Determinants of the 25-Hydroxyvitamin D Response to Vitamin D Supplements

  • Bess Dawson-HughesEmail author


Supplemental vitamin D is now widely recommended, but little guidance is provided on how or when to take vitamin D supplements. The process of vitamin D replacement is complicated by the fact that the increment in 25-hydroxyvitamin D (25OHD) in response to a given dose varies greatly from person to person. This chapter will examine the factors associated with the 25OHD response to supplementation with vitamin D, including genetic determinants, the starting 25OHD level, body mass index, and gastric acid production. It will also consider the effects of a meal and of meal composition with respect to cholesterol and phytosterol intake and the amount and type of dietary fat on the 25OHD response to supplementation.


25-Hydroxyvitamin D Vitamin D absorption Genetics Dietary fat MUFA PUFA 


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Copyright information

© Springer-Verlag London 2013

Authors and Affiliations

  1. 1.Jean Mayer USDA Human Nutrition Research Center on AgingTufts UniversityBostonUSA

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