D. Mortality and cancer incidence in Ontario glass fiber workers. Occup Med (Lond). 2005;55(7):528–34.Google Scholar
  159. 159.
    Stone RA, Youk AO, Marsh GM, Buchanich JM, Smith TJ. Historical cohort study of U.S. man-made vitreous fiber production workers IX: summary of 1992 mortality follow up and analysis of respiratory system cancer among female workers. J Occup Environ Med. 2004;46(1):55–67.PubMedGoogle Scholar
  160. 160.
    Marsh GM, Enterline PE, Stone RA, Henderson VL. Mortality among a cohort of US man-made mineral fiber workers: 1985 follow-up. J Occup Med. 1990;32(7):594–604.PubMedGoogle Scholar
  161. 161.
    Olsen JH, Jensen OM. Cancer incidence among employees in one mineral wool production plant in Denmark. Scand J Work Environ Health. 1984;10(1):17–24.PubMedGoogle Scholar
  162. 162.
    Siemiatycki J, Richardson L, Gérin M, et al. Associations between several sites of cancer and nine organic dusts: results from an hypothesis-generating case-control study in Montreal, 1979–1983. Am J Epidemiol. 1986;123(2):235–49.PubMedGoogle Scholar
  163. 163.
    Robinson C, Stern F, Halperin W, et al. Assessment of mortality in the construction industry in the United States, 1984–1986. Am J Ind Med. 1995;28(1):49–70.PubMedGoogle Scholar
  164. 164.
    Burnett CA, Dosemeci M. Using occupational mortality data for surveillance of work-related diseases of women. J Occup Med. 1994;36(11):1199–203.PubMedGoogle Scholar
  165. 165.
    IARC (International Agency for Research on Cancer). IARC monographs on the evaluation of carcinogenic risks to humans. Silica, some silicates, coal dust and para-aramid fibrils. IARC Monogr Eval Carcinog Risk Chem Hum. 1997;68:1–475.Google Scholar
  166. 166.
    Steenland K. One agent, many diseases: exposure-response data and comparative risks of different outcomes following silica exposure. Am J Ind Med. 2005;48(1):16–23.PubMedGoogle Scholar
  167. 167.
    Cooper WC, Wong O, Trent LS, Harris F. An updated study of taconite miners and millers exposed to silica and non-asbestiform amphiboles. J Occup Med. 1992;34(12):1173–80.PubMedGoogle Scholar
  168. 168.
    Hobbesland A, Kjuus H, Thelle DS. Study of cancer incidence among 8530 male workers in eight Norwegian plants producing ferrosilicon and silicon metal. Occup Environ Med. 1999;56(9):625–31.PubMedCentralPubMedGoogle Scholar
  169. 169.
    Attfield MD, Costello J. Quantitative exposure-response for silica dust and lung cancer in Vermont granite workers. Am J Ind Med. 2004;45(2):129–38.PubMedGoogle Scholar
  170. 170.
    Kolev K, Doitschinov D, Todorov D. Morphologic alterations in the kidneys by silicosis. Med Lav. 1970;61(4):205–10.PubMedGoogle Scholar
  171. 171.
    BL M ć, Arambasić MD. Experimental chronic interstitial nephritis compared with endemic human nephropathy. J Pathol. 1971;103(1):35–40.Google Scholar
  172. 172.
    EL-Safty IA, Gadallah M, Shouman AE, Nessim DE. Subclinical nephrotoxicity caused by smoking and occupational silica exposure among Egyptian industrial workers. Arch Med Res. 2003;34(5):415–21.PubMedGoogle Scholar
  173. 173.
    Boscoe FP, Schymura MJ. Solar ultraviolet-B exposure and cancer incidence and mortality in the United States, 1993–2002. BMC Cancer. 2006;6:264.PubMedCentralPubMedGoogle Scholar
  174. 174.
    Grant WB. The effect of solar UVB doses and vitamin D production, skin cancer action spectra, and smoking in explaining links between skin cancers and solid tumours. Eur J Cancer. 2008;44:12–5.PubMedGoogle Scholar
  175. 175.
    Grant WB, Garland CF. Evidence supporting the role of vitamin D in reducing the risk of cancer. J Intern Med. 2002;252:178–9.PubMedGoogle Scholar
  176. 176.
    Grant WB. An estimate of premature cancer mortality in the U.S. due to inadequate doses of solar ultraviolet-B radiation. Cancer. 2002;94:1867–75.PubMedGoogle Scholar
  177. 177.
    Mohr SB, Gorham ED, Garland CF, Grant WB, Garland FC. Are low ultraviolet B and high animal protein intake associated with risk of renal cancer? Int J Cancer. 2006;119:2705–9.PubMedGoogle Scholar
  178. 178.
    Rafnsson V, Gunnarsdóttir H. Mortality among Icelandic seamen. Int J Epidemiol. 1994;23(4):730–6.PubMedGoogle Scholar
  179. 179.
    Hakansson N, Floderus B, Gustavsson P, Feychting M, Hallin N. Occupational sunlight exposure and cancer incidence among Swedish construction workers. Epidemiology. 2001;12:552–7.PubMedGoogle Scholar
  180. 180.
    Karami S, Boffetta P, Stewart P, et al. Occupational sunlight exposure and risk of renal cell carcinoma. Cancer. 2010;116(8):2001–10.PubMedCentralPubMedGoogle Scholar
  181. 181.
    Calvo MS, Whiting SJ, Barton CN. Vitamin D intake: a global perspective of current status. J Nutr. 2005;135:310–6.PubMedGoogle Scholar
  182. 182.
    John EM, Schwartz GG, Koo J, Wang W, Ingles SA. Sun exposure, vitamin D receptor gene polymorphisms, and breast cancer risk in a multiethnic population. Am J Epidemiol. 2007;166:1409–19.PubMedGoogle Scholar
  183. 183.
    Norman AW. Sunlight, season, skin pigmentation, vitamin D, and 25-hydroxyvitamin D: integral components of the vitamin D endocrine system. Am J Clin Nutr. 1998;67:1108–10.PubMedGoogle Scholar
  184. 184.
    Matsuoka LY, Wortsman J, Haddad JG, Kolm P, Hollis BW. Racial pigmentation and the cutaneous synthesis of vitamin D. Arch Dermatol. 1991;127:536–8.PubMedGoogle Scholar
  185. 185.
    Deeb KK, Trump DL, Johnson CS. Vitamin D signaling pathways in cancer: potential for anticancer therapeutics. Nat Rev Cancer. 2007;7:684–700.PubMedGoogle Scholar
  186. 186.
    Ordonez-Moran P, Larriba MJ, Pendas-Franco N, Aguilera O, Gonzalez-Sancho JM, Munoz A. Vitamin D and cancer: an update of in vitro and in vivo data. Front Biosci. 2005;10:2723–49.PubMedGoogle Scholar
  187. 187.
    Trump DL, Hershberger PA, Bernardi RJ, et al. Anti-tumor activity of calcitriol: pre-clinical and clinical studies. J Steroid Biochem Mol Biol. 2004;89–90:519–26.PubMedGoogle Scholar
  188. 188.
    Gallicchio L, Moore LE, Stevens VL, et al. Circulating 25-hydroxyvitamin D and risk of kidney cancer: cohort consortium vitamin D pooling project of rarer cancers. Am J Epidemiol. 2010;172(1):47–57.PubMedCentralPubMedGoogle Scholar
  189. 189.
    Zheng W, Danforth KN, Tworoger SS, et al. Circulating 25-hydroxyvitamin D and risk of epithelial ovarian cancer: cohort consortium vitamin D pooling project of rarer cancers. Am J Epidemiol. 2010;172(1):70–80.PubMedCentralPubMedGoogle Scholar
  190. 190.
    Zeleniuch-Jacquotte A, Gallicchio L, Hartmuller V, et al. Circulating 25-hydroxyvitamin D and risk of endometrial cancer: cohort consortium vitamin D pooling project of rarer cancers. Am J Epidemiol. 2010;172(1):36–46.PubMedCentralPubMedGoogle Scholar
  191. 191.
    Abnet CC, Chen Y, Chow WH, et al. Circulating 25-hydroxyvitamin D and risk of esophageal and gastric cancer: cohort consortium vitamin D pooling project of rarer cancers. Am J Epidemiol. 2010;172(1):94–106.PubMedCentralPubMedGoogle Scholar
  192. 192.
    Holick MF, Vitamin D. Status: measurement, interpretation, and clinical application. Ann Epidemiol. 2009;19(2):73–8.PubMedCentralPubMedGoogle Scholar

Copyright information

© Springer-Verlag London 2014

Authors and Affiliations

  • Lee E. Moore
    • 1
  • Patricia A. Stewart
    • 2
  • Sara Karami
    • 3
  1. 1.Division of Cancer Epidemiology and GeneticsNational Cancer Institute, National Institutes of HealthRockvilleUSA
  2. 2.Stewart Exposure Assessments, LLCArlingtonUSA
  3. 3.Division of Cancer Epidemiology and GeneticsNational Cancer InstituteRockvilleUSA

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