Abstract
A 25-year-old woman is referred by her primary care provider with headache, arthralgia and sweating. Systematic history and clinical examination suggest growth hormone excess – acromegaly. The diagnosis is confirmed on biochemical testing. This chapter discusses the appropriate investigation and management of patients with acromegaly, with particular emphasis on recent advances in clinical care and insights provided by contemporary research.
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Besser GM. Comprehensive clinical endocrinology. London: Mosby; 2002.
Feenstra J, de Herder WW, ten Have SM, van den Beld AW, Feelders RA, Janssen JA, et al. Combined therapy with somatostatin analogues and weekly pegvisomant in active acromegaly. Lancet. 2005;365(9471):1644–6.
Giustina A, Chanson P, Bronstein MD, Klibanski A, Lamberts S, Casanueva FF, et al. A consensus on criteria for cure of acromegaly. J Clin Endocrinol Metab. 2010;95(7):3141–8.
Kamenicky P, Blanchard A, Gauci C, Salenave S, Letierce A, Lombès M, et al. Pathophysiology of renal calcium handling in acromegaly: what lies behind hypercalciuria? J Clin Endocrinol Metab. 2012;97(6):2124–33.
Korbonits M, Storr H, Kumar AV. Familial pituitary adenomas – who should be tested for AIP mutations? Clin Endocrinol (Oxf). 2012;77(3):351–6.
Melmed S, Colao A, Barkan A, Molitch M, Grossman AB, Kleinberg D, et al. Guidelines for acromegaly management: an update. J Clin Endocrinol Metab. 2009;94(5):1509–17.
Trainer PJ, Drake WM, Katznelson L, Freda PU, Herman-Bonert V, van der Lely AJ, et al. Treatment of acromegaly with growth hormone-receptor antagonist pegvisomant. N Engl J Med. 2000;342(16):1171–7.
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Glynn, N.G.L., Korbonits, M. (2015). A 25-Year-Old Woman with Headache and Joint Pain. In: Ajjan, R., Orme, S. (eds) Endocrinology and Diabetes. Springer, London. https://doi.org/10.1007/978-1-4471-2789-5_8
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DOI: https://doi.org/10.1007/978-1-4471-2789-5_8
Publisher Name: Springer, London
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