Gastroenterological Complications

  • Jo Howard
  • Paul Telfer
Part of the In Clinical Practice book series (ICP)


Gastroenterological symptoms such as abdominal pain, nausea, vomiting, jaundice, diarrhoea, constipation and weight loss are common, and can be due to complications of sickle cell disease (SCD) or other common medical conditions, some of which are more frequent in SCD. Sickle related gastroenterological complications include abdominal crises, acute hepatic sequestration, sickle hepatopathy (intra-hepatic cholestasis) and gallstone-related disease.


Sickle Cell Disease Exchange Transfusion Hepatic Sinusoid Autoimmune Liver Disease Acute Chest Syndrome 
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  1. Ahmed S, Shahid RK, Russo LA. Unusual causes of abdominal pain: sickle cell anemia. Best Pract Res Clin Gastroenterol. 2005;19(2):297–310.CrossRefPubMedGoogle Scholar
  2. Gardner K, Suddle A, Kane P, et al. How we treat sickle hepatopathy and liver transplantation in adults. Blood. 2014;123(15):2302–7.CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag London 2015

Authors and Affiliations

  • Jo Howard
    • 1
  • Paul Telfer
    • 2
  1. 1.Department of HaematologyGuy’s and St Thomas’ HospitalLondonUK
  2. 2.Department of HaematologyRoyal London HospitalLondonUK

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