Gonadal Hormones, Diseases, and Emerging Therapeutics

  • Faryal S. Mirza
  • Liam Zakko
  • Pamela Taxel
Part of the Topics in Bone Biology book series (TBB, volume 7)


Gonadal steroids play a critical role in bone metabolism throughout life. Not only are they essential for normal bone mass accrual and development during adolescence, but they also are critical in the maintenance of bone health through adult and senior life. In this chapter, discussion of normal gonadal hormone synthesis will be reviewed, and commonly encountered disease states and therapies will be considered for both men and women. We will initiate the discussion with disorders that occur at the level of the target organs, the testes and ovaries, and then consider defects of the pituitary and hypothalamus. Discussion will focus on common disorders of primary and secondary hypogonadism in men and women, including their diagnosis and therapeutic strategies for treatment of these diseases.

Key words

Gonadal hormones Androgens Hypogonadism Testosterone Estrogen Klinefelter syndrome 


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Copyright information

© Springer-Verlag London 2012

Authors and Affiliations

  1. 1.Division of Endocrinology and Metabolism, Department of MedicineUniversity of Connecticut Health CenterFarmingtonUSA
  2. 2.Yale Department of MedicineYale New Haven HospitalNew HavenUSA

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