Abstract
Prostate Specific Antigen (PSA), also known as kallikrein 3 (KLK3), is a 34kD glycoprotein, encoded by the KLK3 gene on chromosome 19q13. It is a peptidase secreted into the semen by the epithelial cells of the prostate gland. PSA is also secreted in other body fluids including the female ejaculate, where PSA levels are similar to those found in semen; as well as amniotic fluid, breast milk and the secretions from urethral glands. Serum PSA may also be detectable in uterine, breast and lung cancers.
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References
Schröder FH1, Hugosson J, Roobol MJ, Tammela TL, Ciatto S, Nelen V, Kwiatkowski M, Lujan M, Lilja H, Zappa M, Denis LJ, Recker F, Páez A, Määttänen L, Bangma CH, Aus G, Carlsson S, Villers A, Rebillard X, van der Kwast T, Kujala PM, Blijenberg BG, Stenman UH, Huber A, Taari K, Hakama M, Moss SM, de Koning HJ, Auvinen A. ERSPC Investigators Prostate-cancer mortality at 11 years of follow-up. N Engl J Med. 2012;366(11):981–90.
Hugosson J1, Carlsson S, Aus G, Bergdahl S, Khatami A, Lodding P, Pihl CG, Stranne J, Holmberg E, Lilja H. Mortality results from the Göteborg randomised population-based prostate-cancer screening trial. Lancet Oncol. 2010;11(8):725–32.
Lilja H, Ulmert D, Björk T, Becker C, Serio AM, Nilsson JA, Abrahamsson PA, Vickers AJ, Berglund G. Long-term prediction of prostate cancer up to 25 years before diagnosis of prostate cancer using prostate kallikreins measured at age 44 to 50 years. J Clin Oncol. 2007;25(4):431–6.
Ulmert D1, Cronin AM, Björk T, O’Brien MF, Scardino PT, Eastham JA, Becker C, Berglund G, Vickers AJ, Lilja H. Prostate-specific antigen at or before age 50 as a predictor of advanced prostate cancer diagnosed up to 25 years later: a case-control study. BMC Med. 2008;6:6.
Vickers AJ, Cronin AM, Björk T, Manjer J, Nilsson PM, Dahlin A, Bjartell A, Scardino PT, Ulmert D, Lilja H. Prostate specific antigen concentration at age 60 and death or metastasis from prostate cancer: case-control study. BMJ. 2010;341.
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© 2014 Springer-Verlag London
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Bott, S.R.J., Naranji, I. (2014). Prostate Specific Antigen (PSA). In: Challacombe, B., Bott, S. (eds) Diagnostic Techniques in Urology. Springer, London. https://doi.org/10.1007/978-1-4471-2766-6_1
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DOI: https://doi.org/10.1007/978-1-4471-2766-6_1
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