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Lung Cancer: Mechanisms of Carcinogenesis

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Occupational Cancers

Abstract

Inhaled carcinogenic chemicals, mineral fibers and particulates, and carcinogenic metals are the most significant occupational causes of lung cancer. The gases, fumes, and particulates in industrial environments form complex mixtures, the carcinogenic potential of which may differ from that of each component separately. Particulate matter can absorb chemicals on its surface, which is thought to enhance the deposition of chemicals in the lung, their penetration into lung cells, and carcinogenic action. Personal or involuntary tobacco smoking complicates the exposures even further, since tobacco smoke is also a complex mixture containing carcinogenic agents in chemical and particulate forms.

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Acknowledgments

The writing of this chapter was financially supported by the Jalmari and Rauha Ahokas Foundation, Helsinki (PN), and Helsinki and Uusimaa Health Care District Research Funds (SA).

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Authors and Affiliations

  1. Jorvi Hospital Laboratory of Pathology, Helsinki University Central Hospital, Hospital District of Helsinki and Uusimaa, Laboratory Services, HUSLAB, Helsinki, Finland

    Sisko Anttila MD, PhD

  2. Health and Work Ability, Finnish Institute of Occupational Health, Helsinki, Finland

    Sisko Anttila MD, PhD

  3. New Technologies and Risks, Finnish Institute of Occupational Health, Helsinki, Finland

    Penny E. H. Nymark PhD

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  1. Sisko Anttila MD, PhD
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  2. Penny E. H. Nymark PhD
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Correspondence to Sisko Anttila MD, PhD .

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Editors and Affiliations

  1. Helsinki University Central Hospital and Finnish Institute of Occupational Health, Helsinki, Finland

    Sisko Anttila

  2. Icahn School of Medicine at Mount Sinai, New York, New York, USA

    Paolo Boffetta

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Anttila, S., Nymark, P.E.H. (2014). Lung Cancer: Mechanisms of Carcinogenesis. In: Anttila, S., Boffetta, P. (eds) Occupational Cancers. Springer, London. https://doi.org/10.1007/978-1-4471-2825-0_10

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