Abstract
The brain is particularly vulnerable in children with homozygous sickle cell disease (SCD), and an important aim of management is the prevention of cognitive as well as physical disability due to cerebral damage. Patients who are at risk of neurological complications are not necessarily those who experience frequent painful crises.
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Adams RJ, McKie VC, Carl EM, et al. Long-term stroke risk in children with sickle cell diseasescreened with transcranial Doppler. Ann Neurol 1997;42:699–704.
Adams RJ, McKie VC, Hsu L, et al. Prevention of a first stroke by transfusion in children with sickle cell anemia and abnormal results on transcranial Doppler ultrasonography. N Engl J Med. 1998;339:5–11.
Adams FJ, Brambilla D, STOP 2 Trial Investigators. Discontinuing prophylactic transfusions used to prevent stroke in sickle cell disease. N Engl J Med. 2005;353:2769–78.
Bernandin F, Verlhac S, Arnaud C, et al. Impact of early transcranial Doppler screening and intensive therapy on cerebral vasculopathy outcome in a newborn sickle cell anemia cohort. Blood. 2011;117(4):1130–40.
DeBaun MR, Gordon M, McKinstry RC, et al. A Randomized Trial of Transfusion for Sickle Cell Anemia and Silent Cerebral Infarcts. New Engl J Med. 2014;371: 699–710.
Ganesan V, Kirkham F. Stroke and cerebrovascular disease in childhood. ICNA series of monographs in child neurology. London, UK: MacKeith Press; 2011.
Ohene-Frempong K, Weiner SJ, Sleeper LA, et al. Cerebrovascular accidents in sickle cell disease: rates and risk factors. Blood. 1998;91:288–94.
Ware R, Helms RW, SWiTCH Investigators. Stroke With Transfusions Changing to Hydroxyurea (SWiTCH). Blood. 2012;119(17):3925–32.
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Howard, J., Telfer, P. (2015). Neurological Complications. In: Sickle Cell Disease in Clinical Practice. In Clinical Practice. Springer, London. https://doi.org/10.1007/978-1-4471-2473-3_7
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DOI: https://doi.org/10.1007/978-1-4471-2473-3_7
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