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Gonadal Hormones, Diseases, and Emerging Therapeutics

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Bone-Metabolic Functions and Modulators

Part of the book series: Topics in Bone Biology ((TBB,volume 7))

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Abstract

Gonadal steroids play a critical role in bone metabolism throughout life. Not only are they essential for normal bone mass accrual and development during adolescence, but they also are critical in the maintenance of bone health through adult and senior life. In this chapter, discussion of normal gonadal hormone synthesis will be reviewed, and commonly encountered disease states and therapies will be considered for both men and women. We will initiate the discussion with disorders that occur at the level of the target organs, the testes and ovaries, and then consider defects of the pituitary and hypothalamus. Discussion will focus on common disorders of primary and secondary hypogonadism in men and women, including their diagnosis and therapeutic strategies for treatment of these diseases.

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Authors and Affiliations

  1. Division of Endocrinology and Metabolism, Department of Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT, 06030, USA

    Faryal S. Mirza M.D. & Pamela Taxel M.D.

  2. Yale Department of Medicine, Yale New Haven Hospital, 333 Cedar St, New Haven, CT, 06520, USA

    Liam Zakko M.D.

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  1. Faryal S. Mirza M.D.
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  2. Liam Zakko M.D.
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  3. Pamela Taxel M.D.
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Correspondence to Pamela Taxel M.D. .

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Editors and Affiliations

  1. Health Center, Dept. Pharmacology, University of Connecticut, Farmington Ave. 263, Farmington, 06030-6125, Connecticut, USA

    Felix Bronner

  2. , Department of Biochemistry and Cell Biol, Rice University, 6100 Main Street, Houston, 77005, Texas, USA

    Mary C. Farach-Carson

  3. , General Hospital, University of Southampton, Southampton, SO16 6YD, United Kingdom

    Helmtrud I. Roach

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© 2012 Springer-Verlag London

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Mirza, F.S., Zakko, L., Taxel, P. (2012). Gonadal Hormones, Diseases, and Emerging Therapeutics. In: Bronner, F., Farach-Carson, M., Roach, H. (eds) Bone-Metabolic Functions and Modulators. Topics in Bone Biology, vol 7. Springer, London. https://doi.org/10.1007/978-1-4471-2745-1_3

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  • DOI: https://doi.org/10.1007/978-1-4471-2745-1_3

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