Abstract
In this chapter we discuss the major complications related to the spleen. As discussed in Section 1, the circulation of blood through the spleen requires the red cells to traverse endothelial fensetrations to reach the the splenic sinusoids. Splenic circulation of HbS containing red cells is impaired and this results in splenic damage and dysfunction early in life. Here, we cover the presentation and clinical management of acute splenic sequestration and chronic splenomegaly. Prophylaxis for hyposplenia and asplenia are covered in the following chapter.
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Bibliography
Brousse V, et al. Acute splenic sequestration crisis in sickle cell disease. Br J Hematol. 2012;156:643–8.
Topley JM, et al. Acute splenic sequestration and hypersplenism in the first five years in homozygous sickle cell disease. Archives of Disease in Childhood. 1981;56:765–9.
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Howard, J., Telfer, P. (2015). The Spleen. In: Sickle Cell Disease in Clinical Practice. In Clinical Practice. Springer, London. https://doi.org/10.1007/978-1-4471-2473-3_11
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DOI: https://doi.org/10.1007/978-1-4471-2473-3_11
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